Oxidoreductase-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oxidoreductase-like protein

Species:

Leishmania major

UniProt:

Q4Q8H3_LEIMA

TriTrypDb:

LmjF.28.0940 , LMJLV39_280015500 , LMJSD75_280015500

Length:

973

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q8H3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8H3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.743
CLV_C14_Caspase3-7	287	291	PF00656	0.696
CLV_C14_Caspase3-7	942	946	PF00656	0.390
CLV_NRD_NRD_1	117	119	PF00675	0.548
CLV_NRD_NRD_1	131	133	PF00675	0.585
CLV_NRD_NRD_1	495	497	PF00675	0.550
CLV_NRD_NRD_1	724	726	PF00675	0.552
CLV_NRD_NRD_1	9	11	PF00675	0.783
CLV_NRD_NRD_1	931	933	PF00675	0.494
CLV_NRD_NRD_1	96	98	PF00675	0.579
CLV_PCSK_FUR_1	117	121	PF00082	0.552
CLV_PCSK_KEX2_1	100	102	PF00082	0.563
CLV_PCSK_KEX2_1	117	119	PF00082	0.483
CLV_PCSK_KEX2_1	131	133	PF00082	0.580
CLV_PCSK_KEX2_1	136	138	PF00082	0.540
CLV_PCSK_KEX2_1	495	497	PF00082	0.550
CLV_PCSK_KEX2_1	584	586	PF00082	0.442
CLV_PCSK_KEX2_1	724	726	PF00082	0.552
CLV_PCSK_KEX2_1	9	11	PF00082	0.739
CLV_PCSK_KEX2_1	931	933	PF00082	0.494
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.565
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.436
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.569
CLV_PCSK_PC1ET2_1	584	586	PF00082	0.442
CLV_PCSK_PC7_1	132	138	PF00082	0.621
CLV_PCSK_SKI1_1	104	108	PF00082	0.618
CLV_PCSK_SKI1_1	211	215	PF00082	0.650
CLV_PCSK_SKI1_1	349	353	PF00082	0.657
CLV_PCSK_SKI1_1	390	394	PF00082	0.650
CLV_PCSK_SKI1_1	50	54	PF00082	0.650
CLV_PCSK_SKI1_1	594	598	PF00082	0.376
CLV_PCSK_SKI1_1	672	676	PF00082	0.447
CLV_PCSK_SKI1_1	69	73	PF00082	0.362
CLV_PCSK_SKI1_1	725	729	PF00082	0.507
CLV_PCSK_SKI1_1	891	895	PF00082	0.372
CLV_PCSK_SKI1_1	966	970	PF00082	0.403
CLV_Separin_Metazoa	212	216	PF03568	0.647
DEG_APCC_DBOX_1	402	410	PF00400	0.711
DEG_APCC_DBOX_1	645	653	PF00400	0.335
DEG_SCF_FBW7_1	685	692	PF00400	0.544
DEG_SCF_FBW7_2	401	408	PF00400	0.714
DEG_SPOP_SBC_1	274	278	PF00917	0.667
DEG_SPOP_SBC_1	517	521	PF00917	0.734
DOC_CKS1_1	372	377	PF01111	0.584
DOC_CKS1_1	402	407	PF01111	0.715
DOC_CYCLIN_RxL_1	387	396	PF00134	0.664
DOC_CYCLIN_RxL_1	441	452	PF00134	0.702
DOC_CYCLIN_RxL_1	790	803	PF00134	0.464
DOC_CYCLIN_RxL_1	946	956	PF00134	0.366
DOC_CYCLIN_yCln2_LP_2	700	706	PF00134	0.574
DOC_MAPK_DCC_7	504	513	PF00069	0.697
DOC_MAPK_gen_1	476	484	PF00069	0.704
DOC_MAPK_gen_1	589	598	PF00069	0.395
DOC_MAPK_gen_1	602	611	PF00069	0.335
