FHA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8E4_LEIMA

TriTrypDb:

LmjF.28.1220 , LMJLV39_280019300 , LMJSD75_280019000

Length:

472

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8E4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8E4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.612
CLV_C14_Caspase3-7	324	328	PF00656	0.513
CLV_C14_Caspase3-7	429	433	PF00656	0.626
CLV_C14_Caspase3-7	439	443	PF00656	0.687
CLV_C14_Caspase3-7	458	462	PF00656	0.683
CLV_NRD_NRD_1	214	216	PF00675	0.637
CLV_NRD_NRD_1	402	404	PF00675	0.454
CLV_NRD_NRD_1	412	414	PF00675	0.558
CLV_NRD_NRD_1	469	471	PF00675	0.661
CLV_PCSK_KEX2_1	402	404	PF00082	0.454
CLV_PCSK_KEX2_1	411	413	PF00082	0.549
CLV_PCSK_KEX2_1	467	469	PF00082	0.661
CLV_PCSK_PC1ET2_1	467	469	PF00082	0.636
CLV_PCSK_PC7_1	463	469	PF00082	0.544
CLV_PCSK_SKI1_1	116	120	PF00082	0.627
CLV_PCSK_SKI1_1	19	23	PF00082	0.372
CLV_PCSK_SKI1_1	243	247	PF00082	0.571
CLV_PCSK_SKI1_1	412	416	PF00082	0.656
DEG_APCC_DBOX_1	51	59	PF00400	0.390
DEG_COP1_1	187	197	PF00400	0.621
DEG_SPOP_SBC_1	447	451	PF00917	0.756
DOC_CYCLIN_yCln2_LP_2	134	140	PF00134	0.486
DOC_MAPK_gen_1	16	24	PF00069	0.393
DOC_MAPK_MEF2A_6	16	24	PF00069	0.393
DOC_MAPK_MEF2A_6	243	250	PF00069	0.555
DOC_PP2B_LxvP_1	160	163	PF13499	0.439
DOC_PP2B_LxvP_1	192	195	PF13499	0.545
DOC_PP4_FxxP_1	364	367	PF00568	0.463
DOC_USP7_MATH_1	120	124	PF00917	0.545
DOC_USP7_MATH_1	193	197	PF00917	0.605
DOC_USP7_MATH_1	217	221	PF00917	0.626
DOC_USP7_MATH_1	234	238	PF00917	0.701
DOC_USP7_MATH_1	274	278	PF00917	0.633
DOC_USP7_MATH_1	293	297	PF00917	0.588
DOC_USP7_MATH_1	443	447	PF00917	0.691
DOC_USP7_MATH_1	453	457	PF00917	0.611
DOC_USP7_UBL2_3	366	370	PF12436	0.462
DOC_USP7_UBL2_3	393	397	PF12436	0.638
DOC_WW_Pin1_4	264	269	PF00397	0.770
DOC_WW_Pin1_4	419	424	PF00397	0.652
DOC_WW_Pin1_4	449	454	PF00397	0.622
DOC_WW_Pin1_4	78	83	PF00397	0.553
LIG_14-3-3_CanoR_1	19	25	PF00244	0.398
LIG_14-3-3_CanoR_1	279	284	PF00244	0.616
LIG_BIR_II_1	1	5	PF00653	0.583
LIG_BIR_III_4	368	372	PF00653	0.487
LIG_BRCT_BRCA1_1	360	364	PF00533	0.564
LIG_BRCT_BRCA1_2	360	366	PF00533	0.575
LIG_CSL_BTD_1	58	61	PF09270	0.412
LIG_CtBP_PxDLS_1	157	161	PF00389	0.525
LIG_FHA_1	127	133	PF00498	0.484
LIG_FHA_1	162	168	PF00498	0.538
LIG_FHA_1	371	377	PF00498	0.403
LIG_FHA_2	173	179	PF00498	0.674
LIG_FHA_2	185	191	PF00498	0.549
LIG_HCF-1_HBM_1	28	31	PF13415	0.403
LIG_LIR_Apic_2	361	367	PF02991	0.577
LIG_LIR_Nem_3	332	336	PF02991	0.386
LIG_LIR_Nem_3	396	401	PF02991	0.502
LIG_PCNA_yPIPBox_3	335	344	PF02747	0.416
LIG_PTB_Apo_2	69	76	PF02174	0.424
LIG_SH2_CRK	336	340	PF00017	0.346
LIG_SH2_STAT3	65	68	PF00017	0.385
LIG_SH2_STAT5	31	34	PF00017	0.387
LIG_SH3_3	127	133	PF00018	0.420
LIG_SH3_3	151	157	PF00018	0.542
LIG_SH3_3	418	424	PF00018	0.524
LIG_SH3_3	55	61	PF00018	0.541
LIG_SH3_4	366	373	PF00018	0.444
LIG_SUMO_SIM_anti_2	53	59	PF11976	0.361
