Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q8G3_LEIMA

TriTrypDb:

LmjF.28.1040 , LMJLV39_280016600 , LMJSD75_280016500

Length:

839

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8G3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8G3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	304	308	PF00656	0.609
CLV_C14_Caspase3-7	429	433	PF00656	0.659
CLV_C14_Caspase3-7	576	580	PF00656	0.741
CLV_NRD_NRD_1	282	284	PF00675	0.616
CLV_NRD_NRD_1	366	368	PF00675	0.607
CLV_PCSK_KEX2_1	282	284	PF00082	0.616
CLV_PCSK_KEX2_1	365	367	PF00082	0.601
CLV_PCSK_KEX2_1	50	52	PF00082	0.763
CLV_PCSK_PC1ET2_1	365	367	PF00082	0.531
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.711
CLV_PCSK_SKI1_1	212	216	PF00082	0.631
CLV_PCSK_SKI1_1	251	255	PF00082	0.603
CLV_PCSK_SKI1_1	27	31	PF00082	0.749
CLV_PCSK_SKI1_1	381	385	PF00082	0.606
CLV_PCSK_SKI1_1	390	394	PF00082	0.518
CLV_PCSK_SKI1_1	398	402	PF00082	0.478
CLV_PCSK_SKI1_1	51	55	PF00082	0.775
CLV_PCSK_SKI1_1	559	563	PF00082	0.645
CLV_PCSK_SKI1_1	625	629	PF00082	0.681
CLV_PCSK_SKI1_1	740	744	PF00082	0.737
CLV_PCSK_SKI1_1	77	81	PF00082	0.665
CLV_Separin_Metazoa	520	524	PF03568	0.669
CLV_Separin_Metazoa	810	814	PF03568	0.632
DEG_Nend_UBRbox_1	1	4	PF02207	0.704
DEG_SPOP_SBC_1	522	526	PF00917	0.695
DEG_SPOP_SBC_1	694	698	PF00917	0.701
DEG_SPOP_SBC_1	715	719	PF00917	0.742
DOC_CKS1_1	540	545	PF01111	0.714
DOC_CKS1_1	598	603	PF01111	0.678
DOC_MAPK_DCC_7	4	14	PF00069	0.747
DOC_MAPK_MEF2A_6	164	172	PF00069	0.691
DOC_PP1_SILK_1	398	403	PF00149	0.535
DOC_PP2B_LxvP_1	170	173	PF13499	0.653
DOC_PP2B_LxvP_1	677	680	PF13499	0.713
DOC_PP2B_LxvP_1	743	746	PF13499	0.732
DOC_PP2B_LxvP_1	769	772	PF13499	0.743
DOC_USP7_MATH_1	103	107	PF00917	0.564
DOC_USP7_MATH_1	23	27	PF00917	0.702
DOC_USP7_MATH_1	285	289	PF00917	0.640
DOC_USP7_MATH_1	29	33	PF00917	0.647
DOC_USP7_MATH_1	295	299	PF00917	0.598
DOC_USP7_MATH_1	36	40	PF00917	0.576
DOC_USP7_MATH_1	522	526	PF00917	0.742
DOC_USP7_MATH_1	550	554	PF00917	0.694
DOC_USP7_MATH_1	632	636	PF00917	0.727
DOC_USP7_MATH_1	638	642	PF00917	0.670
DOC_USP7_MATH_1	649	653	PF00917	0.618
DOC_USP7_MATH_1	701	705	PF00917	0.734
DOC_USP7_MATH_1	715	719	PF00917	0.611
DOC_USP7_MATH_1	763	767	PF00917	0.672
DOC_USP7_MATH_1	826	830	PF00917	0.636
DOC_USP7_MATH_1	97	101	PF00917	0.689
DOC_USP7_UBL2_3	398	402	PF12436	0.528
