Gluconokinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gluconokinase

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8F7_LEIMA

TriTrypDb:

LmjF.28.1095 , LMJLV39_280017300 , LMJSD75_280017100

Length:

119

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8F7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8F7

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	2
GO:0006082	organic acid metabolic process	3	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009987	cellular process	1	2
GO:0016052	carbohydrate catabolic process	4	2
GO:0016054	organic acid catabolic process	4	2
GO:0016310	phosphorylation	5	2
GO:0019520	aldonic acid metabolic process	4	2
GO:0019521	D-gluconate metabolic process	5	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0032787	monocarboxylic acid metabolic process	6	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044262	obsolete cellular carbohydrate metabolic process	3	2
GO:0044275	obsolete cellular carbohydrate catabolic process	4	2
GO:0044281	small molecule metabolic process	2	2
GO:0044282	small molecule catabolic process	3	2
GO:0046176	aldonic acid catabolic process	5	2
GO:0046177	D-gluconate catabolic process	6	2
GO:0046395	carboxylic acid catabolic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0072329	monocarboxylic acid catabolic process	6	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	2
GO:0005524	ATP binding	5	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0017076	purine nucleotide binding	4	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.684
CLV_NRD_NRD_1	43	45	PF00675	0.659
CLV_NRD_NRD_1	79	81	PF00675	0.791
CLV_PCSK_KEX2_1	17	19	PF00082	0.684
CLV_PCSK_KEX2_1	43	45	PF00082	0.659
CLV_PCSK_KEX2_1	79	81	PF00082	0.791
CLV_PCSK_SKI1_1	21	25	PF00082	0.678
CLV_PCSK_SKI1_1	47	51	PF00082	0.638
CLV_PCSK_SKI1_1	57	61	PF00082	0.611
DEG_ODPH_VHL_1	24	37	PF01847	0.699
DOC_MAPK_MEF2A_6	30	37	PF00069	0.709
LIG_14-3-3_CanoR_1	30	36	PF00244	0.716
LIG_FHA_1	30	36	PF00498	0.716
LIG_FHA_2	6	12	PF00498	0.713
LIG_SH3_3	20	26	PF00018	0.677
LIG_SH3_3	68	74	PF00018	0.790
LIG_SH3_3	93	99	PF00018	0.790
LIG_SUMO_SIM_anti_2	32	37	PF11976	0.695
MOD_GlcNHglycan	109	112	PF01048	0.801
MOD_GlcNHglycan	2	5	PF01048	0.790
MOD_GlcNHglycan	39	42	PF01048	0.698
MOD_GSK3_1	62	69	PF00069	0.777
MOD_NEK2_1	37	42	PF00069	0.694
MOD_PKA_2	29	35	PF00069	0.721
MOD_PKA_2	50	56	PF00069	0.696
MOD_Plk_4	31	37	PF00069	0.704
MOD_Plk_4	97	103	PF00069	0.777
TRG_ENDOCYTIC_2	46	49	PF00928	0.622
TRG_ER_diArg_1	16	18	PF00400	0.681
TRG_ER_diArg_1	42	44	PF00400	0.674
TRG_ER_diArg_1	78	80	PF00400	0.795
TRG_Pf-PMV_PEXEL_1	17	22	PF00026	0.683

Homologs


Protein	Taxonomy	Sequence identity	Coverage
Q5FQ97	GLUOX	52%	67%
Q9SLE0	ARATH	48%	63%