LSM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8H0_LEIMA

TriTrypDb:

LmjF.28.0970 , LMJLV39_280015800 , LMJSD75_280015800

Length:

165

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8H0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8H0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.513
CLV_NRD_NRD_1	46	48	PF00675	0.454
CLV_PCSK_KEX2_1	124	126	PF00082	0.569
CLV_PCSK_KEX2_1	46	48	PF00082	0.454
CLV_PCSK_SKI1_1	46	50	PF00082	0.498
DOC_CKS1_1	142	147	PF01111	0.541
DOC_MAPK_gen_1	28	35	PF00069	0.656
DOC_MAPK_gen_1	46	52	PF00069	0.453
DOC_PP2B_LxvP_1	147	150	PF13499	0.640
DOC_USP7_MATH_1	16	20	PF00917	0.682
DOC_USP7_MATH_1	23	27	PF00917	0.610
DOC_USP7_MATH_1	3	7	PF00917	0.720
DOC_USP7_MATH_1	65	69	PF00917	0.404
DOC_USP7_MATH_1	85	89	PF00917	0.676
DOC_WW_Pin1_4	141	146	PF00397	0.459
DOC_WW_Pin1_4	154	159	PF00397	0.567
DOC_WW_Pin1_4	21	26	PF00397	0.662
LIG_14-3-3_CanoR_1	46	51	PF00244	0.504
LIG_14-3-3_CanoR_1	80	84	PF00244	0.540
LIG_BIR_II_1	1	5	PF00653	0.600
LIG_FHA_1	142	148	PF00498	0.555
LIG_FHA_1	47	53	PF00498	0.511
LIG_LIR_Gen_1	137	147	PF02991	0.478
LIG_LIR_Gen_1	38	48	PF02991	0.594
LIG_LIR_Nem_3	137	142	PF02991	0.469
LIG_LIR_Nem_3	38	44	PF02991	0.526
LIG_PDZ_Class_1	160	165	PF00595	0.657
LIG_PTB_Apo_2	133	140	PF02174	0.459
LIG_SH2_STAP1	37	41	PF00017	0.544
LIG_SH2_STAT5	81	84	PF00017	0.580
LIG_SH3_1	15	21	PF00018	0.730
LIG_SH3_3	15	21	PF00018	0.770
LIG_SUMO_SIM_par_1	48	53	PF11976	0.459
LIG_TRAF2_1	110	113	PF00917	0.685
LIG_TRAF2_1	89	92	PF00917	0.771
LIG_TYR_ITIM	35	40	PF00017	0.556
MOD_CDK_SPxxK_3	21	28	PF00069	0.667
MOD_CK1_1	24	30	PF00069	0.694
MOD_CK1_1	8	14	PF00069	0.709
MOD_CK1_1	86	92	PF00069	0.672
MOD_CK2_1	107	113	PF00069	0.698
MOD_CK2_1	85	91	PF00069	0.749
MOD_Cter_Amidation	44	47	PF01082	0.472
MOD_GlcNHglycan	1	4	PF01048	0.639
MOD_GlcNHglycan	136	139	PF01048	0.470
MOD_GlcNHglycan	154	157	PF01048	0.451
MOD_GlcNHglycan	7	10	PF01048	0.642
MOD_GSK3_1	24	31	PF00069	0.696
MOD_GSK3_1	46	53	PF00069	0.493
MOD_GSK3_1	79	86	PF00069	0.560
MOD_N-GLC_1	3	8	PF02516	0.686
MOD_NEK2_1	134	139	PF00069	0.518
MOD_NEK2_1	59	64	PF00069	0.486
MOD_PIKK_1	53	59	PF00454	0.629
MOD_PKA_1	46	52	PF00069	0.507
MOD_PKA_2	107	113	PF00069	0.535
MOD_PKA_2	11	17	PF00069	0.717
MOD_PKA_2	46	52	PF00069	0.507
MOD_PKA_2	79	85	PF00069	0.598
MOD_PKA_2	86	92	PF00069	0.671
MOD_Plk_1	3	9	PF00069	0.523
MOD_Plk_4	143	149	PF00069	0.573
MOD_Plk_4	46	52	PF00069	0.507
MOD_ProDKin_1	141	147	PF00069	0.519
MOD_ProDKin_1	154	160	PF00069	0.584
MOD_ProDKin_1	21	27	PF00069	0.659
TRG_ENDOCYTIC_2	37	40	PF00928	0.543
TRG_ER_diArg_1	46	48	PF00400	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHV6	Leptomonas seymouri	62%	100%
A0A3Q8ID22	Leishmania donovani	90%	100%
A0A422MZL4	Trypanosoma rangeli	36%	100%
A4HGE1	Leishmania braziliensis	71%	100%
A4I3H4	Leishmania infantum	90%	100%
E9AZR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%