Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8F6_LEIMA

TriTrypDb:

LmjF.28.1100 , LMJLV39_280017400 , LMJSD75_280017200

Length:

848

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8F6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8F6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004842	ubiquitin-protein transferase activity	4	7
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0016740	transferase activity	2	7
GO:0019787	ubiquitin-like protein transferase activity	3	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0061630	ubiquitin protein ligase activity	5	7
GO:0061659	ubiquitin-like protein ligase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	329	333	PF00656	0.651
CLV_C14_Caspase3-7	366	370	PF00656	0.677
CLV_C14_Caspase3-7	503	507	PF00656	0.618
CLV_MEL_PAP_1	344	350	PF00089	0.589
CLV_NRD_NRD_1	212	214	PF00675	0.555
CLV_NRD_NRD_1	245	247	PF00675	0.733
CLV_NRD_NRD_1	453	455	PF00675	0.566
CLV_NRD_NRD_1	846	848	PF00675	0.726
CLV_PCSK_KEX2_1	211	213	PF00082	0.553
CLV_PCSK_KEX2_1	247	249	PF00082	0.748
CLV_PCSK_KEX2_1	258	260	PF00082	0.744
CLV_PCSK_KEX2_1	346	348	PF00082	0.754
CLV_PCSK_KEX2_1	4	6	PF00082	0.669
CLV_PCSK_KEX2_1	453	455	PF00082	0.566
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.516
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.748
CLV_PCSK_PC1ET2_1	258	260	PF00082	0.744
CLV_PCSK_PC1ET2_1	346	348	PF00082	0.754
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.630
CLV_PCSK_PC7_1	243	249	PF00082	0.734
CLV_PCSK_SKI1_1	270	274	PF00082	0.718
CLV_PCSK_SKI1_1	380	384	PF00082	0.583
CLV_PCSK_SKI1_1	49	53	PF00082	0.627
CLV_PCSK_SKI1_1	593	597	PF00082	0.729
CLV_PCSK_SKI1_1	640	644	PF00082	0.647
CLV_PCSK_SKI1_1	670	674	PF00082	0.571
CLV_PCSK_SKI1_1	701	705	PF00082	0.497
CLV_PCSK_SKI1_1	71	75	PF00082	0.513
DEG_SCF_FBW7_1	254	260	PF00400	0.740
DEG_SPOP_SBC_1	249	253	PF00917	0.752
DOC_CDC14_PxL_1	51	59	PF14671	0.543
DOC_CKS1_1	254	259	PF01111	0.741
DOC_CKS1_1	496	501	PF01111	0.692
DOC_CYCLIN_RxL_1	66	77	PF00134	0.624
DOC_CYCLIN_yCln2_LP_2	22	28	PF00134	0.598
DOC_MAPK_gen_1	14	22	PF00069	0.539
DOC_MAPK_gen_1	4	11	PF00069	0.503
DOC_MAPK_gen_1	44	54	PF00069	0.538
DOC_MAPK_MEF2A_6	14	22	PF00069	0.544
DOC_MAPK_MEF2A_6	47	56	PF00069	0.538
DOC_MAPK_NFAT4_5	47	55	PF00069	0.541
DOC_PP1_RVXF_1	69	75	PF00149	0.609
DOC_PP2B_LxvP_1	22	25	PF13499	0.593
DOC_PP2B_LxvP_1	52	55	PF13499	0.557
DOC_USP7_MATH_1	112	116	PF00917	0.721
DOC_USP7_MATH_1	225	229	PF00917	0.770
DOC_USP7_MATH_1	257	261	PF00917	0.774
DOC_USP7_MATH_1	293	297	PF00917	0.786
DOC_USP7_MATH_1	310	314	PF00917	0.573
DOC_USP7_MATH_1	331	335	PF00917	0.720
DOC_USP7_MATH_1	393	397	PF00917	0.684
DOC_USP7_MATH_1	419	423	PF00917	0.696
DOC_USP7_MATH_1	739	743	PF00917	0.761
DOC_USP7_MATH_1	747	751	PF00917	0.658
DOC_WW_Pin1_4	216	221	PF00397	0.761
DOC_WW_Pin1_4	250	255	PF00397	0.752
DOC_WW_Pin1_4	261	266	PF00397	0.733
DOC_WW_Pin1_4	315	320	PF00397	0.751
DOC_WW_Pin1_4	370	375	PF00397	0.601
DOC_WW_Pin1_4	495	500	PF00397	0.681
DOC_WW_Pin1_4	719	724	PF00397	0.640
