Tctex1 domain-containing protein 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tctex-1 family, putative

Species:

Leishmania major

UniProt:

Q4Q8H2_LEIMA

TriTrypDb:

LmjF.28.0950 , LMJLV39_280015600 , LMJSD75_280015600

Length:

126

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005868	cytoplasmic dynein complex	4	2
GO:0005875	microtubule associated complex	2	2
GO:0030286	dynein complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	2
GO:1902494	catalytic complex	2	2

Expansion

Sequence features

Q4Q8H2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8H2

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	2
GO:0007018	microtubule-based movement	3	2
GO:0009987	cellular process	1	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0045505	dynein intermediate chain binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	74	78	PF00082	0.316
DOC_PP4_FxxP_1	13	16	PF00568	0.529
DOC_USP7_MATH_1	9	13	PF00917	0.580
LIG_APCC_ABBA_1	121	126	PF00400	0.416
LIG_APCC_ABBAyCdc20_2	43	49	PF00400	0.292
LIG_BIR_II_1	1	5	PF00653	0.652
LIG_eIF4E_1	70	76	PF01652	0.316
LIG_FHA_1	115	121	PF00498	0.405
LIG_FHA_1	63	69	PF00498	0.368
LIG_FHA_2	78	84	PF00498	0.297
LIG_LIR_Apic_2	11	16	PF02991	0.510
LIG_LIR_Gen_1	110	121	PF02991	0.371
LIG_LIR_Nem_3	101	107	PF02991	0.315
LIG_LIR_Nem_3	110	116	PF02991	0.276
LIG_LIR_Nem_3	71	76	PF02991	0.292
LIG_Pex14_2	121	125	PF04695	0.399
LIG_SH2_CRK	73	77	PF00017	0.292
LIG_SH2_GRB2like	109	112	PF00017	0.387
LIG_SH2_NCK_1	47	51	PF00017	0.316
LIG_SH2_SRC	47	50	PF00017	0.316
LIG_SH2_STAP1	109	113	PF00017	0.382
LIG_SH2_STAT3	109	112	PF00017	0.368
LIG_SH2_STAT5	107	110	PF00017	0.325
LIG_SH2_STAT5	45	48	PF00017	0.292
LIG_SH2_STAT5	5	8	PF00017	0.554
LIG_SH3_3	38	44	PF00018	0.387
LIG_TRAF2_1	16	19	PF00917	0.446
MOD_CK1_1	20	26	PF00069	0.498
MOD_CK2_1	22	28	PF00069	0.386
MOD_CK2_1	77	83	PF00069	0.323
MOD_GlcNHglycan	24	27	PF01048	0.408
MOD_GSK3_1	103	110	PF00069	0.352
MOD_GSK3_1	79	86	PF00069	0.410
MOD_NEK2_1	114	119	PF00069	0.345
MOD_NEK2_1	22	27	PF00069	0.398
MOD_PIKK_1	83	89	PF00454	0.446
MOD_PKA_2	9	15	PF00069	0.557
MOD_Plk_4	114	120	PF00069	0.320
TRG_DiLeu_BaEn_1	71	76	PF01217	0.328
TRG_DiLeu_LyEn_5	49	54	PF01217	0.289
TRG_ENDOCYTIC_2	113	116	PF00928	0.374
TRG_ENDOCYTIC_2	73	76	PF00928	0.292
TRG_NES_CRM1_1	112	126	PF08389	0.408
TRG_Pf-PMV_PEXEL_1	94	98	PF00026	0.292

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3B2	Leptomonas seymouri	32%	100%
A0A0N1PFP4	Leptomonas seymouri	78%	100%
A0A0S4IQE7	Bodo saltans	60%	100%
A0A0S4JDH6	Bodo saltans	31%	91%
A0A1X0NYC6	Trypanosomatidae	66%	100%
A0A1X0P6I3	Trypanosomatidae	30%	100%
A0A3R7LJS7	Trypanosoma rangeli	62%	100%
A0A3S5H7J0	Leishmania donovani	97%	100%
A0A3S7X9I4	Leishmania donovani	31%	100%
A0A422P2R8	Trypanosoma rangeli	30%	100%
A2VDD2	Xenopus laevis	33%	72%
A4HGD9	Leishmania braziliensis	86%	100%
A4HMV8	Leishmania braziliensis	31%	100%
A4I3H2	Leishmania infantum	97%	100%
A4IBH9	Leishmania infantum	31%	100%
C9ZZ62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
D0A4G7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AFB5	Leishmania major	30%	100%
E9AZR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B6H0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
F1QMY1	Danio rerio	29%	84%
P51807	Mus musculus	26%	100%
P51808	Homo sapiens	25%	100%
P63171	Bos taurus	26%	100%
P63172	Homo sapiens	26%	100%
Q32P71	Bos taurus	29%	83%
Q3B8D7	Xenopus laevis	32%	71%
Q54PG1	Dictyostelium discoideum	26%	100%
Q5NVF5	Pongo abelii	25%	100%
Q66IC8	Danio rerio	29%	73%
Q6XXL8	Ovis aries	27%	100%
Q8N7M0	Homo sapiens	30%	70%
Q8WW35	Homo sapiens	31%	89%
Q9CQ66	Mus musculus	31%	88%
Q9D5I4	Mus musculus	30%	73%
Q9Z336	Rattus norvegicus	26%	100%
V5BTL3	Trypanosoma cruzi	32%	100%