Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8E5_LEIMA

TriTrypDb:

LmjF.28.1210 , LMJLV39_280019200 , LMJSD75_280018900

Length:

788

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8E5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8E5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	19	23	PF00656	0.633
CLV_C14_Caspase3-7	427	431	PF00656	0.546
CLV_C14_Caspase3-7	480	484	PF00656	0.640
CLV_C14_Caspase3-7	489	493	PF00656	0.637
CLV_NRD_NRD_1	162	164	PF00675	0.528
CLV_NRD_NRD_1	220	222	PF00675	0.651
CLV_NRD_NRD_1	259	261	PF00675	0.659
CLV_NRD_NRD_1	293	295	PF00675	0.408
CLV_NRD_NRD_1	386	388	PF00675	0.695
CLV_NRD_NRD_1	464	466	PF00675	0.701
CLV_NRD_NRD_1	569	571	PF00675	0.681
CLV_NRD_NRD_1	577	579	PF00675	0.691
CLV_NRD_NRD_1	596	598	PF00675	0.471
CLV_NRD_NRD_1	72	74	PF00675	0.570
CLV_PCSK_FUR_1	291	295	PF00082	0.501
CLV_PCSK_FUR_1	569	573	PF00082	0.650
CLV_PCSK_FUR_1	594	598	PF00082	0.509
CLV_PCSK_KEX2_1	162	164	PF00082	0.528
CLV_PCSK_KEX2_1	220	222	PF00082	0.651
CLV_PCSK_KEX2_1	242	244	PF00082	0.729
CLV_PCSK_KEX2_1	259	261	PF00082	0.604
CLV_PCSK_KEX2_1	293	295	PF00082	0.408
CLV_PCSK_KEX2_1	385	387	PF00082	0.657
CLV_PCSK_KEX2_1	464	466	PF00082	0.701
CLV_PCSK_KEX2_1	569	571	PF00082	0.833
CLV_PCSK_KEX2_1	577	579	PF00082	0.719
CLV_PCSK_KEX2_1	596	598	PF00082	0.471
CLV_PCSK_KEX2_1	72	74	PF00082	0.570
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.556
CLV_PCSK_PC1ET2_1	385	387	PF00082	0.657
CLV_PCSK_PC1ET2_1	571	573	PF00082	0.838
CLV_PCSK_SKI1_1	174	178	PF00082	0.681
CLV_PCSK_SKI1_1	286	290	PF00082	0.434
CLV_PCSK_SKI1_1	322	326	PF00082	0.710
CLV_PCSK_SKI1_1	571	575	PF00082	0.570
CLV_PCSK_SKI1_1	577	581	PF00082	0.563
DEG_Nend_UBRbox_3	1	3	PF02207	0.581
DEG_ODPH_VHL_1	689	701	PF01847	0.509
DEG_SPOP_SBC_1	145	149	PF00917	0.575
DEG_SPOP_SBC_1	186	190	PF00917	0.614
DEG_SPOP_SBC_1	231	235	PF00917	0.700
DEG_SPOP_SBC_1	37	41	PF00917	0.675
DEG_SPOP_SBC_1	559	563	PF00917	0.616
DEG_SPOP_SBC_1	582	586	PF00917	0.653
DEG_SPOP_SBC_1	81	85	PF00917	0.599
DOC_ANK_TNKS_1	633	640	PF00023	0.623
DOC_CYCLIN_yCln2_LP_2	324	327	PF00134	0.521
DOC_CYCLIN_yCln2_LP_2	693	699	PF00134	0.604
DOC_MAPK_gen_1	594	603	PF00069	0.473
DOC_MAPK_gen_1	72	78	PF00069	0.575
DOC_MAPK_RevD_3	60	73	PF00069	0.614
DOC_PP2B_LxvP_1	324	327	PF13499	0.521
DOC_PP2B_LxvP_1	693	696	PF13499	0.626
DOC_PP2B_LxvP_1	699	702	PF13499	0.588
DOC_USP7_MATH_1	117	121	PF00917	0.747
DOC_USP7_MATH_1	123	127	PF00917	0.640
DOC_USP7_MATH_1	186	190	PF00917	0.611
DOC_USP7_MATH_1	215	219	PF00917	0.706
DOC_USP7_MATH_1	232	236	PF00917	0.764
DOC_USP7_MATH_1	275	279	PF00917	0.411
