ATP-grasp domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-grasp domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q8F8_LEIMA

TriTrypDb:

LmjF.28.1090 , LMJLV39_280017200 , LMJSD75_280017000

Length:

785

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q8F8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8F8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003824	catalytic activity	1	2
GO:0016874	ligase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	61	65	PF00656	0.388
CLV_NRD_NRD_1	385	387	PF00675	0.475
CLV_NRD_NRD_1	411	413	PF00675	0.373
CLV_NRD_NRD_1	439	441	PF00675	0.576
CLV_NRD_NRD_1	447	449	PF00675	0.598
CLV_NRD_NRD_1	452	454	PF00675	0.619
CLV_NRD_NRD_1	680	682	PF00675	0.462
CLV_NRD_NRD_1	720	722	PF00675	0.479
CLV_PCSK_KEX2_1	381	383	PF00082	0.448
CLV_PCSK_KEX2_1	411	413	PF00082	0.373
CLV_PCSK_KEX2_1	447	449	PF00082	0.624
CLV_PCSK_KEX2_1	452	454	PF00082	0.691
CLV_PCSK_KEX2_1	680	682	PF00082	0.503
CLV_PCSK_KEX2_1	720	722	PF00082	0.337
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.484
CLV_PCSK_PC7_1	448	454	PF00082	0.483
CLV_PCSK_SKI1_1	305	309	PF00082	0.442
CLV_PCSK_SKI1_1	576	580	PF00082	0.518
CLV_PCSK_SKI1_1	589	593	PF00082	0.469
CLV_PCSK_SKI1_1	645	649	PF00082	0.470
DEG_Nend_Nbox_1	1	3	PF02207	0.423
DOC_CKS1_1	599	604	PF01111	0.523
DOC_CYCLIN_yCln2_LP_2	278	284	PF00134	0.350
DOC_MAPK_gen_1	381	390	PF00069	0.393
DOC_MAPK_gen_1	546	555	PF00069	0.522
DOC_MAPK_MEF2A_6	67	74	PF00069	0.299
DOC_PP1_RVXF_1	198	204	PF00149	0.422
DOC_PP1_RVXF_1	303	309	PF00149	0.417
DOC_PP2B_LxvP_1	278	281	PF13499	0.487
DOC_PP4_FxxP_1	599	602	PF00568	0.466
DOC_PP4_FxxP_1	610	613	PF00568	0.452
DOC_USP7_MATH_1	155	159	PF00917	0.480
DOC_USP7_MATH_1	233	237	PF00917	0.446
DOC_USP7_MATH_1	406	410	PF00917	0.510
DOC_USP7_MATH_1	547	551	PF00917	0.630
DOC_USP7_MATH_1	631	635	PF00917	0.507
DOC_USP7_MATH_1	639	643	PF00917	0.460
DOC_USP7_MATH_1	754	758	PF00917	0.538
DOC_USP7_MATH_1	98	102	PF00917	0.606
DOC_USP7_UBL2_3	85	89	PF12436	0.466
DOC_USP7_UBL2_3	93	97	PF12436	0.515
DOC_WW_Pin1_4	109	114	PF00397	0.747
DOC_WW_Pin1_4	124	129	PF00397	0.432
DOC_WW_Pin1_4	455	460	PF00397	0.662
DOC_WW_Pin1_4	598	603	PF00397	0.533
DOC_WW_Pin1_4	609	614	PF00397	0.369
LIG_14-3-3_CanoR_1	109	113	PF00244	0.710
LIG_14-3-3_CanoR_1	305	311	PF00244	0.350
LIG_14-3-3_CanoR_1	38	42	PF00244	0.509
LIG_14-3-3_CanoR_1	394	398	PF00244	0.466
LIG_14-3-3_CanoR_1	488	495	PF00244	0.370
LIG_14-3-3_CanoR_1	576	584	PF00244	0.505
LIG_14-3-3_CanoR_1	604	608	PF00244	0.438
