HMG box domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8F9_LEIMA

TriTrypDb:

LmjF.28.1080 , LMJLV39_280017100 , LMJSD75_280016900

Length:

613

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0020023	kinetoplast	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q8F9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8F9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	340	344	PF00656	0.492
CLV_NRD_NRD_1	17	19	PF00675	0.554
CLV_NRD_NRD_1	244	246	PF00675	0.461
CLV_NRD_NRD_1	315	317	PF00675	0.660
CLV_NRD_NRD_1	325	327	PF00675	0.485
CLV_NRD_NRD_1	466	468	PF00675	0.697
CLV_PCSK_FUR_1	15	19	PF00082	0.683
CLV_PCSK_KEX2_1	15	17	PF00082	0.554
CLV_PCSK_KEX2_1	277	279	PF00082	0.501
CLV_PCSK_KEX2_1	317	319	PF00082	0.692
CLV_PCSK_KEX2_1	466	468	PF00082	0.584
CLV_PCSK_KEX2_1	81	83	PF00082	0.511
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.454
CLV_PCSK_PC1ET2_1	317	319	PF00082	0.636
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.569
CLV_PCSK_SKI1_1	195	199	PF00082	0.547
CLV_PCSK_SKI1_1	246	250	PF00082	0.473
CLV_PCSK_SKI1_1	286	290	PF00082	0.549
CLV_PCSK_SKI1_1	326	330	PF00082	0.566
CLV_PCSK_SKI1_1	356	360	PF00082	0.442
CLV_PCSK_SKI1_1	401	405	PF00082	0.599
CLV_PCSK_SKI1_1	41	45	PF00082	0.465
CLV_PCSK_SKI1_1	53	57	PF00082	0.552
DOC_CKS1_1	366	371	PF01111	0.620
DOC_CKS1_1	475	480	PF01111	0.741
DOC_CYCLIN_yCln2_LP_2	165	168	PF00134	0.524
DOC_CYCLIN_yCln2_LP_2	359	365	PF00134	0.622
DOC_MAPK_FxFP_2	363	366	PF00069	0.677
DOC_MAPK_gen_1	187	196	PF00069	0.686
DOC_MAPK_gen_1	602	610	PF00069	0.712
DOC_MAPK_gen_1	7	14	PF00069	0.680
DOC_MAPK_gen_1	81	89	PF00069	0.450
DOC_MAPK_MEF2A_6	189	198	PF00069	0.674
DOC_MAPK_MEF2A_6	602	610	PF00069	0.728
DOC_PP1_RVXF_1	29	35	PF00149	0.523
DOC_PP1_RVXF_1	39	46	PF00149	0.461
DOC_PP2B_LxvP_1	165	168	PF13499	0.524
DOC_PP2B_LxvP_1	97	100	PF13499	0.571
DOC_PP4_FxxP_1	108	111	PF00568	0.588
DOC_PP4_FxxP_1	34	37	PF00568	0.528
DOC_PP4_FxxP_1	363	366	PF00568	0.532
DOC_USP7_MATH_1	436	440	PF00917	0.600
DOC_USP7_MATH_1	441	445	PF00917	0.641
DOC_USP7_MATH_1	484	488	PF00917	0.756
DOC_USP7_MATH_1	545	549	PF00917	0.763
DOC_USP7_MATH_2	168	174	PF00917	0.531
DOC_WW_Pin1_4	365	370	PF00397	0.576
DOC_WW_Pin1_4	474	479	PF00397	0.708
DOC_WW_Pin1_4	543	548	PF00397	0.702
DOC_WW_Pin1_4	588	593	PF00397	0.737
LIG_14-3-3_CanoR_1	135	139	PF00244	0.561
LIG_14-3-3_CanoR_1	195	205	PF00244	0.429
LIG_14-3-3_CanoR_1	219	223	PF00244	0.609
LIG_14-3-3_CanoR_1	347	352	PF00244	0.482
LIG_14-3-3_CanoR_1	528	536	PF00244	0.616
LIG_14-3-3_CanoR_1	66	74	PF00244	0.547
LIG_APCC_ABBA_1	290	295	PF00400	0.515
LIG_BIR_II_1	1	5	PF00653	0.402
LIG_BRCT_BRCA1_1	172	176	PF00533	0.559
LIG_deltaCOP1_diTrp_1	103	108	PF00928	0.561
LIG_deltaCOP1_diTrp_1	170	176	PF00928	0.551
