AN1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AN1-like zinc finger, putative

Species:

Leishmania major

UniProt:

Q4Q8E9_LEIMA

TriTrypDb:

LmjF.28.1170 , LMJLV39_280018800 , LMJSD75_280018500

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8E9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8E9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0008270	zinc ion binding	6	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0046914	transition metal ion binding	5	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	63	65	PF00675	0.516
CLV_NRD_NRD_1	73	75	PF00675	0.528
CLV_NRD_NRD_1	86	88	PF00675	0.576
CLV_PCSK_FUR_1	61	65	PF00082	0.586
CLV_PCSK_KEX2_1	63	65	PF00082	0.531
CLV_PCSK_KEX2_1	72	74	PF00082	0.466
CLV_PCSK_KEX2_1	86	88	PF00082	0.555
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.510
CLV_PCSK_SKI1_1	50	54	PF00082	0.461
CLV_PCSK_SKI1_1	88	92	PF00082	0.470
LIG_14-3-3_CanoR_1	27	35	PF00244	0.328
LIG_BIR_II_1	1	5	PF00653	0.543
LIG_SH2_STAT5	28	31	PF00017	0.443
LIG_SH3_3	13	19	PF00018	0.337
MOD_SUMO_for_1	19	22	PF00179	0.337
MOD_SUMO_rev_2	70	79	PF00179	0.553
TRG_ER_diArg_1	61	64	PF00400	0.583
TRG_ER_diArg_1	73	75	PF00400	0.609
TRG_NLS_Bipartite_1	72	92	PF00514	0.514
TRG_NLS_MonoExtC_3	86	91	PF00514	0.597
TRG_NLS_MonoExtN_4	86	92	PF00514	0.543
TRG_Pf-PMV_PEXEL_1	64	69	PF00026	0.617

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCY9	Leptomonas seymouri	78%	100%
A0A0S4KJP3	Bodo saltans	36%	100%
A0A1X0NYL9	Trypanosomatidae	60%	68%
A0A3Q8IGQ3	Leishmania donovani	95%	99%
A4HGG4	Leishmania braziliensis	85%	99%
A4I3J6	Leishmania infantum	95%	84%
E9AZT6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%