LIG_14-3-3_CanoR_1	720	730	PF00244	0.512
LIG_Actin_WH2_2	360	378	PF00022	0.472
LIG_BIR_III_4	422	426	PF00653	0.369
LIG_CSL_BTD_1	537	540	PF09270	0.377
LIG_deltaCOP1_diTrp_1	351	356	PF00928	0.289
LIG_eIF4E_1	135	141	PF01652	0.517
LIG_eIF4E_1	392	398	PF01652	0.472
LIG_eIF4E_1	495	501	PF01652	0.310
LIG_EVH1_1	538	542	PF00568	0.377
LIG_FHA_1	136	142	PF00498	0.559
LIG_FHA_1	144	150	PF00498	0.522
LIG_FHA_1	22	28	PF00498	0.496
LIG_FHA_1	275	281	PF00498	0.441
LIG_FHA_1	362	368	PF00498	0.512
LIG_FHA_1	488	494	PF00498	0.326
LIG_FHA_1	555	561	PF00498	0.351
LIG_FHA_1	586	592	PF00498	0.536
LIG_FHA_1	604	610	PF00498	0.277
LIG_FHA_1	612	618	PF00498	0.456
LIG_FHA_1	650	656	PF00498	0.527
LIG_FHA_1	688	694	PF00498	0.477
LIG_FHA_1	732	738	PF00498	0.584
LIG_FHA_2	262	268	PF00498	0.474
LIG_FHA_2	298	304	PF00498	0.368
LIG_FHA_2	562	568	PF00498	0.477
LIG_FHA_2	575	581	PF00498	0.448
LIG_FHA_2	652	658	PF00498	0.411
LIG_FHA_2	703	709	PF00498	0.602
LIG_Integrin_isoDGR_2	107	109	PF01839	0.616
LIG_LIR_Apic_2	354	359	PF02991	0.294
LIG_LIR_Apic_2	608	613	PF02991	0.414
LIG_LIR_Gen_1	153	161	PF02991	0.406
LIG_LIR_Gen_1	163	173	PF02991	0.336
LIG_LIR_Gen_1	220	229	PF02991	0.590
LIG_LIR_Gen_1	292	301	PF02991	0.308
LIG_LIR_Gen_1	496	504	PF02991	0.327
LIG_LIR_Gen_1	583	592	PF02991	0.431
LIG_LIR_Gen_1	769	778	PF02991	0.418
LIG_LIR_Nem_3	115	121	PF02991	0.426
LIG_LIR_Nem_3	153	159	PF02991	0.375
LIG_LIR_Nem_3	163	168	PF02991	0.352
LIG_LIR_Nem_3	220	226	PF02991	0.609
LIG_LIR_Nem_3	292	297	PF02991	0.308
LIG_LIR_Nem_3	340	346	PF02991	0.370
LIG_LIR_Nem_3	496	501	PF02991	0.344
LIG_LIR_Nem_3	535	541	PF02991	0.464
LIG_LIR_Nem_3	583	587	PF02991	0.379
LIG_Rb_pABgroove_1	386	394	PF01858	0.364
LIG_SH2_CRK	156	160	PF00017	0.431
LIG_SH2_CRK	223	227	PF00017	0.480
LIG_SH2_CRK	343	347	PF00017	0.368
LIG_SH2_CRK	498	502	PF00017	0.356
LIG_SH2_GRB2like	152	155	PF00017	0.500
LIG_SH2_GRB2like	184	187	PF00017	0.414
LIG_SH2_GRB2like	764	767	PF00017	0.491
LIG_SH2_GRB2like	79	82	PF00017	0.419
LIG_SH2_NCK_1	152	156	PF00017	0.417
LIG_SH2_NCK_1	223	227	PF00017	0.480
LIG_SH2_SRC	152	155	PF00017	0.522
LIG_SH2_SRC	167	170	PF00017	0.489
LIG_SH2_SRC	184	187	PF00017	0.293
LIG_SH2_SRC	330	333	PF00017	0.274
LIG_SH2_SRC	62	65	PF00017	0.383
LIG_SH2_SRC	79	82	PF00017	0.302
LIG_SH2_STAP1	152	156	PF00017	0.352
LIG_SH2_STAP1	498	502	PF00017	0.341
LIG_SH2_STAT3	392	395	PF00017	0.474
LIG_SH2_STAT5	167	170	PF00017	0.457
LIG_SH2_STAT5	184	187	PF00017	0.251
LIG_SH2_STAT5	223	226	PF00017	0.487
LIG_SH2_STAT5	257	260	PF00017	0.354
