J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q8D9_LEIMA

TriTrypDb:

LmjF.28.1270 , LMJLV39_280019900 , LMJSD75_280019500

Length:

472

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8D9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8D9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.618
CLV_C14_Caspase3-7	177	181	PF00656	0.530
CLV_MEL_PAP_1	194	200	PF00089	0.597
CLV_NRD_NRD_1	429	431	PF00675	0.560
CLV_NRD_NRD_1	73	75	PF00675	0.303
CLV_PCSK_KEX2_1	427	429	PF00082	0.567
CLV_PCSK_KEX2_1	72	74	PF00082	0.304
CLV_PCSK_PC1ET2_1	427	429	PF00082	0.567
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.304
CLV_PCSK_SKI1_1	407	411	PF00082	0.447
DEG_Nend_UBRbox_2	1	3	PF02207	0.608
DEG_SPOP_SBC_1	116	120	PF00917	0.679
DEG_SPOP_SBC_1	337	341	PF00917	0.553
DEG_SPOP_SBC_1	459	463	PF00917	0.599
DOC_CDC14_PxL_1	439	447	PF14671	0.543
DOC_MAPK_gen_1	205	212	PF00069	0.586
DOC_MAPK_gen_1	240	247	PF00069	0.474
DOC_MAPK_gen_1	27	36	PF00069	0.304
DOC_MAPK_gen_1	427	437	PF00069	0.519
DOC_MAPK_MEF2A_6	190	198	PF00069	0.593
DOC_MAPK_MEF2A_6	27	36	PF00069	0.304
DOC_MAPK_MEF2A_6	430	439	PF00069	0.559
DOC_PP2B_LxvP_1	158	161	PF13499	0.617
DOC_PP2B_LxvP_1	456	459	PF13499	0.591
DOC_USP7_MATH_1	116	120	PF00917	0.709
DOC_USP7_MATH_1	265	269	PF00917	0.620
DOC_USP7_MATH_1	332	336	PF00917	0.658
DOC_USP7_MATH_1	337	341	PF00917	0.611
DOC_USP7_MATH_1	429	433	PF00917	0.643
DOC_USP7_UBL2_3	427	431	PF12436	0.563
DOC_WW_Pin1_4	117	122	PF00397	0.679
DOC_WW_Pin1_4	222	227	PF00397	0.637
DOC_WW_Pin1_4	300	305	PF00397	0.624
DOC_WW_Pin1_4	333	338	PF00397	0.645
DOC_WW_Pin1_4	381	386	PF00397	0.626
DOC_WW_Pin1_4	464	469	PF00397	0.544
LIG_14-3-3_CanoR_1	105	115	PF00244	0.515
LIG_14-3-3_CanoR_1	190	195	PF00244	0.635
LIG_14-3-3_CanoR_1	59	67	PF00244	0.311
LIG_14-3-3_CanoR_1	90	95	PF00244	0.440
LIG_Actin_WH2_2	184	199	PF00022	0.641
LIG_APCC_ABBA_1	34	39	PF00400	0.304
LIG_BIR_III_4	180	184	PF00653	0.608
LIG_BRCT_BRCA1_1	169	173	PF00533	0.625
LIG_Clathr_ClatBox_1	244	248	PF01394	0.597
LIG_FHA_1	110	116	PF00498	0.605
LIG_FHA_1	232	238	PF00498	0.690
LIG_FHA_1	274	280	PF00498	0.713
LIG_FHA_1	307	313	PF00498	0.681
LIG_FHA_1	339	345	PF00498	0.634
LIG_FHA_1	465	471	PF00498	0.540
LIG_FHA_2	120	126	PF00498	0.743
LIG_FHA_2	141	147	PF00498	0.640
LIG_GBD_Chelix_1	269	277	PF00786	0.549
LIG_HCF-1_HBM_1	342	345	PF13415	0.477
LIG_LIR_Apic_2	221	227	PF02991	0.532
LIG_LIR_Gen_1	342	353	PF02991	0.531
LIG_LIR_Gen_1	438	445	PF02991	0.572
LIG_LIR_Gen_1	61	70	PF02991	0.331
LIG_LIR_Nem_3	234	238	PF02991	0.536
LIG_LIR_Nem_3	342	348	PF02991	0.546
LIG_LIR_Nem_3	352	358	PF02991	0.492
LIG_LIR_Nem_3	438	442	PF02991	0.556
LIG_LIR_Nem_3	61	67	PF02991	0.350
LIG_LYPXL_SIV_4	349	357	PF13949	0.572
LIG_MYND_1	381	385	PF01753	0.477
LIG_PDZ_Class_2	467	472	PF00595	0.629
LIG_Pex14_1	235	239	PF04695	0.536
LIG_SH2_CRK	11	15	PF00017	0.337
LIG_SH2_CRK	215	219	PF00017	0.570
LIG_SH2_CRK	29	33	PF00017	0.315
LIG_SH2_CRK	345	349	PF00017	0.557
LIG_SH2_CRK	350	354	PF00017	0.538
LIG_SH2_CRK	355	359	PF00017	0.540
LIG_SH2_CRK	57	61	PF00017	0.304
LIG_SH2_CRK	64	68	PF00017	0.352
LIG_SH2_NCK_1	224	228	PF00017	0.510
LIG_SH2_NCK_1	350	354	PF00017	0.551
LIG_SH2_NCK_1	355	359	PF00017	0.554
LIG_SH2_STAP1	231	235	PF00017	0.608
LIG_SH2_STAP1	350	354	PF00017	0.486
LIG_SH2_STAT5	187	190	PF00017	0.600
