Amastin surface glycofamily protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Amastin surface glycoprotein, putative

Species:

Leishmania major

UniProt:

Q4Q8F3_LEIMA

TriTrypDb:

LmjF.28.1130 , LMJLV39_280017900 , LMJSD75_280017600

Length:

519

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

Q4Q8F3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8F3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	356	358	PF00082	0.490
CLV_PCSK_KEX2_1	398	400	PF00082	0.471
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.490
CLV_PCSK_PC1ET2_1	398	400	PF00082	0.495
CLV_PCSK_SKI1_1	148	152	PF00082	0.296
CLV_PCSK_SKI1_1	398	402	PF00082	0.461
DOC_CYCLIN_yCln2_LP_2	420	426	PF00134	0.270
DOC_CYCLIN_yCln2_LP_2	496	502	PF00134	0.229
DOC_MAPK_gen_1	398	406	PF00069	0.308
DOC_MAPK_gen_1	428	437	PF00069	0.467
DOC_MAPK_gen_1	78	87	PF00069	0.594
DOC_MAPK_MEF2A_6	148	155	PF00069	0.457
DOC_PP2B_LxvP_1	376	379	PF13499	0.245
DOC_PP2B_LxvP_1	420	423	PF13499	0.270
DOC_PP2B_LxvP_1	496	499	PF13499	0.232
DOC_PP2B_LxvP_1	514	517	PF13499	0.352
DOC_PP2B_PxIxI_1	202	208	PF00149	0.223
DOC_USP7_MATH_1	55	59	PF00917	0.638
DOC_WW_Pin1_4	137	142	PF00397	0.556
DOC_WW_Pin1_4	5	10	PF00397	0.691
LIG_14-3-3_CanoR_1	190	195	PF00244	0.316
LIG_14-3-3_CanoR_1	248	252	PF00244	0.438
LIG_14-3-3_CanoR_1	368	372	PF00244	0.289
LIG_14-3-3_CanoR_1	392	400	PF00244	0.332
LIG_14-3-3_CanoR_1	456	465	PF00244	0.286
LIG_14-3-3_CanoR_1	54	60	PF00244	0.642
LIG_BIR_II_1	1	5	PF00653	0.756
LIG_BRCT_BRCA1_1	341	345	PF00533	0.435
LIG_BRCT_BRCA1_1	402	406	PF00533	0.293
LIG_BRCT_BRCA1_1	433	437	PF00533	0.339
LIG_CaM_NSCaTE_8	503	510	PF13499	0.270
LIG_EH1_1	436	444	PF00400	0.270
LIG_eIF4E_1	251	257	PF01652	0.333
LIG_eIF4E_1	371	377	PF01652	0.290
LIG_FHA_1	119	125	PF00498	0.677
LIG_FHA_1	147	153	PF00498	0.477
LIG_FHA_1	287	293	PF00498	0.300
LIG_FHA_1	31	37	PF00498	0.675
LIG_FHA_1	359	365	PF00498	0.271
LIG_FHA_1	372	378	PF00498	0.236
LIG_FHA_2	109	115	PF00498	0.644
LIG_GBD_Chelix_1	311	319	PF00786	0.353
LIG_IRF3_LxIS_1	442	448	PF10401	0.314
LIG_LIR_Apic_2	119	125	PF02991	0.645
LIG_LIR_Gen_1	234	243	PF02991	0.323
LIG_LIR_Gen_1	250	261	PF02991	0.456
LIG_LIR_Gen_1	332	343	PF02991	0.333
LIG_LIR_Gen_1	403	414	PF02991	0.327
LIG_LIR_Gen_1	434	445	PF02991	0.439
LIG_LIR_Nem_3	234	238	PF02991	0.473
LIG_LIR_Nem_3	249	254	PF02991	0.444
LIG_LIR_Nem_3	258	262	PF02991	0.317
LIG_LIR_Nem_3	332	338	PF02991	0.347
LIG_LIR_Nem_3	342	348	PF02991	0.315
LIG_LIR_Nem_3	403	409	PF02991	0.355
LIG_LIR_Nem_3	434	440	PF02991	0.328