DOC_USP7_MATH_1	346	350	PF00917	0.719
DOC_USP7_MATH_1	35	39	PF00917	0.750
DOC_USP7_MATH_1	431	435	PF00917	0.640
DOC_USP7_MATH_1	534	538	PF00917	0.594
DOC_USP7_MATH_1	582	586	PF00917	0.630
DOC_USP7_MATH_1	702	706	PF00917	0.634
DOC_USP7_MATH_1	728	732	PF00917	0.762
DOC_USP7_MATH_1	743	747	PF00917	0.509
DOC_USP7_MATH_1	81	85	PF00917	0.621
DOC_WW_Pin1_4	209	214	PF00397	0.611
DOC_WW_Pin1_4	224	229	PF00397	0.589
DOC_WW_Pin1_4	27	32	PF00397	0.765
DOC_WW_Pin1_4	33	38	PF00397	0.615
DOC_WW_Pin1_4	389	394	PF00397	0.675
DOC_WW_Pin1_4	44	49	PF00397	0.797
DOC_WW_Pin1_4	458	463	PF00397	0.587
DOC_WW_Pin1_4	504	509	PF00397	0.657
DOC_WW_Pin1_4	552	557	PF00397	0.667
DOC_WW_Pin1_4	564	569	PF00397	0.773
LIG_14-3-3_CanoR_1	144	151	PF00244	0.632
LIG_14-3-3_CanoR_1	174	179	PF00244	0.572
LIG_14-3-3_CanoR_1	269	276	PF00244	0.585
LIG_14-3-3_CanoR_1	370	379	PF00244	0.614
LIG_14-3-3_CanoR_1	386	393	PF00244	0.551
LIG_14-3-3_CanoR_1	520	526	PF00244	0.746
LIG_14-3-3_CanoR_1	558	568	PF00244	0.654
LIG_14-3-3_CanoR_1	736	744	PF00244	0.619
LIG_deltaCOP1_diTrp_1	545	552	PF00928	0.579
LIG_FHA_1	140	146	PF00498	0.716
LIG_FHA_1	231	237	PF00498	0.604
LIG_FHA_1	400	406	PF00498	0.622
LIG_FHA_1	473	479	PF00498	0.692
LIG_FHA_1	766	772	PF00498	0.560
LIG_FHA_2	414	420	PF00498	0.539
LIG_FHA_2	485	491	PF00498	0.644
LIG_FHA_2	775	781	PF00498	0.608
LIG_Integrin_RGD_1	245	247	PF01839	0.558
LIG_LIR_Apic_2	334	340	PF02991	0.557
LIG_LIR_Apic_2	607	612	PF02991	0.457
LIG_LIR_Nem_3	284	288	PF02991	0.417
LIG_LIR_Nem_3	413	417	PF02991	0.532
LIG_SH2_CRK	598	602	PF00017	0.483
LIG_SH2_STAT3	3	6	PF00017	0.577
LIG_SH2_STAT3	616	619	PF00017	0.541
LIG_SH2_STAT5	538	541	PF00017	0.604
LIG_SH3_2	459	464	PF14604	0.578
LIG_SH3_3	31	37	PF00018	0.713
LIG_SH3_3	375	381	PF00018	0.619
LIG_SH3_3	401	407	PF00018	0.560
LIG_SH3_3	456	462	PF00018	0.650
LIG_SH3_3	553	559	PF00018	0.636
LIG_SH3_3	659	665	PF00018	0.622
LIG_SH3_3	698	704	PF00018	0.760
LIG_SH3_3	720	726	PF00018	0.548
LIG_SH3_3	75	81	PF00018	0.612
LIG_SH3_3	87	93	PF00018	0.644
LIG_SUMO_SIM_par_1	475	484	PF11976	0.625
LIG_TRAF2_1	573	576	PF00917	0.576
LIG_TRAF2_1	777	780	PF00917	0.551
LIG_TRAF2_2	393	398	PF00917	0.551
LIG_WW_3	461	465	PF00397	0.553
MOD_CDC14_SPxK_1	461	464	PF00782	0.549
MOD_CDC14_SPxK_1	555	558	PF00782	0.687
MOD_CDC14_SPxK_1	567	570	PF00782	0.619
MOD_CDK_SPK_2	564	569	PF00069	0.728
MOD_CDK_SPxK_1	458	464	PF00069	0.549
MOD_CDK_SPxK_1	552	558	PF00069	0.707
MOD_CDK_SPxK_1	564	570	PF00069	0.685
MOD_CDK_SPxxK_3	458	465	PF00069	0.552
MOD_CDK_SPxxK_3	564	571	PF00069	0.766
MOD_CK1_1	109	115	PF00069	0.684