LIG_14-3-3_CanoR_1	133	137	PF00244	0.528
LIG_14-3-3_CanoR_1	248	254	PF00244	0.750
LIG_14-3-3_CanoR_1	446	451	PF00244	0.675
LIG_14-3-3_CanoR_1	649	657	PF00244	0.658
LIG_AP2alpha_2	409	411	PF02296	0.680
LIG_BIR_II_1	1	5	PF00653	0.618
LIG_BIR_III_2	369	373	PF00653	0.734
LIG_BRCT_BRCA1_1	313	317	PF00533	0.845
LIG_BRCT_BRCA1_1	612	616	PF00533	0.761
LIG_BRCT_BRCA1_1	766	770	PF00533	0.580
LIG_FHA_1	112	118	PF00498	0.614
LIG_FHA_1	142	148	PF00498	0.479
LIG_FHA_1	250	256	PF00498	0.853
LIG_FHA_1	556	562	PF00498	0.544
LIG_FHA_1	653	659	PF00498	0.646
LIG_FHA_1	688	694	PF00498	0.639
LIG_FHA_1	74	80	PF00498	0.547
LIG_FHA_2	121	127	PF00498	0.598
LIG_FHA_2	148	154	PF00498	0.506
LIG_FHA_2	27	33	PF00498	0.617
LIG_GBD_Chelix_1	811	819	PF00786	0.650
LIG_Integrin_isoDGR_2	339	341	PF01839	0.748
LIG_KLC1_Yacidic_2	6	10	PF13176	0.480
LIG_LIR_Gen_1	6	15	PF02991	0.488
LIG_LIR_Gen_1	641	650	PF02991	0.702
LIG_LIR_Gen_1	772	781	PF02991	0.665
LIG_LIR_Nem_3	537	543	PF02991	0.608
LIG_LIR_Nem_3	554	560	PF02991	0.410
LIG_LIR_Nem_3	6	11	PF02991	0.475
LIG_LIR_Nem_3	641	646	PF02991	0.690
LIG_LIR_Nem_3	772	778	PF02991	0.660
LIG_Pex14_1	180	184	PF04695	0.639
LIG_Pex14_2	7	11	PF04695	0.465
LIG_PTB_Apo_2	686	693	PF02174	0.586
LIG_REV1ctd_RIR_1	689	699	PF16727	0.617
LIG_SH2_CRK	217	221	PF00017	0.591
LIG_SH2_NCK_1	217	221	PF00017	0.591
LIG_SH2_STAP1	762	766	PF00017	0.597
LIG_SH2_STAT3	140	143	PF00017	0.531
LIG_SH2_STAT3	564	567	PF00017	0.651
LIG_SH2_STAT3	581	584	PF00017	0.425
LIG_SH2_STAT5	140	143	PF00017	0.531
LIG_SH2_STAT5	146	149	PF00017	0.473
LIG_SH2_STAT5	415	418	PF00017	0.629
LIG_SH2_STAT5	564	567	PF00017	0.651
LIG_SH2_STAT5	797	800	PF00017	0.657
LIG_SH2_STAT5	8	11	PF00017	0.467
LIG_SH3_2	254	259	PF14604	0.741
LIG_SH3_2	587	592	PF14604	0.587
LIG_SH3_3	196	202	PF00018	0.728
LIG_SH3_3	251	257	PF00018	0.742
LIG_SH3_3	318	324	PF00018	0.757
LIG_SH3_3	404	410	PF00018	0.716
LIG_SH3_3	475	481	PF00018	0.475
LIG_SH3_3	584	590	PF00018	0.582
LIG_SUMO_SIM_par_1	18	23	PF11976	0.524
LIG_UBA3_1	50	58	PF00899	0.552
MOD_CDK_SPK_2	253	258	PF00069	0.741
MOD_CDK_SPxK_1	253	259	PF00069	0.742
MOD_CDK_SPxK_1	495	501	PF00069	0.690
MOD_CK1_1	102	108	PF00069	0.633
MOD_CK1_1	115	121	PF00069	0.653
MOD_CK1_1	218	224	PF00069	0.697
MOD_CK1_1	253	259	PF00069	0.736
MOD_CK1_1	260	266	PF00069	0.743
MOD_CK1_1	315	321	PF00069	0.638
MOD_CK1_1	546	552	PF00069	0.556
MOD_CK2_1	120	126	PF00069	0.600
MOD_CK2_1	225	231	PF00069	0.654
MOD_CK2_1	348	354	PF00069	0.588
MOD_CK2_1	505	511	PF00069	0.618
MOD_Cter_Amidation	344	347	PF01082	0.831
MOD_Cter_Amidation	845	848	PF01082	0.635
MOD_DYRK1A_RPxSP_1	250	254	PF00069	0.728
MOD_GlcNHglycan	101	104	PF01048	0.617
MOD_GlcNHglycan	223	226	PF01048	0.801
MOD_GlcNHglycan	227	230	PF01048	0.744
MOD_GlcNHglycan	26	29	PF01048	0.504
MOD_GlcNHglycan	266	269	PF01048	0.740
MOD_GlcNHglycan	314	317	PF01048	0.721
MOD_GlcNHglycan	350	353	PF01048	0.735
MOD_GlcNHglycan	506	510	PF01048	0.607
MOD_GlcNHglycan	601	604	PF01048	0.703
MOD_GlcNHglycan	606	609	PF01048	0.675
MOD_GlcNHglycan	640	643	PF01048	0.599
