Tc-38 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8I3_LEIMA

TriTrypDb:

LmjF.28.0840 , LMJLV39_280014500 , LMJSD75_280014500

Length:

869

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8I3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8I3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	450	454	PF00656	0.558
CLV_C14_Caspase3-7	791	795	PF00656	0.677
CLV_NRD_NRD_1	203	205	PF00675	0.600
CLV_NRD_NRD_1	290	292	PF00675	0.511
CLV_NRD_NRD_1	593	595	PF00675	0.540
CLV_NRD_NRD_1	679	681	PF00675	0.402
CLV_NRD_NRD_1	718	720	PF00675	0.526
CLV_NRD_NRD_1	83	85	PF00675	0.362
CLV_NRD_NRD_1	841	843	PF00675	0.549
CLV_NRD_NRD_1	94	96	PF00675	0.277
CLV_PCSK_KEX2_1	290	292	PF00082	0.651
CLV_PCSK_KEX2_1	593	595	PF00082	0.540
CLV_PCSK_KEX2_1	679	681	PF00082	0.402
CLV_PCSK_KEX2_1	83	85	PF00082	0.362
CLV_PCSK_KEX2_1	841	843	PF00082	0.549
CLV_PCSK_SKI1_1	505	509	PF00082	0.526
CLV_PCSK_SKI1_1	512	516	PF00082	0.485
CLV_PCSK_SKI1_1	63	67	PF00082	0.299
CLV_PCSK_SKI1_1	732	736	PF00082	0.544
CLV_PCSK_SKI1_1	95	99	PF00082	0.401
DEG_APCC_DBOX_1	111	119	PF00400	0.250
DEG_APCC_DBOX_1	290	298	PF00400	0.392
DEG_Nend_UBRbox_1	1	4	PF02207	0.622
DEG_SCF_FBW7_1	32	37	PF00400	0.630
DEG_SPOP_SBC_1	602	606	PF00917	0.574
DOC_CDC14_PxL_1	418	426	PF14671	0.443
DOC_CYCLIN_RxL_1	502	510	PF00134	0.411
DOC_CYCLIN_yCln2_LP_2	555	561	PF00134	0.351
DOC_MAPK_gen_1	464	472	PF00069	0.451
DOC_MAPK_gen_1	693	701	PF00069	0.364
DOC_MAPK_gen_1	83	93	PF00069	0.303
DOC_MAPK_HePTP_8	337	349	PF00069	0.455
DOC_MAPK_MEF2A_6	340	349	PF00069	0.442
DOC_MAPK_MEF2A_6	805	814	PF00069	0.451
DOC_PP1_RVXF_1	503	510	PF00149	0.411
DOC_PP1_RVXF_1	537	544	PF00149	0.578
DOC_PP2B_LxvP_1	162	165	PF13499	0.607
DOC_PP4_FxxP_1	247	250	PF00568	0.511
DOC_PP4_FxxP_1	724	727	PF00568	0.493
DOC_SPAK_OSR1_1	805	809	PF12202	0.533
DOC_USP7_MATH_1	22	26	PF00917	0.617
DOC_USP7_MATH_1	226	230	PF00917	0.648
DOC_USP7_MATH_1	601	605	PF00917	0.612
DOC_USP7_MATH_1	607	611	PF00917	0.686
DOC_USP7_MATH_1	642	646	PF00917	0.518
DOC_USP7_MATH_1	651	655	PF00917	0.460
DOC_USP7_MATH_1	666	670	PF00917	0.377
DOC_USP7_MATH_1	785	789	PF00917	0.772
DOC_USP7_MATH_2	164	170	PF00917	0.508
DOC_WW_Pin1_4	160	165	PF00397	0.539
DOC_WW_Pin1_4	217	222	PF00397	0.613
DOC_WW_Pin1_4	227	232	PF00397	0.623
DOC_WW_Pin1_4	30	35	PF00397	0.628
DOC_WW_Pin1_4	603	608	PF00397	0.607
DOC_WW_Pin1_4	679	684	PF00397	0.378
DOC_WW_Pin1_4	723	728	PF00397	0.502
LIG_14-3-3_CanoR_1	112	116	PF00244	0.250
LIG_14-3-3_CanoR_1	204	211	PF00244	0.552
