Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8H7_LEIMA

TriTrypDb:

LmjF.28.0900 , LMJLV39_280015100 , LMJSD75_280015100

Length:

290

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8H7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8H7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.527
CLV_NRD_NRD_1	149	151	PF00675	0.570
CLV_NRD_NRD_1	227	229	PF00675	0.589
CLV_NRD_NRD_1	3	5	PF00675	0.625
CLV_NRD_NRD_1	38	40	PF00675	0.492
CLV_NRD_NRD_1	74	76	PF00675	0.646
CLV_PCSK_FUR_1	104	108	PF00082	0.603
CLV_PCSK_KEX2_1	106	108	PF00082	0.517
CLV_PCSK_KEX2_1	149	151	PF00082	0.570
CLV_PCSK_KEX2_1	271	273	PF00082	0.507
CLV_PCSK_KEX2_1	278	280	PF00082	0.565
CLV_PCSK_KEX2_1	3	5	PF00082	0.620
CLV_PCSK_KEX2_1	74	76	PF00082	0.642
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.536
CLV_PCSK_PC1ET2_1	271	273	PF00082	0.507
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.565
CLV_PCSK_PC7_1	102	108	PF00082	0.505
CLV_PCSK_SKI1_1	223	227	PF00082	0.389
CLV_PCSK_SKI1_1	39	43	PF00082	0.492
CLV_PCSK_SKI1_1	79	83	PF00082	0.434
CLV_Separin_Metazoa	261	265	PF03568	0.450
DEG_APCC_DBOX_1	83	91	PF00400	0.481
DOC_MAPK_gen_1	104	112	PF00069	0.515
DOC_MAPK_gen_1	186	196	PF00069	0.514
DOC_MAPK_gen_1	37	46	PF00069	0.496
DOC_MAPK_MEF2A_6	189	198	PF00069	0.526
DOC_MAPK_MEF2A_6	37	46	PF00069	0.496
DOC_MAPK_NFAT4_5	39	47	PF00069	0.513
DOC_MAPK_RevD_3	27	40	PF00069	0.407
DOC_PP1_RVXF_1	37	44	PF00149	0.486
DOC_USP7_MATH_1	243	247	PF00917	0.397
DOC_WW_Pin1_4	61	66	PF00397	0.648
LIG_14-3-3_CanoR_1	207	211	PF00244	0.463
LIG_14-3-3_CanoR_1	231	235	PF00244	0.543
LIG_14-3-3_CanoR_1	3	9	PF00244	0.624
LIG_14-3-3_CterR_2	285	290	PF00244	0.499
LIG_Actin_WH2_2	123	141	PF00022	0.481
LIG_Actin_WH2_2	191	209	PF00022	0.471
LIG_Actin_WH2_2	255	273	PF00022	0.503
LIG_APCC_ABBAyCdc20_2	39	45	PF00400	0.493
LIG_BIR_II_1	1	5	PF00653	0.602
LIG_Clathr_ClatBox_1	41	45	PF01394	0.493
LIG_FHA_1	17	23	PF00498	0.532
LIG_FHA_1	183	189	PF00498	0.532
LIG_FHA_2	177	183	PF00498	0.424
LIG_FHA_2	197	203	PF00498	0.491
LIG_FHA_2	62	68	PF00498	0.627
LIG_LIR_Gen_1	185	194	PF02991	0.464
LIG_LIR_Nem_3	185	190	PF02991	0.439
LIG_LIR_Nem_3	236	242	PF02991	0.514
LIG_LIR_Nem_3	273	277	PF02991	0.538
LIG_LRP6_Inhibitor_1	31	37	PF00058	0.444
LIG_NRBOX	258	264	PF00104	0.448
LIG_PCNA_PIPBox_1	155	164	PF02747	0.398
LIG_SH2_CRK	239	243	PF00017	0.509
LIG_SH2_GRB2like	97	100	PF00017	0.485
LIG_SH2_STAT5	275	278	PF00017	0.555
LIG_SH3_3	281	287	PF00018	0.651
LIG_SH3_3	60	66	PF00018	0.675
LIG_SUMO_SIM_anti_2	28	33	PF11976	0.454
LIG_TRAF2_1	253	256	PF00917	0.499
LIG_TRAF2_1	69	72	PF00917	0.514
MOD_CK1_1	2	8	PF00069	0.538
MOD_CK2_1	176	182	PF00069	0.429
MOD_CK2_1	218	224	PF00069	0.494
MOD_CK2_1	230	236	PF00069	0.592
MOD_CK2_1	61	67	PF00069	0.635
MOD_GlcNHglycan	245	248	PF01048	0.391
MOD_GlcNHglycan	50	53	PF01048	0.646
MOD_GSK3_1	141	148	PF00069	0.481
MOD_GSK3_1	219	226	PF00069	0.379
MOD_N-GLC_1	218	223	PF02516	0.452
MOD_NEK2_1	270	275	PF00069	0.440
MOD_PKA_2	2	8	PF00069	0.631
MOD_PKA_2	206	212	PF00069	0.464
MOD_PKA_2	230	236	PF00069	0.470
MOD_Plk_1	223	229	PF00069	0.460
MOD_Plk_1	58	64	PF00069	0.618
MOD_ProDKin_1	61	67	PF00069	0.650
MOD_SUMO_rev_2	267	273	PF00179	0.480
MOD_SUMO_rev_2	33	42	PF00179	0.475
MOD_SUMO_rev_2	85	90	PF00179	0.459
TRG_DiLeu_BaEn_4	171	177	PF01217	0.466
TRG_DiLeu_BaEn_4	254	260	PF01217	0.494
TRG_DiLeu_BaEn_4	71	77	PF01217	0.490
TRG_ENDOCYTIC_2	239	242	PF00928	0.513
TRG_ENDOCYTIC_2	274	277	PF00928	0.508
TRG_ER_diArg_1	101	104	PF00400	0.594
TRG_ER_diArg_1	149	152	PF00400	0.519
TRG_ER_diArg_1	166	169	PF00400	0.486
TRG_ER_diArg_1	74	76	PF00400	0.651

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM76	Leptomonas seymouri	54%	93%
A0A1X0NYF4	Trypanosomatidae	33%	97%
A0A3S7X1C2	Leishmania donovani	92%	96%
A4HGD4	Leishmania braziliensis	70%	94%
A4I3G7	Leishmania infantum	92%	96%
E9AZQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	96%