DOC_MAPK_gen_1	724	731	PF00069	0.363
DOC_MAPK_gen_1	812	821	PF00069	0.568
DOC_MAPK_MEF2A_6	604	613	PF00069	0.335
DOC_PP1_RVXF_1	67	73	PF00149	0.638
DOC_PP1_RVXF_1	793	800	PF00149	0.665
DOC_PP2B_LxvP_1	272	275	PF13499	0.553
DOC_PP2B_LxvP_1	700	703	PF13499	0.578
DOC_PP4_FxxP_1	72	75	PF00568	0.523
DOC_PP4_MxPP_1	324	327	PF00568	0.672
DOC_SPAK_OSR1_1	864	868	PF12202	0.335
DOC_USP7_MATH_1	190	194	PF00917	0.668
DOC_USP7_MATH_1	256	260	PF00917	0.763
DOC_USP7_MATH_1	275	279	PF00917	0.780
DOC_USP7_MATH_1	388	392	PF00917	0.663
DOC_USP7_MATH_1	426	430	PF00917	0.692
DOC_USP7_MATH_1	518	522	PF00917	0.728
DOC_USP7_MATH_1	782	786	PF00917	0.659
DOC_USP7_MATH_1	806	810	PF00917	0.510
DOC_USP7_MATH_1	858	862	PF00917	0.424
DOC_USP7_UBL2_3	115	119	PF12436	0.540
DOC_WD40_RPTOR_TOS_1	650	656	PF00400	0.378
DOC_WW_Pin1_4	254	259	PF00397	0.816
DOC_WW_Pin1_4	337	342	PF00397	0.644
DOC_WW_Pin1_4	371	376	PF00397	0.740
DOC_WW_Pin1_4	401	406	PF00397	0.680
DOC_WW_Pin1_4	506	511	PF00397	0.581
DOC_WW_Pin1_4	513	518	PF00397	0.627
DOC_WW_Pin1_4	685	690	PF00397	0.547
DOC_WW_Pin1_4	776	781	PF00397	0.534
DOC_WW_Pin1_4	836	841	PF00397	0.355
DOC_WW_Pin1_4	921	926	PF00397	0.335
LIG_14-3-3_CanoR_1	205	214	PF00244	0.674
LIG_14-3-3_CanoR_1	592	597	PF00244	0.447
LIG_14-3-3_CanoR_1	615	621	PF00244	0.447
LIG_14-3-3_CanoR_1	724	730	PF00244	0.517
LIG_14-3-3_CanoR_1	88	93	PF00244	0.568
LIG_14-3-3_CanoR_1	899	905	PF00244	0.402
LIG_APCC_ABBA_1	743	748	PF00400	0.712
LIG_BIR_II_1	1	5	PF00653	0.749
LIG_BIR_III_2	857	861	PF00653	0.376
LIG_BRCT_BRCA1_1	275	279	PF00533	0.703
LIG_Clathr_ClatBox_1	223	227	PF01394	0.601
LIG_Clathr_ClatBox_1	448	452	PF01394	0.677
LIG_Clathr_ClatBox_1	649	653	PF01394	0.335
LIG_deltaCOP1_diTrp_1	51	58	PF00928	0.534
LIG_deltaCOP1_diTrp_1	641	650	PF00928	0.350
LIG_deltaCOP1_diTrp_1	656	663	PF00928	0.312
LIG_deltaCOP1_diTrp_1	718	723	PF00928	0.401
LIG_EVH1_2	325	329	PF00568	0.701
LIG_FAT_LD_1	439	447	PF03623	0.698
LIG_FHA_1	201	207	PF00498	0.720
LIG_FHA_1	307	313	PF00498	0.646
LIG_FHA_1	333	339	PF00498	0.588
LIG_FHA_1	402	408	PF00498	0.718
LIG_FHA_1	42	48	PF00498	0.643
LIG_FHA_1	432	438	PF00498	0.623
LIG_FHA_1	593	599	PF00498	0.363
LIG_FHA_1	622	628	PF00498	0.355
LIG_FHA_1	690	696	PF00498	0.470
LIG_FHA_1	726	732	PF00498	0.558
LIG_FHA_1	915	921	PF00498	0.335
LIG_FHA_2	10	16	PF00498	0.800
LIG_FHA_2	264	270	PF00498	0.807
LIG_FHA_2	285	291	PF00498	0.768
LIG_FHA_2	394	400	PF00498	0.706
LIG_FHA_2	464	470	PF00498	0.690
LIG_FHA_2	802	808	PF00498	0.527
