Cilia- and flagella-associated protein 52

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania major

UniProt:

Q4Q8F5_LEIMA

TriTrypDb:

LmjF.28.1110 , LMJLV39_280017500 , LMJSD75_280017300

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0005840	ribosome	5	12
GO:0005929	cilium	4	12
GO:0005930	axoneme	2	2
GO:0031514	motile cilium	5	12
GO:0032991	protein-containing complex	1	12
GO:0036064	ciliary basal body	3	2
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0005737	cytoplasm	2	10

Expansion

Sequence features

Q4Q8F5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8F5

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0030030	cell projection organization	4	2
GO:0030031	cell projection assembly	5	2
GO:0044782	cilium organization	5	2
GO:0060271	cilium assembly	6	2
GO:0070925	organelle assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0120031	plasma membrane bounded cell projection assembly	6	2
GO:0120036	plasma membrane bounded cell projection organization	5	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	403	407	PF00656	0.521
CLV_C14_Caspase3-7	47	51	PF00656	0.396
CLV_NRD_NRD_1	185	187	PF00675	0.407
CLV_NRD_NRD_1	199	201	PF00675	0.367
CLV_NRD_NRD_1	500	502	PF00675	0.359
CLV_NRD_NRD_1	98	100	PF00675	0.355
CLV_PCSK_KEX2_1	199	201	PF00082	0.392
CLV_PCSK_KEX2_1	500	502	PF00082	0.362
CLV_PCSK_KEX2_1	98	100	PF00082	0.370
CLV_PCSK_SKI1_1	103	107	PF00082	0.336
CLV_PCSK_SKI1_1	167	171	PF00082	0.327
CLV_PCSK_SKI1_1	399	403	PF00082	0.386
CLV_PCSK_SKI1_1	436	440	PF00082	0.333
CLV_PCSK_SKI1_1	452	456	PF00082	0.446
CLV_PCSK_SKI1_1	572	576	PF00082	0.244
CLV_Separin_Metazoa	358	362	PF03568	0.342
DEG_APCC_DBOX_1	102	110	PF00400	0.337
DOC_ANK_TNKS_1	598	605	PF00023	0.487
DOC_MAPK_gen_1	108	116	PF00069	0.280
DOC_MAPK_gen_1	186	193	PF00069	0.480
DOC_MAPK_gen_1	199	207	PF00069	0.294
DOC_MAPK_gen_1	415	425	PF00069	0.406
DOC_MAPK_gen_1	98	106	PF00069	0.347
DOC_MAPK_HePTP_8	183	195	PF00069	0.457
DOC_MAPK_MEF2A_6	186	195	PF00069	0.534
DOC_MAPK_MEF2A_6	581	589	PF00069	0.424
DOC_MAPK_MEF2A_6	63	71	PF00069	0.389
DOC_PP1_RVXF_1	154	161	PF00149	0.358
DOC_PP1_RVXF_1	397	403	PF00149	0.383
DOC_SPAK_OSR1_1	563	567	PF12202	0.455
DOC_USP7_MATH_1	51	55	PF00917	0.519
DOC_USP7_UBL2_3	418	422	PF12436	0.539
DOC_WW_Pin1_4	4	9	PF00397	0.501
DOC_WW_Pin1_4	556	561	PF00397	0.548
DOC_WW_Pin1_4	598	603	PF00397	0.455
LIG_14-3-3_CanoR_1	186	192	PF00244	0.427
LIG_14-3-3_CanoR_1	199	203	PF00244	0.407
LIG_14-3-3_CanoR_1	317	327	PF00244	0.363
LIG_14-3-3_CanoR_1	506	510	PF00244	0.482
LIG_APCC_ABBAyCdc20_2	529	535	PF00400	0.326
LIG_BH_BH3_1	244	260	PF00452	0.409
LIG_BRCT_BRCA1_1	336	340	PF00533	0.327