LIG_SH2_STAT5	261	264	PF00017	0.363
LIG_SH2_STAT5	299	302	PF00017	0.303
LIG_SH2_STAT5	330	333	PF00017	0.274
LIG_SH2_STAT5	336	339	PF00017	0.274
LIG_SH2_STAT5	416	419	PF00017	0.320
LIG_SH2_STAT5	503	506	PF00017	0.332
LIG_SH2_STAT5	62	65	PF00017	0.369
LIG_SH2_STAT5	764	767	PF00017	0.393
LIG_SH2_STAT5	79	82	PF00017	0.308
LIG_SH3_3	280	286	PF00018	0.400
LIG_SH3_3	534	540	PF00018	0.398
LIG_SH3_3	591	597	PF00018	0.670
LIG_SH3_4	85	92	PF00018	0.434
LIG_SH3_5	180	184	PF00018	0.334
LIG_SUMO_SIM_par_1	472	477	PF11976	0.361
LIG_SUMO_SIM_par_1	605	612	PF11976	0.430
LIG_TRAF2_1	32	35	PF00917	0.483
LIG_TRAF2_1	370	373	PF00917	0.551
LIG_TRAF2_1	563	566	PF00917	0.490
LIG_TYR_ITIM	341	346	PF00017	0.362
LIG_WRC_WIRS_1	581	586	PF05994	0.361
MOD_CDC14_SPxK_1	127	130	PF00782	0.411
MOD_CDK_SPK_2	124	129	PF00069	0.396
MOD_CDK_SPxK_1	124	130	PF00069	0.393
MOD_CDK_SPxK_1	598	604	PF00069	0.531
MOD_CDK_SPxxK_3	455	462	PF00069	0.508
MOD_CK1_1	112	118	PF00069	0.598
MOD_CK1_1	193	199	PF00069	0.429
MOD_CK1_1	236	242	PF00069	0.543
MOD_CK1_1	260	266	PF00069	0.398
MOD_CK1_1	317	323	PF00069	0.417
MOD_CK1_1	611	617	PF00069	0.480
MOD_CK1_1	634	640	PF00069	0.413
MOD_CK1_1	722	728	PF00069	0.404
MOD_CK2_1	306	312	PF00069	0.348
MOD_CK2_1	367	373	PF00069	0.447
MOD_CK2_1	561	567	PF00069	0.473
MOD_CK2_1	574	580	PF00069	0.415
MOD_CK2_1	651	657	PF00069	0.440
MOD_CMANNOS	353	356	PF00535	0.289
MOD_DYRK1A_RPxSP_1	109	113	PF00069	0.479
MOD_GlcNHglycan	100	103	PF01048	0.679
MOD_GlcNHglycan	173	176	PF01048	0.464
MOD_GlcNHglycan	18	21	PF01048	0.432
MOD_GlcNHglycan	287	290	PF01048	0.308
MOD_GlcNHglycan	369	372	PF01048	0.504
MOD_GlcNHglycan	408	411	PF01048	0.411
MOD_GlcNHglycan	636	639	PF01048	0.430
MOD_GlcNHglycan	641	644	PF01048	0.386
MOD_GlcNHglycan	682	685	PF01048	0.537
MOD_GlcNHglycan	687	690	PF01048	0.608
MOD_GSK3_1	108	115	PF00069	0.687
MOD_GSK3_1	12	19	PF00069	0.477
MOD_GSK3_1	217	224	PF00069	0.518
MOD_GSK3_1	22	29	PF00069	0.446
MOD_GSK3_1	232	239	PF00069	0.568
MOD_GSK3_1	257	264	PF00069	0.455
MOD_GSK3_1	285	292	PF00069	0.274
MOD_GSK3_1	293	300	PF00069	0.274
MOD_GSK3_1	313	320	PF00069	0.336
MOD_GSK3_1	361	368	PF00069	0.443
MOD_GSK3_1	512	519	PF00069	0.599
MOD_GSK3_1	576	583	PF00069	0.441
MOD_GSK3_1	608	615	PF00069	0.516
MOD_GSK3_1	651	658	PF00069	0.484
MOD_GSK3_1	721	728	PF00069	0.440
MOD_N-GLC_1	80	85	PF02516	0.495
MOD_N-GLC_2	428	430	PF02516	0.422
MOD_N-GLC_2	707	709	PF02516	0.475
MOD_NEK2_1	12	17	PF00069	0.435
MOD_NEK2_1	555	560	PF00069	0.439
MOD_NEK2_1	587	592	PF00069	0.496
