CNH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8I0_LEIMA

TriTrypDb:

LmjF.28.0870 , LMJLV39_280014800 , LMJSD75_280014800

Length:

578

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q8I0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8I0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016874	ligase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.578
CLV_NRD_NRD_1	120	122	PF00675	0.559
CLV_NRD_NRD_1	195	197	PF00675	0.566
CLV_NRD_NRD_1	234	236	PF00675	0.391
CLV_PCSK_FUR_1	232	236	PF00082	0.391
CLV_PCSK_KEX2_1	118	120	PF00082	0.572
CLV_PCSK_KEX2_1	195	197	PF00082	0.566
CLV_PCSK_KEX2_1	234	236	PF00082	0.389
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.572
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.389
CLV_PCSK_SKI1_1	206	210	PF00082	0.493
CLV_PCSK_SKI1_1	258	262	PF00082	0.442
CLV_PCSK_SKI1_1	384	388	PF00082	0.372
CLV_PCSK_SKI1_1	503	507	PF00082	0.441
CLV_PCSK_SKI1_1	544	548	PF00082	0.348
CLV_PCSK_SKI1_1	567	571	PF00082	0.437
CLV_Separin_Metazoa	500	504	PF03568	0.616
DEG_Nend_Nbox_1	1	3	PF02207	0.535
DEG_SPOP_SBC_1	360	364	PF00917	0.667
DOC_ANK_TNKS_1	120	127	PF00023	0.670
DOC_CKS1_1	458	463	PF01111	0.750
DOC_CKS1_1	464	469	PF01111	0.703
DOC_CYCLIN_yClb3_PxF_3	433	441	PF00134	0.639
DOC_MAPK_gen_1	422	430	PF00069	0.555
DOC_MAPK_MEF2A_6	210	219	PF00069	0.652
DOC_MAPK_MEF2A_6	441	448	PF00069	0.654
DOC_PP1_RVXF_1	78	85	PF00149	0.299
DOC_PP1_SILK_1	206	211	PF00149	0.676
DOC_PP4_FxxP_1	430	433	PF00568	0.656
DOC_PP4_FxxP_1	569	572	PF00568	0.659
DOC_USP7_MATH_1	154	158	PF00917	0.715
DOC_USP7_MATH_1	166	170	PF00917	0.681
DOC_USP7_MATH_1	222	226	PF00917	0.679
DOC_USP7_MATH_1	360	364	PF00917	0.667
DOC_USP7_MATH_1	73	77	PF00917	0.504
DOC_USP7_UBL2_3	123	127	PF12436	0.801
DOC_USP7_UBL2_3	145	149	PF12436	0.793
DOC_USP7_UBL2_3	15	19	PF12436	0.491
DOC_USP7_UBL2_3	156	160	PF12436	0.811
DOC_USP7_UBL2_3	367	371	PF12436	0.615
DOC_WW_Pin1_4	194	199	PF00397	0.764
DOC_WW_Pin1_4	201	206	PF00397	0.668
DOC_WW_Pin1_4	218	223	PF00397	0.558
DOC_WW_Pin1_4	457	462	PF00397	0.729
DOC_WW_Pin1_4	463	468	PF00397	0.713
DOC_WW_Pin1_4	570	575	PF00397	0.727
LIG_14-3-3_CanoR_1	235	240	PF00244	0.591
LIG_14-3-3_CanoR_1	258	267	PF00244	0.688
LIG_14-3-3_CanoR_1	296	304	PF00244	0.547
LIG_14-3-3_CanoR_1	326	332	PF00244	0.573
LIG_14-3-3_CanoR_1	333	337	PF00244	0.576
LIG_14-3-3_CanoR_1	424	431	PF00244	0.545
LIG_14-3-3_CanoR_1	55	60	PF00244	0.299
LIG_14-3-3_CanoR_1	567	572	PF00244	0.579
LIG_Actin_WH2_2	410	426	PF00022	0.576
LIG_AP2alpha_1	297	301	PF02296	0.624
