SGL domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SMP-30/Gluconolaconase/LRE-like region, putative

Species:

Leishmania major

UniProt:

Q4Q8E3_LEIMA

TriTrypDb:

LmjF.28.1230 , LMJLV39_280019400 , LMJSD75_280019100

Length:

413

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8E3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8E3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.496
CLV_NRD_NRD_1	10	12	PF00675	0.338
CLV_NRD_NRD_1	184	186	PF00675	0.261
CLV_NRD_NRD_1	319	321	PF00675	0.204
CLV_PCSK_KEX2_1	10	12	PF00082	0.348
CLV_PCSK_KEX2_1	184	186	PF00082	0.231
CLV_PCSK_SKI1_1	289	293	PF00082	0.246
CLV_Separin_Metazoa	313	317	PF03568	0.446
DOC_CKS1_1	241	246	PF01111	0.476
DOC_MAPK_RevD_3	306	321	PF00069	0.404
DOC_PP2B_LxvP_1	398	401	PF13499	0.401
DOC_PP2B_LxvP_1	65	68	PF13499	0.492
DOC_USP7_MATH_1	166	170	PF00917	0.446
DOC_USP7_MATH_1	203	207	PF00917	0.474
DOC_USP7_MATH_1	255	259	PF00917	0.398
DOC_USP7_MATH_1	369	373	PF00917	0.397
DOC_USP7_MATH_1	401	405	PF00917	0.452
DOC_USP7_UBL2_3	387	391	PF12436	0.380
DOC_WW_Pin1_4	131	136	PF00397	0.511
DOC_WW_Pin1_4	205	210	PF00397	0.471
DOC_WW_Pin1_4	229	234	PF00397	0.446
DOC_WW_Pin1_4	23	28	PF00397	0.482
DOC_WW_Pin1_4	240	245	PF00397	0.446
LIG_14-3-3_CanoR_1	119	127	PF00244	0.398
LIG_14-3-3_CanoR_1	143	149	PF00244	0.492
LIG_14-3-3_CanoR_1	289	294	PF00244	0.446
LIG_BIR_II_1	1	5	PF00653	0.445
LIG_BIR_III_4	299	303	PF00653	0.484
LIG_BRCT_BRCA1_1	212	216	PF00533	0.476
LIG_BRCT_BRCA1_1	345	349	PF00533	0.446
LIG_FHA_1	331	337	PF00498	0.454
LIG_FHA_1	354	360	PF00498	0.470
LIG_FHA_2	26	32	PF00498	0.492
LIG_FHA_2	323	329	PF00498	0.492
LIG_FHA_2	363	369	PF00498	0.400
LIG_LIR_Gen_1	58	67	PF02991	0.457
LIG_LIR_Nem_3	58	62	PF02991	0.481
LIG_RPA_C_Fungi	358	370	PF08784	0.416
LIG_SH2_CRK	253	257	PF00017	0.323
LIG_SH2_SRC	139	142	PF00017	0.302
LIG_SH2_STAP1	112	116	PF00017	0.345
LIG_SH2_STAP1	382	386	PF00017	0.322
LIG_SH2_STAT3	251	254	PF00017	0.280
LIG_SH2_STAT3	47	50	PF00017	0.345
LIG_SH2_STAT5	109	112	PF00017	0.281
LIG_SH2_STAT5	277	280	PF00017	0.260
LIG_SH2_STAT5	358	361	PF00017	0.281
LIG_SH2_STAT5	47	50	PF00017	0.281
LIG_SH3_3	215	221	PF00018	0.351
LIG_SH3_3	238	244	PF00018	0.311
LIG_SH3_3	333	339	PF00018	0.281
LIG_SH3_3	45	51	PF00018	0.345
LIG_SH3_3	9	15	PF00018	0.339
LIG_SUMO_SIM_anti_2	60	66	PF11976	0.309
MOD_CK1_1	111	117	PF00069	0.345
MOD_CK1_1	205	211	PF00069	0.339
MOD_CK1_1	403	409	PF00069	0.512
MOD_CK2_1	25	31	PF00069	0.345
MOD_CK2_1	282	288	PF00069	0.274
MOD_CK2_1	322	328	PF00069	0.359
MOD_CK2_1	362	368	PF00069	0.390
MOD_GlcNHglycan	188	191	PF01048	0.236
MOD_GlcNHglycan	205	208	PF01048	0.171
MOD_GlcNHglycan	257	260	PF01048	0.217
MOD_GlcNHglycan	299	303	PF01048	0.281
MOD_GlcNHglycan	405	408	PF01048	0.470
MOD_GlcNHglycan	92	95	PF01048	0.294
MOD_GSK3_1	107	114	PF00069	0.304
MOD_GSK3_1	203	210	PF00069	0.341
MOD_GSK3_1	353	360	PF00069	0.383
MOD_N-GLC_1	221	226	PF02516	0.294
MOD_NEK2_1	107	112	PF00069	0.281
MOD_NEK2_1	343	348	PF00069	0.281
MOD_NEK2_1	357	362	PF00069	0.281
MOD_NEK2_1	5	10	PF00069	0.364
MOD_NEK2_2	369	374	PF00069	0.543
MOD_PIKK_1	100	106	PF00454	0.281
MOD_PKA_2	118	124	PF00069	0.345
MOD_PKA_2	362	368	PF00069	0.369
MOD_PKB_1	287	295	PF00069	0.345
MOD_Plk_1	166	172	PF00069	0.367
MOD_Plk_1	221	227	PF00069	0.354
MOD_Plk_1	352	358	PF00069	0.345
MOD_Plk_1	401	407	PF00069	0.463
MOD_Plk_2-3	25	31	PF00069	0.281
MOD_Plk_4	144	150	PF00069	0.345
MOD_Plk_4	166	172	PF00069	0.271
MOD_Plk_4	188	194	PF00069	0.359
MOD_Plk_4	353	359	PF00069	0.281
MOD_ProDKin_1	131	137	PF00069	0.372
MOD_ProDKin_1	205	211	PF00069	0.315
MOD_ProDKin_1	229	235	PF00069	0.281
MOD_ProDKin_1	23	29	PF00069	0.331
MOD_ProDKin_1	240	246	PF00069	0.281
MOD_SUMO_rev_2	313	322	PF00179	0.347
TRG_DiLeu_BaEn_4	31	37	PF01217	0.280
TRG_ENDOCYTIC_2	253	256	PF00928	0.323
TRG_ENDOCYTIC_2	279	282	PF00928	0.345
TRG_ENDOCYTIC_2	97	100	PF00928	0.359
TRG_ER_diArg_1	10	13	PF00400	0.347
TRG_ER_diArg_1	183	185	PF00400	0.302
TRG_ER_diArg_1	397	400	PF00400	0.450

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9S4	Leptomonas seymouri	57%	100%
A0A3Q8IAY9	Leishmania donovani	92%	100%
A4HGH0	Leishmania braziliensis	77%	100%
A4I3K2	Leishmania infantum	92%	100%
E9AZU2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
O34940	Bacillus subtilis (strain 168)	24%	100%
P0DOV6	Pseudomonas putida	26%	100%
Q9I922	Xenopus laevis	23%	100%