DOC_WW_Pin1_4	101	106	PF00397	0.656
DOC_WW_Pin1_4	405	410	PF00397	0.777
DOC_WW_Pin1_4	528	533	PF00397	0.679
DOC_WW_Pin1_4	539	544	PF00397	0.624
DOC_WW_Pin1_4	597	602	PF00397	0.678
DOC_WW_Pin1_4	617	622	PF00397	0.520
DOC_WW_Pin1_4	695	700	PF00397	0.737
DOC_WW_Pin1_4	728	733	PF00397	0.763
DOC_WW_Pin1_4	741	746	PF00397	0.595
LIG_14-3-3_CanoR_1	164	169	PF00244	0.642
LIG_14-3-3_CanoR_1	177	186	PF00244	0.525
LIG_14-3-3_CanoR_1	300	306	PF00244	0.650
LIG_14-3-3_CanoR_1	381	386	PF00244	0.464
LIG_14-3-3_CanoR_1	4	9	PF00244	0.708
LIG_14-3-3_CanoR_1	523	528	PF00244	0.696
LIG_14-3-3_CanoR_1	820	826	PF00244	0.675
LIG_BIR_III_2	510	514	PF00653	0.690
LIG_BRCT_BRCA1_1	378	382	PF00533	0.616
LIG_Clathr_ClatBox_1	165	169	PF01394	0.726
LIG_CtBP_PxDLS_1	756	760	PF00389	0.673
LIG_EVH1_1	769	773	PF00568	0.734
LIG_FHA_1	179	185	PF00498	0.588
LIG_FHA_1	221	227	PF00498	0.567
LIG_FHA_1	269	275	PF00498	0.528
LIG_FHA_1	331	337	PF00498	0.491
LIG_FHA_1	347	353	PF00498	0.349
LIG_FHA_1	447	453	PF00498	0.621
LIG_FHA_1	469	475	PF00498	0.726
LIG_FHA_1	532	538	PF00498	0.667
LIG_FHA_1	598	604	PF00498	0.764
LIG_FHA_1	626	632	PF00498	0.720
LIG_FHA_1	78	84	PF00498	0.616
LIG_FHA_1	807	813	PF00498	0.625
LIG_FHA_2	105	111	PF00498	0.670
LIG_FHA_2	189	195	PF00498	0.615
LIG_FHA_2	255	261	PF00498	0.538
LIG_FHA_2	302	308	PF00498	0.626
LIG_FHA_2	421	427	PF00498	0.702
LIG_FHA_2	505	511	PF00498	0.657
LIG_FHA_2	552	558	PF00498	0.695
LIG_Integrin_isoDGR_2	61	63	PF01839	0.604
LIG_LIR_Gen_1	26	36	PF02991	0.670
LIG_LIR_Gen_1	379	389	PF02991	0.608
LIG_LIR_Gen_1	524	533	PF02991	0.645
LIG_LIR_Nem_3	26	31	PF02991	0.671
LIG_LIR_Nem_3	313	317	PF02991	0.514
LIG_LIR_Nem_3	379	385	PF02991	0.620
LIG_LIR_Nem_3	524	530	PF02991	0.646
LIG_LIR_Nem_3	558	564	PF02991	0.680
LIG_MAD2	593	601	PF02301	0.585
LIG_MYND_1	601	605	PF01753	0.679
LIG_MYND_1	757	761	PF01753	0.770
LIG_PTAP_UEV_1	764	769	PF05743	0.578
LIG_RPA_C_Fungi	795	807	PF08784	0.623
LIG_SH2_CRK	375	379	PF00017	0.607
LIG_SH2_STAT3	315	318	PF00017	0.580
LIG_SH2_STAT3	374	377	PF00017	0.612
LIG_SH3_3	403	409	PF00018	0.694
LIG_SH3_3	511	517	PF00018	0.676
LIG_SH3_3	535	541	PF00018	0.710
LIG_SH3_3	581	587	PF00018	0.697
LIG_SH3_3	664	670	PF00018	0.729
LIG_SH3_3	706	712	PF00018	0.791
LIG_SH3_3	721	727	PF00018	0.612
LIG_SH3_3	739	745	PF00018	0.612