MOD_NEK2_1	649	654	PF00069	0.462
MOD_NEK2_1	719	724	PF00069	0.462
MOD_NEK2_1	80	85	PF00069	0.525
MOD_NEK2_2	62	67	PF00069	0.376
MOD_PIKK_1	314	320	PF00454	0.276
MOD_PIKK_1	709	715	PF00454	0.507
MOD_PIKK_1	754	760	PF00454	0.553
MOD_PK_1	386	392	PF00069	0.362
MOD_PKA_1	386	392	PF00069	0.530
MOD_PKA_1	680	686	PF00069	0.528
MOD_PKA_2	108	114	PF00069	0.529
MOD_PKA_2	236	242	PF00069	0.542
MOD_PKA_2	314	320	PF00069	0.417
MOD_PKA_2	37	43	PF00069	0.568
MOD_PKA_2	393	399	PF00069	0.408
MOD_PKA_2	487	493	PF00069	0.356
MOD_PKA_2	547	553	PF00069	0.514
MOD_PKA_2	585	591	PF00069	0.470
MOD_PKA_2	603	609	PF00069	0.329
MOD_PKA_2	680	686	PF00069	0.487
MOD_PKA_2	719	725	PF00069	0.500
MOD_PKB_1	546	554	PF00069	0.439
MOD_Plk_1	414	420	PF00069	0.415
MOD_Plk_1	728	734	PF00069	0.553
MOD_Plk_1	768	774	PF00069	0.533
MOD_Plk_2-3	702	708	PF00069	0.767
MOD_Plk_4	155	161	PF00069	0.462
MOD_Plk_4	26	32	PF00069	0.487
MOD_Plk_4	274	280	PF00069	0.482
MOD_Plk_4	393	399	PF00069	0.426
MOD_Plk_4	496	502	PF00069	0.478
MOD_Plk_4	555	561	PF00069	0.383
MOD_Plk_4	728	734	PF00069	0.473
MOD_ProDKin_1	109	115	PF00069	0.736
MOD_ProDKin_1	124	130	PF00069	0.430
MOD_ProDKin_1	455	461	PF00069	0.662
MOD_ProDKin_1	598	604	PF00069	0.531
MOD_ProDKin_1	609	615	PF00069	0.365
MOD_SUMO_for_1	271	274	PF00179	0.364
MOD_SUMO_for_1	463	466	PF00179	0.584
TRG_DiLeu_BaEn_1	274	279	PF01217	0.374
TRG_DiLeu_BaEn_1	4	9	PF01217	0.515
TRG_DiLeu_BaEn_4	565	571	PF01217	0.266
TRG_DiLeu_BaLyEn_6	121	126	PF01217	0.422
TRG_ENDOCYTIC_2	156	159	PF00928	0.350
TRG_ENDOCYTIC_2	223	226	PF00928	0.487
TRG_ENDOCYTIC_2	343	346	PF00928	0.362
TRG_ENDOCYTIC_2	498	501	PF00928	0.297
TRG_ENDOCYTIC_2	767	770	PF00928	0.467
TRG_ER_diArg_1	121	124	PF00400	0.369
TRG_ER_diArg_1	411	413	PF00400	0.366
TRG_ER_diArg_1	446	448	PF00400	0.623
TRG_ER_diArg_1	452	454	PF00400	0.695
TRG_ER_diArg_1	545	548	PF00400	0.582
TRG_ER_diArg_1	679	681	PF00400	0.346
TRG_ER_diArg_1	719	721	PF00400	0.456
TRG_Pf-PMV_PEXEL_1	411	415	PF00026	0.386
TRG_Pf-PMV_PEXEL_1	576	580	PF00026	0.548

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P453	Leptomonas seymouri	51%	93%
A0A0S4IPI1	Bodo saltans	31%	100%
A0A1X0NYA4	Trypanosomatidae	36%	100%
A0A3S7X1H2	Leishmania donovani	94%	100%
A0A422N237	Trypanosoma rangeli	36%	100%
A4HGF3	Leishmania braziliensis	78%	100%
A4I3I4	Leishmania infantum	94%	100%
D0A7V8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AZS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	90%
V5BEJ5	Trypanosoma cruzi	33%	94%