LIG_14-3-3_CanoR_1	285	290	PF00244	0.542
LIG_14-3-3_CanoR_1	291	295	PF00244	0.478
LIG_14-3-3_CanoR_1	344	350	PF00244	0.422
LIG_14-3-3_CanoR_1	575	579	PF00244	0.462
LIG_14-3-3_CanoR_1	614	623	PF00244	0.582
LIG_14-3-3_CanoR_1	696	702	PF00244	0.357
LIG_14-3-3_CanoR_1	706	715	PF00244	0.381
LIG_14-3-3_CanoR_1	821	825	PF00244	0.607
LIG_Actin_WH2_2	619	637	PF00022	0.380
LIG_BRCT_BRCA1_1	207	211	PF00533	0.654
LIG_CaM_IQ_9	458	473	PF13499	0.460
LIG_CaMK_CASK_1	90	95	PF00069	0.362
LIG_Clathr_ClatBox_1	514	518	PF01394	0.339
LIG_CSL_BTD_1	91	94	PF09270	0.299
LIG_deltaCOP1_diTrp_1	238	247	PF00928	0.554
LIG_deltaCOP1_diTrp_1	769	780	PF00928	0.443
LIG_deltaCOP1_diTrp_1	90	98	PF00928	0.362
LIG_EH_1	306	310	PF12763	0.415
LIG_EVH1_2	568	572	PF00568	0.436
LIG_FHA_1	128	134	PF00498	0.310
LIG_FHA_1	217	223	PF00498	0.634
LIG_FHA_1	262	268	PF00498	0.516
LIG_FHA_1	31	37	PF00498	0.630
LIG_FHA_1	318	324	PF00498	0.406
LIG_FHA_1	326	332	PF00498	0.412
LIG_FHA_1	356	362	PF00498	0.475
LIG_FHA_1	606	612	PF00498	0.620
LIG_FHA_1	64	70	PF00498	0.299
LIG_FHA_2	112	118	PF00498	0.352
LIG_FHA_2	161	167	PF00498	0.609
LIG_FHA_2	398	404	PF00498	0.396
LIG_FHA_2	448	454	PF00498	0.527
LIG_FHA_2	680	686	PF00498	0.577
LIG_FHA_2	856	862	PF00498	0.672
LIG_HCF-1_HBM_1	338	341	PF13415	0.399
LIG_HP1_1	642	646	PF01393	0.399
LIG_LIR_Apic_2	502	506	PF02991	0.403
LIG_LIR_Apic_2	723	727	PF02991	0.387
LIG_LIR_Gen_1	152	162	PF02991	0.545
LIG_LIR_Gen_1	238	247	PF02991	0.554
LIG_LIR_Gen_1	318	327	PF02991	0.442
LIG_LIR_Gen_1	343	352	PF02991	0.420
LIG_LIR_Nem_3	152	157	PF02991	0.504
LIG_LIR_Nem_3	238	244	PF02991	0.573
LIG_LIR_Nem_3	274	280	PF02991	0.468
LIG_LIR_Nem_3	318	322	PF02991	0.405
LIG_LIR_Nem_3	343	349	PF02991	0.384
LIG_LIR_Nem_3	547	552	PF02991	0.330
LIG_LIR_Nem_3	687	692	PF02991	0.471
LIG_LYPXL_yS_3	421	424	PF13949	0.427
LIG_LYPXL_yS_3	689	692	PF13949	0.391
LIG_MLH1_MIPbox_1	207	211	PF16413	0.654
LIG_MYND_1	233	237	PF01753	0.591
LIG_NRBOX	423	429	PF00104	0.447
LIG_NRBOX	861	867	PF00104	0.611
LIG_Pex14_1	621	625	PF04695	0.400
LIG_Pex14_1	677	681	PF04695	0.457
LIG_Pex14_2	19	23	PF04695	0.534
LIG_Pex14_2	617	621	PF04695	0.434
LIG_PTB_Apo_2	304	311	PF02174	0.481
LIG_PTB_Apo_2	318	325	PF02174	0.360
LIG_PTB_Apo_2	759	766	PF02174	0.452
LIG_REV1ctd_RIR_1	307	315	PF16727	0.407
LIG_REV1ctd_RIR_1	458	468	PF16727	0.470
LIG_REV1ctd_RIR_1	506	516	PF16727	0.416
LIG_SH2_CRK	319	323	PF00017	0.424
LIG_SH2_GRB2like	319	322	PF00017	0.409
LIG_SH2_NCK_1	681	685	PF00017	0.360
LIG_SH2_PTP2	108	111	PF00017	0.362