LIG_SH3_3	748	754	PF00018	0.701
LIG_SH3_3	757	763	PF00018	0.722
LIG_SH3_3	767	773	PF00018	0.642
LIG_SH3_3	775	781	PF00018	0.543
LIG_SH3_3	782	788	PF00018	0.558
LIG_Sin3_3	456	463	PF02671	0.629
LIG_SUMO_SIM_anti_2	110	115	PF11976	0.599
LIG_SUMO_SIM_anti_2	455	461	PF11976	0.632
LIG_SUMO_SIM_par_1	164	169	PF11976	0.614
LIG_TRAF2_1	40	43	PF00917	0.677
LIG_TRAF2_1	517	520	PF00917	0.720
LIG_UBA3_1	215	224	PF00899	0.619
LIG_UBA3_1	594	599	PF00899	0.588
MOD_CDC14_SPxK_1	408	411	PF00782	0.789
MOD_CDK_SPxK_1	405	411	PF00069	0.780
MOD_CK1_1	104	110	PF00069	0.625
MOD_CK1_1	145	151	PF00069	0.658
MOD_CK1_1	187	193	PF00069	0.627
MOD_CK1_1	298	304	PF00069	0.665
MOD_CK1_1	502	508	PF00069	0.681
MOD_CK1_1	553	559	PF00069	0.693
MOD_CK1_1	641	647	PF00069	0.712
MOD_CK1_1	704	710	PF00069	0.709
MOD_CK1_1	718	724	PF00069	0.591
MOD_CK1_1	78	84	PF00069	0.620
MOD_CK1_1	821	827	PF00069	0.677
MOD_CK2_1	104	110	PF00069	0.677
MOD_CK2_1	254	260	PF00069	0.537
MOD_CK2_1	36	42	PF00069	0.656
MOD_CK2_1	420	426	PF00069	0.715
MOD_CK2_1	522	528	PF00069	0.642
MOD_CK2_1	623	629	PF00069	0.705
MOD_DYRK1A_RPxSP_1	405	409	PF00069	0.701
MOD_GlcNHglycan	152	155	PF01048	0.749
MOD_GlcNHglycan	21	24	PF01048	0.556
MOD_GlcNHglycan	378	381	PF01048	0.590
MOD_GlcNHglycan	38	41	PF01048	0.752
MOD_GlcNHglycan	385	388	PF01048	0.539
MOD_GlcNHglycan	471	474	PF01048	0.693
MOD_GlcNHglycan	503	507	PF01048	0.680
MOD_GlcNHglycan	587	590	PF01048	0.689
MOD_GlcNHglycan	6	9	PF01048	0.708
MOD_GlcNHglycan	634	637	PF01048	0.717
MOD_GlcNHglycan	64	67	PF01048	0.706
MOD_GlcNHglycan	650	654	PF01048	0.555
MOD_GlcNHglycan	672	675	PF01048	0.770
MOD_GlcNHglycan	748	751	PF01048	0.690
MOD_GlcNHglycan	765	768	PF01048	0.682
MOD_GlcNHglycan	828	831	PF01048	0.629
MOD_GSK3_1	134	141	PF00069	0.677
MOD_GSK3_1	164	171	PF00069	0.643
MOD_GSK3_1	17	24	PF00069	0.712
MOD_GSK3_1	184	191	PF00069	0.648
MOD_GSK3_1	290	297	PF00069	0.680
MOD_GSK3_1	330	337	PF00069	0.492
MOD_GSK3_1	381	388	PF00069	0.561
MOD_GSK3_1	446	453	PF00069	0.653
MOD_GSK3_1	461	468	PF00069	0.604
MOD_GSK3_1	619	626	PF00069	0.632
MOD_GSK3_1	637	644	PF00069	0.661
MOD_GSK3_1	645	652	PF00069	0.697
MOD_GSK3_1	654	661	PF00069	0.558
MOD_GSK3_1	684	691	PF00069	0.622
MOD_GSK3_1	714	721	PF00069	0.740
MOD_GSK3_1	73	80	PF00069	0.790
MOD_GSK3_1	97	104	PF00069	0.677
MOD_N-GLC_1	145	150	PF02516	0.630
