Serine incorporator

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Serine incorporator

Gene product:

Serine incorporator (Serinc), putative

Species:

Leishmania major

UniProt:

Q4Q8G8_LEIMA

TriTrypDb:

LmjF.28.0990 , LMJLV39_280016200 , LMJSD75_280016200

Length:

416

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

Q4Q8G8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8G8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.486
CLV_MEL_PAP_1	83	89	PF00089	0.265
CLV_NRD_NRD_1	12	14	PF00675	0.497
CLV_PCSK_KEX2_1	11	13	PF00082	0.472
CLV_PCSK_SKI1_1	119	123	PF00082	0.230
CLV_PCSK_SKI1_1	125	129	PF00082	0.259
CLV_PCSK_SKI1_1	276	280	PF00082	0.551
DEG_MDM2_SWIB_1	389	396	PF02201	0.362
DEG_Nend_UBRbox_1	1	4	PF02207	0.535
DEG_SPOP_SBC_1	281	285	PF00917	0.321
DOC_CDC14_PxL_1	55	63	PF14671	0.322
DOC_MAPK_gen_1	30	39	PF00069	0.378
DOC_MAPK_HePTP_8	27	39	PF00069	0.490
DOC_MAPK_MEF2A_6	125	134	PF00069	0.274
DOC_MAPK_MEF2A_6	30	39	PF00069	0.349
DOC_MAPK_NFAT4_5	32	40	PF00069	0.403
DOC_PP1_RVXF_1	84	90	PF00149	0.252
DOC_PP2B_LxvP_1	395	398	PF13499	0.252
DOC_PP4_FxxP_1	137	140	PF00568	0.262
DOC_USP7_MATH_1	195	199	PF00917	0.368
DOC_USP7_MATH_1	244	248	PF00917	0.414
DOC_USP7_MATH_1	309	313	PF00917	0.462
DOC_USP7_MATH_1	329	333	PF00917	0.383
DOC_USP7_MATH_1	66	70	PF00917	0.308
DOC_WW_Pin1_4	21	26	PF00397	0.542
LIG_14-3-3_CanoR_1	119	129	PF00244	0.499
LIG_14-3-3_CanoR_1	280	289	PF00244	0.311
LIG_14-3-3_CanoR_1	380	385	PF00244	0.300
LIG_14-3-3_CanoR_1	48	58	PF00244	0.367
LIG_14-3-3_CanoR_1	86	90	PF00244	0.252
LIG_Actin_WH2_2	16	34	PF00022	0.626
LIG_Actin_WH2_2	47	64	PF00022	0.314
LIG_APCC_ABBA_1	213	218	PF00400	0.311
LIG_BRCT_BRCA1_1	251	255	PF00533	0.337
LIG_eIF4E_1	147	153	PF01652	0.300
LIG_eIF4E_1	257	263	PF01652	0.403
LIG_eIF4E_1	36	42	PF01652	0.283
LIG_FHA_1	104	110	PF00498	0.424
LIG_FHA_1	124	130	PF00498	0.265
LIG_FHA_1	134	140	PF00498	0.232
LIG_FHA_1	236	242	PF00498	0.297
LIG_FHA_1	256	262	PF00498	0.304
LIG_FHA_1	283	289	PF00498	0.245
LIG_FHA_1	292	298	PF00498	0.293
LIG_FHA_1	341	347	PF00498	0.287
LIG_FHA_2	267	273	PF00498	0.283
LIG_LIR_Apic_2	136	140	PF02991	0.262
LIG_LIR_Gen_1	145	153	PF02991	0.273
LIG_LIR_Gen_1	155	166	PF02991	0.199
LIG_LIR_Gen_1	209	215	PF02991	0.296
LIG_LIR_Gen_1	283	293	PF02991	0.314
LIG_LIR_Gen_1	298	308	PF02991	0.364
LIG_LIR_Gen_1	336	346	PF02991	0.427
LIG_LIR_Gen_1	349	355	PF02991	0.221
LIG_LIR_Gen_1	382	392	PF02991	0.282
LIG_LIR_LC3C_4	126	131	PF02991	0.387
LIG_LIR_Nem_3	145	150	PF02991	0.279
LIG_LIR_Nem_3	185	190	PF02991	0.381
LIG_LIR_Nem_3	209	213	PF02991	0.274
LIG_LIR_Nem_3	283	289	PF02991	0.299
LIG_LIR_Nem_3	291	296	PF02991	0.312
LIG_LIR_Nem_3	298	303	PF02991	0.239
LIG_LIR_Nem_3	336	341	PF02991	0.445
LIG_LIR_Nem_3	92	97	PF02991	0.366
LIG_PDZ_Class_3	411	416	PF00595	0.645
LIG_PDZ_Wminus1_1	414	416	PF00595	0.659
LIG_Pex14_1	385	389	PF04695	0.387
LIG_Pex14_2	133	137	PF04695	0.228
LIG_Pex14_2	165	169	PF04695	0.281
LIG_Pex14_2	389	393	PF04695	0.387
LIG_Pex14_2	89	93	PF04695	0.302
LIG_PTB_Apo_2	138	145	PF02174	0.254
LIG_PTB_Apo_2	159	166	PF02174	0.281
LIG_REV1ctd_RIR_1	119	129	PF16727	0.424
LIG_SH2_CRK	147	151	PF00017	0.261
LIG_SH2_CRK	286	290	PF00017	0.305
LIG_SH2_CRK	304	308	PF00017	0.147
LIG_SH2_NCK_1	304	308	PF00017	0.245
LIG_SH2_PTP2	149	152	PF00017	0.337