MOD_CK1_1	136	142	PF00069	0.780
MOD_CK1_1	168	174	PF00069	0.577
MOD_CK1_1	237	243	PF00069	0.705
MOD_CK1_1	249	255	PF00069	0.605
MOD_CK1_1	265	271	PF00069	0.585
MOD_CK1_1	29	35	PF00069	0.620
MOD_CK1_1	36	42	PF00069	0.682
MOD_CK1_1	469	475	PF00069	0.748
MOD_CK1_1	484	490	PF00069	0.598
MOD_CK1_1	496	502	PF00069	0.682
MOD_CK1_1	504	510	PF00069	0.635
MOD_CK1_1	537	543	PF00069	0.604
MOD_CK1_1	544	550	PF00069	0.616
MOD_CK1_1	551	557	PF00069	0.659
MOD_CK1_1	561	567	PF00069	0.738
MOD_CK1_1	585	591	PF00069	0.567
MOD_CK1_1	706	712	PF00069	0.570
MOD_CK1_1	713	719	PF00069	0.584
MOD_CK2_1	370	376	PF00069	0.634
MOD_CK2_1	413	419	PF00069	0.536
MOD_CK2_1	431	437	PF00069	0.617
MOD_CK2_1	774	780	PF00069	0.546
MOD_Cter_Amidation	291	294	PF01082	0.443
MOD_Cter_Amidation	70	73	PF01082	0.555
MOD_GlcNHglycan	108	111	PF01048	0.746
MOD_GlcNHglycan	114	117	PF01048	0.649
MOD_GlcNHglycan	148	151	PF01048	0.727
MOD_GlcNHglycan	170	173	PF01048	0.585
MOD_GlcNHglycan	200	203	PF01048	0.604
MOD_GlcNHglycan	24	27	PF01048	0.805
MOD_GlcNHglycan	247	251	PF01048	0.674
MOD_GlcNHglycan	253	256	PF01048	0.786
MOD_GlcNHglycan	264	267	PF01048	0.550
MOD_GlcNHglycan	270	273	PF01048	0.461
MOD_GlcNHglycan	306	309	PF01048	0.624
MOD_GlcNHglycan	352	355	PF01048	0.800
MOD_GlcNHglycan	367	370	PF01048	0.757
MOD_GlcNHglycan	372	375	PF01048	0.653
MOD_GlcNHglycan	387	390	PF01048	0.544
MOD_GlcNHglycan	40	43	PF01048	0.788
MOD_GlcNHglycan	433	436	PF01048	0.692
MOD_GlcNHglycan	468	471	PF01048	0.637
MOD_GlcNHglycan	492	496	PF01048	0.682
MOD_GlcNHglycan	511	514	PF01048	0.561
MOD_GlcNHglycan	516	519	PF01048	0.595
MOD_GlcNHglycan	55	58	PF01048	0.662
MOD_GlcNHglycan	657	660	PF01048	0.707
MOD_GlcNHglycan	69	72	PF01048	0.503
MOD_GlcNHglycan	708	711	PF01048	0.546
MOD_GlcNHglycan	715	718	PF01048	0.568
MOD_GlcNHglycan	730	733	PF01048	0.589
MOD_GlcNHglycan	739	742	PF01048	0.571
MOD_GlcNHglycan	753	756	PF01048	0.551
MOD_GlcNHglycan	84	87	PF01048	0.650
MOD_GlcNHglycan	94	97	PF01048	0.705
MOD_GSK3_1	102	109	PF00069	0.622
MOD_GSK3_1	112	119	PF00069	0.634
MOD_GSK3_1	133	140	PF00069	0.726
MOD_GSK3_1	186	193	PF00069	0.604
MOD_GSK3_1	215	222	PF00069	0.728
MOD_GSK3_1	22	29	PF00069	0.564
MOD_GSK3_1	226	233	PF00069	0.630
MOD_GSK3_1	234	241	PF00069	0.693
MOD_GSK3_1	246	253	PF00069	0.531
MOD_GSK3_1	261	268	PF00069	0.641
MOD_GSK3_1	299	306	PF00069	0.441
MOD_GSK3_1	33	40	PF00069	0.698
MOD_GSK3_1	346	353	PF00069	0.803
MOD_GSK3_1	381	388	PF00069	0.694
MOD_GSK3_1	468	475	PF00069	0.699
MOD_GSK3_1	479	486	PF00069	0.809
MOD_GSK3_1	491	498	PF00069	0.674
MOD_GSK3_1	500	507	PF00069	0.698
MOD_GSK3_1	51	58	PF00069	0.626
