Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

Q4Q8I1_LEIMA

TriTrypDb:

LmjF.28.0860 , LMJLV39_280014700 , LMJSD75_280014700

Length:

504

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 2
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8I1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8I1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	277	281	PF00656	0.553
CLV_C14_Caspase3-7	368	372	PF00656	0.600
CLV_NRD_NRD_1	11	13	PF00675	0.482
CLV_PCSK_KEX2_1	11	13	PF00082	0.482
CLV_PCSK_KEX2_1	366	368	PF00082	0.758
CLV_PCSK_KEX2_1	395	397	PF00082	0.727
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.758
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.727
CLV_PCSK_SKI1_1	104	108	PF00082	0.736
CLV_PCSK_SKI1_1	11	15	PF00082	0.574
CLV_PCSK_SKI1_1	154	158	PF00082	0.751
CLV_PCSK_SKI1_1	269	273	PF00082	0.682
CLV_PCSK_SKI1_1	343	347	PF00082	0.762
CLV_PCSK_SKI1_1	396	400	PF00082	0.599
DEG_APCC_DBOX_1	385	393	PF00400	0.604
DEG_SPOP_SBC_1	231	235	PF00917	0.772
DEG_SPOP_SBC_1	288	292	PF00917	0.815
DOC_CKS1_1	16	21	PF01111	0.471
DOC_CYCLIN_RxL_1	7	18	PF00134	0.475
DOC_CYCLIN_yCln2_LP_2	16	22	PF00134	0.518
DOC_CYCLIN_yCln2_LP_2	346	352	PF00134	0.835
DOC_MAPK_DCC_7	343	352	PF00069	0.603
DOC_MAPK_gen_1	11	17	PF00069	0.478
DOC_PP2B_LxvP_1	195	198	PF13499	0.808
DOC_PP2B_LxvP_1	346	349	PF13499	0.836
DOC_USP7_MATH_1	230	234	PF00917	0.765
DOC_USP7_MATH_1	245	249	PF00917	0.607
DOC_USP7_MATH_1	276	280	PF00917	0.786
DOC_USP7_MATH_1	288	292	PF00917	0.562
DOC_USP7_MATH_1	357	361	PF00917	0.674
DOC_USP7_MATH_1	428	432	PF00917	0.604
DOC_USP7_MATH_1	96	100	PF00917	0.756
DOC_WW_Pin1_4	123	128	PF00397	0.729
DOC_WW_Pin1_4	15	20	PF00397	0.541
DOC_WW_Pin1_4	172	177	PF00397	0.792
DOC_WW_Pin1_4	284	289	PF00397	0.793
DOC_WW_Pin1_4	290	295	PF00397	0.748
DOC_WW_Pin1_4	306	311	PF00397	0.663
DOC_WW_Pin1_4	396	401	PF00397	0.735
DOC_WW_Pin1_4	406	411	PF00397	0.660
DOC_WW_Pin1_4	490	495	PF00397	0.566
DOC_WW_Pin1_4	78	83	PF00397	0.823
LIG_14-3-3_CanoR_1	219	224	PF00244	0.750
LIG_14-3-3_CanoR_1	246	251	PF00244	0.805
LIG_14-3-3_CanoR_1	269	274	PF00244	0.680
LIG_14-3-3_CanoR_1	406	410	PF00244	0.649
LIG_14-3-3_CanoR_1	416	425	PF00244	0.813
LIG_BIR_II_1	1	5	PF00653	0.485
LIG_BIR_III_2	79	83	PF00653	0.574
LIG_Clathr_ClatBox_1	106	110	PF01394	0.734
LIG_FHA_1	165	171	PF00498	0.758
LIG_FHA_1	190	196	PF00498	0.661