LIG_SH2_SRC	147	150	PF00017	0.268
LIG_SH2_SRC	242	245	PF00017	0.358
LIG_SH2_STAP1	257	261	PF00017	0.297
LIG_SH2_STAP1	304	308	PF00017	0.403
LIG_SH2_STAP1	33	37	PF00017	0.302
LIG_SH2_STAP1	342	346	PF00017	0.325
LIG_SH2_STAT5	149	152	PF00017	0.279
LIG_SH2_STAT5	158	161	PF00017	0.293
LIG_SH2_STAT5	190	193	PF00017	0.266
LIG_SH2_STAT5	236	239	PF00017	0.300
LIG_SH2_STAT5	242	245	PF00017	0.319
LIG_SH2_STAT5	257	260	PF00017	0.256
LIG_SH2_STAT5	342	345	PF00017	0.290
LIG_SH2_STAT5	351	354	PF00017	0.265
LIG_SH2_STAT5	36	39	PF00017	0.265
LIG_SH2_STAT5	391	394	PF00017	0.288
LIG_SH2_STAT5	399	402	PF00017	0.440
LIG_SH3_3	238	244	PF00018	0.203
LIG_Sin3_3	38	45	PF02671	0.257
LIG_SUMO_SIM_anti_2	126	132	PF11976	0.281
LIG_SUMO_SIM_par_1	98	104	PF11976	0.277
LIG_TYR_ITIM	302	307	PF00017	0.279
LIG_UBA3_1	27	32	PF00899	0.528
LIG_UBA3_1	50	57	PF00899	0.292
LIG_WRC_WIRS_1	134	139	PF05994	0.329
LIG_WRC_WIRS_1	196	201	PF05994	0.385
MOD_CK1_1	103	109	PF00069	0.444
MOD_CK1_1	120	126	PF00069	0.364
MOD_CK1_1	282	288	PF00069	0.266
MOD_CK1_1	312	318	PF00069	0.508
MOD_CK2_1	266	272	PF00069	0.331
MOD_GlcNHglycan	15	18	PF01048	0.414
MOD_GlcNHglycan	154	157	PF01048	0.281
MOD_GlcNHglycan	311	314	PF01048	0.252
MOD_GlcNHglycan	330	334	PF01048	0.192
MOD_GlcNHglycan	361	364	PF01048	0.424
MOD_GSK3_1	167	174	PF00069	0.440
MOD_GSK3_1	244	251	PF00069	0.426
MOD_GSK3_1	262	269	PF00069	0.380
MOD_GSK3_1	276	283	PF00069	0.148
MOD_GSK3_1	284	291	PF00069	0.236
MOD_GSK3_1	298	305	PF00069	0.263
MOD_GSK3_1	329	336	PF00069	0.490
MOD_GSK3_1	355	362	PF00069	0.304
MOD_GSK3_1	365	372	PF00069	0.193
MOD_GSK3_1	85	92	PF00069	0.399
MOD_N-GLC_2	222	224	PF02516	0.522
MOD_NEK2_1	117	122	PF00069	0.523
MOD_NEK2_1	133	138	PF00069	0.230
MOD_NEK2_1	152	157	PF00069	0.281
MOD_NEK2_1	237	242	PF00069	0.331
MOD_NEK2_1	255	260	PF00069	0.143
MOD_NEK2_1	262	267	PF00069	0.252
MOD_NEK2_1	295	300	PF00069	0.324
MOD_NEK2_1	302	307	PF00069	0.266
MOD_NEK2_1	340	345	PF00069	0.303
MOD_NEK2_1	354	359	PF00069	0.238
MOD_NEK2_1	369	374	PF00069	0.224
MOD_NEK2_1	41	46	PF00069	0.306
MOD_NEK2_1	50	55	PF00069	0.236
MOD_NEK2_1	89	94	PF00069	0.371
MOD_NEK2_2	142	147	PF00069	0.308
MOD_PKA_2	266	272	PF00069	0.327
MOD_PKA_2	279	285	PF00069	0.322
MOD_PKA_2	379	385	PF00069	0.358
MOD_PKA_2	85	91	PF00069	0.288
MOD_PKB_1	11	19	PF00069	0.667
MOD_Plk_1	167	173	PF00069	0.408
MOD_Plk_1	365	371	PF00069	0.165
MOD_Plk_4	123	129	PF00069	0.258
MOD_Plk_4	133	139	PF00069	0.241
MOD_Plk_4	195	201	PF00069	0.271
MOD_Plk_4	206	212	PF00069	0.306
MOD_Plk_4	237	243	PF00069	0.429
MOD_Plk_4	244	250	PF00069	0.479
MOD_Plk_4	284	290	PF00069	0.239
MOD_Plk_4	302	308	PF00069	0.170
MOD_Plk_4	340	346	PF00069	0.281
MOD_Plk_4	380	386	PF00069	0.265
MOD_Plk_4	41	47	PF00069	0.265
MOD_Plk_4	50	56	PF00069	0.281
MOD_Plk_4	89	95	PF00069	0.349
MOD_ProDKin_1	21	27	PF00069	0.535
TRG_ENDOCYTIC_2	147	150	PF00928	0.289
TRG_ENDOCYTIC_2	158	161	PF00928	0.280
TRG_ENDOCYTIC_2	236	239	PF00928	0.337
TRG_ENDOCYTIC_2	286	289	PF00928	0.323
TRG_ENDOCYTIC_2	304	307	PF00928	0.160
TRG_ENDOCYTIC_2	338	341	PF00928	0.260
TRG_ENDOCYTIC_2	342	345	PF00928	0.256
TRG_ENDOCYTIC_2	351	354	PF00928	0.233
TRG_ENDOCYTIC_2	36	39	PF00928	0.297
TRG_ER_diArg_1	109	112	PF00400	0.418
TRG_ER_diArg_1	11	13	PF00400	0.695
TRG_ER_FFAT_2	116	126	PF00635	0.418
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.236