LIG_DLG_GKlike_1	347	354	PF00625	0.497
LIG_eIF4E_1	160	166	PF01652	0.548
LIG_FHA_1	107	113	PF00498	0.473
LIG_FHA_1	248	254	PF00498	0.439
LIG_FHA_1	544	550	PF00498	0.778
LIG_FHA_1	570	576	PF00498	0.731
LIG_FHA_2	435	441	PF00498	0.635
LIG_FHA_2	510	516	PF00498	0.666
LIG_FHA_2	554	560	PF00498	0.779
LIG_FHA_2	99	105	PF00498	0.441
LIG_LIR_Apic_2	106	111	PF02991	0.601
LIG_LIR_Apic_2	360	366	PF02991	0.638
LIG_LIR_Apic_2	472	478	PF02991	0.751
LIG_LIR_Gen_1	103	112	PF02991	0.598
LIG_LIR_Gen_1	150	161	PF02991	0.464
LIG_LIR_Gen_1	345	354	PF02991	0.543
LIG_LIR_Gen_1	374	384	PF02991	0.576
LIG_LIR_Gen_1	426	436	PF02991	0.584
LIG_LIR_Gen_1	69	79	PF02991	0.526
LIG_LIR_Nem_3	103	108	PF02991	0.449
LIG_LIR_Nem_3	150	156	PF02991	0.441
LIG_LIR_Nem_3	173	179	PF02991	0.574
LIG_LIR_Nem_3	269	273	PF02991	0.448
LIG_LIR_Nem_3	345	351	PF02991	0.531
LIG_LIR_Nem_3	360	364	PF02991	0.625
LIG_LIR_Nem_3	374	380	PF02991	0.323
LIG_LIR_Nem_3	386	391	PF02991	0.548
LIG_LIR_Nem_3	426	432	PF02991	0.559
LIG_LIR_Nem_3	69	75	PF02991	0.521
LIG_MYND_3	166	170	PF01753	0.477
LIG_PCNA_yPIPBox_3	219	232	PF02747	0.574
LIG_PDZ_Class_2	608	613	PF00595	0.775
LIG_Pex14_1	172	176	PF04695	0.559
LIG_Pex14_2	361	365	PF04695	0.668
LIG_PTB_Apo_2	397	404	PF02174	0.668
LIG_SH2_CRK	348	352	PF00017	0.566
LIG_SH2_CRK	388	392	PF00017	0.602
LIG_SH2_SRC	422	425	PF00017	0.617
LIG_SH2_STAP1	122	126	PF00017	0.538
LIG_SH2_STAP1	203	207	PF00017	0.489
LIG_SH2_STAT3	20	23	PF00017	0.640
LIG_SH2_STAT5	155	158	PF00017	0.493
LIG_SH2_STAT5	160	163	PF00017	0.516
LIG_SH2_STAT5	332	335	PF00017	0.448
LIG_SH2_STAT5	364	367	PF00017	0.622
LIG_SH2_STAT5	495	498	PF00017	0.623
LIG_SH3_3	182	188	PF00018	0.557
LIG_SH3_3	363	369	PF00018	0.568
LIG_SH3_3	40	46	PF00018	0.536
LIG_SH3_3	430	436	PF00018	0.626
LIG_SH3_3	572	578	PF00018	0.686
LIG_TRAF2_1	221	224	PF00917	0.561
LIG_TRAF2_1	304	307	PF00917	0.574
LIG_TRAF2_1	415	418	PF00917	0.632
LIG_TRAF2_1	512	515	PF00917	0.649
LIG_TRFH_1	365	369	PF08558	0.629
LIG_TRFH_1	432	436	PF08558	0.624
LIG_UBA3_1	402	410	PF00899	0.489
LIG_UBA3_1	75	81	PF00899	0.491
MOD_CDK_SPxK_1	474	480	PF00069	0.715
MOD_CK1_1	128	134	PF00069	0.539
MOD_CK1_1	218	224	PF00069	0.525
MOD_CK1_1	301	307	PF00069	0.506
MOD_CK1_1	439	445	PF00069	0.607
MOD_CK1_1	446	452	PF00069	0.719
MOD_CK1_1	462	468	PF00069	0.652
MOD_CK1_1	482	488	PF00069	0.745
MOD_CK1_1	600	606	PF00069	0.770
MOD_CK2_1	218	224	PF00069	0.460
MOD_CK2_1	256	262	PF00069	0.449
MOD_CK2_1	301	307	PF00069	0.560
MOD_CK2_1	412	418	PF00069	0.536
MOD_CK2_1	434	440	PF00069	0.700
MOD_CK2_1	447	453	PF00069	0.742
MOD_CK2_1	509	515	PF00069	0.682
MOD_CK2_1	545	551	PF00069	0.763
MOD_CK2_1	553	559	PF00069	0.773
MOD_Cter_Amidation	314	317	PF01082	0.595
MOD_Cter_Amidation	324	327	PF01082	0.487