LIG_SH3_1	224	230	PF00018	0.504
LIG_SH3_3	154	160	PF00018	0.681
LIG_SH3_3	224	230	PF00018	0.591
LIG_SH3_3	261	267	PF00018	0.616
LIG_SH3_3	382	388	PF00018	0.483
LIG_SH3_3	451	457	PF00018	0.522
LIG_SUMO_SIM_par_1	243	248	PF11976	0.469
LIG_TYR_ITIM	213	218	PF00017	0.502
LIG_TYR_ITIM	348	353	PF00017	0.566
LIG_WW_1	8	11	PF00397	0.397
LIG_WW_3	159	163	PF00397	0.642
MOD_CDK_SPK_2	464	469	PF00069	0.552
MOD_CDK_SPxxK_3	226	233	PF00069	0.546
MOD_CK1_1	106	112	PF00069	0.540
MOD_CK1_1	117	123	PF00069	0.651
MOD_CK1_1	175	181	PF00069	0.626
MOD_CK1_1	19	25	PF00069	0.368
MOD_CK1_1	3	9	PF00069	0.685
MOD_CK1_1	300	306	PF00069	0.677
MOD_CK1_1	311	317	PF00069	0.652
MOD_CK1_1	318	324	PF00069	0.605
MOD_CK1_1	335	341	PF00069	0.524
MOD_CK1_1	447	453	PF00069	0.572
MOD_CK2_1	119	125	PF00069	0.767
MOD_CK2_1	222	228	PF00069	0.542
MOD_CK2_1	336	342	PF00069	0.554
MOD_CK2_1	399	405	PF00069	0.475
MOD_CK2_1	446	452	PF00069	0.548
MOD_CK2_1	65	71	PF00069	0.328
MOD_DYRK1A_RPxSP_1	222	226	PF00069	0.511
MOD_GlcNHglycan	138	141	PF01048	0.707
MOD_GlcNHglycan	299	302	PF01048	0.719
MOD_GlcNHglycan	317	320	PF01048	0.652
MOD_GlcNHglycan	401	404	PF01048	0.479
MOD_GlcNHglycan	446	449	PF01048	0.507
MOD_GSK3_1	100	107	PF00069	0.521
MOD_GSK3_1	115	122	PF00069	0.724
MOD_GSK3_1	132	139	PF00069	0.627
MOD_GSK3_1	168	175	PF00069	0.690
MOD_GSK3_1	218	225	PF00069	0.584
MOD_GSK3_1	293	300	PF00069	0.614
MOD_GSK3_1	311	318	PF00069	0.705
MOD_GSK3_1	332	339	PF00069	0.644
MOD_GSK3_1	395	402	PF00069	0.493
MOD_GSK3_1	458	465	PF00069	0.596
MOD_N-GLC_1	273	278	PF02516	0.599
MOD_N-GLC_1	395	400	PF02516	0.551
MOD_N-GLC_1	452	457	PF02516	0.574
MOD_NEK2_1	115	120	PF00069	0.624
MOD_NEK2_1	348	353	PF00069	0.663
MOD_NEK2_1	444	449	PF00069	0.570
MOD_NEK2_1	460	465	PF00069	0.506
MOD_PIKK_1	100	106	PF00454	0.485
MOD_PKA_1	30	36	PF00069	0.304
MOD_PKA_2	104	110	PF00069	0.526
MOD_PKA_2	168	174	PF00069	0.595
MOD_PKA_2	256	262	PF00069	0.511
MOD_PKA_2	297	303	PF00069	0.646
MOD_PKA_2	429	435	PF00069	0.521
MOD_PKA_2	58	64	PF00069	0.304
MOD_Plk_1	140	146	PF00069	0.627
MOD_Plk_1	273	279	PF00069	0.598
MOD_Plk_1	388	394	PF00069	0.563
MOD_Plk_1	395	401	PF00069	0.499
MOD_Plk_1	452	458	PF00069	0.576
MOD_Plk_2-3	172	178	PF00069	0.608
MOD_Plk_4	265	271	PF00069	0.550
MOD_Plk_4	273	279	PF00069	0.589
MOD_Plk_4	388	394	PF00069	0.526
MOD_Plk_4	90	96	PF00069	0.512
MOD_ProDKin_1	117	123	PF00069	0.680
MOD_ProDKin_1	222	228	PF00069	0.637
MOD_ProDKin_1	300	306	PF00069	0.627
MOD_ProDKin_1	333	339	PF00069	0.639
MOD_ProDKin_1	381	387	PF00069	0.626
MOD_ProDKin_1	464	470	PF00069	0.549
TRG_DiLeu_BaLyEn_6	283	288	PF01217	0.598
TRG_ENDOCYTIC_2	11	14	PF00928	0.304
TRG_ENDOCYTIC_2	215	218	PF00928	0.569
TRG_ENDOCYTIC_2	29	32	PF00928	0.352
TRG_ENDOCYTIC_2	345	348	PF00928	0.552
TRG_ENDOCYTIC_2	350	353	PF00928	0.537
TRG_ENDOCYTIC_2	355	358	PF00928	0.540
TRG_ENDOCYTIC_2	57	60	PF00928	0.310
TRG_ENDOCYTIC_2	64	67	PF00928	0.352
TRG_NES_CRM1_1	186	201	PF08389	0.577
TRG_NLS_MonoExtC_3	426	431	PF00514	0.565
TRG_NLS_MonoExtN_4	427	434	PF00514	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILU4	Leptomonas seymouri	42%	100%
A0A3Q8IEL1	Leishmania donovani	87%	100%
A4HGH4	Leishmania braziliensis	70%	100%
A4I3K6	Leishmania infantum	87%	100%
E9AZU6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	99%