LIG_BRCT_BRCA1_1	52	56	PF00533	0.467
LIG_CaM_IQ_9	264	280	PF13499	0.497
LIG_Clathr_ClatBox_1	359	363	PF01394	0.443
LIG_FHA_1	131	137	PF00498	0.511
LIG_FHA_1	153	159	PF00498	0.442
LIG_FHA_1	168	174	PF00498	0.247
LIG_FHA_1	178	184	PF00498	0.341
LIG_FHA_1	202	208	PF00498	0.346
LIG_FHA_1	253	259	PF00498	0.451
LIG_FHA_1	301	307	PF00498	0.393
LIG_FHA_1	355	361	PF00498	0.521
LIG_FHA_1	453	459	PF00498	0.449
LIG_FHA_1	477	483	PF00498	0.476
LIG_FHA_1	494	500	PF00498	0.429
LIG_FHA_1	5	11	PF00498	0.440
LIG_FHA_1	548	554	PF00498	0.350
LIG_FHA_1	66	72	PF00498	0.533
LIG_FHA_2	217	223	PF00498	0.353
LIG_FHA_2	340	346	PF00498	0.463
LIG_FHA_2	481	487	PF00498	0.548
LIG_GBD_Chelix_1	491	499	PF00786	0.348
LIG_KLC1_Yacidic_2	514	518	PF13176	0.400
LIG_LIR_Nem_3	508	513	PF02991	0.329
LIG_MLH1_MIPbox_1	53	57	PF16413	0.501
LIG_PCNA_yPIPBox_3	563	577	PF02747	0.487
LIG_PDZ_Class_3	624	629	PF00595	0.591
LIG_Pex14_2	332	336	PF04695	0.381
LIG_SH2_STAT5	122	125	PF00017	0.455
LIG_SH2_STAT5	213	216	PF00017	0.322
LIG_SH2_STAT5	298	301	PF00017	0.325
LIG_SH2_STAT5	307	310	PF00017	0.301
LIG_SH2_STAT5	498	501	PF00017	0.462
LIG_SH2_STAT5	509	512	PF00017	0.349
LIG_SH2_STAT5	516	519	PF00017	0.350
LIG_SH2_STAT5	75	78	PF00017	0.361
LIG_SH3_3	123	129	PF00018	0.548
LIG_SH3_3	24	30	PF00018	0.500
LIG_SH3_3	327	333	PF00018	0.325
LIG_SH3_3	78	84	PF00018	0.494
LIG_SUMO_SIM_anti_2	288	295	PF11976	0.364
LIG_SUMO_SIM_par_1	130	138	PF11976	0.511
LIG_SUMO_SIM_par_1	179	184	PF11976	0.494
LIG_SUMO_SIM_par_1	203	208	PF11976	0.361
LIG_SUMO_SIM_par_1	606	613	PF11976	0.444
LIG_SUMO_SIM_par_1	67	72	PF11976	0.402
LIG_UBA3_1	100	108	PF00899	0.401
MOD_CDK_SPK_2	4	9	PF00069	0.501
MOD_CDK_SPxxK_3	556	563	PF00069	0.424
MOD_CDK_SPxxK_3	598	605	PF00069	0.294
MOD_CK1_1	201	207	PF00069	0.491
MOD_CK1_1	365	371	PF00069	0.417
MOD_CK1_1	383	389	PF00069	0.452
MOD_CK1_1	65	71	PF00069	0.408
MOD_CK2_1	114	120	PF00069	0.279
MOD_CK2_1	352	358	PF00069	0.386
MOD_CK2_1	458	464	PF00069	0.279
MOD_Cter_Amidation	603	606	PF01082	0.313
MOD_GlcNHglycan	18	21	PF01048	0.454
MOD_GlcNHglycan	219	222	PF01048	0.362
MOD_GlcNHglycan	243	246	PF01048	0.408
MOD_GlcNHglycan	261	264	PF01048	0.462
MOD_GlcNHglycan	279	282	PF01048	0.369
MOD_GlcNHglycan	382	385	PF01048	0.323
MOD_GlcNHglycan	396	399	PF01048	0.445
MOD_GlcNHglycan	71	74	PF01048	0.364
MOD_GlcNHglycan	77	80	PF01048	0.320
MOD_GSK3_1	203	210	PF00069	0.380
MOD_GSK3_1	246	253	PF00069	0.365
MOD_GSK3_1	273	280	PF00069	0.448
MOD_GSK3_1	335	342	PF00069	0.436
MOD_GSK3_1	372	379	PF00069	0.320
MOD_GSK3_1	454	461	PF00069	0.423
MOD_GSK3_1	472	479	PF00069	0.200
MOD_GSK3_1	482	489	PF00069	0.267
MOD_GSK3_1	517	524	PF00069	0.321
MOD_GSK3_1	552	559	PF00069	0.287