MOD_GlcNHglycan	95	98	PF01048	0.536
MOD_GSK3_1	111	118	PF00069	0.650
MOD_GSK3_1	221	228	PF00069	0.711
MOD_GSK3_1	249	256	PF00069	0.751
MOD_GSK3_1	257	264	PF00069	0.737
MOD_GSK3_1	301	308	PF00069	0.797
MOD_GSK3_1	311	318	PF00069	0.632
MOD_GSK3_1	331	338	PF00069	0.716
MOD_GSK3_1	393	400	PF00069	0.738
MOD_GSK3_1	434	441	PF00069	0.574
MOD_GSK3_1	442	449	PF00069	0.579
MOD_GSK3_1	469	476	PF00069	0.404
MOD_GSK3_1	626	633	PF00069	0.562
MOD_GSK3_1	648	655	PF00069	0.749
MOD_GSK3_1	735	742	PF00069	0.752
MOD_GSK3_1	811	818	PF00069	0.626
MOD_N-GLC_1	652	657	PF02516	0.679
MOD_N-GLC_2	412	414	PF02516	0.598
MOD_N-GLC_2	80	82	PF02516	0.564
MOD_NEK2_1	120	125	PF00069	0.599
MOD_NEK2_1	141	146	PF00069	0.496
MOD_NEK2_1	284	289	PF00069	0.709
MOD_NEK2_1	434	439	PF00069	0.551
MOD_NEK2_1	463	468	PF00069	0.620
MOD_NEK2_1	469	474	PF00069	0.487
MOD_NEK2_1	638	643	PF00069	0.542
MOD_NEK2_1	687	692	PF00069	0.521
MOD_NEK2_1	815	820	PF00069	0.664
MOD_NEK2_2	26	31	PF00069	0.508
MOD_NEK2_2	668	673	PF00069	0.567
MOD_OFUCOSY	432	438	PF10250	0.559
MOD_PIKK_1	189	195	PF00454	0.665
MOD_PIKK_1	301	307	PF00454	0.816
MOD_PIKK_1	813	819	PF00454	0.646
MOD_PKA_1	346	352	PF00069	0.745
MOD_PKA_2	132	138	PF00069	0.556
MOD_PKA_2	141	147	PF00069	0.489
MOD_PKA_2	242	248	PF00069	0.760
MOD_PKA_2	249	255	PF00069	0.715
MOD_PKA_2	260	266	PF00069	0.608
MOD_PKA_2	301	307	PF00069	0.777
MOD_PKA_2	335	341	PF00069	0.656
MOD_PKA_2	346	352	PF00069	0.769
MOD_PKA_2	513	519	PF00069	0.548
MOD_PKA_2	648	654	PF00069	0.736
MOD_PKB_1	246	254	PF00069	0.749
MOD_Plk_1	115	121	PF00069	0.626
MOD_Plk_1	38	44	PF00069	0.556
MOD_Plk_1	535	541	PF00069	0.714
MOD_Plk_1	687	693	PF00069	0.574
MOD_Plk_1	771	777	PF00069	0.531
MOD_Plk_2-3	536	542	PF00069	0.712
MOD_Plk_4	293	299	PF00069	0.700
MOD_Plk_4	393	399	PF00069	0.693
MOD_Plk_4	463	469	PF00069	0.405
MOD_Plk_4	65	71	PF00069	0.627
MOD_Plk_4	687	693	PF00069	0.557
MOD_ProDKin_1	216	222	PF00069	0.762
MOD_ProDKin_1	250	256	PF00069	0.751
MOD_ProDKin_1	261	267	PF00069	0.733
MOD_ProDKin_1	315	321	PF00069	0.751
MOD_ProDKin_1	370	376	PF00069	0.597
MOD_ProDKin_1	495	501	PF00069	0.690
MOD_ProDKin_1	719	725	PF00069	0.643
MOD_SUMO_for_1	3	6	PF00179	0.643
MOD_SUMO_rev_2	6	15	PF00179	0.488
TRG_DiLeu_BaEn_1	116	121	PF01217	0.624
TRG_DiLeu_BaLyEn_6	46	51	PF01217	0.636
TRG_DiLeu_BaLyEn_6	68	73	PF01217	0.608
TRG_ENDOCYTIC_2	452	455	PF00928	0.556
TRG_ENDOCYTIC_2	458	461	PF00928	0.542
TRG_ENDOCYTIC_2	618	621	PF00928	0.721
TRG_ENDOCYTIC_2	8	11	PF00928	0.467
TRG_ER_diArg_1	452	454	PF00400	0.555
TRG_NES_CRM1_1	776	788	PF08389	0.584
TRG_NLS_Bipartite_1	246	262	PF00514	0.745
TRG_NLS_MonoExtC_3	245	250	PF00514	0.744
TRG_NLS_MonoExtN_4	243	250	PF00514	0.737
TRG_NLS_MonoExtN_4	257	262	PF00514	0.736
TRG_Pf-PMV_PEXEL_1	238	242	PF00026	0.627
TRG_Pf-PMV_PEXEL_1	701	706	PF00026	0.628

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU94	Leptomonas seymouri	63%	99%
A0A3S7X1F3	Leishmania donovani	94%	100%
A4HGF5	Leishmania braziliensis	79%	100%
A4I3I6	Leishmania infantum	94%	100%
E9AZS8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%