Dioxygenase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Dioxygenase

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8E8_LEIMA

TriTrypDb:

LmjF.28.1180 , LMJLV39_280018900 , LMJSD75_280018600

Length:

226

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8E8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8E8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.600
CLV_NRD_NRD_1	142	144	PF00675	0.588
CLV_PCSK_KEX2_1	142	144	PF00082	0.588
CLV_PCSK_SKI1_1	216	220	PF00082	0.595
CLV_PCSK_SKI1_1	67	71	PF00082	0.717
DOC_CYCLIN_RxL_1	64	73	PF00134	0.603
DOC_PP1_RVXF_1	214	221	PF00149	0.595
DOC_PP2B_LxvP_1	88	91	PF13499	0.521
DOC_USP7_MATH_1	147	151	PF00917	0.512
DOC_USP7_MATH_1	175	179	PF00917	0.567
DOC_USP7_MATH_1	186	190	PF00917	0.452
DOC_USP7_MATH_1	91	95	PF00917	0.727
DOC_WW_Pin1_4	59	64	PF00397	0.614
LIG_14-3-3_CanoR_1	107	113	PF00244	0.526
LIG_14-3-3_CanoR_1	40	49	PF00244	0.569
LIG_BIR_II_1	1	5	PF00653	0.611
LIG_BIR_III_2	204	208	PF00653	0.594
LIG_BRCT_MDC1_1	222	226	PF00533	0.556
LIG_eIF4E_1	64	70	PF01652	0.579
LIG_FHA_1	149	155	PF00498	0.571
LIG_FHA_1	52	58	PF00498	0.645
LIG_FHA_1	75	81	PF00498	0.603
LIG_FHA_2	114	120	PF00498	0.621
LIG_FHA_2	126	132	PF00498	0.499
LIG_FHA_2	150	156	PF00498	0.694
LIG_FHA_2	210	216	PF00498	0.613
LIG_LIR_Apic_2	168	173	PF02991	0.540
LIG_LIR_Nem_3	161	166	PF02991	0.734
LIG_LIR_Nem_3	17	22	PF02991	0.527
LIG_REV1ctd_RIR_1	34	44	PF16727	0.718
LIG_SH2_CRK	163	167	PF00017	0.656
LIG_SH2_GRB2like	9	12	PF00017	0.601
LIG_SH2_STAP1	201	205	PF00017	0.597
LIG_SH2_STAT5	201	204	PF00017	0.538
LIG_SH3_3	134	140	PF00018	0.668
LIG_SH3_3	163	169	PF00018	0.635
MOD_CK1_1	106	112	PF00069	0.710
MOD_CK1_1	47	53	PF00069	0.681
MOD_CK1_1	96	102	PF00069	0.734
MOD_CK2_1	125	131	PF00069	0.580
MOD_CK2_1	135	141	PF00069	0.513
MOD_CK2_1	149	155	PF00069	0.591
MOD_CK2_1	4	10	PF00069	0.661
MOD_GlcNHglycan	12	16	PF01048	0.697
MOD_GlcNHglycan	95	98	PF01048	0.661
MOD_GSK3_1	101	108	PF00069	0.666
MOD_GSK3_1	11	18	PF00069	0.582
MOD_GSK3_1	131	138	PF00069	0.689
MOD_GSK3_1	154	161	PF00069	0.667
MOD_GSK3_1	216	223	PF00069	0.630
MOD_GSK3_1	32	39	PF00069	0.549
MOD_GSK3_1	43	50	PF00069	0.543
MOD_GSK3_1	70	77	PF00069	0.596
MOD_N-GLC_1	4	9	PF02516	0.492
MOD_N-GLC_1	51	56	PF02516	0.623
MOD_NEK2_1	102	107	PF00069	0.627
MOD_NEK2_1	135	140	PF00069	0.604
MOD_NEK2_1	154	159	PF00069	0.530
MOD_NEK2_1	36	41	PF00069	0.653
MOD_NEK2_1	43	48	PF00069	0.649
MOD_NEK2_1	58	63	PF00069	0.647
MOD_NEK2_1	70	75	PF00069	0.535
MOD_NEK2_2	187	192	PF00069	0.572
MOD_NEK2_2	32	37	PF00069	0.622
MOD_NEK2_2	65	70	PF00069	0.600
MOD_PIKK_1	41	47	PF00454	0.581
MOD_PIKK_1	91	97	PF00454	0.658
MOD_PKA_2	106	112	PF00069	0.524
MOD_PKA_2	15	21	PF00069	0.593
MOD_Plk_1	125	131	PF00069	0.580
MOD_Plk_1	176	182	PF00069	0.563
MOD_Plk_1	209	215	PF00069	0.637
MOD_Plk_1	4	10	PF00069	0.493
MOD_Plk_2-3	131	137	PF00069	0.578
MOD_Plk_4	15	21	PF00069	0.518
MOD_Plk_4	176	182	PF00069	0.548
MOD_Plk_4	32	38	PF00069	0.531
MOD_Plk_4	4	10	PF00069	0.670
MOD_Plk_4	52	58	PF00069	0.724
MOD_Plk_4	75	81	PF00069	0.660
MOD_ProDKin_1	59	65	PF00069	0.608
TRG_ENDOCYTIC_2	163	166	PF00928	0.730
TRG_ER_diArg_1	142	145	PF00400	0.593
TRG_ER_diArg_1	222	225	PF00400	0.596
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NYM4	Trypanosomatidae	43%	94%
A0A3Q8IDW1	Leishmania donovani	95%	100%
A0A422N2Z7	Trypanosoma rangeli	37%	89%
A4HGG5	Leishmania braziliensis	83%	100%
A4I3J7	Leishmania infantum	95%	100%
D0A7U6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	91%
E9AZT7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%