LIG_SH2_PTP2	643	646	PF00017	0.516
LIG_SH2_SRC	314	317	PF00017	0.369
LIG_SH2_SRC	431	434	PF00017	0.544
LIG_SH2_STAP1	319	323	PF00017	0.396
LIG_SH2_STAT5	108	111	PF00017	0.362
LIG_SH2_STAT5	210	213	PF00017	0.654
LIG_SH2_STAT5	319	322	PF00017	0.345
LIG_SH2_STAT5	341	344	PF00017	0.404
LIG_SH2_STAT5	372	375	PF00017	0.414
LIG_SH2_STAT5	386	389	PF00017	0.351
LIG_SH2_STAT5	484	487	PF00017	0.426
LIG_SH2_STAT5	625	628	PF00017	0.545
LIG_SH2_STAT5	643	646	PF00017	0.351
LIG_SH2_STAT5	681	684	PF00017	0.357
LIG_SH3_1	29	35	PF00018	0.547
LIG_SH3_3	29	35	PF00018	0.631
LIG_SH3_3	408	414	PF00018	0.438
LIG_SH3_3	790	796	PF00018	0.557
LIG_SH3_3	88	94	PF00018	0.299
LIG_TYR_ITIM	641	646	PF00017	0.495
LIG_UBA3_1	728	736	PF00899	0.489
MOD_CK1_1	160	166	PF00069	0.540
MOD_CK1_1	212	218	PF00069	0.658
MOD_CK1_1	229	235	PF00069	0.588
MOD_CK1_1	293	299	PF00069	0.485
MOD_CK1_1	44	50	PF00069	0.622
MOD_CK1_1	605	611	PF00069	0.604
MOD_CK1_1	815	821	PF00069	0.530
MOD_CK2_1	160	166	PF00069	0.629
MOD_CK2_1	785	791	PF00069	0.800
MOD_CK2_1	820	826	PF00069	0.572
MOD_GlcNHglycan	121	124	PF01048	0.376
MOD_GlcNHglycan	197	200	PF01048	0.699
MOD_GlcNHglycan	211	214	PF01048	0.516
MOD_GlcNHglycan	414	417	PF01048	0.483
MOD_GlcNHglycan	617	620	PF01048	0.518
MOD_GlcNHglycan	740	743	PF01048	0.626
MOD_GlcNHglycan	749	752	PF01048	0.385
MOD_GlcNHglycan	787	790	PF01048	0.808
MOD_GlcNHglycan	800	803	PF01048	0.565
MOD_GlcNHglycan	814	817	PF01048	0.396
MOD_GlcNHglycan	858	861	PF01048	0.652
MOD_GSK3_1	195	202	PF00069	0.638
MOD_GSK3_1	205	212	PF00069	0.578
MOD_GSK3_1	271	278	PF00069	0.405
MOD_GSK3_1	293	300	PF00069	0.485
MOD_GSK3_1	30	37	PF00069	0.632
MOD_GSK3_1	393	400	PF00069	0.608
MOD_GSK3_1	41	48	PF00069	0.550
MOD_GSK3_1	434	441	PF00069	0.584
MOD_GSK3_1	601	608	PF00069	0.577
MOD_GSK3_1	820	827	PF00069	0.663
MOD_GSK3_1	856	863	PF00069	0.649
MOD_N-GLC_1	205	210	PF02516	0.654
MOD_N-GLC_1	253	258	PF02516	0.503
MOD_N-GLC_1	550	555	PF02516	0.401
MOD_N-GLC_1	615	620	PF02516	0.577
MOD_N-GLC_2	585	587	PF02516	0.406
MOD_NEK2_1	118	123	PF00069	0.268
MOD_NEK2_1	157	162	PF00069	0.495
MOD_NEK2_1	253	258	PF00069	0.503
MOD_NEK2_1	345	350	PF00069	0.409
MOD_NEK2_1	355	360	PF00069	0.349
MOD_NEK2_1	36	41	PF00069	0.778
MOD_NEK2_1	380	385	PF00069	0.452
MOD_NEK2_1	485	490	PF00069	0.426
MOD_NEK2_1	507	512	PF00069	0.452
MOD_NEK2_1	550	555	PF00069	0.404
MOD_NEK2_1	627	632	PF00069	0.457
MOD_NEK2_1	740	745	PF00069	0.574
MOD_NEK2_1	746	751	PF00069	0.459
MOD_NEK2_1	774	779	PF00069	0.572
MOD_NEK2_1	798	803	PF00069	0.571
