Putative ATP-dependent RNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-dependent RNA helicase, putative

Species:

Leishmania major

UniProt:

Q4Q8D5_LEIMA

TriTrypDb:

LmjF.28.1310 , LMJLV39_280020300 , LMJSD75_280019900

Length:

900

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q8D5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8D5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003724	RNA helicase activity	3	10
GO:0003743	translation initiation factor activity	4	10
GO:0008135	translation factor activity, RNA binding	3	10
GO:0008186	ATP-dependent activity, acting on RNA	2	10
GO:0016787	hydrolase activity	2	10
GO:0045182	translation regulator activity	1	10
GO:0090079	translation regulator activity, nucleic acid binding	2	10
GO:0140098	catalytic activity, acting on RNA	3	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	581	585	PF00656	0.654
CLV_C14_Caspase3-7	586	590	PF00656	0.598
CLV_C14_Caspase3-7	674	678	PF00656	0.497
CLV_C14_Caspase3-7	811	815	PF00656	0.635
CLV_C14_Caspase3-7	879	883	PF00656	0.624
CLV_NRD_NRD_1	12	14	PF00675	0.408
CLV_NRD_NRD_1	184	186	PF00675	0.223
CLV_NRD_NRD_1	355	357	PF00675	0.207
CLV_NRD_NRD_1	547	549	PF00675	0.519
CLV_NRD_NRD_1	643	645	PF00675	0.507
CLV_NRD_NRD_1	763	765	PF00675	0.441
CLV_NRD_NRD_1	766	768	PF00675	0.447
CLV_NRD_NRD_1	775	777	PF00675	0.484
CLV_NRD_NRD_1	858	860	PF00675	0.598
CLV_PCSK_FUR_1	764	768	PF00082	0.474
CLV_PCSK_KEX2_1	12	14	PF00082	0.395
CLV_PCSK_KEX2_1	186	188	PF00082	0.209
CLV_PCSK_KEX2_1	309	311	PF00082	0.207
CLV_PCSK_KEX2_1	355	357	PF00082	0.207
CLV_PCSK_KEX2_1	642	644	PF00082	0.501
CLV_PCSK_KEX2_1	763	765	PF00082	0.447
CLV_PCSK_KEX2_1	766	768	PF00082	0.455
CLV_PCSK_KEX2_1	860	862	PF00082	0.567
CLV_PCSK_KEX2_1	894	896	PF00082	0.711
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.207
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.207
CLV_PCSK_PC1ET2_1	642	644	PF00082	0.501
CLV_PCSK_PC1ET2_1	860	862	PF00082	0.591
CLV_PCSK_PC1ET2_1	894	896	PF00082	0.691
CLV_PCSK_SKI1_1	12	16	PF00082	0.406
CLV_PCSK_SKI1_1	167	171	PF00082	0.310
CLV_PCSK_SKI1_1	335	339	PF00082	0.207
CLV_PCSK_SKI1_1	485	489	PF00082	0.244
CLV_PCSK_SKI1_1	49	53	PF00082	0.383
CLV_PCSK_SKI1_1	518	522	PF00082	0.464
CLV_PCSK_SKI1_1	572	576	PF00082	0.585
CLV_PCSK_SKI1_1	662	666	PF00082	0.678
CLV_PCSK_SKI1_1	826	830	PF00082	0.556
DEG_APCC_DBOX_1	184	192	PF00400	0.422
DEG_Nend_UBRbox_1	1	4	PF02207	0.634