LIG_SUMO_SIM_par_1	126	131	PF11976	0.490
LIG_SUMO_SIM_par_1	136	141	PF11976	0.454
LIG_SUMO_SIM_par_1	190	196	PF11976	0.601
LIG_SUMO_SIM_par_1	20	25	PF11976	0.388
MOD_CDK_SPK_2	449	454	PF00069	0.579
MOD_CDK_SPxxK_3	78	85	PF00069	0.581
MOD_CK1_1	218	224	PF00069	0.714
MOD_CK1_1	264	270	PF00069	0.773
MOD_CK1_1	422	428	PF00069	0.604
MOD_CK1_1	433	439	PF00069	0.637
MOD_CK1_1	446	452	PF00069	0.649
MOD_CK1_1	457	463	PF00069	0.654
MOD_CK1_1	97	103	PF00069	0.473
MOD_CK2_1	184	190	PF00069	0.614
MOD_CK2_1	208	214	PF00069	0.655
MOD_CK2_1	293	299	PF00069	0.637
MOD_CK2_1	388	394	PF00069	0.444
MOD_CK2_1	428	434	PF00069	0.647
MOD_CK2_1	438	444	PF00069	0.668
MOD_GlcNHglycan	109	112	PF01048	0.488
MOD_GlcNHglycan	122	125	PF01048	0.480
MOD_GlcNHglycan	195	198	PF01048	0.531
MOD_GlcNHglycan	236	239	PF01048	0.694
MOD_GlcNHglycan	262	266	PF01048	0.600
MOD_GlcNHglycan	295	298	PF01048	0.615
MOD_GlcNHglycan	360	363	PF01048	0.558
MOD_GlcNHglycan	40	43	PF01048	0.469
MOD_GlcNHglycan	444	448	PF01048	0.816
MOD_GlcNHglycan	457	460	PF01048	0.597
MOD_GlcNHglycan	5	8	PF01048	0.576
MOD_GlcNHglycan	95	99	PF01048	0.564
MOD_GSK3_1	116	123	PF00069	0.538
MOD_GSK3_1	177	184	PF00069	0.739
MOD_GSK3_1	218	225	PF00069	0.668
MOD_GSK3_1	260	267	PF00069	0.607
MOD_GSK3_1	270	277	PF00069	0.587
MOD_GSK3_1	325	332	PF00069	0.487
MOD_GSK3_1	419	426	PF00069	0.564
MOD_GSK3_1	430	437	PF00069	0.635
MOD_GSK3_1	443	450	PF00069	0.654
MOD_GSK3_1	453	460	PF00069	0.768
MOD_N-GLC_1	234	239	PF02516	0.664
MOD_N-GLC_1	454	459	PF02516	0.684
MOD_NEK2_1	109	114	PF00069	0.598
MOD_NEK2_1	138	143	PF00069	0.485
MOD_NEK2_1	76	81	PF00069	0.573
MOD_NEK2_1	94	99	PF00069	0.448
MOD_NEK2_2	150	155	PF00069	0.454
MOD_NEK2_2	163	168	PF00069	0.421
MOD_PIKK_1	138	144	PF00454	0.554
MOD_PKA_1	215	221	PF00069	0.678
MOD_PKA_2	218	224	PF00069	0.646
MOD_PKA_2	401	407	PF00069	0.466
MOD_PKA_2	453	459	PF00069	0.584
MOD_Plk_1	349	355	PF00069	0.482
MOD_Plk_1	426	432	PF00069	0.608
MOD_Plk_2-3	126	132	PF00069	0.598
MOD_Plk_2-3	208	214	PF00069	0.652
MOD_Plk_2-3	428	434	PF00069	0.641
MOD_Plk_2-3	435	441	PF00069	0.655
MOD_Plk_4	71	77	PF00069	0.424
MOD_Plk_4	97	103	PF00069	0.530
MOD_ProDKin_1	264	270	PF00069	0.773
MOD_ProDKin_1	419	425	PF00069	0.664
MOD_ProDKin_1	449	455	PF00069	0.623
MOD_ProDKin_1	78	84	PF00069	0.548
MOD_SUMO_rev_2	208	218	PF00179	0.677
MOD_SUMO_rev_2	318	328	PF00179	0.540
TRG_ENDOCYTIC_2	336	339	PF00928	0.358
TRG_ER_diArg_1	401	403	PF00400	0.443
TRG_ER_diArg_1	411	413	PF00400	0.549
TRG_ER_diArg_1	468	470	PF00400	0.675
TRG_NLS_MonoCore_2	465	470	PF00514	0.637
TRG_NLS_MonoExtC_3	465	470	PF00514	0.637
TRG_NLS_MonoExtN_4	463	470	PF00514	0.632
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J3	Leptomonas seymouri	54%	98%
A0A3Q8IQI6	Leishmania donovani	87%	100%
A4HGG9	Leishmania braziliensis	73%	100%
A4I3K1	Leishmania infantum	87%	100%
E9AZU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%