Electron transfer flavoprotein subunit alpha

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

electron-transfer-flavoprotein, alpha polypeptide, putative

Species:

Leishmania major

UniProt:

Q4Q8F2_LEIMA

TriTrypDb:

LmjF.28.1140 , LMJLV39_280018000 , LMJSD75_280017700

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0005759	mitochondrial matrix	5	11
GO:0031974	membrane-enclosed lumen	2	11
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	11
GO:0070013	intracellular organelle lumen	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q8F2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8F2

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006629	lipid metabolic process	3	2
GO:0006631	fatty acid metabolic process	4	2
GO:0006635	fatty acid beta-oxidation	6	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009062	fatty acid catabolic process	5	2
GO:0009987	cellular process	1	2
GO:0016042	lipid catabolic process	4	2
GO:0016054	organic acid catabolic process	4	2
GO:0019395	fatty acid oxidation	5	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0030258	lipid modification	4	2
GO:0032787	monocarboxylic acid metabolic process	6	2
GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase	7	2
GO:0034440	lipid oxidation	5	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044242	cellular lipid catabolic process	4	2
GO:0044248	cellular catabolic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044282	small molecule catabolic process	3	2
GO:0046395	carboxylic acid catabolic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0072329	monocarboxylic acid catabolic process	6	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0009055	electron transfer activity	3	11
GO:0016491	oxidoreductase activity	2	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0050660	flavin adenine dinucleotide binding	4	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	212	216	PF00082	0.224
DEG_Nend_Nbox_1	1	3	PF02207	0.496
DOC_CDC14_PxL_1	309	317	PF14671	0.311
DOC_CYCLIN_yCln2_LP_2	226	232	PF00134	0.436
DOC_MAPK_gen_1	58	67	PF00069	0.461
DOC_MAPK_MEF2A_6	36	44	PF00069	0.451
DOC_MAPK_MEF2A_6	60	69	PF00069	0.428
DOC_PIKK_1	218	226	PF02985	0.477
DOC_PP2B_LxvP_1	226	229	PF13499	0.394
DOC_USP7_MATH_1	114	118	PF00917	0.436
DOC_USP7_MATH_1	45	49	PF00917	0.451
DOC_USP7_MATH_1	99	103	PF00917	0.436
DOC_USP7_UBL2_3	147	151	PF12436	0.477
DOC_WW_Pin1_4	177	182	PF00397	0.519
DOC_WW_Pin1_4	21	26	PF00397	0.519
LIG_14-3-3_CanoR_1	115	122	PF00244	0.428
LIG_14-3-3_CanoR_1	135	139	PF00244	0.416
LIG_14-3-3_CanoR_1	3	9	PF00244	0.452
LIG_FHA_1	123	129	PF00498	0.428
LIG_FHA_1	178	184	PF00498	0.594
LIG_FHA_1	2	8	PF00498	0.499
LIG_FHA_1	235	241	PF00498	0.436
LIG_FHA_1	314	320	PF00498	0.331
LIG_FHA_2	158	164	PF00498	0.418
LIG_FHA_2	288	294	PF00498	0.405
LIG_FHA_2	66	72	PF00498	0.492
LIG_LIR_Nem_3	218	223	PF02991	0.424
LIG_LIR_Nem_3	293	299	PF02991	0.330
LIG_LIR_Nem_3	307	312	PF02991	0.296
LIG_LIR_Nem_3	79	84	PF02991	0.436
LIG_MAD2	221	229	PF02301	0.383
LIG_SH2_CRK	154	158	PF00017	0.477
LIG_SH2_CRK	81	85	PF00017	0.436
LIG_SH2_NCK_1	94	98	PF00017	0.437
LIG_SH2_STAP1	94	98	PF00017	0.436
LIG_SH2_STAT5	154	157	PF00017	0.451
LIG_SH2_STAT5	245	248	PF00017	0.436
LIG_SH2_STAT5	264	267	PF00017	0.471
LIG_SH2_STAT5	94	97	PF00017	0.452
LIG_SUMO_SIM_par_1	64	71	PF11976	0.451
LIG_TRAF2_1	290	293	PF00917	0.472
LIG_TYR_ITIM	152	157	PF00017	0.477
MOD_CK1_1	24	30	PF00069	0.486
MOD_CK1_1	61	67	PF00069	0.423
MOD_CK2_1	157	163	PF00069	0.418
MOD_CK2_1	287	293	PF00069	0.465
MOD_CK2_1	65	71	PF00069	0.428
MOD_GlcNHglycan	101	104	PF01048	0.224
MOD_GlcNHglycan	170	173	PF01048	0.269
MOD_GlcNHglycan	208	211	PF01048	0.326
MOD_GlcNHglycan	269	272	PF01048	0.238
MOD_GlcNHglycan	28	31	PF01048	0.251
MOD_GlcNHglycan	47	50	PF01048	0.258
MOD_GSK3_1	1	8	PF00069	0.616
MOD_GSK3_1	141	148	PF00069	0.425
MOD_GSK3_1	153	160	PF00069	0.423
MOD_GSK3_1	61	68	PF00069	0.528
MOD_NEK2_1	1	6	PF00069	0.483
MOD_NEK2_1	157	162	PF00069	0.466
MOD_NEK2_1	279	284	PF00069	0.491
MOD_NEK2_1	98	103	PF00069	0.481
MOD_NEK2_2	142	147	PF00069	0.477
MOD_PK_1	58	64	PF00069	0.512
MOD_PKA_2	114	120	PF00069	0.428
MOD_PKA_2	134	140	PF00069	0.416
MOD_PKA_2	157	163	PF00069	0.430
MOD_PKA_2	2	8	PF00069	0.465
MOD_Plk_1	129	135	PF00069	0.429
MOD_Plk_4	129	135	PF00069	0.412
MOD_Plk_4	203	209	PF00069	0.477
MOD_Plk_4	61	67	PF00069	0.428
MOD_ProDKin_1	177	183	PF00069	0.519
MOD_ProDKin_1	21	27	PF00069	0.519
MOD_SUMO_for_1	49	52	PF00179	0.451
TRG_DiLeu_LyEn_5	80	85	PF01217	0.477
TRG_ENDOCYTIC_2	154	157	PF00928	0.477
TRG_ENDOCYTIC_2	81	84	PF00928	0.436
TRG_ENDOCYTIC_2	94	97	PF00928	0.436
TRG_Pf-PMV_PEXEL_1	221	225	PF00026	0.277