DEG_SCF_FBW7_1	419	426	PF00400	0.311
DEG_SPOP_SBC_1	60	64	PF00917	0.581
DOC_CKS1_1	195	200	PF01111	0.407
DOC_CKS1_1	420	425	PF01111	0.300
DOC_CKS1_1	91	96	PF01111	0.391
DOC_CYCLIN_yCln2_LP_2	381	387	PF00134	0.407
DOC_CYCLIN_yCln2_LP_2	502	508	PF00134	0.272
DOC_MAPK_gen_1	133	142	PF00069	0.442
DOC_MAPK_gen_1	185	193	PF00069	0.407
DOC_MAPK_gen_1	299	307	PF00069	0.244
DOC_MAPK_gen_1	338	347	PF00069	0.415
DOC_MAPK_gen_1	352	361	PF00069	0.389
DOC_MAPK_gen_1	365	372	PF00069	0.407
DOC_MAPK_gen_1	655	665	PF00069	0.465
DOC_MAPK_MEF2A_6	186	195	PF00069	0.407
DOC_MAPK_MEF2A_6	355	363	PF00069	0.418
DOC_MAPK_MEF2A_6	97	104	PF00069	0.510
DOC_MAPK_NFAT4_5	97	105	PF00069	0.510
DOC_PP1_RVXF_1	117	124	PF00149	0.407
DOC_PP1_RVXF_1	313	320	PF00149	0.407
DOC_PP1_RVXF_1	377	384	PF00149	0.407
DOC_PP1_RVXF_1	475	482	PF00149	0.244
DOC_PP1_RVXF_1	660	666	PF00149	0.619
DOC_PP2B_LxvP_1	502	505	PF13499	0.270
DOC_PP4_FxxP_1	123	126	PF00568	0.407
DOC_PP4_FxxP_1	420	423	PF00568	0.292
DOC_USP7_MATH_1	235	239	PF00917	0.462
DOC_USP7_MATH_1	264	268	PF00917	0.362
DOC_USP7_MATH_1	508	512	PF00917	0.304
DOC_USP7_MATH_1	60	64	PF00917	0.648
DOC_USP7_MATH_1	604	608	PF00917	0.690
DOC_USP7_MATH_1	611	615	PF00917	0.737
DOC_USP7_MATH_1	691	695	PF00917	0.640
DOC_USP7_MATH_1	794	798	PF00917	0.634
DOC_USP7_UBL2_3	15	19	PF12436	0.574
DOC_USP7_UBL2_3	335	339	PF12436	0.418
DOC_WW_Pin1_4	145	150	PF00397	0.407
DOC_WW_Pin1_4	194	199	PF00397	0.429
DOC_WW_Pin1_4	281	286	PF00397	0.370
DOC_WW_Pin1_4	419	424	PF00397	0.299
DOC_WW_Pin1_4	885	890	PF00397	0.597
DOC_WW_Pin1_4	90	95	PF00397	0.367
LIG_14-3-3_CanoR_1	135	142	PF00244	0.442
LIG_14-3-3_CanoR_1	247	251	PF00244	0.407
LIG_14-3-3_CanoR_1	272	279	PF00244	0.485
LIG_14-3-3_CanoR_1	365	372	PF00244	0.474
LIG_14-3-3_CanoR_1	414	419	PF00244	0.311
LIG_14-3-3_CanoR_1	776	781	PF00244	0.528
LIG_14-3-3_CanoR_1	863	869	PF00244	0.610
LIG_Actin_WH2_2	425	442	PF00022	0.319
LIG_APCC_ABBAyCdc20_2	572	578	PF00400	0.525
LIG_APCC_ABBAyCdc20_2	832	838	PF00400	0.591
LIG_BIR_III_4	677	681	PF00653	0.502
LIG_BRCT_BRCA1_1	248	252	PF00533	0.462
LIG_BRCT_BRCA1_1	416	420	PF00533	0.294
LIG_BRCT_BRCA1_1	477	481	PF00533	0.244
LIG_Clathr_ClatBox_1	218	222	PF01394	0.450
LIG_DLG_GKlike_1	414	421	PF00625	0.305
LIG_EH1_1	157	165	PF00400	0.418
LIG_EH1_1	188	196	PF00400	0.474
LIG_FAT_LD_1	301	309	PF03623	0.407
LIG_FHA_1	148	154	PF00498	0.423
LIG_FHA_1	235	241	PF00498	0.474
LIG_FHA_1	255	261	PF00498	0.315
LIG_FHA_1	274	280	PF00498	0.502
