DNA replication licensing factor MCM2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA replication licensing factor MCM2, putative

Species:

Leishmania major

UniProt:

Q4Q8I2_LEIMA

TriTrypDb:

LmjF.28.0850 , LMJLV39_280014600 , LMJSD75_280014600

Length:

969

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0032991	protein-containing complex	1	12
GO:0042555	MCM complex	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

Q4Q8I2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8I2

Function

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Biological processes
Term	Name	Level	Count
GO:0000724	double-strand break repair via homologous recombination	7	2
GO:0000725	recombinational repair	6	2
GO:0000727	double-strand break repair via break-induced replication	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006268	DNA unwinding involved in DNA replication	9	12
GO:0006270	DNA replication initiation	5	12
GO:0006281	DNA repair	5	2
GO:0006302	double-strand break repair	6	2
GO:0006310	DNA recombination	5	2

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003678	DNA helicase activity	3	12
GO:0003697	single-stranded DNA binding	5	2
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008094	ATP-dependent activity, acting on DNA	2	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	20	24	PF00656	0.785
CLV_C14_Caspase3-7	767	771	PF00656	0.686
CLV_NRD_NRD_1	11	13	PF00675	0.675
CLV_NRD_NRD_1	112	114	PF00675	0.266
CLV_NRD_NRD_1	123	125	PF00675	0.224
CLV_NRD_NRD_1	15	17	PF00675	0.674
CLV_NRD_NRD_1	213	215	PF00675	0.406
CLV_NRD_NRD_1	295	297	PF00675	0.275
CLV_NRD_NRD_1	31	33	PF00675	0.638
CLV_NRD_NRD_1	335	337	PF00675	0.247

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P860	Leptomonas seymouri	87%	98%
A0A0N1I383	Leptomonas seymouri	32%	95%
A0A0S4IK09	Bodo saltans	64%	98%
A0A1X0NZT6	Trypanosomatidae	75%	100%
A0A3Q8IAX4	Leishmania donovani	98%	100%
A0A3R7K9K0	Trypanosoma rangeli	31%	100%
A0A3R7NBN0	Trypanosoma rangeli	76%	100%
A0A3S7WY81	Leishmania donovani	30%	100%
A0A3S7X726	Leishmania donovani	32%	100%
A0A422NDD9	Trypanosoma rangeli	29%	100%

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