LIG_FHA_1	325	331	PF00498	0.730
LIG_FHA_1	335	341	PF00498	0.761
LIG_FHA_1	388	394	PF00498	0.795
LIG_FHA_1	418	424	PF00498	0.715
LIG_FHA_1	494	500	PF00498	0.454
LIG_FHA_1	50	56	PF00498	0.798
LIG_FHA_2	233	239	PF00498	0.622
LIG_FHA_2	270	276	PF00498	0.718
LIG_FHA_2	366	372	PF00498	0.601
LIG_Integrin_RGD_1	116	118	PF01839	0.837
LIG_LIR_Apic_2	424	428	PF02991	0.743
LIG_LIR_Gen_1	498	504	PF02991	0.541
LIG_LIR_Gen_1	5	14	PF02991	0.472
LIG_LIR_Nem_3	484	490	PF02991	0.619
LIG_LIR_Nem_3	498	504	PF02991	0.586
LIG_LIR_Nem_3	5	9	PF02991	0.469
LIG_LIR_Nem_3	58	64	PF02991	0.761
LIG_NRBOX	12	18	PF00104	0.475
LIG_PCNA_PIPBox_1	264	273	PF02747	0.670
LIG_PCNA_yPIPBox_3	257	271	PF02747	0.670
LIG_PDZ_Class_3	499	504	PF00595	0.626
LIG_Pex14_1	497	501	PF04695	0.626
LIG_SH2_CRK	487	491	PF00017	0.579
LIG_SH2_GRB2like	61	64	PF00017	0.682
LIG_SH2_STAT5	203	206	PF00017	0.826
LIG_SH2_STAT5	425	428	PF00017	0.818
LIG_SH2_STAT5	487	490	PF00017	0.581
LIG_SH3_3	194	200	PF00018	0.729
LIG_SH3_3	239	245	PF00018	0.679
LIG_SH3_3	250	256	PF00018	0.564
LIG_SH3_3	309	315	PF00018	0.834
LIG_SH3_3	79	85	PF00018	0.660
LIG_SUMO_SIM_anti_2	25	30	PF11976	0.587
LIG_SUMO_SIM_par_1	456	462	PF11976	0.676
LIG_TRAF2_1	272	275	PF00917	0.688
LIG_TRAF2_1	316	319	PF00917	0.818
LIG_TRFH_1	473	477	PF08558	0.516
LIG_TYR_ITIM	485	490	PF00017	0.575
LIG_WW_3	126	130	PF00397	0.684
LIG_WW_3	243	247	PF00397	0.733
MOD_CDC14_SPxK_1	126	129	PF00782	0.723
MOD_CDC14_SPxK_1	293	296	PF00782	0.627
MOD_CDK_SPK_2	396	401	PF00069	0.599
MOD_CDK_SPxK_1	123	129	PF00069	0.731
MOD_CDK_SPxK_1	172	178	PF00069	0.635
MOD_CDK_SPxK_1	290	296	PF00069	0.629
MOD_CDK_SPxxK_3	306	313	PF00069	0.668
MOD_CK1_1	158	164	PF00069	0.783
MOD_CK1_1	2	8	PF00069	0.559
MOD_CK1_1	202	208	PF00069	0.761
MOD_CK1_1	209	215	PF00069	0.634
MOD_CK1_1	279	285	PF00069	0.799
MOD_CK1_1	287	293	PF00069	0.817
MOD_CK1_1	299	305	PF00069	0.510
MOD_CK1_1	306	312	PF00069	0.527
MOD_CK1_1	362	368	PF00069	0.818
MOD_CK1_1	370	376	PF00069	0.709
MOD_CK1_1	421	427	PF00069	0.778
MOD_CK1_1	493	499	PF00069	0.563
MOD_CK1_1	78	84	PF00069	0.823
MOD_CK1_1	99	105	PF00069	0.806
MOD_CK2_1	162	168	PF00069	0.830
MOD_CK2_1	269	275	PF00069	0.721
MOD_CK2_1	421	427	PF00069	0.681
MOD_GlcNHglycan	1	4	PF01048	0.493
MOD_GlcNHglycan	138	141	PF01048	0.747
MOD_GlcNHglycan	164	167	PF01048	0.752
MOD_GlcNHglycan	216	219	PF01048	0.762