LIG_FHA_2	898	904	PF00498	0.330
LIG_FHA_2	97	103	PF00498	0.566
LIG_Integrin_isoDGR_2	844	846	PF01839	0.480
LIG_LIR_Gen_1	276	285	PF02991	0.593
LIG_LIR_Gen_1	299	310	PF02991	0.535
LIG_LIR_Gen_1	57	65	PF02991	0.593
LIG_LIR_Gen_1	661	671	PF02991	0.335
LIG_LIR_Gen_1	718	727	PF02991	0.442
LIG_LIR_Gen_1	87	96	PF02991	0.547
LIG_LIR_LC3C_4	340	344	PF02991	0.670
LIG_LIR_Nem_3	105	110	PF02991	0.537
LIG_LIR_Nem_3	276	282	PF02991	0.720
LIG_LIR_Nem_3	299	305	PF02991	0.542
LIG_LIR_Nem_3	456	462	PF02991	0.746
LIG_LIR_Nem_3	526	531	PF02991	0.570
LIG_LIR_Nem_3	57	61	PF02991	0.594
LIG_LIR_Nem_3	661	666	PF02991	0.335
LIG_LIR_Nem_3	718	722	PF02991	0.421
LIG_LIR_Nem_3	796	802	PF02991	0.555
LIG_LIR_Nem_3	87	93	PF02991	0.545
LIG_LIR_Nem_3	873	879	PF02991	0.322
LIG_LIR_Nem_3	958	964	PF02991	0.390
LIG_LIR_Nem_3	967	971	PF02991	0.382
LIG_NRBOX	142	148	PF00104	0.686
LIG_PCNA_yPIPBox_3	547	560	PF02747	0.572
LIG_PCNA_yPIPBox_3	957	969	PF02747	0.528
LIG_Pex14_1	54	58	PF04695	0.606
LIG_Pex14_1	719	723	PF04695	0.395
LIG_Pex14_2	964	968	PF04695	0.363
LIG_REV1ctd_RIR_1	720	729	PF16727	0.497
LIG_SH2_CRK	313	317	PF00017	0.554
LIG_SH2_CRK	563	567	PF00017	0.433
LIG_SH2_CRK	671	675	PF00017	0.447
LIG_SH2_CRK	90	94	PF00017	0.535
LIG_SH2_GRB2like	911	914	PF00017	0.378
LIG_SH2_NCK_1	531	535	PF00017	0.658
LIG_SH2_NCK_1	90	94	PF00017	0.554
LIG_SH2_SRC	315	318	PF00017	0.561
LIG_SH2_SRC	531	534	PF00017	0.654
LIG_SH2_STAP1	41	45	PF00017	0.664
LIG_SH2_STAP1	607	611	PF00017	0.447
LIG_SH2_STAP1	691	695	PF00017	0.468
LIG_SH2_STAP1	802	806	PF00017	0.535
LIG_SH2_STAT3	121	124	PF00017	0.715
LIG_SH2_STAT3	320	323	PF00017	0.665
LIG_SH2_STAT3	354	357	PF00017	0.605
LIG_SH2_STAT3	802	805	PF00017	0.565
LIG_SH2_STAT5	121	124	PF00017	0.715
LIG_SH2_STAT5	315	318	PF00017	0.561
LIG_SH2_STAT5	347	350	PF00017	0.571
LIG_SH2_STAT5	354	357	PF00017	0.558
LIG_SH2_STAT5	528	531	PF00017	0.578
LIG_SH2_STAT5	691	694	PF00017	0.475
LIG_SH2_STAT5	78	81	PF00017	0.560
LIG_SH2_STAT5	83	86	PF00017	0.528
LIG_SH2_STAT5	90	93	PF00017	0.502
LIG_SH3_3	164	170	PF00018	0.770
LIG_SH3_3	2	8	PF00018	0.733
LIG_SH3_3	257	263	PF00018	0.789
LIG_SH3_3	335	341	PF00018	0.708
LIG_SH3_3	369	375	PF00018	0.571
LIG_SH3_3	399	405	PF00018	0.762
LIG_SH3_3	432	438	PF00018	0.749
LIG_SH3_3	728	734	PF00018	0.601
LIG_SH3_3	76	82	PF00018	0.616
LIG_SH3_3	857	863	PF00018	0.480
LIG_Sin3_3	359	366	PF02671	0.713
LIG_SUMO_SIM_anti_2	447	452	PF11976	0.674
LIG_SUMO_SIM_par_1	159	165	PF11976	0.677
LIG_SUMO_SIM_par_1	340	346	PF11976	0.684
