Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8H9_LEIMA

TriTrypDb:

LmjF.28.0880 , LMJLV39_280014900 , LMJSD75_280014900

Length:

176

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4Q8H9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8H9

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.545
CLV_NRD_NRD_1	123	125	PF00675	0.666
CLV_NRD_NRD_1	77	79	PF00675	0.562
CLV_NRD_NRD_1	9	11	PF00675	0.572
CLV_PCSK_KEX2_1	106	108	PF00082	0.537
CLV_PCSK_KEX2_1	125	127	PF00082	0.633
CLV_PCSK_KEX2_1	77	79	PF00082	0.576
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.537
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.633
CLV_PCSK_SKI1_1	46	50	PF00082	0.585

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM05	Leptomonas seymouri	73%	100%
A0A0S4IWE5	Bodo saltans	28%	100%
A0A0S4IZV2	Bodo saltans	28%	100%
A0A1X0NYD0	Trypanosomatidae	39%	99%
A0A3R7KRX2	Trypanosoma rangeli	41%	96%
A0A3S7X1F6	Leishmania donovani	98%	100%
A4HGD2	Leishmania braziliensis	87%	100%
A4I3G5	Leishmania infantum	97%	100%
D0A7X5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AZQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%

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