RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8D6_LEIMA

TriTrypDb:

LmjF.28.1300 , LMJLV39_280020200 , LMJSD75_280019800

Length:

398

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q8D6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8D6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	44	48	PF00656	0.636
CLV_NRD_NRD_1	10	12	PF00675	0.683
CLV_NRD_NRD_1	104	106	PF00675	0.461
CLV_NRD_NRD_1	15	17	PF00675	0.802
CLV_NRD_NRD_1	171	173	PF00675	0.517
CLV_NRD_NRD_1	381	383	PF00675	0.482
CLV_PCSK_KEX2_1	104	106	PF00082	0.418
CLV_PCSK_KEX2_1	114	116	PF00082	0.443
CLV_PCSK_KEX2_1	125	127	PF00082	0.381
CLV_PCSK_KEX2_1	171	173	PF00082	0.513
CLV_PCSK_KEX2_1	63	65	PF00082	0.517
CLV_PCSK_KEX2_1	88	90	PF00082	0.514
CLV_PCSK_KEX2_1	9	11	PF00082	0.687
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.594
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.496
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.572
CLV_PCSK_PC1ET2_1	88	90	PF00082	0.535
CLV_PCSK_SKI1_1	104	108	PF00082	0.476
CLV_PCSK_SKI1_1	122	126	PF00082	0.338
CLV_PCSK_SKI1_1	330	334	PF00082	0.381
CLV_PCSK_SKI1_1	95	99	PF00082	0.642
DEG_Nend_UBRbox_2	1	3	PF02207	0.510
DOC_ANK_TNKS_1	371	378	PF00023	0.381
DOC_CDC14_PxL_1	298	306	PF14671	0.271
DOC_CYCLIN_RxL_1	122	132	PF00134	0.443
DOC_CYCLIN_RxL_1	60	70	PF00134	0.382
DOC_MAPK_gen_1	208	217	PF00069	0.495
DOC_PP1_RVXF_1	123	130	PF00149	0.461
DOC_PP4_FxxP_1	290	293	PF00568	0.390
DOC_USP7_UBL2_3	110	114	PF12436	0.425
DOC_USP7_UBL2_3	330	334	PF12436	0.381
DOC_WW_Pin1_4	377	382	PF00397	0.634
LIG_Actin_WH2_2	357	374	PF00022	0.546
LIG_APCC_ABBA_1	30	35	PF00400	0.533
LIG_BRCT_BRCA1_1	314	318	PF00533	0.436
LIG_FHA_1	221	227	PF00498	0.613
LIG_FHA_1	259	265	PF00498	0.406
LIG_FHA_1	267	273	PF00498	0.245
LIG_FHA_1	32	38	PF00498	0.619
LIG_FHA_1	54	60	PF00498	0.586
LIG_FHA_2	199	205	PF00498	0.491
LIG_FHA_2	20	26	PF00498	0.608
LIG_FHA_2	39	45	PF00498	0.677
LIG_GBD_Chelix_1	68	76	PF00786	0.396
LIG_LIR_Apic_2	289	293	PF02991	0.357
LIG_LIR_Apic_2	303	308	PF02991	0.218
LIG_LIR_Nem_3	394	398	PF02991	0.523
LIG_LRP6_Inhibitor_1	343	349	PF00058	0.422
LIG_PCNA_yPIPBox_3	114	128	PF02747	0.524
LIG_Rb_LxCxE_1	289	309	PF01857	0.335
LIG_SH2_CRK	212	216	PF00017	0.492
LIG_SH2_CRK	305	309	PF00017	0.404
LIG_SH2_GRB2like	277	280	PF00017	0.270
LIG_SH2_SRC	277	280	PF00017	0.371
LIG_SH2_STAT3	225	228	PF00017	0.519
LIG_SH2_STAT5	174	177	PF00017	0.477
LIG_SH2_STAT5	225	228	PF00017	0.519
LIG_SH2_STAT5	351	354	PF00017	0.344
LIG_SH3_3	347	353	PF00018	0.457
LIG_TRAF2_1	106	109	PF00917	0.530
LIG_TRAF2_1	201	204	PF00917	0.495
LIG_UBA3_1	127	135	PF00899	0.420
LIG_UBA3_1	137	141	PF00899	0.401
LIG_UBA3_1	152	157	PF00899	0.448
LIG_UBA3_1	364	368	PF00899	0.408
MOD_CDC14_SPxK_1	380	383	PF00782	0.646
MOD_CDK_SPK_2	377	382	PF00069	0.454
MOD_CDK_SPxK_1	377	383	PF00069	0.636
MOD_CK1_1	220	226	PF00069	0.360
MOD_CK1_1	312	318	PF00069	0.372
MOD_CK2_1	19	25	PF00069	0.609
MOD_CK2_1	198	204	PF00069	0.492
MOD_CK2_1	38	44	PF00069	0.752
MOD_GlcNHglycan	25	29	PF01048	0.782
MOD_GlcNHglycan	373	376	PF01048	0.630
MOD_GSK3_1	264	271	PF00069	0.526
MOD_GSK3_1	38	45	PF00069	0.771
MOD_GSK3_1	387	394	PF00069	0.656
MOD_NEK2_1	129	134	PF00069	0.462
MOD_NEK2_1	145	150	PF00069	0.461
MOD_NEK2_1	193	198	PF00069	0.536
MOD_NEK2_1	263	268	PF00069	0.500
MOD_NEK2_1	324	329	PF00069	0.422
MOD_NEK2_1	59	64	PF00069	0.519
MOD_NEK2_1	72	77	PF00069	0.308
MOD_PIKK_1	117	123	PF00454	0.525
MOD_PIKK_1	129	135	PF00454	0.516
MOD_PIKK_1	338	344	PF00454	0.469
MOD_PKA_2	371	377	PF00069	0.512
MOD_PKA_2	387	393	PF00069	0.391
MOD_PKB_1	9	17	PF00069	0.598
MOD_Plk_1	264	270	PF00069	0.423
MOD_Plk_1	72	78	PF00069	0.465
MOD_Plk_2-3	155	161	PF00069	0.503
MOD_Plk_2-3	38	44	PF00069	0.596
MOD_Plk_4	300	306	PF00069	0.261
MOD_ProDKin_1	377	383	PF00069	0.636
MOD_SUMO_for_1	106	109	PF00179	0.521
MOD_SUMO_for_1	113	116	PF00179	0.489
MOD_SUMO_rev_2	154	159	PF00179	0.450
TRG_DiLeu_BaEn_4	154	160	PF01217	0.453
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.433
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.539
TRG_DiLeu_BaLyEn_6	245	250	PF01217	0.394
TRG_ENDOCYTIC_2	212	215	PF00928	0.505
TRG_ER_diArg_1	103	105	PF00400	0.573
TRG_ER_diArg_1	149	152	PF00400	0.503
TRG_ER_diArg_1	170	172	PF00400	0.464
TRG_ER_diArg_1	8	11	PF00400	0.671
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6L8	Leptomonas seymouri	65%	100%
A0A1X0P3W0	Trypanosomatidae	46%	100%
A0A3R7KVC5	Trypanosoma rangeli	45%	100%
A0A3S7X1G5	Leishmania donovani	92%	100%
A4HGH7	Leishmania braziliensis	79%	100%
A4I3K9	Leishmania infantum	92%	100%
C9ZPW1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	98%
E9AZU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5AUY7	Trypanosoma cruzi	49%	88%