LIG_LIR_Nem_3	441	447	PF02991	0.314
LIG_LIR_Nem_3	468	473	PF02991	0.281
LIG_LIR_Nem_3	485	490	PF02991	0.267
LIG_LYPXL_yS_3	202	205	PF13949	0.223
LIG_LYPXL_yS_3	473	476	PF13949	0.274
LIG_MYND_1	137	141	PF01753	0.534
LIG_NRBOX	306	312	PF00104	0.310
LIG_NRBOX	441	447	PF00104	0.208
LIG_PAM2_1	255	267	PF00658	0.333
LIG_PAM2_1	296	308	PF00658	0.270
LIG_PCNA_yPIPBox_3	188	201	PF02747	0.201
LIG_PDZ_Wminus1_1	517	519	PF00595	0.560
LIG_Pex14_1	253	257	PF04695	0.333
LIG_Pex14_1	355	359	PF04695	0.285
LIG_Pex14_2	158	162	PF04695	0.358
LIG_SH2_CRK	122	126	PF00017	0.678
LIG_SH2_CRK	220	224	PF00017	0.237
LIG_SH2_CRK	335	339	PF00017	0.345
LIG_SH2_SRC	131	134	PF00017	0.572
LIG_SH2_STAP1	396	400	PF00017	0.231
LIG_SH2_STAT3	18	21	PF00017	0.649
LIG_SH2_STAT3	490	493	PF00017	0.290
LIG_SH2_STAT5	122	125	PF00017	0.622
LIG_SH2_STAT5	131	134	PF00017	0.580
LIG_SH3_3	135	141	PF00018	0.598
LIG_SH3_3	471	477	PF00018	0.294
LIG_SH3_3	6	12	PF00018	0.719
LIG_SUMO_SIM_anti_2	363	368	PF11976	0.216
LIG_SUMO_SIM_anti_2	438	444	PF11976	0.298
LIG_SUMO_SIM_par_1	312	317	PF11976	0.300
LIG_TRAF2_1	112	115	PF00917	0.594
LIG_TYR_ITSM	247	254	PF00017	0.208
LIG_WRC_WIRS_1	232	237	PF05994	0.319
LIG_WRC_WIRS_1	256	261	PF05994	0.333
MOD_CK1_1	17	23	PF00069	0.555
MOD_CK1_1	234	240	PF00069	0.443
MOD_CK1_1	246	252	PF00069	0.515
MOD_CK1_1	30	36	PF00069	0.553
MOD_CK1_1	358	364	PF00069	0.209
MOD_CK1_1	394	400	PF00069	0.460
MOD_CK1_1	438	444	PF00069	0.374
MOD_CK1_1	448	454	PF00069	0.374
MOD_CK1_1	8	14	PF00069	0.575
MOD_CK2_1	108	114	PF00069	0.546
MOD_CK2_1	13	19	PF00069	0.746
MOD_GlcNHglycan	240	243	PF01048	0.351
MOD_GlcNHglycan	245	248	PF01048	0.317
MOD_GlcNHglycan	393	396	PF01048	0.267
MOD_GlcNHglycan	477	480	PF01048	0.398
MOD_GlcNHglycan	63	66	PF01048	0.531
MOD_GlcNHglycan	87	90	PF01048	0.541
MOD_GSK3_1	1	8	PF00069	0.560
MOD_GSK3_1	10	17	PF00069	0.588
MOD_GSK3_1	219	226	PF00069	0.333
MOD_GSK3_1	234	241	PF00069	0.378
MOD_GSK3_1	243	250	PF00069	0.362
MOD_GSK3_1	271	278	PF00069	0.357
MOD_GSK3_1	284	291	PF00069	0.261
MOD_GSK3_1	35	42	PF00069	0.726
MOD_GSK3_1	358	365	PF00069	0.470
MOD_GSK3_1	367	374	PF00069	0.440
MOD_GSK3_1	380	387	PF00069	0.321
MOD_GSK3_1	431	438	PF00069	0.363
MOD_GSK3_1	55	62	PF00069	0.667
MOD_GSK3_1	65	72	PF00069	0.661
MOD_GSK3_1	81	88	PF00069	0.449
MOD_N-GLC_1	379	384	PF02516	0.375
MOD_N-GLC_1	465	470	PF02516	0.239
MOD_N-GLC_1	5	10	PF02516	0.592
MOD_N-GLC_2	459	461	PF02516	0.250
MOD_NEK2_1	1	6	PF00069	0.567
MOD_NEK2_1	108	113	PF00069	0.632
MOD_NEK2_1	162	167	PF00069	0.346