LIG_APCC_ABBA_1	20	25	PF00400	0.421
LIG_APCC_ABBA_1	444	449	PF00400	0.580
LIG_APCC_ABBAyCdc20_2	19	25	PF00400	0.483
LIG_BRCT_BRCA1_1	57	61	PF00533	0.402
LIG_FHA_1	24	30	PF00498	0.401
LIG_FHA_1	266	272	PF00498	0.649
LIG_FHA_1	287	293	PF00498	0.611
LIG_FHA_1	347	353	PF00498	0.642
LIG_FHA_1	464	470	PF00498	0.586
LIG_FHA_1	5	11	PF00498	0.543
LIG_FHA_2	195	201	PF00498	0.781
LIG_FHA_2	470	476	PF00498	0.576
LIG_FHA_2	511	517	PF00498	0.659
LIG_HP1_1	413	417	PF01393	0.512
LIG_LIR_Gen_1	257	267	PF02991	0.603
LIG_LIR_Gen_1	298	306	PF02991	0.611
LIG_LIR_Gen_1	440	448	PF02991	0.563
LIG_LIR_Gen_1	58	69	PF02991	0.459
LIG_LIR_Nem_3	225	229	PF02991	0.627
LIG_LIR_Nem_3	298	304	PF02991	0.537
LIG_LIR_Nem_3	440	446	PF02991	0.565
LIG_LIR_Nem_3	58	64	PF02991	0.446
LIG_NRBOX	30	36	PF00104	0.361
LIG_PCNA_PIPBox_1	528	537	PF02747	0.598
LIG_PCNA_yPIPBox_3	309	318	PF02747	0.634
LIG_Pex14_2	297	301	PF04695	0.661
LIG_Rb_pABgroove_1	529	537	PF01858	0.667
LIG_SH2_CRK	443	447	PF00017	0.634
LIG_SH2_STAP1	280	284	PF00017	0.631
LIG_SH2_STAT3	280	283	PF00017	0.662
LIG_SH2_STAT3	456	459	PF00017	0.693
LIG_SH2_STAT3	535	538	PF00017	0.662
LIG_SH2_STAT5	21	24	PF00017	0.483
LIG_SH2_STAT5	226	229	PF00017	0.553
LIG_SH3_3	412	418	PF00018	0.685
LIG_SH3_3	430	436	PF00018	0.619
LIG_SH3_3	455	461	PF00018	0.611
LIG_SH3_3	480	486	PF00018	0.661
LIG_SUMO_SIM_anti_2	214	221	PF11976	0.560
LIG_SUMO_SIM_anti_2	340	347	PF11976	0.572
LIG_SUMO_SIM_anti_2	351	356	PF11976	0.533
LIG_SUMO_SIM_anti_2	412	418	PF11976	0.583
LIG_SUMO_SIM_anti_2	60	66	PF11976	0.487
LIG_SUMO_SIM_par_1	340	347	PF11976	0.604
LIG_SUMO_SIM_par_1	70	76	PF11976	0.418
LIG_TRAF2_1	148	151	PF00917	0.704
LIG_UBA3_1	568	576	PF00899	0.680
LIG_WRC_WIRS_1	470	475	PF05994	0.634
MOD_CDC14_SPxK_1	573	576	PF00782	0.702
MOD_CDK_SPK_2	201	206	PF00069	0.686
MOD_CDK_SPxK_1	570	576	PF00069	0.670
MOD_CK1_1	169	175	PF00069	0.727
MOD_CK1_1	194	200	PF00069	0.794
MOD_CK1_1	307	313	PF00069	0.625
MOD_CK1_1	341	347	PF00069	0.658
MOD_CK1_1	4	10	PF00069	0.482
MOD_CK2_1	107	113	PF00069	0.790
MOD_CK2_1	510	516	PF00069	0.614
MOD_CK2_1	91	97	PF00069	0.689
MOD_GlcNHglycan	151	154	PF01048	0.645
MOD_GlcNHglycan	156	159	PF01048	0.663
MOD_GlcNHglycan	171	174	PF01048	0.427
MOD_GlcNHglycan	3	6	PF01048	0.729
MOD_GlcNHglycan	306	309	PF01048	0.443
MOD_GlcNHglycan	373	376	PF01048	0.447
MOD_GlcNHglycan	425	428	PF01048	0.343
MOD_GlcNHglycan	50	53	PF01048	0.701
MOD_GlcNHglycan	516	520	PF01048	0.493
MOD_GlcNHglycan	550	553	PF01048	0.405
MOD_GlcNHglycan	557	560	PF01048	0.381
MOD_GSK3_1	137	144	PF00069	0.813
