LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q8I4_LEIMA
TriTrypDb:
LmjF.28.0835 , LMJLV39_280014400 * , LMJSD75_280014400
Length:
177

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8I4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8I4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 134 136 PF00675 0.485
CLV_PCSK_KEX2_1 134 136 PF00082 0.438
CLV_PCSK_KEX2_1 14 16 PF00082 0.434
CLV_PCSK_PC1ET2_1 14 16 PF00082 0.351
CLV_PCSK_SKI1_1 139 143 PF00082 0.423
DEG_Nend_UBRbox_3 1 3 PF02207 0.529
DOC_MAPK_MEF2A_6 149 157 PF00069 0.475
DOC_USP7_MATH_1 82 86 PF00917 0.660
DOC_WW_Pin1_4 95 100 PF00397 0.667
LIG_14-3-3_CanoR_1 149 157 PF00244 0.479
LIG_14-3-3_CanoR_1 55 61 PF00244 0.591
LIG_Actin_WH2_2 25 42 PF00022 0.436
LIG_BIR_III_2 96 100 PF00653 0.666
LIG_LIR_Nem_3 29 34 PF02991 0.425
LIG_LIR_Nem_3 3 9 PF02991 0.566
LIG_RPA_C_Plants 46 57 PF08784 0.455
LIG_SH2_STAP1 117 121 PF00017 0.359
LIG_SH2_STAT3 21 24 PF00017 0.461
LIG_SH2_STAT5 6 9 PF00017 0.490
LIG_TRAF2_1 98 101 PF00917 0.518
LIG_TYR_ITIM 4 9 PF00017 0.457
MOD_CK1_1 156 162 PF00069 0.487
MOD_CK2_1 95 101 PF00069 0.540
MOD_Cter_Amidation 12 15 PF01082 0.355
MOD_GlcNHglycan 78 81 PF01048 0.648
MOD_GSK3_1 34 41 PF00069 0.415
MOD_NEK2_1 7 12 PF00069 0.511
MOD_NEK2_2 83 88 PF00069 0.679
MOD_PKA_2 148 154 PF00069 0.478
MOD_Plk_1 83 89 PF00069 0.772
MOD_ProDKin_1 95 101 PF00069 0.667
TRG_DiLeu_BaEn_2 2 8 PF01217 0.528
TRG_ENDOCYTIC_2 6 9 PF00928 0.454
TRG_Pf-PMV_PEXEL_1 26 30 PF00026 0.435

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PFQ6 Leptomonas seymouri 55% 97%
A0A3Q8IQF9 Leishmania donovani 91% 100%
A4HGC8 Leishmania braziliensis 65% 94%
A4I3G0 Leishmania infantum 91% 100%
D0A7X8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
E9AZP9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS