PPR_long domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8G5_LEIMA

TriTrypDb:

LmjF.28.1020 , LMJLV39_280016500 , LMJSD75_280016400

Length:

627

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8G5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8G5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	234	238	PF00656	0.630
CLV_C14_Caspase3-7	368	372	PF00656	0.556
CLV_NRD_NRD_1	214	216	PF00675	0.680
CLV_NRD_NRD_1	258	260	PF00675	0.399
CLV_NRD_NRD_1	264	266	PF00675	0.390
CLV_NRD_NRD_1	28	30	PF00675	0.445
CLV_NRD_NRD_1	426	428	PF00675	0.424
CLV_NRD_NRD_1	455	457	PF00675	0.399
CLV_NRD_NRD_1	541	543	PF00675	0.475
CLV_NRD_NRD_1	92	94	PF00675	0.497
CLV_PCSK_KEX2_1	214	216	PF00082	0.680
CLV_PCSK_KEX2_1	258	260	PF00082	0.381
CLV_PCSK_KEX2_1	28	30	PF00082	0.445
CLV_PCSK_KEX2_1	426	428	PF00082	0.424
CLV_PCSK_KEX2_1	455	457	PF00082	0.399
CLV_PCSK_KEX2_1	540	542	PF00082	0.429
CLV_PCSK_KEX2_1	547	549	PF00082	0.468
CLV_PCSK_KEX2_1	92	94	PF00082	0.487
CLV_PCSK_PC1ET2_1	547	549	PF00082	0.538
CLV_PCSK_PC7_1	210	216	PF00082	0.542
CLV_PCSK_SKI1_1	154	158	PF00082	0.349
CLV_PCSK_SKI1_1	28	32	PF00082	0.472
CLV_PCSK_SKI1_1	346	350	PF00082	0.410
CLV_PCSK_SKI1_1	4	8	PF00082	0.449
CLV_PCSK_SKI1_1	416	420	PF00082	0.410
CLV_PCSK_SKI1_1	98	102	PF00082	0.549
DEG_Nend_UBRbox_2	1	3	PF02207	0.574
DOC_CYCLIN_yCln2_LP_2	304	307	PF00134	0.371
DOC_MAPK_DCC_7	265	275	PF00069	0.412
DOC_MAPK_gen_1	375	384	PF00069	0.368
DOC_MAPK_MEF2A_6	286	294	PF00069	0.381
DOC_MAPK_MEF2A_6	378	386	PF00069	0.422
DOC_PP1_SILK_1	292	297	PF00149	0.426
DOC_PP2B_LxvP_1	304	307	PF13499	0.371
DOC_PP4_FxxP_1	556	559	PF00568	0.364
DOC_USP7_MATH_1	191	195	PF00917	0.713
DOC_USP7_MATH_1	213	217	PF00917	0.706
DOC_USP7_MATH_1	440	444	PF00917	0.436
DOC_WW_Pin1_4	197	202	PF00397	0.621
DOC_WW_Pin1_4	242	247	PF00397	0.508
DOC_WW_Pin1_4	268	273	PF00397	0.384
DOC_WW_Pin1_4	620	625	PF00397	0.605
LIG_14-3-3_CanoR_1	360	366	PF00244	0.597
LIG_14-3-3_CanoR_1	378	383	PF00244	0.375
LIG_14-3-3_CanoR_1	430	435	PF00244	0.474
LIG_14-3-3_CanoR_1	459	464	PF00244	0.454
LIG_14-3-3_CanoR_1	98	107	PF00244	0.445
LIG_Actin_WH2_2	141	156	PF00022	0.434
LIG_APCC_ABBA_1	549	554	PF00400	0.421
LIG_APCC_ABBAyCdc20_2	548	554	PF00400	0.434
LIG_BRCT_BRCA1_1	191	195	PF00533	0.609
LIG_BRCT_BRCA1_1	622	626	PF00533	0.608
LIG_deltaCOP1_diTrp_1	486	490	PF00928	0.370
LIG_eIF4E_1	506	512	PF01652	0.423
LIG_FHA_1	148	154	PF00498	0.355
LIG_FHA_1	269	275	PF00498	0.370
LIG_FHA_1	99	105	PF00498	0.336
LIG_FHA_2	232	238	PF00498	0.554
LIG_FHA_2	534	540	PF00498	0.458
LIG_FHA_2	604	610	PF00498	0.580
LIG_FHA_2	620	626	PF00498	0.498
LIG_LIR_Apic_2	401	405	PF02991	0.310
LIG_LIR_Apic_2	553	559	PF02991	0.401
LIG_LIR_Gen_1	252	261	PF02991	0.397
LIG_LIR_Gen_1	385	395	PF02991	0.381
LIG_LIR_Gen_1	417	425	PF02991	0.358
LIG_LIR_Gen_1	449	458	PF02991	0.392
LIG_LIR_Gen_1	504	513	PF02991	0.350
LIG_LIR_Gen_1	520	530	PF02991	0.331
LIG_LIR_Nem_3	252	257	PF02991	0.346
LIG_LIR_Nem_3	385	390	PF02991	0.418
LIG_LIR_Nem_3	417	422	PF02991	0.416
LIG_LIR_Nem_3	449	454	PF02991	0.536
LIG_LIR_Nem_3	486	490	PF02991	0.472
LIG_LIR_Nem_3	520	525	PF02991	0.570
LIG_LIR_Nem_3	89	94	PF02991	0.464
LIG_PCNA_yPIPBox_3	248	259	PF02747	0.347
LIG_Pex14_1	415	419	PF04695	0.425
LIG_SH2_CRK	522	526	PF00017	0.409
LIG_SH2_CRK	91	95	PF00017	0.412
LIG_SH2_PTP2	87	90	PF00017	0.390
LIG_SH2_STAP1	310	314	PF00017	0.348
LIG_SH2_STAP1	437	441	PF00017	0.379
LIG_SH2_STAP1	552	556	PF00017	0.506
LIG_SH2_STAP1	613	617	PF00017	0.525
LIG_SH2_STAT3	318	321	PF00017	0.369
LIG_SH2_STAT5	152	155	PF00017	0.311
LIG_SH2_STAT5	474	477	PF00017	0.385
LIG_SH2_STAT5	517	520	PF00017	0.364
LIG_SH2_STAT5	87	90	PF00017	0.379
LIG_SH3_3	429	435	PF00018	0.487
LIG_SUMO_SIM_anti_2	469	474	PF11976	0.438
LIG_SUMO_SIM_par_1	271	277	PF11976	0.386
LIG_TRAF2_1	167	170	PF00917	0.603
LIG_TRAF2_1	204	207	PF00917	0.613
LIG_TRAF2_1	250	253	PF00917	0.381
LIG_TRAF2_1	351	354	PF00917	0.338
LIG_TRAF2_1	356	359	PF00917	0.360
LIG_TRFH_1	556	560	PF08558	0.402
MOD_CK1_1	189	195	PF00069	0.676
MOD_CK1_1	197	203	PF00069	0.667
MOD_CK1_1	242	248	PF00069	0.486
MOD_CK2_1	164	170	PF00069	0.666
MOD_CK2_1	187	193	PF00069	0.800
MOD_CK2_1	353	359	PF00069	0.375
MOD_CK2_1	440	446	PF00069	0.320
MOD_CK2_1	459	465	PF00069	0.355
MOD_CK2_1	533	539	PF00069	0.397
MOD_CK2_1	619	625	PF00069	0.645
MOD_GlcNHglycan	166	169	PF01048	0.640
MOD_GlcNHglycan	189	192	PF01048	0.728
MOD_GlcNHglycan	239	244	PF01048	0.537
MOD_GlcNHglycan	353	358	PF01048	0.387
MOD_GlcNHglycan	367	370	PF01048	0.627
MOD_GlcNHglycan	375	378	PF01048	0.424
MOD_GlcNHglycan	432	435	PF01048	0.423
MOD_GlcNHglycan	595	598	PF01048	0.517
MOD_GSK3_1	183	190	PF00069	0.701
MOD_GSK3_1	264	271	PF00069	0.613
MOD_GSK3_1	349	356	PF00069	0.470
MOD_GSK3_1	361	368	PF00069	0.470
MOD_GSK3_1	378	385	PF00069	0.497
MOD_GSK3_1	40	47	PF00069	0.415
MOD_GSK3_1	593	600	PF00069	0.513
MOD_LATS_1	134	140	PF00433	0.513
MOD_N-GLC_1	136	141	PF02516	0.534
MOD_N-GLC_1	533	538	PF02516	0.456
MOD_NEK2_1	10	15	PF00069	0.437
MOD_NEK2_1	157	162	PF00069	0.397
MOD_NEK2_1	274	279	PF00069	0.367
MOD_NEK2_1	290	295	PF00069	0.300
MOD_NEK2_1	333	338	PF00069	0.440
MOD_NEK2_1	365	370	PF00069	0.631
MOD_NEK2_1	382	387	PF00069	0.347
MOD_NEK2_1	458	463	PF00069	0.486
MOD_NEK2_2	310	315	PF00069	0.330
MOD_PIKK_1	183	189	PF00454	0.697
MOD_PIKK_1	276	282	PF00454	0.412
MOD_PIKK_1	40	46	PF00454	0.414
MOD_PIKK_1	533	539	PF00454	0.408
MOD_PIKK_1	611	617	PF00454	0.577
MOD_PKA_1	214	220	PF00069	0.541
MOD_PKA_2	10	16	PF00069	0.496
MOD_PKA_2	213	219	PF00069	0.669
MOD_PKA_2	264	270	PF00069	0.379
MOD_PKA_2	361	367	PF00069	0.573
MOD_PKA_2	458	464	PF00069	0.469
MOD_PKA_2	593	599	PF00069	0.497
MOD_PKB_1	96	104	PF00069	0.372
MOD_Plk_1	310	316	PF00069	0.329
MOD_Plk_1	341	347	PF00069	0.355
MOD_Plk_1	533	539	PF00069	0.500
MOD_Plk_4	157	163	PF00069	0.455
MOD_Plk_4	290	296	PF00069	0.419
MOD_Plk_4	382	388	PF00069	0.352
MOD_Plk_4	466	472	PF00069	0.463
MOD_Plk_4	521	527	PF00069	0.421
MOD_ProDKin_1	197	203	PF00069	0.622
MOD_ProDKin_1	242	248	PF00069	0.504
MOD_ProDKin_1	268	274	PF00069	0.375
MOD_ProDKin_1	620	626	PF00069	0.612
MOD_SUMO_for_1	204	207	PF00179	0.587
MOD_SUMO_rev_2	539	549	PF00179	0.524
TRG_AP2beta_CARGO_1	417	426	PF09066	0.434
TRG_DiLeu_BaEn_1	453	458	PF01217	0.422
TRG_DiLeu_BaEn_4	252	258	PF01217	0.388
TRG_DiLeu_BaEn_4	553	559	PF01217	0.430
TRG_DiLeu_BaLyEn_6	507	512	PF01217	0.355
TRG_DiLeu_LyEn_5	269	274	PF01217	0.470
TRG_ENDOCYTIC_2	506	509	PF00928	0.413
TRG_ENDOCYTIC_2	522	525	PF00928	0.341
TRG_ENDOCYTIC_2	87	90	PF00928	0.352
TRG_ENDOCYTIC_2	91	94	PF00928	0.365
TRG_ER_diArg_1	257	259	PF00400	0.357
TRG_ER_diArg_1	425	427	PF00400	0.410
TRG_ER_diArg_1	454	456	PF00400	0.427
TRG_ER_diArg_1	482	485	PF00400	0.376
TRG_ER_diArg_1	540	542	PF00400	0.486
TRG_ER_diArg_1	548	551	PF00400	0.516
TRG_ER_diArg_1	91	93	PF00400	0.437
TRG_ER_diArg_1	96	99	PF00400	0.427
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	19	24	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	500	504	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	510	514	PF00026	0.312

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P278	Leptomonas seymouri	67%	100%
A0A0S4IQ65	Bodo saltans	31%	88%
A0A1X0NYR6	Trypanosomatidae	46%	100%
A0A3Q8IDU9	Leishmania donovani	95%	100%
A4HGE6	Leishmania braziliensis	86%	100%
A4I3J2	Leishmania infantum	95%	100%
E9AZR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%