Putative P27 protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

P27 protein, putative

Species:

Leishmania major

UniProt:

Q4Q8G9_LEIMA

TriTrypDb:

LmjF.28.0980 , LMJLV39_280015900 , LMJSD75_280015900

Length:

240

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q8G9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8G9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	200	204	PF00082	0.668
DOC_CYCLIN_RxL_1	194	208	PF00134	0.399
DOC_PP1_RVXF_1	120	126	PF00149	0.390
DOC_PP1_RVXF_1	78	85	PF00149	0.628
DOC_PP2B_LxvP_1	219	222	PF13499	0.491
DOC_PP4_FxxP_1	125	128	PF00568	0.403
DOC_USP7_MATH_1	233	237	PF00917	0.552
DOC_USP7_MATH_2	222	228	PF00917	0.456
LIG_14-3-3_CanoR_1	122	126	PF00244	0.419
LIG_BIR_II_1	1	5	PF00653	0.722
LIG_BRCT_BRCA1_1	115	119	PF00533	0.308
LIG_BRCT_BRCA1_1	68	72	PF00533	0.730
LIG_EH_1	29	33	PF12763	0.682
LIG_FHA_1	170	176	PF00498	0.448
LIG_FHA_1	3	9	PF00498	0.723
LIG_IBAR_NPY_1	76	78	PF08397	0.656
LIG_LIR_Apic_2	124	128	PF02991	0.429
LIG_LIR_Nem_3	116	121	PF02991	0.336
LIG_LIR_Nem_3	42	48	PF02991	0.542
LIG_Pex14_1	55	59	PF04695	0.647
LIG_REV1ctd_RIR_1	70	76	PF16727	0.634
LIG_SH2_CRK	61	65	PF00017	0.677
LIG_SH2_GRB2like	205	208	PF00017	0.394
LIG_SH2_PTP2	23	26	PF00017	0.649
LIG_SH2_SRC	189	192	PF00017	0.375
LIG_SH2_STAP1	115	119	PF00017	0.327
LIG_SH2_STAT5	189	192	PF00017	0.503
LIG_SH2_STAT5	225	228	PF00017	0.500
LIG_SH2_STAT5	23	26	PF00017	0.655
LIG_SH2_STAT5	44	47	PF00017	0.627
LIG_SH2_STAT5	81	84	PF00017	0.643
LIG_SH3_4	141	148	PF00018	0.463
LIG_SUMO_SIM_anti_2	110	116	PF11976	0.425
LIG_SUMO_SIM_par_1	106	112	PF11976	0.363
MOD_CK1_1	2	8	PF00069	0.712
MOD_CK1_1	9	15	PF00069	0.696
MOD_CK1_1	99	105	PF00069	0.547
MOD_CK2_1	85	91	PF00069	0.617
MOD_GlcNHglycan	226	229	PF01048	0.697
MOD_GlcNHglycan	235	238	PF01048	0.737
MOD_GlcNHglycan	48	51	PF01048	0.426
MOD_GlcNHglycan	8	11	PF01048	0.538
MOD_GlcNHglycan	98	101	PF01048	0.324
MOD_GSK3_1	109	116	PF00069	0.332
MOD_GSK3_1	117	124	PF00069	0.363
MOD_GSK3_1	2	9	PF00069	0.749
MOD_GSK3_1	99	106	PF00069	0.523
MOD_NEK2_1	117	122	PF00069	0.506
MOD_NEK2_1	137	142	PF00069	0.279
MOD_NEK2_1	85	90	PF00069	0.617
MOD_NEK2_2	128	133	PF00069	0.393
MOD_PKA_2	121	127	PF00069	0.427
MOD_PKA_2	2	8	PF00069	0.704
MOD_Plk_1	128	134	PF00069	0.391
MOD_Plk_1	167	173	PF00069	0.474
MOD_Plk_1	200	206	PF00069	0.474
MOD_Plk_1	85	91	PF00069	0.617
MOD_Plk_2-3	86	92	PF00069	0.617
MOD_Plk_4	103	109	PF00069	0.356
MOD_Plk_4	113	119	PF00069	0.313
MOD_Plk_4	121	127	PF00069	0.293
MOD_Plk_4	200	206	PF00069	0.469
TRG_ENDOCYTIC_2	160	163	PF00928	0.446
TRG_ENDOCYTIC_2	61	64	PF00928	0.677
TRG_NES_CRM1_1	173	187	PF08389	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYK0	Leptomonas seymouri	62%	99%
A0A0S4IVH5	Bodo saltans	46%	99%
A0A0S4IXX7	Bodo saltans	46%	91%
A0A1X0NYZ9	Trypanosomatidae	62%	100%
A0A3Q8IGT4	Leishmania donovani	60%	99%
A0A422MZK8	Trypanosoma rangeli	61%	100%
A4HGE2	Leishmania braziliensis	80%	100%
A4HLG1	Leishmania braziliensis	59%	99%
A4I3H5	Leishmania infantum	94%	100%
A4I8X2	Leishmania infantum	60%	99%
E9AZR4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9B3U1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	99%
I1ZAQ0	Leishmania donovani	94%	100%
Q4Q483	Leishmania major	61%	100%
V5AL49	Trypanosoma cruzi	62%	94%