MOD_GSK3_1	190	197	PF00069	0.738
MOD_GSK3_1	218	225	PF00069	0.644
MOD_GSK3_1	230	237	PF00069	0.624
MOD_GSK3_1	282	289	PF00069	0.593
MOD_GSK3_1	312	319	PF00069	0.634
MOD_GSK3_1	459	466	PF00069	0.777
MOD_GSK3_1	469	476	PF00069	0.602
MOD_GSK3_1	544	551	PF00069	0.518
MOD_LATS_1	147	153	PF00433	0.686
MOD_LATS_1	565	571	PF00433	0.577
MOD_N-GLC_1	23	28	PF02516	0.659
MOD_N-GLC_1	510	515	PF02516	0.366
MOD_N-GLC_2	311	313	PF02516	0.405
MOD_NEK2_1	1	6	PF00069	0.509
MOD_NEK2_1	190	195	PF00069	0.803
MOD_NEK2_1	286	291	PF00069	0.612
MOD_NEK2_1	297	302	PF00069	0.538
MOD_NEK2_1	304	309	PF00069	0.507
MOD_NEK2_1	327	332	PF00069	0.590
MOD_NEK2_1	35	40	PF00069	0.489
MOD_NEK2_1	387	392	PF00069	0.688
MOD_NEK2_1	423	428	PF00069	0.567
MOD_NEK2_1	548	553	PF00069	0.597
MOD_NEK2_1	555	560	PF00069	0.575
MOD_NEK2_2	451	456	PF00069	0.618
MOD_NEK2_2	510	515	PF00069	0.631
MOD_PIKK_1	107	113	PF00454	0.755
MOD_PIKK_1	312	318	PF00454	0.597
MOD_PIKK_1	460	466	PF00454	0.751
MOD_PKA_1	234	240	PF00069	0.638
MOD_PKA_2	234	240	PF00069	0.621
MOD_PKA_2	295	301	PF00069	0.554
MOD_PKA_2	332	338	PF00069	0.633
MOD_PKA_2	395	401	PF00069	0.656
MOD_PKA_2	423	429	PF00069	0.547
MOD_Plk_1	23	29	PF00069	0.454
MOD_Plk_1	286	292	PF00069	0.648
MOD_Plk_1	510	516	PF00069	0.578
MOD_Plk_4	204	210	PF00069	0.611
MOD_Plk_4	222	228	PF00069	0.643
MOD_Plk_4	235	241	PF00069	0.570
MOD_Plk_4	297	303	PF00069	0.567
MOD_Plk_4	338	344	PF00069	0.639
MOD_Plk_4	387	393	PF00069	0.612
MOD_Plk_4	451	457	PF00069	0.616
MOD_Plk_4	510	516	PF00069	0.580
MOD_Plk_4	544	550	PF00069	0.588
MOD_Plk_4	86	92	PF00069	0.719
MOD_ProDKin_1	194	200	PF00069	0.766
MOD_ProDKin_1	201	207	PF00069	0.661
MOD_ProDKin_1	218	224	PF00069	0.558
MOD_ProDKin_1	457	463	PF00069	0.738
MOD_ProDKin_1	570	576	PF00069	0.736
MOD_SUMO_for_1	148	151	PF00179	0.680
TRG_DiLeu_BaEn_1	214	219	PF01217	0.623
TRG_ENDOCYTIC_2	226	229	PF00928	0.553
TRG_ENDOCYTIC_2	443	446	PF00928	0.554
TRG_ENDOCYTIC_2	498	501	PF00928	0.650
TRG_ER_diArg_1	119	121	PF00400	0.769
TRG_NES_CRM1_1	262	274	PF08389	0.527
TRG_NLS_Bipartite_1	102	122	PF00514	0.699
TRG_NLS_MonoCore_2	117	122	PF00514	0.748
TRG_NLS_MonoExtN_4	232	238	PF00514	0.580
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	55	60	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7S9	Leptomonas seymouri	62%	100%
A0A1X0NYG1	Trypanosomatidae	43%	100%
A0A3S7X1B3	Leishmania donovani	92%	100%
A0A422N3T8	Trypanosoma rangeli	42%	100%
A4HGD1	Leishmania braziliensis	76%	100%
E9AZQ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BKS9	Trypanosoma cruzi	40%	100%