MARVEL domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8F4_LEIMA

TriTrypDb:

LmjF.28.1120 , LMJLV39_280017600 , LMJSD75_280017400

Length:

254

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4Q8F4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8F4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.290
CLV_C14_Caspase3-7	7	11	PF00656	0.664
CLV_NRD_NRD_1	74	76	PF00675	0.434
CLV_PCSK_KEX2_1	74	76	PF00082	0.466
CLV_PCSK_SKI1_1	248	252	PF00082	0.382
DEG_APCC_DBOX_1	77	85	PF00400	0.492
DEG_Nend_Nbox_1	1	3	PF02207	0.666
DOC_CKS1_1	101	106	PF01111	0.351
DOC_CYCLIN_yCln2_LP_2	101	107	PF00134	0.426
DOC_MAPK_gen_1	78	87	PF00069	0.545
DOC_MAPK_MEF2A_6	147	156	PF00069	0.320
DOC_PP1_RVXF_1	216	223	PF00149	0.311
DOC_USP7_MATH_1	145	149	PF00917	0.321
DOC_USP7_UBL2_3	39	43	PF12436	0.605
DOC_WW_Pin1_4	100	105	PF00397	0.296
DOC_WW_Pin1_4	64	69	PF00397	0.683
LIG_14-3-3_CanoR_1	109	117	PF00244	0.458
LIG_Actin_WH2_2	233	250	PF00022	0.339
LIG_BIR_III_4	48	52	PF00653	0.664
LIG_BRCT_BRCA1_1	118	122	PF00533	0.259
LIG_EH1_1	182	190	PF00400	0.555
LIG_eIF4E_1	155	161	PF01652	0.311
LIG_eIF4E_1	183	189	PF01652	0.458
LIG_FHA_1	110	116	PF00498	0.358
LIG_FHA_1	17	23	PF00498	0.724
LIG_FHA_1	180	186	PF00498	0.565
LIG_FHA_1	229	235	PF00498	0.320
LIG_FHA_1	3	9	PF00498	0.604
LIG_FHA_1	87	93	PF00498	0.433
LIG_FHA_2	144	150	PF00498	0.284
LIG_FHA_2	36	42	PF00498	0.664
LIG_GBD_Chelix_1	152	160	PF00786	0.311
LIG_GBD_Chelix_1	197	205	PF00786	0.385
LIG_LIR_Gen_1	148	159	PF02991	0.273
LIG_LIR_Gen_1	241	250	PF02991	0.336
LIG_LIR_Gen_1	97	107	PF02991	0.300
LIG_LIR_Nem_3	148	154	PF02991	0.337
LIG_LIR_Nem_3	169	174	PF02991	0.409
LIG_LIR_Nem_3	241	247	PF02991	0.336
LIG_LIR_Nem_3	97	102	PF02991	0.300
LIG_NRBOX	153	159	PF00104	0.415
LIG_NRBOX	233	239	PF00104	0.446
LIG_PALB2_WD40_1	189	197	PF16756	0.227
LIG_PTB_Apo_2	216	223	PF02174	0.312
LIG_SH2_GRB2like	60	63	PF00017	0.667
LIG_SH2_PTP2	155	158	PF00017	0.311
LIG_SH2_STAT5	151	154	PF00017	0.287
LIG_SH2_STAT5	155	158	PF00017	0.302
LIG_SH2_STAT5	183	186	PF00017	0.310
LIG_SH2_STAT5	60	63	PF00017	0.695
LIG_SH2_STAT5	66	69	PF00017	0.616
LIG_SH3_2	70	75	PF14604	0.614
LIG_SH3_3	67	73	PF00018	0.646
LIG_SUMO_SIM_anti_2	187	192	PF11976	0.227
LIG_SUMO_SIM_anti_2	82	89	PF11976	0.503
LIG_SUMO_SIM_par_1	236	241	PF11976	0.371
LIG_SUMO_SIM_par_1	82	89	PF11976	0.555
LIG_UBA3_1	243	251	PF00899	0.368
MOD_CK1_1	111	117	PF00069	0.339
MOD_CK1_1	12	18	PF00069	0.571
MOD_CK1_1	236	242	PF00069	0.379
MOD_CK1_1	35	41	PF00069	0.608
MOD_CK1_1	4	10	PF00069	0.664
MOD_CK1_1	47	53	PF00069	0.554
MOD_CK2_1	122	128	PF00069	0.394
MOD_GlcNHglycan	124	127	PF01048	0.669
MOD_GlcNHglycan	48	52	PF01048	0.404
MOD_GSK3_1	107	114	PF00069	0.352
MOD_GSK3_1	12	19	PF00069	0.655
MOD_GSK3_1	4	11	PF00069	0.706
MOD_N-GLC_1	213	218	PF02516	0.462
MOD_N-GLC_1	44	49	PF02516	0.574
MOD_N-GLC_2	210	212	PF02516	0.542
MOD_NEK2_1	1	6	PF00069	0.709
MOD_NEK2_1	122	127	PF00069	0.282
MOD_NEK2_1	166	171	PF00069	0.331
MOD_NEK2_1	179	184	PF00069	0.573
MOD_NEK2_1	228	233	PF00069	0.328
MOD_NEK2_1	238	243	PF00069	0.282
MOD_NEK2_1	94	99	PF00069	0.428
MOD_PK_1	116	122	PF00069	0.318
MOD_PKA_1	74	80	PF00069	0.598
MOD_PKA_2	108	114	PF00069	0.330
MOD_PKA_2	16	22	PF00069	0.656
MOD_PKA_2	74	80	PF00069	0.669
MOD_Plk_1	213	219	PF00069	0.284
MOD_Plk_1	56	62	PF00069	0.723
MOD_Plk_1	9	15	PF00069	0.702
MOD_Plk_4	135	141	PF00069	0.412
MOD_Plk_4	166	172	PF00069	0.386
MOD_Plk_4	179	185	PF00069	0.486
MOD_Plk_4	56	62	PF00069	0.689
MOD_Plk_4	86	92	PF00069	0.388
MOD_Plk_4	94	100	PF00069	0.345
MOD_ProDKin_1	100	106	PF00069	0.296
MOD_ProDKin_1	64	70	PF00069	0.681
MOD_SUMO_rev_2	35	44	PF00179	0.601
TRG_ENDOCYTIC_2	151	154	PF00928	0.382
TRG_ENDOCYTIC_2	155	158	PF00928	0.421
TRG_ER_diArg_1	73	75	PF00400	0.672
TRG_ER_diArg_1	78	81	PF00400	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1D0	Leptomonas seymouri	47%	100%
A0A1X0NYY6	Trypanosomatidae	22%	100%
A0A3Q8IEK1	Leishmania donovani	82%	100%
A4I3I8	Leishmania infantum	83%	100%
D0A7V4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AZT0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%