MOD_NEK2_1	219	224	PF00069	0.372
MOD_NEK2_1	238	243	PF00069	0.314
MOD_NEK2_1	255	260	PF00069	0.271
MOD_NEK2_1	262	267	PF00069	0.316
MOD_NEK2_1	271	276	PF00069	0.373
MOD_NEK2_1	286	291	PF00069	0.332
MOD_NEK2_1	296	301	PF00069	0.248
MOD_NEK2_1	339	344	PF00069	0.417
MOD_NEK2_1	384	389	PF00069	0.462
MOD_NEK2_1	400	405	PF00069	0.363
MOD_NEK2_1	407	412	PF00069	0.419
MOD_NEK2_1	445	450	PF00069	0.399
MOD_NEK2_1	507	512	PF00069	0.441
MOD_NEK2_2	55	60	PF00069	0.533
MOD_PIKK_1	17	23	PF00454	0.717
MOD_PIKK_1	35	41	PF00454	0.828
MOD_PIKK_1	65	71	PF00454	0.668
MOD_PK_1	362	368	PF00069	0.224
MOD_PK_1	431	437	PF00069	0.270
MOD_PK_1	81	87	PF00069	0.439
MOD_PKA_2	243	249	PF00069	0.318
MOD_PKA_2	284	290	PF00069	0.310
MOD_PKA_2	367	373	PF00069	0.440
MOD_PKA_2	391	397	PF00069	0.437
MOD_PKA_2	457	463	PF00069	0.340
MOD_PKB_1	5	13	PF00069	0.567
MOD_Plk_1	118	124	PF00069	0.594
MOD_Plk_1	14	20	PF00069	0.546
MOD_Plk_1	362	368	PF00069	0.346
MOD_Plk_1	65	71	PF00069	0.668
MOD_Plk_4	224	230	PF00069	0.363
MOD_Plk_4	231	237	PF00069	0.382
MOD_Plk_4	296	302	PF00069	0.319
MOD_Plk_4	330	336	PF00069	0.396
MOD_Plk_4	339	345	PF00069	0.395
MOD_Plk_4	350	356	PF00069	0.305
MOD_Plk_4	362	368	PF00069	0.285
MOD_Plk_4	380	386	PF00069	0.421
MOD_Plk_4	431	437	PF00069	0.313
MOD_Plk_4	465	471	PF00069	0.289
MOD_Plk_4	507	513	PF00069	0.347
MOD_Plk_4	81	87	PF00069	0.564
MOD_ProDKin_1	137	143	PF00069	0.415
MOD_ProDKin_1	5	11	PF00069	0.613
MOD_SUMO_for_1	112	115	PF00179	0.538
TRG_DiLeu_BaEn_1	66	71	PF01217	0.476
TRG_ENDOCYTIC_2	202	205	PF00928	0.337
TRG_ENDOCYTIC_2	220	223	PF00928	0.198
TRG_ENDOCYTIC_2	251	254	PF00928	0.313
TRG_ENDOCYTIC_2	335	338	PF00928	0.397
TRG_ENDOCYTIC_2	473	476	PF00928	0.333
TRG_ER_diArg_1	175	178	PF00400	0.250
TRG_ER_diArg_1	75	78	PF00400	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6X2	Leptomonas seymouri	31%	100%
A0A0N1PC74	Leptomonas seymouri	57%	100%
A0A0N1PCA2	Leptomonas seymouri	28%	100%
A0A3Q8I8Q6	Leishmania donovani	27%	100%
A0A3S7WR28	Leishmania donovani	25%	100%
A0A3S7X1E1	Leishmania donovani	88%	100%
A4H605	Leishmania braziliensis	28%	100%
A4H606	Leishmania braziliensis	27%	100%
A4HGF8	Leishmania braziliensis	69%	99%
A4HUD2	Leishmania infantum	27%	100%
A4HUD3	Leishmania infantum	25%	100%
A4I3I9	Leishmania infantum	89%	100%
E9AN32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AN33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AZT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
Q4QHJ3	Leishmania major	25%	100%
Q4QHJ4	Leishmania major	28%	100%