LIG_SUMO_SIM_par_1	404	411	PF11976	0.706
LIG_SUMO_SIM_par_1	42	49	PF11976	0.690
LIG_SUMO_SIM_par_1	447	452	PF11976	0.674
LIG_SUMO_SIM_par_1	594	599	PF11976	0.335
LIG_SUMO_SIM_par_1	733	738	PF11976	0.605
LIG_TRAF2_1	521	524	PF00917	0.721
LIG_TRFH_1	936	940	PF08558	0.581
LIG_TYR_ITIM	561	566	PF00017	0.447
LIG_WW_3	6	10	PF00397	0.740
MOD_CDK_SPK_2	921	926	PF00069	0.335
MOD_CDK_SPxxK_3	921	928	PF00069	0.335
MOD_CK1_1	175	181	PF00069	0.743
MOD_CK1_1	273	279	PF00069	0.737
MOD_CK1_1	319	325	PF00069	0.661
MOD_CK1_1	377	383	PF00069	0.697
MOD_CK1_1	516	522	PF00069	0.676
MOD_CK1_1	776	782	PF00069	0.541
MOD_CK1_1	914	920	PF00069	0.335
MOD_CK2_1	204	210	PF00069	0.682
MOD_CK2_1	263	269	PF00069	0.808
MOD_CK2_1	414	420	PF00069	0.741
MOD_CK2_1	517	523	PF00069	0.619
MOD_CK2_1	54	60	PF00069	0.572
MOD_CK2_1	801	807	PF00069	0.516
MOD_CK2_1	867	873	PF00069	0.300
MOD_CK2_1	96	102	PF00069	0.567
MOD_GlcNHglycan	143	146	PF01048	0.717
MOD_GlcNHglycan	184	187	PF01048	0.786
MOD_GlcNHglycan	190	193	PF01048	0.762
MOD_GlcNHglycan	206	209	PF01048	0.516
MOD_GlcNHglycan	271	275	PF01048	0.745
MOD_GlcNHglycan	499	502	PF01048	0.633
MOD_GlcNHglycan	62	65	PF01048	0.637
MOD_GlcNHglycan	770	773	PF01048	0.720
MOD_GlcNHglycan	780	783	PF01048	0.725
MOD_GlcNHglycan	784	787	PF01048	0.721
MOD_GlcNHglycan	869	872	PF01048	0.335
MOD_GlcNHglycan	900	903	PF01048	0.335
MOD_GSK3_1	182	189	PF00069	0.792
MOD_GSK3_1	200	207	PF00069	0.550
MOD_GSK3_1	270	277	PF00069	0.767
MOD_GSK3_1	286	293	PF00069	0.512
MOD_GSK3_1	388	395	PF00069	0.707
MOD_GSK3_1	513	520	PF00069	0.630
MOD_GSK3_1	592	599	PF00069	0.447
MOD_GSK3_1	616	623	PF00069	0.447
MOD_GSK3_1	681	688	PF00069	0.335
MOD_GSK3_1	774	781	PF00069	0.654
MOD_GSK3_1	84	91	PF00069	0.543
MOD_GSK3_1	880	887	PF00069	0.335
MOD_GSK3_1	914	921	PF00069	0.322
MOD_N-GLC_1	172	177	PF02516	0.778
MOD_N-GLC_1	366	371	PF02516	0.619
MOD_N-GLC_1	793	798	PF02516	0.603
MOD_N-GLC_1	867	872	PF02516	0.349
MOD_NEK2_1	204	209	PF00069	0.726
MOD_NEK2_1	303	308	PF00069	0.530
MOD_NEK2_1	392	397	PF00069	0.714
MOD_NEK2_1	609	614	PF00069	0.335
MOD_NEK2_1	621	626	PF00069	0.335
MOD_NEK2_1	706	711	PF00069	0.492
MOD_NEK2_1	746	751	PF00069	0.686
MOD_NEK2_1	84	89	PF00069	0.550
MOD_NEK2_1	879	884	PF00069	0.430
MOD_NEK2_1	897	902	PF00069	0.192
MOD_NEK2_1	953	958	PF00069	0.401
MOD_NEK2_2	485	490	PF00069	0.677
MOD_NEK2_2	54	59	PF00069	0.450
MOD_PIKK_1	303	309	PF00454	0.512
MOD_PIKK_1	319	325	PF00454	0.505
MOD_PIKK_1	426	432	PF00454	0.741
