Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8D7_LEIMA

TriTrypDb:

LmjF.28.1290 , LMJLV39_280020100 , LMJSD75_280019700

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8D7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8D7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.536
CLV_C14_Caspase3-7	286	290	PF00656	0.675
CLV_C14_Caspase3-7	86	90	PF00656	0.600
CLV_NRD_NRD_1	18	20	PF00675	0.459
CLV_NRD_NRD_1	404	406	PF00675	0.508
CLV_NRD_NRD_1	423	425	PF00675	0.509
CLV_NRD_NRD_1	8	10	PF00675	0.569
CLV_NRD_NRD_1	83	85	PF00675	0.454
CLV_PCSK_KEX2_1	114	116	PF00082	0.548
CLV_PCSK_KEX2_1	306	308	PF00082	0.722
CLV_PCSK_KEX2_1	423	425	PF00082	0.600
CLV_PCSK_KEX2_1	8	10	PF00082	0.584
CLV_PCSK_KEX2_1	83	85	PF00082	0.454
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.575
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.721
CLV_PCSK_PC7_1	302	308	PF00082	0.524
CLV_PCSK_PC7_1	4	10	PF00082	0.709
CLV_PCSK_SKI1_1	114	118	PF00082	0.536
CLV_PCSK_SKI1_1	147	151	PF00082	0.501
DEG_APCC_KENBOX_2	214	218	PF00400	0.579
DEG_SPOP_SBC_1	273	277	PF00917	0.678
DOC_MAPK_gen_1	114	124	PF00069	0.507
DOC_MAPK_MEF2A_6	118	126	PF00069	0.505
DOC_USP7_MATH_1	185	189	PF00917	0.561
DOC_USP7_MATH_1	190	194	PF00917	0.629
DOC_USP7_MATH_1	272	276	PF00917	0.678
DOC_USP7_MATH_1	31	35	PF00917	0.545
DOC_USP7_UBL2_3	114	118	PF12436	0.563
DOC_WW_Pin1_4	231	236	PF00397	0.435
DOC_WW_Pin1_4	348	353	PF00397	0.602
DOC_WW_Pin1_4	361	366	PF00397	0.523
DOC_WW_Pin1_4	382	387	PF00397	0.657
DOC_WW_Pin1_4	430	435	PF00397	0.612
LIG_14-3-3_CanoR_1	147	153	PF00244	0.434
LIG_14-3-3_CanoR_1	19	23	PF00244	0.607
LIG_CSL_BTD_1	431	434	PF09270	0.613
LIG_FHA_1	251	257	PF00498	0.392
LIG_FHA_1	41	47	PF00498	0.510
LIG_FHA_1	5	11	PF00498	0.611
LIG_FHA_2	153	159	PF00498	0.500
LIG_FHA_2	174	180	PF00498	0.548
LIG_FHA_2	345	351	PF00498	0.594
LIG_Integrin_RGD_1	328	330	PF01839	0.563
LIG_LIR_Gen_1	158	167	PF02991	0.421
LIG_LIR_Gen_1	89	99	PF02991	0.462
LIG_LIR_Nem_3	108	113	PF02991	0.459
LIG_LIR_Nem_3	158	162	PF02991	0.396
LIG_LIR_Nem_3	216	222	PF02991	0.541
LIG_LIR_Nem_3	330	336	PF02991	0.517
LIG_LIR_Nem_3	89	94	PF02991	0.494
LIG_LYPXL_S_1	109	113	PF13949	0.479
LIG_LYPXL_yS_3	110	113	PF13949	0.486
LIG_PDZ_Class_3	434	439	PF00595	0.631
LIG_Pex14_2	333	337	PF04695	0.480
LIG_SH2_CRK	159	163	PF00017	0.377
LIG_SH2_CRK	75	79	PF00017	0.404
LIG_SH2_CRK	91	95	PF00017	0.255
LIG_SH2_STAP1	148	152	PF00017	0.466
LIG_SH2_STAP1	159	163	PF00017	0.309
LIG_SH3_1	75	81	PF00018	0.402
LIG_SH3_2	3	8	PF14604	0.513
LIG_SH3_2	78	83	PF14604	0.417
LIG_SH3_3	113	119	PF00018	0.536
LIG_SH3_3	186	192	PF00018	0.456
LIG_SH3_3	71	77	PF00018	0.366
LIG_Sin3_3	203	210	PF02671	0.546
LIG_SUMO_SIM_par_1	135	141	PF11976	0.357
LIG_TRAF2_1	283	286	PF00917	0.553
LIG_TRAF2_1	61	64	PF00917	0.551
LIG_WRC_WIRS_1	130	135	PF05994	0.487