MOD_GSK3_1	589	596	PF00069	0.338
MOD_GSK3_1	65	72	PF00069	0.361
MOD_GSK3_1	75	82	PF00069	0.335
MOD_N-GLC_1	162	167	PF02516	0.389
MOD_N-GLC_1	273	278	PF02516	0.410
MOD_N-GLC_1	365	370	PF02516	0.504
MOD_N-GLC_2	354	356	PF02516	0.506
MOD_NEK2_1	16	21	PF00069	0.513
MOD_NEK2_1	198	203	PF00069	0.442
MOD_NEK2_1	259	264	PF00069	0.336
MOD_NEK2_1	318	323	PF00069	0.410
MOD_NEK2_1	380	385	PF00069	0.333
MOD_NEK2_1	400	405	PF00069	0.504
MOD_NEK2_1	458	463	PF00069	0.357
MOD_NEK2_1	564	569	PF00069	0.294
MOD_NEK2_1	589	594	PF00069	0.279
MOD_NEK2_1	67	72	PF00069	0.349
MOD_NEK2_2	335	340	PF00069	0.400
MOD_PIKK_1	517	523	PF00454	0.383
MOD_PK_1	187	193	PF00069	0.322
MOD_PK_1	606	612	PF00069	0.279
MOD_PKA_1	241	247	PF00069	0.462
MOD_PKA_2	198	204	PF00069	0.519
MOD_PKA_2	318	324	PF00069	0.351
MOD_PKA_2	505	511	PF00069	0.485
MOD_Plk_1	130	136	PF00069	0.373
MOD_Plk_1	273	279	PF00069	0.392
MOD_Plk_1	458	464	PF00069	0.309
MOD_Plk_1	493	499	PF00069	0.405
MOD_Plk_1	517	523	PF00069	0.338
MOD_Plk_4	130	136	PF00069	0.373
MOD_Plk_4	172	178	PF00069	0.497
MOD_Plk_4	22	28	PF00069	0.409
MOD_Plk_4	247	253	PF00069	0.372
MOD_Plk_4	335	341	PF00069	0.394
MOD_Plk_4	376	382	PF00069	0.290
MOD_Plk_4	505	511	PF00069	0.433
MOD_ProDKin_1	4	10	PF00069	0.487
MOD_ProDKin_1	556	562	PF00069	0.424
MOD_ProDKin_1	598	604	PF00069	0.294
MOD_SUMO_rev_2	459	468	PF00179	0.282
MOD_SUMO_rev_2	601	607	PF00179	0.294
TRG_DiLeu_BaLyEn_6	96	101	PF01217	0.487
TRG_ER_diArg_1	198	200	PF00400	0.419
TRG_ER_diArg_1	317	320	PF00400	0.520
TRG_ER_diArg_1	499	501	PF00400	0.367
TRG_ER_diArg_1	98	100	PF00400	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB29	Leptomonas seymouri	87%	100%
A0A0S4JJ02	Bodo saltans	59%	100%
A0A0S4JL38	Bodo saltans	22%	100%
A0A0S4JL93	Bodo saltans	24%	87%
A0A0S4KEW0	Bodo saltans	23%	98%
A0A1X0NYB9	Trypanosomatidae	67%	100%
A0A3R7N3I7	Trypanosoma rangeli	66%	99%
A0A3S7X1E5	Leishmania donovani	98%	100%
A4HGF6	Leishmania braziliensis	94%	100%
A4I3I7	Leishmania infantum	98%	100%
A8ILK1	Chlamydomonas reinhardtii	46%	100%
D0A7V6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E1BKF9	Bos taurus	42%	100%
E9AX72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AZS9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
F1SS88	Sus scrofa	42%	100%
Q06078	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	67%
Q26613	Strongylocentrotus purpuratus	21%	92%
Q4QAA4	Leishmania major	23%	100%
Q5F201	Mus musculus	41%	100%
Q8N1V2	Homo sapiens	40%	100%
Q95JL5	Macaca fascicularis	35%	100%
Q9LFE2	Arabidopsis thaliana	20%	72%
Q9VPR4	Drosophila melanogaster	22%	100%
Q9Y1C1	Lytechinus variegatus	21%	95%
V5BIZ5	Trypanosoma cruzi	66%	100%