MOD_N-GLC_1	188	193	PF02516	0.554
MOD_N-GLC_1	260	265	PF02516	0.536
MOD_NEK2_1	109	114	PF00069	0.569
MOD_NEK2_1	12	17	PF00069	0.784
MOD_NEK2_1	138	143	PF00069	0.615
MOD_NEK2_1	254	259	PF00069	0.537
MOD_NEK2_1	716	721	PF00069	0.746
MOD_NEK2_1	811	816	PF00069	0.610
MOD_NEK2_2	285	290	PF00069	0.526
MOD_PIKK_1	21	27	PF00454	0.672
MOD_PIKK_1	29	35	PF00454	0.657
MOD_PIKK_1	307	313	PF00454	0.589
MOD_PIKK_1	359	365	PF00454	0.475
MOD_PIKK_1	821	827	PF00454	0.677
MOD_PK_1	164	170	PF00069	0.691
MOD_PKA_2	142	148	PF00069	0.743
MOD_PKA_2	178	184	PF00069	0.586
MOD_PKA_2	254	260	PF00069	0.537
MOD_PKA_2	299	305	PF00069	0.598
MOD_PKA_2	359	365	PF00069	0.541
MOD_PKA_2	427	433	PF00069	0.662
MOD_PKA_2	522	528	PF00069	0.690
MOD_PKA_2	62	68	PF00069	0.658
MOD_PKA_2	707	713	PF00069	0.745
MOD_PKA_2	73	79	PF00069	0.655
MOD_PKA_2	819	825	PF00069	0.679
MOD_PKB_1	2	10	PF00069	0.710
MOD_Plk_1	109	115	PF00069	0.640
MOD_Plk_1	168	174	PF00069	0.653
MOD_Plk_1	210	216	PF00069	0.635
MOD_Plk_1	260	266	PF00069	0.537
MOD_Plk_1	285	291	PF00069	0.606
MOD_Plk_1	420	426	PF00069	0.715
MOD_Plk_1	623	629	PF00069	0.716
MOD_Plk_2-3	504	510	PF00069	0.612
MOD_Plk_2-3	623	629	PF00069	0.716
MOD_Plk_4	109	115	PF00069	0.585
MOD_Plk_4	228	234	PF00069	0.536
MOD_Plk_4	658	664	PF00069	0.585
MOD_ProDKin_1	101	107	PF00069	0.645
MOD_ProDKin_1	405	411	PF00069	0.780
MOD_ProDKin_1	528	534	PF00069	0.678
MOD_ProDKin_1	539	545	PF00069	0.624
MOD_ProDKin_1	597	603	PF00069	0.679
MOD_ProDKin_1	617	623	PF00069	0.520
MOD_ProDKin_1	695	701	PF00069	0.738
MOD_ProDKin_1	728	734	PF00069	0.763
MOD_ProDKin_1	741	747	PF00069	0.593
MOD_SUMO_rev_2	39	46	PF00179	0.668
MOD_SUMO_rev_2	553	561	PF00179	0.655
MOD_SUMO_rev_2	620	627	PF00179	0.688
TRG_DiLeu_BaEn_1	211	216	PF01217	0.634
TRG_DiLeu_BaLyEn_6	161	166	PF01217	0.643
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.527
TRG_DiLeu_BaLyEn_6	49	54	PF01217	0.716
TRG_ENDOCYTIC_2	314	317	PF00928	0.587
TRG_ENDOCYTIC_2	375	378	PF00928	0.607
TRG_ER_diArg_1	1	4	PF00400	0.685
TRG_ER_diArg_1	281	283	PF00400	0.610
TRG_ER_diArg_1	812	815	PF00400	0.609
TRG_Pf-PMV_PEXEL_1	273	278	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X1D3	Leishmania donovani	90%	99%
A4HGE8	Leishmania braziliensis	49%	93%
A4I3H9	Leishmania infantum	90%	87%
E9AZS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%