MOD_DYRK1A_RPxSP_1	588	592	PF00069	0.698
MOD_GlcNHglycan	395	398	PF01048	0.664
MOD_GlcNHglycan	443	446	PF01048	0.723
MOD_GlcNHglycan	461	464	PF01048	0.647
MOD_GlcNHglycan	562	565	PF01048	0.780
MOD_GSK3_1	106	113	PF00069	0.477
MOD_GSK3_1	125	132	PF00069	0.371
MOD_GSK3_1	134	141	PF00069	0.595
MOD_GSK3_1	435	442	PF00069	0.572
MOD_GSK3_1	443	450	PF00069	0.655
MOD_GSK3_1	451	458	PF00069	0.566
MOD_GSK3_1	465	472	PF00069	0.740
MOD_GSK3_1	476	483	PF00069	0.660
MOD_GSK3_1	545	552	PF00069	0.720
MOD_GSK3_1	588	595	PF00069	0.789
MOD_GSK3_1	66	73	PF00069	0.477
MOD_LATS_1	596	602	PF00433	0.587
MOD_N-GLC_1	49	54	PF02516	0.633
MOD_NEK2_1	120	125	PF00069	0.524
MOD_NEK2_1	136	141	PF00069	0.599
MOD_NEK2_1	273	278	PF00069	0.426
MOD_NEK2_1	390	395	PF00069	0.534
MOD_NEK2_1	48	53	PF00069	0.578
MOD_NEK2_2	148	153	PF00069	0.576
MOD_NEK2_2	309	314	PF00069	0.574
MOD_PIKK_1	138	144	PF00454	0.387
MOD_PIKK_1	298	304	PF00454	0.542
MOD_PIKK_1	342	348	PF00454	0.556
MOD_PIKK_1	484	490	PF00454	0.728
MOD_PIKK_1	569	575	PF00454	0.766
MOD_PKA_1	317	323	PF00069	0.669
MOD_PKA_2	134	140	PF00069	0.520
MOD_PKA_2	218	224	PF00069	0.610
MOD_PKA_2	309	315	PF00069	0.562
MOD_PKA_2	317	323	PF00069	0.620
MOD_PKA_2	465	471	PF00069	0.704
MOD_PKA_2	527	533	PF00069	0.497
MOD_PKA_2	65	71	PF00069	0.533
MOD_Plk_1	10	16	PF00069	0.643
MOD_Plk_1	49	55	PF00069	0.697
MOD_Plk_1	506	512	PF00069	0.745
MOD_Plk_2-3	412	418	PF00069	0.661
MOD_Plk_4	125	131	PF00069	0.503
MOD_Plk_4	148	154	PF00069	0.566
MOD_Plk_4	266	272	PF00069	0.530
MOD_ProDKin_1	365	371	PF00069	0.571
MOD_ProDKin_1	474	480	PF00069	0.709
MOD_ProDKin_1	543	549	PF00069	0.703
MOD_ProDKin_1	588	594	PF00069	0.737
MOD_SUMO_rev_2	242	248	PF00179	0.554
MOD_SUMO_rev_2	259	266	PF00179	0.429
MOD_SUMO_rev_2	269	279	PF00179	0.509
MOD_SUMO_rev_2	27	32	PF00179	0.506
MOD_SUMO_rev_2	301	309	PF00179	0.555
MOD_SUMO_rev_2	529	534	PF00179	0.686
TRG_DiLeu_BaEn_1	224	229	PF01217	0.457
TRG_DiLeu_BaEn_1	83	88	PF01217	0.357
TRG_ENDOCYTIC_2	133	136	PF00928	0.546
TRG_ENDOCYTIC_2	311	314	PF00928	0.456
TRG_ENDOCYTIC_2	348	351	PF00928	0.563
TRG_ENDOCYTIC_2	364	367	PF00928	0.508
TRG_ENDOCYTIC_2	381	384	PF00928	0.409
TRG_ENDOCYTIC_2	388	391	PF00928	0.587
TRG_ENDOCYTIC_2	429	432	PF00928	0.665
TRG_ER_diArg_1	14	17	PF00400	0.576
TRG_NES_CRM1_1	86	98	PF08389	0.535
TRG_Pf-PMV_PEXEL_1	85	90	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4J5	Leptomonas seymouri	42%	94%
A0A1X0NYQ6	Trypanosomatidae	31%	100%
A0A3Q8IAY3	Leishmania donovani	93%	85%
A0A3R7LLJ8	Trypanosoma rangeli	30%	100%
A4HGF2	Leishmania braziliensis	74%	84%
A4I3I3	Leishmania infantum	93%	85%
D0A7W0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AZS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	85%
V5DAI7	Trypanosoma cruzi	31%	100%