LIG_FHA_1	424	430	PF00498	0.332
LIG_FHA_1	739	745	PF00498	0.629
LIG_FHA_1	819	825	PF00498	0.609
LIG_FHA_1	97	103	PF00498	0.451
LIG_FHA_2	420	426	PF00498	0.303
LIG_FHA_2	545	551	PF00498	0.514
LIG_FHA_2	60	66	PF00498	0.660
LIG_FHA_2	628	634	PF00498	0.521
LIG_FHA_2	777	783	PF00498	0.532
LIG_FHA_2	839	845	PF00498	0.681
LIG_GBD_Chelix_1	153	161	PF00786	0.207
LIG_GBD_Chelix_1	293	301	PF00786	0.303
LIG_HCF-1_HBM_1	65	68	PF13415	0.522
LIG_Integrin_RGD_1	582	584	PF01839	0.658
LIG_IRF3_LxIS_1	71	77	PF10401	0.484
LIG_LIR_Apic_2	120	126	PF02991	0.407
LIG_LIR_Apic_2	417	423	PF02991	0.301
LIG_LIR_Gen_1	454	464	PF02991	0.314
LIG_LIR_Gen_1	65	76	PF02991	0.397
LIG_LIR_Nem_3	357	363	PF02991	0.407
LIG_LIR_Nem_3	382	386	PF02991	0.407
LIG_LIR_Nem_3	454	459	PF02991	0.311
LIG_LIR_Nem_3	65	71	PF02991	0.425
LIG_LIR_Nem_3	867	871	PF02991	0.692
LIG_MAD2	335	343	PF02301	0.418
LIG_MLH1_MIPbox_1	477	481	PF16413	0.259
LIG_NRBOX	300	306	PF00104	0.407
LIG_NRP_CendR_1	897	900	PF00754	0.657
LIG_Pex14_1	388	392	PF04695	0.407
LIG_PTB_Apo_2	267	274	PF02174	0.384
LIG_PTB_Phospho_1	267	273	PF10480	0.387
LIG_SH2_CRK	89	93	PF00017	0.418
LIG_SH2_NCK_1	392	396	PF00017	0.432
LIG_SH2_SRC	242	245	PF00017	0.510
LIG_SH2_SRC	431	434	PF00017	0.498
LIG_SH2_SRC	809	812	PF00017	0.612
LIG_SH2_STAP1	809	813	PF00017	0.555
LIG_SH2_STAT3	466	469	PF00017	0.244
LIG_SH2_STAT5	242	245	PF00017	0.511
LIG_SH2_STAT5	273	276	PF00017	0.404
LIG_SH2_STAT5	401	404	PF00017	0.407
LIG_SH2_STAT5	431	434	PF00017	0.498
LIG_SH2_STAT5	475	478	PF00017	0.244
LIG_SH2_STAT5	480	483	PF00017	0.244
LIG_SH2_STAT5	89	92	PF00017	0.515
LIG_SH3_2	889	894	PF14604	0.579
LIG_SH3_3	192	198	PF00018	0.445
LIG_SH3_3	502	508	PF00018	0.272
LIG_SH3_3	883	889	PF00018	0.665
LIG_TRAF2_1	33	36	PF00917	0.535
LIG_TRAF2_1	451	454	PF00917	0.441
LIG_TRAF2_1	630	633	PF00917	0.624
LIG_TRAF2_1	672	675	PF00917	0.618
LIG_TRAF2_1	701	704	PF00917	0.616
LIG_TYR_ITIM	164	169	PF00017	0.304
LIG_UBA3_1	262	269	PF00899	0.497
LIG_UBA3_1	304	309	PF00899	0.244
LIG_UBA3_1	428	435	PF00899	0.345
LIG_WRC_WIRS_1	360	365	PF05994	0.259
MOD_CDC14_SPxK_1	148	151	PF00782	0.244
MOD_CDK_SPK_2	419	424	PF00069	0.359
MOD_CDK_SPxK_1	145	151	PF00069	0.244
MOD_CDK_SPxK_1	194	200	PF00069	0.244
MOD_CDK_SPxxK_3	90	97	PF00069	0.387
MOD_CK1_1	117	123	PF00069	0.244
MOD_CK1_1	30	36	PF00069	0.447
MOD_CK1_1	397	403	PF00069	0.244
MOD_CK1_1	544	550	PF00069	0.592
MOD_CK1_1	69	75	PF00069	0.407
MOD_CK1_1	694	700	PF00069	0.717