MOD_NEK2_1	820	825	PF00069	0.529
MOD_NEK2_1	833	838	PF00069	0.664
MOD_NEK2_2	24	29	PF00069	0.538
MOD_NEK2_2	393	398	PF00069	0.441
MOD_NEK2_2	666	671	PF00069	0.440
MOD_PIKK_1	182	188	PF00454	0.636
MOD_PIKK_1	199	205	PF00454	0.625
MOD_PIKK_1	22	28	PF00454	0.618
MOD_PIKK_1	550	556	PF00454	0.412
MOD_PIKK_1	740	746	PF00454	0.516
MOD_PKA_1	204	210	PF00069	0.542
MOD_PKA_1	290	296	PF00069	0.510
MOD_PKA_2	111	117	PF00069	0.250
MOD_PKA_2	12	18	PF00069	0.621
MOD_PKA_2	199	205	PF00069	0.625
MOD_PKA_2	290	296	PF00069	0.489
MOD_PKA_2	574	580	PF00069	0.502
MOD_PKA_2	785	791	PF00069	0.632
MOD_PKA_2	820	826	PF00069	0.660
MOD_PKB_1	283	291	PF00069	0.476
MOD_Plk_1	116	122	PF00069	0.299
MOD_Plk_1	380	386	PF00069	0.447
MOD_Plk_1	447	453	PF00069	0.541
MOD_Plk_1	550	556	PF00069	0.398
MOD_Plk_1	666	672	PF00069	0.446
MOD_Plk_1	860	866	PF00069	0.647
MOD_Plk_2-3	438	444	PF00069	0.561
MOD_Plk_2-3	835	841	PF00069	0.632
MOD_Plk_4	253	259	PF00069	0.479
MOD_Plk_4	290	296	PF00069	0.510
MOD_Plk_4	356	362	PF00069	0.481
MOD_Plk_4	393	399	PF00069	0.435
MOD_Plk_4	815	821	PF00069	0.530
MOD_ProDKin_1	160	166	PF00069	0.544
MOD_ProDKin_1	217	223	PF00069	0.615
MOD_ProDKin_1	227	233	PF00069	0.624
MOD_ProDKin_1	30	36	PF00069	0.631
MOD_ProDKin_1	603	609	PF00069	0.609
MOD_ProDKin_1	679	685	PF00069	0.377
MOD_ProDKin_1	723	729	PF00069	0.495
MOD_SUMO_rev_2	429	437	PF00179	0.562
TRG_DiLeu_BaEn_2	686	692	PF01217	0.476
TRG_DiLeu_BaLyEn_6	218	223	PF01217	0.609
TRG_DiLeu_BaLyEn_6	419	424	PF01217	0.417
TRG_DiLeu_BaLyEn_6	724	729	PF01217	0.490
TRG_DiLeu_BaLyEn_6	742	747	PF01217	0.389
TRG_DiLeu_BaLyEn_6	793	798	PF01217	0.591
TRG_DiLeu_BaLyEn_6	861	866	PF01217	0.555
TRG_ENDOCYTIC_2	306	309	PF00928	0.455
TRG_ENDOCYTIC_2	319	322	PF00928	0.380
TRG_ENDOCYTIC_2	421	424	PF00928	0.427
TRG_ENDOCYTIC_2	643	646	PF00928	0.516
TRG_ENDOCYTIC_2	681	684	PF00928	0.357
TRG_ENDOCYTIC_2	689	692	PF00928	0.391
TRG_ER_diArg_1	289	291	PF00400	0.536
TRG_ER_diArg_1	332	335	PF00400	0.403
TRG_ER_diArg_1	519	522	PF00400	0.364
TRG_ER_diArg_1	632	635	PF00400	0.435
TRG_ER_diArg_1	678	680	PF00400	0.402
TRG_ER_FFAT_2	207	215	PF00635	0.572
TRG_NES_CRM1_1	659	672	PF08389	0.326
TRG_Pf-PMV_PEXEL_1	426	430	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	693	697	PF00026	0.386
TRG_Pf-PMV_PEXEL_1	864	869	PF00026	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7T3	Leptomonas seymouri	47%	100%
A0A3S7X1B1	Leishmania donovani	90%	100%
A4I3G1	Leishmania infantum	90%	100%
E9AZQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%