DRBM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8G7_LEIMA

TriTrypDb:

LmjF.28.1000 , LMJLV39_280016300 , LMJSD75_280016300

Length:

939

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8G7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8G7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	859	863	PF00656	0.709
CLV_NRD_NRD_1	193	195	PF00675	0.704
CLV_NRD_NRD_1	197	199	PF00675	0.625
CLV_NRD_NRD_1	496	498	PF00675	0.447
CLV_NRD_NRD_1	749	751	PF00675	0.514
CLV_NRD_NRD_1	769	771	PF00675	0.278
CLV_NRD_NRD_1	788	790	PF00675	0.282
CLV_NRD_NRD_1	797	799	PF00675	0.385
CLV_PCSK_FUR_1	494	498	PF00082	0.473
CLV_PCSK_KEX2_1	193	195	PF00082	0.656
CLV_PCSK_KEX2_1	197	199	PF00082	0.616
CLV_PCSK_KEX2_1	496	498	PF00082	0.440
CLV_PCSK_KEX2_1	646	648	PF00082	0.443
CLV_PCSK_KEX2_1	719	721	PF00082	0.448
CLV_PCSK_KEX2_1	749	751	PF00082	0.514
CLV_PCSK_KEX2_1	769	771	PF00082	0.278
CLV_PCSK_KEX2_1	788	790	PF00082	0.282
CLV_PCSK_PC1ET2_1	646	648	PF00082	0.490
CLV_PCSK_PC1ET2_1	719	721	PF00082	0.448
CLV_PCSK_PC7_1	193	199	PF00082	0.613
CLV_PCSK_PC7_1	745	751	PF00082	0.521
CLV_PCSK_PC7_1	765	771	PF00082	0.303
CLV_PCSK_SKI1_1	189	193	PF00082	0.698
CLV_PCSK_SKI1_1	213	217	PF00082	0.644
CLV_PCSK_SKI1_1	231	235	PF00082	0.472
CLV_PCSK_SKI1_1	303	307	PF00082	0.660
CLV_PCSK_SKI1_1	481	485	PF00082	0.337
CLV_PCSK_SKI1_1	533	537	PF00082	0.434
CLV_PCSK_SKI1_1	724	728	PF00082	0.423
CLV_PCSK_SKI1_1	789	793	PF00082	0.371
CLV_PCSK_SKI1_1	794	798	PF00082	0.396
CLV_PCSK_SKI1_1	920	924	PF00082	0.589
DEG_APCC_DBOX_1	212	220	PF00400	0.535
DEG_APCC_DBOX_1	517	525	PF00400	0.349
DEG_APCC_DBOX_1	630	638	PF00400	0.457
DEG_Nend_Nbox_1	1	3	PF02207	0.526
DEG_SCF_FBW7_1	589	596	PF00400	0.346
DEG_SCF_FBW7_1	816	823	PF00400	0.422
DOC_CDC14_PxL_1	677	685	PF14671	0.383
DOC_CDC14_PxL_1	705	713	PF14671	0.467
DOC_CKS1_1	442	447	PF01111	0.414
DOC_CYCLIN_RxL_1	228	238	PF00134	0.537
DOC_CYCLIN_RxL_1	297	310	PF00134	0.508
DOC_CYCLIN_yClb5_NLxxxL_5	474	483	PF00134	0.430
DOC_MAPK_gen_1	355	363	PF00069	0.290
DOC_MAPK_gen_1	394	403	PF00069	0.387
DOC_MAPK_gen_1	57	65	PF00069	0.450
DOC_MAPK_HePTP_8	393	405	PF00069	0.417
DOC_MAPK_MEF2A_6	396	405	PF00069	0.361
DOC_MAPK_MEF2A_6	518	526	PF00069	0.348
DOC_MAPK_MEF2A_6	570	577	PF00069	0.324
DOC_MAPK_MEF2A_6	631	638	PF00069	0.536
DOC_MAPK_MEF2A_6	85	94	PF00069	0.366
DOC_MAPK_NFAT4_5	631	639	PF00069	0.401
DOC_MAPK_RevD_3	634	647	PF00069	0.344
DOC_PP1_RVXF_1	301	307	PF00149	0.573
DOC_PP2B_LxvP_1	403	406	PF13499	0.400
DOC_PP2B_LxvP_1	575	578	PF13499	0.355
DOC_PP2B_LxvP_1	636	639	PF13499	0.342
DOC_PP2B_LxvP_1	660	663	PF13499	0.536
DOC_PP2B_LxvP_1	90	93	PF13499	0.375
DOC_PP4_FxxP_1	46	49	PF00568	0.473
DOC_PP4_FxxP_1	884	887	PF00568	0.576
DOC_USP7_MATH_1	138	142	PF00917	0.566
DOC_USP7_MATH_1	264	268	PF00917	0.672
DOC_USP7_MATH_1	275	279	PF00917	0.635
DOC_USP7_MATH_1	354	358	PF00917	0.411
DOC_USP7_MATH_1	495	499	PF00917	0.477
DOC_USP7_MATH_1	553	557	PF00917	0.340
DOC_USP7_MATH_1	593	597	PF00917	0.340
DOC_USP7_MATH_1	898	902	PF00917	0.625
DOC_USP7_MATH_1	927	931	PF00917	0.625
DOC_USP7_MATH_2	122	128	PF00917	0.467
DOC_USP7_UBL2_3	390	394	PF12436	0.603
DOC_WW_Pin1_4	14	19	PF00397	0.387
DOC_WW_Pin1_4	338	343	PF00397	0.461
DOC_WW_Pin1_4	441	446	PF00397	0.464
DOC_WW_Pin1_4	526	531	PF00397	0.383
DOC_WW_Pin1_4	589	594	PF00397	0.338
DOC_WW_Pin1_4	670	675	PF00397	0.391
DOC_WW_Pin1_4	816	821	PF00397	0.557
DOC_WW_Pin1_4	900	905	PF00397	0.648
DOC_WW_Pin1_4	921	926	PF00397	0.565
LIG_14-3-3_CanoR_1	152	158	PF00244	0.504
LIG_14-3-3_CanoR_1	309	317	PF00244	0.513
LIG_14-3-3_CanoR_1	494	503	PF00244	0.512
LIG_14-3-3_CanoR_1	570	574	PF00244	0.386
LIG_14-3-3_CanoR_1	650	660	PF00244	0.517
LIG_14-3-3_CanoR_1	8	13	PF00244	0.654
LIG_APCC_ABBA_1	688	693	PF00400	0.385
LIG_BRCT_BRCA1_1	555	559	PF00533	0.444
LIG_CaM_IQ_9	142	157	PF13499	0.460
LIG_Clathr_ClatBox_1	521	525	PF01394	0.331
LIG_CtBP_PxDLS_1	122	126	PF00389	0.472
LIG_FHA_1	15	21	PF00498	0.357
LIG_FHA_1	398	404	PF00498	0.327
LIG_FHA_1	469	475	PF00498	0.508
LIG_FHA_1	570	576	PF00498	0.438
LIG_FHA_1	643	649	PF00498	0.320
LIG_FHA_1	821	827	PF00498	0.452
LIG_FHA_1	900	906	PF00498	0.780
LIG_FHA_2	112	118	PF00498	0.546
LIG_FHA_2	362	368	PF00498	0.480
LIG_FHA_2	415	421	PF00498	0.483
LIG_FHA_2	442	448	PF00498	0.408
LIG_FHA_2	652	658	PF00498	0.597
LIG_FHA_2	698	704	PF00498	0.451
LIG_FHA_2	817	823	PF00498	0.423
LIG_FHA_2	852	858	PF00498	0.539
LIG_LIR_Apic_2	44	49	PF02991	0.460
LIG_LIR_Apic_2	883	887	PF02991	0.577
LIG_LIR_Gen_1	151	162	PF02991	0.504
LIG_LIR_Gen_1	209	219	PF02991	0.556
LIG_LIR_Gen_1	400	410	PF02991	0.544
LIG_LIR_Gen_1	556	563	PF02991	0.391
LIG_LIR_Gen_1	693	702	PF02991	0.377
LIG_LIR_Gen_1	753	764	PF02991	0.316
LIG_LIR_Gen_1	819	829	PF02991	0.426
LIG_LIR_Nem_3	126	132	PF02991	0.438
LIG_LIR_Nem_3	151	157	PF02991	0.618
LIG_LIR_Nem_3	209	214	PF02991	0.575
LIG_LIR_Nem_3	400	405	PF02991	0.497
LIG_LIR_Nem_3	485	490	PF02991	0.573
LIG_LIR_Nem_3	529	535	PF02991	0.417
LIG_LIR_Nem_3	556	562	PF02991	0.328
LIG_LIR_Nem_3	571	577	PF02991	0.343
LIG_LIR_Nem_3	735	740	PF02991	0.376
LIG_LIR_Nem_3	753	759	PF02991	0.279
LIG_LIR_Nem_3	819	824	PF02991	0.514
LIG_PCNA_APIM_2	356	362	PF02747	0.289
LIG_Pex14_1	42	46	PF04695	0.443
LIG_PTB_Apo_2	278	285	PF02174	0.646
LIG_PTB_Phospho_1	278	284	PF10480	0.644
LIG_SH2_CRK	442	446	PF00017	0.416
LIG_SH2_CRK	487	491	PF00017	0.525
LIG_SH2_CRK	756	760	PF00017	0.395
LIG_SH2_NCK_1	587	591	PF00017	0.364
LIG_SH2_PTP2	758	761	PF00017	0.273
LIG_SH2_SRC	691	694	PF00017	0.385
LIG_SH2_SRC	754	757	PF00017	0.304
LIG_SH2_SRC	806	809	PF00017	0.450
LIG_SH2_STAP1	29	33	PF00017	0.534
LIG_SH2_STAP1	301	305	PF00017	0.565
LIG_SH2_STAP1	399	403	PF00017	0.314
LIG_SH2_STAP1	452	456	PF00017	0.362
LIG_SH2_STAP1	554	558	PF00017	0.332
LIG_SH2_STAP1	644	648	PF00017	0.463
LIG_SH2_STAT5	129	132	PF00017	0.490
LIG_SH2_STAT5	359	362	PF00017	0.472
LIG_SH2_STAT5	399	402	PF00017	0.323
LIG_SH2_STAT5	561	564	PF00017	0.365
LIG_SH2_STAT5	574	577	PF00017	0.371
LIG_SH2_STAT5	642	645	PF00017	0.455
LIG_SH2_STAT5	754	757	PF00017	0.465
LIG_SH2_STAT5	758	761	PF00017	0.384
LIG_SH2_STAT5	806	809	PF00017	0.450
LIG_SH3_2	406	411	PF14604	0.322
LIG_SH3_3	125	131	PF00018	0.432
LIG_SH3_3	290	296	PF00018	0.727
LIG_SH3_3	403	409	PF00018	0.415
LIG_SH3_3	463	469	PF00018	0.463
LIG_SH3_3	547	553	PF00018	0.319
LIG_SH3_3	570	576	PF00018	0.383
LIG_SH3_3	659	665	PF00018	0.590
LIG_SH3_3	919	925	PF00018	0.632
LIG_SUMO_SIM_anti_2	523	529	PF11976	0.555
LIG_SUMO_SIM_par_1	119	127	PF11976	0.477
LIG_SUMO_SIM_par_1	520	525	PF11976	0.392
LIG_TRAF2_1	376	379	PF00917	0.542
LIG_TRAF2_1	417	420	PF00917	0.455
LIG_TRAF2_1	690	693	PF00917	0.394
LIG_TYR_ITIM	299	304	PF00017	0.440
LIG_WRC_WIRS_1	43	48	PF05994	0.448
LIG_WRC_WIRS_1	514	519	PF05994	0.380
LIG_WRC_WIRS_1	543	548	PF05994	0.417
LIG_WW_1	674	677	PF00397	0.355
MOD_CDK_SPK_2	14	19	PF00069	0.387
MOD_CDK_SPxxK_3	338	345	PF00069	0.447
MOD_CDK_SPxxK_3	526	533	PF00069	0.299
MOD_CK1_1	153	159	PF00069	0.706
MOD_CK1_1	161	167	PF00069	0.743
MOD_CK1_1	173	179	PF00069	0.677
MOD_CK1_1	371	377	PF00069	0.552
MOD_CK1_1	588	594	PF00069	0.329
MOD_CK1_1	903	909	PF00069	0.628
MOD_CK2_1	111	117	PF00069	0.555
MOD_CK2_1	248	254	PF00069	0.673
MOD_CK2_1	414	420	PF00069	0.579
MOD_CK2_1	441	447	PF00069	0.409
MOD_CK2_1	588	594	PF00069	0.450
MOD_CK2_1	651	657	PF00069	0.636
MOD_Cter_Amidation	786	789	PF01082	0.364
MOD_GlcNHglycan	140	143	PF01048	0.575
MOD_GlcNHglycan	160	163	PF01048	0.741
MOD_GlcNHglycan	175	178	PF01048	0.680
MOD_GlcNHglycan	250	253	PF01048	0.671
MOD_GlcNHglycan	266	269	PF01048	0.606
MOD_GlcNHglycan	311	314	PF01048	0.650
MOD_GlcNHglycan	555	558	PF01048	0.385
MOD_GlcNHglycan	683	686	PF01048	0.511
MOD_GlcNHglycan	905	908	PF01048	0.740
MOD_GlcNHglycan	914	917	PF01048	0.621
MOD_GSK3_1	153	160	PF00069	0.729
MOD_GSK3_1	173	180	PF00069	0.644
MOD_GSK3_1	218	225	PF00069	0.682
MOD_GSK3_1	244	251	PF00069	0.549
MOD_GSK3_1	367	374	PF00069	0.477
MOD_GSK3_1	4	11	PF00069	0.547
MOD_GSK3_1	564	571	PF00069	0.474
MOD_GSK3_1	585	592	PF00069	0.432
MOD_GSK3_1	638	645	PF00069	0.419
MOD_GSK3_1	651	658	PF00069	0.578
MOD_GSK3_1	666	673	PF00069	0.457
MOD_GSK3_1	816	823	PF00069	0.413
MOD_GSK3_1	894	901	PF00069	0.639
MOD_NEK2_1	123	128	PF00069	0.532
MOD_NEK2_1	157	162	PF00069	0.642
MOD_NEK2_1	2	7	PF00069	0.689
MOD_NEK2_1	222	227	PF00069	0.614
MOD_NEK2_1	368	373	PF00069	0.431
MOD_NEK2_1	389	394	PF00069	0.547
MOD_NEK2_1	683	688	PF00069	0.471
MOD_NEK2_1	727	732	PF00069	0.366
MOD_NEK2_1	856	861	PF00069	0.557
MOD_NEK2_2	569	574	PF00069	0.372
MOD_PIKK_1	177	183	PF00454	0.679
MOD_PIKK_1	284	290	PF00454	0.523
MOD_PIKK_1	415	421	PF00454	0.487
MOD_PIKK_1	564	570	PF00454	0.474
MOD_PIKK_1	727	733	PF00454	0.337
MOD_PKA_2	284	290	PF00069	0.523
MOD_PKA_2	354	360	PF00069	0.490
MOD_PKA_2	361	367	PF00069	0.449
MOD_PKA_2	495	501	PF00069	0.555
MOD_PKA_2	569	575	PF00069	0.333
MOD_PKA_2	630	636	PF00069	0.394
MOD_Plk_1	123	129	PF00069	0.468
MOD_Plk_1	368	374	PF00069	0.453
MOD_Plk_1	593	599	PF00069	0.338
MOD_Plk_1	727	733	PF00069	0.337