MOD_CK1_1	77	83	PF00069	0.309
MOD_CK1_1	775	781	PF00069	0.529
MOD_CK1_1	820	826	PF00069	0.550
MOD_CK2_1	30	36	PF00069	0.421
MOD_CK2_1	419	425	PF00069	0.296
MOD_CK2_1	448	454	PF00069	0.483
MOD_CK2_1	544	550	PF00069	0.516
MOD_CK2_1	59	65	PF00069	0.582
MOD_CK2_1	627	633	PF00069	0.511
MOD_CK2_1	669	675	PF00069	0.660
MOD_CK2_1	776	782	PF00069	0.504
MOD_CK2_1	813	819	PF00069	0.702
MOD_GlcNHglycan	116	119	PF01048	0.266
MOD_GlcNHglycan	170	173	PF01048	0.261
MOD_GlcNHglycan	252	255	PF01048	0.256
MOD_GlcNHglycan	367	370	PF01048	0.356
MOD_GlcNHglycan	396	399	PF01048	0.249
MOD_GlcNHglycan	518	521	PF01048	0.603
MOD_GlcNHglycan	536	539	PF01048	0.648
MOD_GlcNHglycan	586	589	PF01048	0.751
MOD_GlcNHglycan	606	609	PF01048	0.651
MOD_GlcNHglycan	613	616	PF01048	0.737
MOD_GlcNHglycan	684	687	PF01048	0.700
MOD_GlcNHglycan	781	785	PF01048	0.548
MOD_GlcNHglycan	788	791	PF01048	0.612
MOD_GlcNHglycan	802	807	PF01048	0.734
MOD_GlcNHglycan	855	858	PF01048	0.613
MOD_GSK3_1	246	253	PF00069	0.259
MOD_GSK3_1	273	280	PF00069	0.424
MOD_GSK3_1	341	348	PF00069	0.312
MOD_GSK3_1	371	378	PF00069	0.406
MOD_GSK3_1	419	426	PF00069	0.311
MOD_GSK3_1	578	585	PF00069	0.598
MOD_GSK3_1	772	779	PF00069	0.507
MOD_GSK3_1	780	787	PF00069	0.524
MOD_GSK3_1	813	820	PF00069	0.602
MOD_GSK3_1	834	841	PF00069	0.660
MOD_GSK3_1	847	854	PF00069	0.616
MOD_N-GLC_1	60	65	PF02516	0.642
MOD_N-GLC_1	704	709	PF02516	0.569
MOD_N-GLC_1	864	869	PF02516	0.694
MOD_N-GLC_1	876	881	PF02516	0.669
MOD_NEK2_1	250	255	PF00069	0.258
MOD_NEK2_1	319	324	PF00069	0.244
MOD_NEK2_1	331	336	PF00069	0.244
MOD_NEK2_1	345	350	PF00069	0.228
MOD_NEK2_1	448	453	PF00069	0.339
MOD_NEK2_1	498	503	PF00069	0.252
MOD_NEK2_1	516	521	PF00069	0.448
MOD_NEK2_1	740	745	PF00069	0.433
MOD_NEK2_1	851	856	PF00069	0.544
MOD_NEK2_1	893	898	PF00069	0.682
MOD_NEK2_2	264	269	PF00069	0.369
MOD_NEK2_2	475	480	PF00069	0.259
MOD_PIKK_1	252	258	PF00454	0.252
MOD_PIKK_1	273	279	PF00454	0.534
MOD_PIKK_1	449	455	PF00454	0.431
MOD_PIKK_1	74	80	PF00454	0.331
MOD_PKA_1	776	782	PF00069	0.547
MOD_PKA_1	859	865	PF00069	0.617
MOD_PKA_2	134	140	PF00069	0.322
MOD_PKA_2	246	252	PF00069	0.254
MOD_PKA_2	772	778	PF00069	0.530
MOD_PKB_1	133	141	PF00069	0.175
MOD_Plk_1	704	710	PF00069	0.660
MOD_Plk_1	847	853	PF00069	0.722
MOD_Plk_1	864	870	PF00069	0.542
MOD_Plk_2-3	589	595	PF00069	0.556
MOD_Plk_2-3	669	675	PF00069	0.698
MOD_Plk_2-3	727	733	PF00069	0.652
MOD_Plk_2-3	834	840	PF00069	0.590