MOD_PIKK_1	658	664	PF00454	0.335
MOD_PIKK_1	801	807	PF00454	0.559
MOD_PKA_1	9	15	PF00069	0.729
MOD_PKA_2	130	136	PF00069	0.598
MOD_PKA_2	204	210	PF00069	0.704
MOD_PKA_2	761	767	PF00069	0.717
MOD_PKA_2	898	904	PF00069	0.335
MOD_PKA_2	9	15	PF00069	0.729
MOD_PKA_2	96	102	PF00069	0.550
MOD_Plk_1	41	47	PF00069	0.619
MOD_Plk_1	485	491	PF00069	0.540
MOD_Plk_1	793	799	PF00069	0.662
MOD_Plk_1	867	873	PF00069	0.346
MOD_Plk_2-3	452	458	PF00069	0.648
MOD_Plk_4	592	598	PF00069	0.408
MOD_Plk_4	609	615	PF00069	0.263
MOD_Plk_4	616	622	PF00069	0.335
MOD_Plk_4	813	819	PF00069	0.492
MOD_Plk_4	88	94	PF00069	0.646
MOD_ProDKin_1	254	260	PF00069	0.818
MOD_ProDKin_1	337	343	PF00069	0.642
MOD_ProDKin_1	371	377	PF00069	0.744
MOD_ProDKin_1	401	407	PF00069	0.677
MOD_ProDKin_1	506	512	PF00069	0.588
MOD_ProDKin_1	513	519	PF00069	0.627
MOD_ProDKin_1	685	691	PF00069	0.547
MOD_ProDKin_1	776	782	PF00069	0.533
MOD_ProDKin_1	836	842	PF00069	0.355
MOD_ProDKin_1	921	927	PF00069	0.335
MOD_SUMO_for_1	135	138	PF00179	0.572
TRG_DiLeu_BaEn_1	212	217	PF01217	0.646
TRG_DiLeu_BaEn_1	299	304	PF01217	0.670
TRG_DiLeu_BaEn_4	30	36	PF01217	0.750
TRG_DiLeu_BaLyEn_6	157	162	PF01217	0.672
TRG_ENDOCYTIC_2	313	316	PF00928	0.525
TRG_ENDOCYTIC_2	531	534	PF00928	0.571
TRG_ENDOCYTIC_2	563	566	PF00928	0.427
TRG_ENDOCYTIC_2	570	573	PF00928	0.385
TRG_ENDOCYTIC_2	671	674	PF00928	0.447
TRG_ENDOCYTIC_2	90	93	PF00928	0.538
TRG_ENDOCYTIC_2	961	964	PF00928	0.372
TRG_ENDOCYTIC_2	965	968	PF00928	0.369
TRG_ER_diArg_1	117	120	PF00400	0.546
TRG_ER_diArg_1	130	132	PF00400	0.583
TRG_ER_diArg_1	495	497	PF00400	0.550
TRG_ER_diArg_1	667	670	PF00400	0.389
TRG_ER_diArg_1	723	725	PF00400	0.520
TRG_ER_diArg_1	8	10	PF00400	0.746
TRG_NES_CRM1_1	440	452	PF08389	0.676
TRG_NLS_Bipartite_1	100	122	PF00514	0.560
TRG_NLS_MonoExtC_3	282	288	PF00514	0.754
TRG_NLS_MonoExtN_4	115	122	PF00514	0.546
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.709
TRG_Pf-PMV_PEXEL_1	416	420	PF00026	0.747
TRG_Pf-PMV_PEXEL_1	625	629	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	795	800	PF00026	0.653

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P863	Leptomonas seymouri	70%	97%
A0A1X0NZS2	Trypanosomatidae	55%	100%
A0A3R7KME7	Trypanosoma rangeli	54%	100%
A0A3S7X1C4	Leishmania donovani	93%	100%
A4HGD8	Leishmania braziliensis	80%	100%
A4I3H1	Leishmania infantum	93%	100%
D0A7W5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AZR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BG64	Trypanosoma cruzi	51%	100%