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HS92	Leptomonas seymouri	75%	100%
A0A0S4JS67	Bodo saltans	39%	90%
A0A0S4KHE1	Bodo saltans	31%	100%
A0A1X0NWP2	Trypanosomatidae	54%	100%
A0A3Q8II09	Leishmania donovani	93%	100%
A0A3R7M259	Trypanosoma rangeli	55%	100%
A4FUZ5	Bos taurus	22%	88%
A4HGE3	Leishmania braziliensis	84%	100%
A4I3H6	Leishmania infantum	93%	100%
A7S4N4	Nematostella vectensis	24%	91%
D0A7F8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AZR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q12116	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	88%
Q13530	Homo sapiens	24%	88%
Q3MHV9	Bos taurus	25%	92%
Q4R6L9	Macaca fascicularis	24%	98%
Q54UF8	Dictyostelium discoideum	24%	100%
Q58CW5	Bos taurus	24%	92%
Q5R419	Pongo abelii	25%	92%
Q5R533	Pongo abelii	24%	88%
Q63175	Rattus norvegicus	23%	90%
Q7TNK0	Rattus norvegicus	26%	92%
Q803X0	Danio rerio	21%	90%
Q86VE9	Homo sapiens	23%	98%
Q8BHJ6	Mus musculus	22%	90%
Q8K0E7	Mus musculus	24%	92%
Q96SA4	Homo sapiens	25%	91%
Q9HDY3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	94%
Q9NRX5	Homo sapiens	26%	92%
Q9QZI8	Mus musculus	25%	92%
Q9QZI9	Mus musculus	25%	88%
V5BWF9	Trypanosoma cruzi	54%	100%