MOD_Plk_2-3	876	882	PF00069	0.689
MOD_Plk_4	235	241	PF00069	0.313
MOD_Plk_4	246	252	PF00069	0.188
MOD_Plk_4	397	403	PF00069	0.244
MOD_Plk_4	414	420	PF00069	0.292
MOD_Plk_4	427	433	PF00069	0.311
MOD_Plk_4	616	622	PF00069	0.620
MOD_Plk_4	87	93	PF00069	0.398
MOD_ProDKin_1	145	151	PF00069	0.244
MOD_ProDKin_1	194	200	PF00069	0.274
MOD_ProDKin_1	281	287	PF00069	0.365
MOD_ProDKin_1	419	425	PF00069	0.296
MOD_ProDKin_1	885	891	PF00069	0.591
MOD_ProDKin_1	90	96	PF00069	0.251
MOD_SUMO_for_1	464	467	PF00179	0.259
MOD_SUMO_for_1	599	602	PF00179	0.579
MOD_SUMO_rev_2	180	188	PF00179	0.244
MOD_SUMO_rev_2	46	54	PF00179	0.471
TRG_DiLeu_BaEn_1	223	228	PF01217	0.244
TRG_DiLeu_BaEn_4	183	189	PF01217	0.259
TRG_DiLeu_BaEn_4	35	41	PF01217	0.517
TRG_DiLeu_BaEn_4	846	852	PF01217	0.502
TRG_DiLeu_BaLyEn_6	823	828	PF01217	0.584
TRG_DiLeu_LyEn_5	223	228	PF01217	0.244
TRG_ENDOCYTIC_2	166	169	PF00928	0.304
TRG_ENDOCYTIC_2	559	562	PF00928	0.483
TRG_ENDOCYTIC_2	68	71	PF00928	0.391
TRG_ENDOCYTIC_2	868	871	PF00928	0.698
TRG_ENDOCYTIC_2	89	92	PF00928	0.372
TRG_ER_diArg_1	11	13	PF00400	0.413
TRG_ER_diArg_1	185	188	PF00400	0.262
TRG_ER_diArg_1	354	356	PF00400	0.244
TRG_ER_diArg_1	652	655	PF00400	0.447
TRG_ER_diArg_1	718	721	PF00400	0.623
TRG_ER_diArg_1	762	764	PF00400	0.482
TRG_ER_diArg_1	765	767	PF00400	0.438
TRG_ER_diArg_1	897	900	PF00400	0.795
TRG_NLS_MonoCore_2	641	646	PF00514	0.578
TRG_NLS_MonoExtC_3	759	764	PF00514	0.471
TRG_NLS_MonoExtC_3	858	863	PF00514	0.689
TRG_NLS_MonoExtN_4	335	342	PF00514	0.259
TRG_NLS_MonoExtN_4	640	646	PF00514	0.488
TRG_NLS_MonoExtN_4	758	764	PF00514	0.473
TRG_NLS_MonoExtN_4	859	864	PF00514	0.584
TRG_NLS_MonoExtN_4	891	898	PF00514	0.689
TRG_Pf-PMV_PEXEL_1	151	156	PF00026	0.244
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	644	648	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	766	771	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J1	Leptomonas seymouri	73%	100%
A0A0S4JDX4	Bodo saltans	55%	100%
A0A1X0P3K1	Trypanosomatidae	53%	96%
A0A3S7X1H1	Leishmania donovani	94%	100%
A0A422NYB4	Trypanosoma rangeli	58%	100%
A4HGH8	Leishmania braziliensis	85%	100%
A4HP48	Leishmania braziliensis	39%	100%
A4I3L0	Leishmania infantum	94%	100%
C9ZPV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AZV0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q0UMB9	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	39%	100%
Q9H8H2	Homo sapiens	30%	100%
V5DAZ9	Trypanosoma cruzi	60%	95%