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVZ5	Leptomonas seymouri	78%	100%
A0A0S4II76	Bodo saltans	65%	100%
A0A1X0NYC9	Trypanosomatidae	67%	100%
A0A3S5H7J1	Leishmania donovani	96%	100%
A0A422N351	Trypanosoma rangeli	64%	100%
A2XNR6	Oryza sativa subsp. indica	48%	91%
A4HGF9	Leishmania braziliensis	86%	100%
A4I3J0	Leishmania infantum	97%	100%
D0A7V3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AZT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
G3KIM6	Anaerotignum propionicum	35%	89%
H6LBB1	Acetobacterium woodii (strain ATCC 29683 / DSM 1030 / JCM 2381 / KCTC 1655 / WB1)	28%	78%
H6LGM8	Acetobacterium woodii (strain ATCC 29683 / DSM 1030 / JCM 2381 / KCTC 1655 / WB1)	37%	82%
O33096	Mycobacterium leprae (strain TN)	37%	100%
O85692	Megasphaera elsdenii	34%	96%
P09819	Rhizobium meliloti (strain 1021)	30%	92%
P0CN60	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	44%	94%
P0CN61	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	44%	94%
P13803	Rattus norvegicus	52%	98%
P13804	Homo sapiens	52%	98%
P38974	Paracoccus denitrificans	52%	100%
P52039	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	37%	97%
P53573	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	49%	100%
P53578	Clostridium saccharobutylicum	36%	97%
P71153	Thermoanaerobacterium thermosaccharolyticum (strain ATCC 7956 / DSM 571 / NCIMB 9385 / NCA 3814 / NCTC 13789 / WDCM 00135 / 2032)	39%	98%
P78790	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	95%
P94551	Bacillus subtilis (strain 168)	36%	100%
P9WNG8	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	37%	100%
P9WNG9	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	37%	100%
Q12480	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	41%	94%
Q2KJE4	Bos taurus	52%	98%
Q46907	Escherichia coli (strain K12)	31%	100%
Q54FD7	Dictyostelium discoideum	48%	92%
Q5RC31	Pongo abelii	52%	98%
Q5Y223	Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071)	46%	94%
Q75LJ3	Oryza sativa subsp. japonica	48%	91%
Q8HXY0	Macaca fascicularis	51%	98%
Q8J112	Cryptococcus neoformans var. grubii	45%	94%
Q93615	Caenorhabditis elegans	52%	98%
Q99LC5	Mus musculus	52%	98%
Q9C6I6	Arabidopsis thaliana	43%	90%
Q9HZP7	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	52%	100%