Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8G2_LEIMA

TriTrypDb:

LmjF.28.1050 , LMJLV39_280016700 , LMJSD75_280016600

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8G2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8G2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	195	197	PF00675	0.528
CLV_NRD_NRD_1	249	251	PF00675	0.406
CLV_NRD_NRD_1	332	334	PF00675	0.383
CLV_NRD_NRD_1	82	84	PF00675	0.514
CLV_PCSK_KEX2_1	195	197	PF00082	0.528
CLV_PCSK_KEX2_1	249	251	PF00082	0.406
CLV_PCSK_KEX2_1	331	333	PF00082	0.640
DEG_APCC_DBOX_1	180	188	PF00400	0.373
DEG_APCC_DBOX_1	82	90	PF00400	0.417
DEG_ODPH_VHL_1	133	146	PF01847	0.456
DEG_SPOP_SBC_1	134	138	PF00917	0.602
DOC_CYCLIN_RxL_1	283	294	PF00134	0.316
DOC_MAPK_RevD_3	182	196	PF00069	0.388
DOC_PP1_RVXF_1	284	291	PF00149	0.348
DOC_PP2B_LxvP_1	378	381	PF13499	0.333
DOC_USP7_MATH_1	135	139	PF00917	0.574
DOC_USP7_MATH_1	15	19	PF00917	0.657
DOC_USP7_MATH_1	23	27	PF00917	0.619
DOC_USP7_MATH_1	233	237	PF00917	0.533
DOC_USP7_MATH_1	239	243	PF00917	0.406
DOC_USP7_MATH_1	312	316	PF00917	0.506
DOC_USP7_MATH_1	396	400	PF00917	0.471
DOC_USP7_MATH_1	66	70	PF00917	0.517
DOC_WW_Pin1_4	114	119	PF00397	0.539
DOC_WW_Pin1_4	19	24	PF00397	0.534
DOC_WW_Pin1_4	225	230	PF00397	0.610
DOC_WW_Pin1_4	293	298	PF00397	0.429
DOC_WW_Pin1_4	345	350	PF00397	0.395
LIG_14-3-3_CanoR_1	216	225	PF00244	0.544
LIG_14-3-3_CanoR_1	249	259	PF00244	0.500
LIG_14-3-3_CanoR_1	331	336	PF00244	0.478
LIG_14-3-3_CanoR_1	400	404	PF00244	0.336
LIG_14-3-3_CanoR_1	9	16	PF00244	0.616
LIG_BIR_II_1	1	5	PF00653	0.649
LIG_BIR_III_2	205	209	PF00653	0.564
LIG_BIR_III_4	49	53	PF00653	0.551
LIG_BRCT_BRCA1_1	218	222	PF00533	0.571
LIG_DLG_GKlike_1	331	338	PF00625	0.465
LIG_FHA_2	166	172	PF00498	0.432
LIG_LIR_Apic_2	265	271	PF02991	0.440
LIG_LIR_Gen_1	219	229	PF02991	0.575
LIG_LIR_Gen_1	284	295	PF02991	0.271
LIG_LIR_Nem_3	219	225	PF02991	0.577
LIG_LIR_Nem_3	284	290	PF02991	0.264
LIG_LIR_Nem_3	334	338	PF02991	0.418
LIG_NRBOX	222	228	PF00104	0.555
LIG_RPA_C_Fungi	395	407	PF08784	0.417
LIG_SH2_PTP2	268	271	PF00017	0.447
LIG_SH2_SRC	150	153	PF00017	0.358
LIG_SH2_STAP1	70	74	PF00017	0.362
LIG_SH2_STAT5	102	105	PF00017	0.364
LIG_SH2_STAT5	150	153	PF00017	0.358
LIG_SH2_STAT5	268	271	PF00017	0.447
LIG_SH2_STAT5	358	361	PF00017	0.372
LIG_SH3_2	101	106	PF14604	0.450
LIG_SH3_3	150	156	PF00018	0.370
LIG_SH3_3	98	104	PF00018	0.495
LIG_SUMO_SIM_anti_2	399	405	PF11976	0.403
MOD_CK1_1	228	234	PF00069	0.560
MOD_CK1_1	24	30	PF00069	0.590
MOD_CK1_1	399	405	PF00069	0.444
MOD_GlcNHglycan	17	20	PF01048	0.745
MOD_GlcNHglycan	343	346	PF01048	0.360
MOD_GlcNHglycan	404	407	PF01048	0.354
MOD_GlcNHglycan	55	58	PF01048	0.527
MOD_GlcNHglycan	92	95	PF01048	0.498
MOD_GSK3_1	133	140	PF00069	0.724
MOD_GSK3_1	15	22	PF00069	0.663
MOD_GSK3_1	233	240	PF00069	0.477
MOD_GSK3_1	258	265	PF00069	0.336
MOD_GSK3_1	327	334	PF00069	0.576
MOD_GSK3_1	341	348	PF00069	0.271
MOD_GSK3_1	90	97	PF00069	0.457
MOD_LATS_1	28	34	PF00433	0.550
MOD_N-GLC_1	113	118	PF02516	0.518
MOD_N-GLC_1	396	401	PF02516	0.459
MOD_NEK2_1	113	118	PF00069	0.559
MOD_NEK2_1	262	267	PF00069	0.416
MOD_NEK2_1	313	318	PF00069	0.431
MOD_NEK2_1	327	332	PF00069	0.570
MOD_NEK2_1	341	346	PF00069	0.308
MOD_NEK2_1	79	84	PF00069	0.480
MOD_NEK2_2	281	286	PF00069	0.340
MOD_PIKK_1	239	245	PF00454	0.444
MOD_PKA_1	331	337	PF00069	0.581
MOD_PKA_2	331	337	PF00069	0.581
MOD_PKA_2	399	405	PF00069	0.416
MOD_PKA_2	8	14	PF00069	0.650
MOD_Plk_4	142	148	PF00069	0.399
MOD_Plk_4	380	386	PF00069	0.511
MOD_ProDKin_1	114	120	PF00069	0.546
MOD_ProDKin_1	19	25	PF00069	0.531
MOD_ProDKin_1	225	231	PF00069	0.604
MOD_ProDKin_1	293	299	PF00069	0.425
MOD_ProDKin_1	345	351	PF00069	0.389
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.444
TRG_DiLeu_BaLyEn_6	373	378	PF01217	0.481
TRG_ENDOCYTIC_2	102	105	PF00928	0.364
TRG_ENDOCYTIC_2	150	153	PF00928	0.358
TRG_ER_diArg_1	194	196	PF00400	0.498
TRG_ER_diArg_1	248	250	PF00400	0.406
TRG_ER_diArg_1	331	333	PF00400	0.465
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	286	291	PF00026	0.307
TRG_Pf-PMV_PEXEL_1	37	41	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NYD6	Trypanosomatidae	34%	83%
A0A3S7X1C6	Leishmania donovani	89%	100%
A4HGE9	Leishmania braziliensis	70%	100%
A4I3I0	Leishmania infantum	88%	100%
E9AZS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%