MOD_Plk_1	856	862	PF00069	0.489
MOD_Plk_2-3	468	474	PF00069	0.479
MOD_Plk_4	124	130	PF00069	0.364
MOD_Plk_4	222	228	PF00069	0.650
MOD_Plk_4	244	250	PF00069	0.612
MOD_Plk_4	331	337	PF00069	0.469
MOD_Plk_4	394	400	PF00069	0.424
MOD_Plk_4	569	575	PF00069	0.317
MOD_Plk_4	593	599	PF00069	0.358
MOD_Plk_4	638	644	PF00069	0.435
MOD_Plk_4	851	857	PF00069	0.527
MOD_ProDKin_1	14	20	PF00069	0.379
MOD_ProDKin_1	338	344	PF00069	0.455
MOD_ProDKin_1	441	447	PF00069	0.464
MOD_ProDKin_1	526	532	PF00069	0.374
MOD_ProDKin_1	589	595	PF00069	0.334
MOD_ProDKin_1	670	676	PF00069	0.382
MOD_ProDKin_1	816	822	PF00069	0.562
MOD_ProDKin_1	900	906	PF00069	0.650
MOD_ProDKin_1	921	927	PF00069	0.565
MOD_SUMO_rev_2	468	477	PF00179	0.487
MOD_SUMO_rev_2	51	59	PF00179	0.414
MOD_SUMO_rev_2	525	535	PF00179	0.394
MOD_SUMO_rev_2	716	721	PF00179	0.437
TRG_DiLeu_BaEn_1	531	536	PF01217	0.394
TRG_DiLeu_BaEn_1	632	637	PF01217	0.413
TRG_DiLeu_BaLyEn_6	16	21	PF01217	0.471
TRG_DiLeu_BaLyEn_6	229	234	PF01217	0.525
TRG_DiLeu_BaLyEn_6	457	462	PF01217	0.414
TRG_ENDOCYTIC_2	129	132	PF00928	0.484
TRG_ENDOCYTIC_2	301	304	PF00928	0.522
TRG_ENDOCYTIC_2	487	490	PF00928	0.402
TRG_ENDOCYTIC_2	532	535	PF00928	0.333
TRG_ENDOCYTIC_2	574	577	PF00928	0.382
TRG_ENDOCYTIC_2	677	680	PF00928	0.417
TRG_ENDOCYTIC_2	691	694	PF00928	0.427
TRG_ENDOCYTIC_2	756	759	PF00928	0.323
TRG_ER_diArg_1	192	194	PF00400	0.652
TRG_ER_diArg_1	197	199	PF00400	0.606
TRG_ER_diArg_1	308	311	PF00400	0.442
TRG_ER_diArg_1	493	496	PF00400	0.629
TRG_ER_diArg_1	749	751	PF00400	0.617
TRG_ER_diArg_1	769	771	PF00400	0.310
TRG_ER_diArg_1	788	790	PF00400	0.282
TRG_NES_CRM1_1	240	254	PF08389	0.517
TRG_NES_CRM1_1	424	435	PF08389	0.320
TRG_Pf-PMV_PEXEL_1	104	109	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.589
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.377
TRG_Pf-PMV_PEXEL_1	481	485	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2W5	Leptomonas seymouri	49%	89%
A0A1X0NZW9	Trypanosomatidae	35%	95%
A0A3Q8IDR2	Leishmania donovani	94%	100%
A0A3R7M3D8	Trypanosoma rangeli	35%	100%
A4HGE4	Leishmania braziliensis	76%	90%
A4I3H7	Leishmania infantum	94%	100%
E9AZR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5D1P8	Trypanosoma cruzi	35%	100%