MOD_GlcNHglycan	223	226	PF01048	0.655
MOD_GlcNHglycan	297	301	PF01048	0.628
MOD_GlcNHglycan	305	308	PF01048	0.739
MOD_GlcNHglycan	31	34	PF01048	0.769
MOD_GlcNHglycan	37	40	PF01048	0.687
MOD_GlcNHglycan	371	375	PF01048	0.642
MOD_GlcNHglycan	382	385	PF01048	0.644
MOD_GlcNHglycan	430	433	PF01048	0.609
MOD_GSK3_1	118	125	PF00069	0.796
MOD_GSK3_1	127	134	PF00069	0.679
MOD_GSK3_1	158	165	PF00069	0.806
MOD_GSK3_1	199	206	PF00069	0.794
MOD_GSK3_1	207	214	PF00069	0.707
MOD_GSK3_1	221	228	PF00069	0.590
MOD_GSK3_1	284	291	PF00069	0.773
MOD_GSK3_1	299	306	PF00069	0.594
MOD_GSK3_1	365	372	PF00069	0.771
MOD_GSK3_1	414	421	PF00069	0.784
MOD_GSK3_1	423	430	PF00069	0.664
MOD_GSK3_1	462	469	PF00069	0.627
MOD_GSK3_1	49	56	PF00069	0.774
MOD_GSK3_1	71	78	PF00069	0.702
MOD_GSK3_1	96	103	PF00069	0.736
MOD_N-GLC_1	158	163	PF02516	0.745
MOD_N-GLC_1	352	357	PF02516	0.832
MOD_N-GLC_2	183	185	PF02516	0.661
MOD_NEK2_1	155	160	PF00069	0.594
MOD_NEK2_1	369	374	PF00069	0.718
MOD_NEK2_1	418	423	PF00069	0.595
MOD_NEK2_2	191	196	PF00069	0.701
MOD_PIKK_1	211	217	PF00454	0.582
MOD_PKA_2	122	128	PF00069	0.734
MOD_PKA_2	177	183	PF00069	0.700
MOD_PKA_2	206	212	PF00069	0.586
MOD_PKA_2	245	251	PF00069	0.733
MOD_PKA_2	362	368	PF00069	0.629
MOD_PKA_2	405	411	PF00069	0.651
MOD_PKA_2	421	427	PF00069	0.741
MOD_PKA_2	53	59	PF00069	0.646
MOD_Plk_1	96	102	PF00069	0.650
MOD_Plk_4	110	116	PF00069	0.818
MOD_Plk_4	199	205	PF00069	0.787
MOD_Plk_4	388	394	PF00069	0.842
MOD_Plk_4	436	442	PF00069	0.594
MOD_ProDKin_1	123	129	PF00069	0.731
MOD_ProDKin_1	15	21	PF00069	0.543
MOD_ProDKin_1	172	178	PF00069	0.791
MOD_ProDKin_1	284	290	PF00069	0.794
MOD_ProDKin_1	306	312	PF00069	0.770
MOD_ProDKin_1	396	402	PF00069	0.736
MOD_ProDKin_1	406	412	PF00069	0.659
MOD_ProDKin_1	490	496	PF00069	0.569
MOD_ProDKin_1	78	84	PF00069	0.823
MOD_SUMO_rev_2	421	431	PF00179	0.744
TRG_DiLeu_BaLyEn_6	101	106	PF01217	0.812
TRG_ENDOCYTIC_2	487	490	PF00928	0.581
TRG_ER_diArg_1	10	12	PF00400	0.481
TRG_ER_diArg_1	340	343	PF00400	0.834
TRG_ER_diArg_1	361	364	PF00400	0.609
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.736
TRG_Pf-PMV_PEXEL_1	269	274	PF00026	0.668

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IER7	Leishmania donovani	85%	100%
A4HGD0	Leishmania braziliensis	57%	100%
A4I3G3	Leishmania infantum	86%	100%
E9AZQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%