LIG_WRC_WIRS_1	96	101	PF05994	0.393
MOD_CK1_1	132	138	PF00069	0.529
MOD_CK1_1	151	157	PF00069	0.332
MOD_CK1_1	18	24	PF00069	0.530
MOD_CK1_1	234	240	PF00069	0.538
MOD_CK1_1	277	283	PF00069	0.738
MOD_CK1_1	287	293	PF00069	0.748
MOD_CK1_1	348	354	PF00069	0.641
MOD_CK1_1	378	384	PF00069	0.732
MOD_CK1_1	419	425	PF00069	0.707
MOD_CK1_1	95	101	PF00069	0.390
MOD_CK2_1	152	158	PF00069	0.537
MOD_CK2_1	280	286	PF00069	0.711
MOD_CK2_1	344	350	PF00069	0.577
MOD_CK2_1	351	357	PF00069	0.719
MOD_CK2_1	58	64	PF00069	0.547
MOD_CK2_1	95	101	PF00069	0.420
MOD_GlcNHglycan	101	104	PF01048	0.472
MOD_GlcNHglycan	134	137	PF01048	0.358
MOD_GlcNHglycan	193	196	PF01048	0.702
MOD_GlcNHglycan	203	206	PF01048	0.604
MOD_GlcNHglycan	279	282	PF01048	0.796
MOD_GlcNHglycan	289	292	PF01048	0.798
MOD_GlcNHglycan	302	305	PF01048	0.710
MOD_GlcNHglycan	346	350	PF01048	0.540
MOD_GlcNHglycan	353	356	PF01048	0.641
MOD_GlcNHglycan	380	383	PF01048	0.757
MOD_GSK3_1	147	154	PF00069	0.475
MOD_GSK3_1	169	176	PF00069	0.547
MOD_GSK3_1	231	238	PF00069	0.448
MOD_GSK3_1	273	280	PF00069	0.662
MOD_GSK3_1	281	288	PF00069	0.692
MOD_GSK3_1	344	351	PF00069	0.552
MOD_GSK3_1	378	385	PF00069	0.746
MOD_GSK3_1	95	102	PF00069	0.504
MOD_N-GLC_1	173	178	PF02516	0.563
MOD_N-GLC_1	416	421	PF02516	0.646
MOD_NEK2_1	152	157	PF00069	0.443
MOD_NEK2_1	375	380	PF00069	0.690
MOD_NEK2_1	416	421	PF00069	0.668
MOD_NEK2_1	428	433	PF00069	0.579
MOD_NEK2_1	99	104	PF00069	0.486
MOD_NEK2_2	218	223	PF00069	0.493
MOD_PIKK_1	235	241	PF00454	0.579
MOD_PIKK_1	281	287	PF00454	0.551
MOD_PIKK_1	394	400	PF00454	0.613
MOD_PKA_2	18	24	PF00069	0.661
MOD_PKA_2	277	283	PF00069	0.677
MOD_Plk_1	173	179	PF00069	0.546
MOD_Plk_4	173	179	PF00069	0.561
MOD_Plk_4	223	229	PF00069	0.389
MOD_Plk_4	363	369	PF00069	0.649
MOD_Plk_4	95	101	PF00069	0.390
MOD_ProDKin_1	231	237	PF00069	0.438
MOD_ProDKin_1	348	354	PF00069	0.615
MOD_ProDKin_1	361	367	PF00069	0.523
MOD_ProDKin_1	382	388	PF00069	0.659
MOD_ProDKin_1	430	436	PF00069	0.613
TRG_DiLeu_BaEn_1	158	163	PF01217	0.499
TRG_ENDOCYTIC_2	110	113	PF00928	0.486
TRG_ENDOCYTIC_2	159	162	PF00928	0.375
TRG_ENDOCYTIC_2	219	222	PF00928	0.464
TRG_ENDOCYTIC_2	91	94	PF00928	0.489
TRG_ER_diArg_1	122	125	PF00400	0.562
TRG_ER_diArg_1	423	425	PF00400	0.620
TRG_ER_diArg_1	8	10	PF00400	0.584
TRG_ER_diArg_1	82	84	PF00400	0.422
TRG_Pf-PMV_PEXEL_1	44	49	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFK1	Leptomonas seymouri	62%	100%
A0A0S4JAC2	Bodo saltans	28%	100%
A0A1X0P2Q2	Trypanosomatidae	40%	100%
A0A3Q8ID39	Leishmania donovani	95%	100%
A0A422NY97	Trypanosoma rangeli	40%	100%
A4HGH6	Leishmania braziliensis	82%	100%
A4I3K8	Leishmania infantum	95%	100%
C9ZPW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AZU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BAD6	Trypanosoma cruzi	41%	100%