MOD_GSK3_1	533	540	PF00069	0.597
MOD_GSK3_1	541	548	PF00069	0.607
MOD_GSK3_1	558	565	PF00069	0.655
MOD_GSK3_1	581	588	PF00069	0.615
MOD_GSK3_1	639	646	PF00069	0.685
MOD_GSK3_1	702	709	PF00069	0.658
MOD_GSK3_1	9	16	PF00069	0.634
MOD_N-GLC_1	145	150	PF02516	0.587
MOD_N-GLC_1	44	49	PF02516	0.681
MOD_N-GLC_1	484	489	PF02516	0.604
MOD_N-GLC_1	652	657	PF02516	0.660
MOD_NEK2_1	121	126	PF00069	0.618
MOD_NEK2_1	137	142	PF00069	0.610
MOD_NEK2_1	399	404	PF00069	0.750
MOD_NEK2_1	468	473	PF00069	0.621
MOD_NEK2_1	502	507	PF00069	0.662
MOD_NEK2_1	737	742	PF00069	0.627
MOD_NEK2_1	82	87	PF00069	0.648
MOD_PIKK_1	215	221	PF00454	0.665
MOD_PIKK_1	405	411	PF00454	0.569
MOD_PIKK_1	444	450	PF00454	0.650
MOD_PIKK_1	615	621	PF00454	0.475
MOD_PIKK_1	680	686	PF00454	0.563
MOD_PKA_1	385	391	PF00069	0.661
MOD_PKA_2	156	162	PF00069	0.504
MOD_PKA_2	219	225	PF00069	0.657
MOD_PKA_2	261	267	PF00069	0.766
MOD_PKA_2	268	274	PF00069	0.618
MOD_PKA_2	385	391	PF00069	0.706
MOD_PKA_2	453	459	PF00069	0.601
MOD_PKA_2	633	639	PF00069	0.653
MOD_PKB_1	260	268	PF00069	0.689
MOD_Plk_1	346	352	PF00069	0.682
MOD_Plk_2-3	413	419	PF00069	0.536
MOD_Plk_4	29	35	PF00069	0.633
MOD_Plk_4	506	512	PF00069	0.572
MOD_Plk_4	534	540	PF00069	0.582
MOD_Plk_4	710	716	PF00069	0.760
MOD_ProDKin_1	209	215	PF00069	0.612
MOD_ProDKin_1	224	230	PF00069	0.588
MOD_ProDKin_1	27	33	PF00069	0.767
MOD_ProDKin_1	389	395	PF00069	0.674
MOD_ProDKin_1	44	50	PF00069	0.798
MOD_ProDKin_1	458	464	PF00069	0.593
MOD_ProDKin_1	504	510	PF00069	0.658
MOD_ProDKin_1	552	558	PF00069	0.668
MOD_ProDKin_1	564	570	PF00069	0.772
MOD_SUMO_for_1	573	576	PF00179	0.567
TRG_DiLeu_BaEn_1	413	418	PF01217	0.505
TRG_DiLeu_BaEn_4	779	785	PF01217	0.605
TRG_DiLeu_BaLyEn_6	733	738	PF01217	0.570
TRG_ENDOCYTIC_2	285	288	PF00928	0.438
TRG_ENDOCYTIC_2	598	601	PF00928	0.492
TRG_ER_diArg_1	161	163	PF00400	0.512
TRG_ER_diArg_1	220	223	PF00400	0.652
TRG_ER_diArg_1	259	262	PF00400	0.609
TRG_ER_diArg_1	291	294	PF00400	0.519
TRG_ER_diArg_1	340	343	PF00400	0.670
TRG_ER_diArg_1	463	465	PF00400	0.660
TRG_ER_diArg_1	568	570	PF00400	0.790
TRG_ER_diArg_1	577	579	PF00400	0.809
TRG_ER_diArg_1	594	597	PF00400	0.444
TRG_ER_diArg_1	72	74	PF00400	0.570
TRG_NLS_MonoExtC_3	241	247	PF00514	0.555
TRG_NLS_MonoExtC_3	569	574	PF00514	0.686
TRG_NLS_MonoExtN_4	568	575	PF00514	0.690
TRG_Pf-PMV_PEXEL_1	415	419	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I844	Leptomonas seymouri	35%	100%
A0A3S7X1G0	Leishmania donovani	87%	100%
A4HGG8	Leishmania braziliensis	62%	100%
A4I3K0	Leishmania infantum	87%	100%
E9AZU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%