4-hydroxybenzoate polyprenyltransferase, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

prenyltransferase, putative

Species:

Leishmania major

UniProt:

Q4Q8D4_LEIMA

TriTrypDb:

LmjF.28.1320 , LMJLV39_280020400 , LMJSD75_280020000

Length:

489

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8D4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8D4

Function

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Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	11
GO:0006720	isoprenoid metabolic process	4	11
GO:0006743	ubiquinone metabolic process	5	11
GO:0006744	ubiquinone biosynthetic process	6	11
GO:0008152	metabolic process	1	11
GO:0008299	isoprenoid biosynthetic process	4	11
GO:0008610	lipid biosynthetic process	4	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0042180	cellular ketone metabolic process	3	11

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Molecular functions
Term	Name	Level	Count
GO:0002083	4-hydroxybenzoate decaprenyltransferase activity	6	11
GO:0002094	polyprenyltransferase activity	5	11
GO:0003824	catalytic activity	1	11
GO:0004659	prenyltransferase activity	4	11
GO:0008412	4-hydroxybenzoate octaprenyltransferase activity	6	11
GO:0016740	transferase activity	2	11
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	11
GO:0047293	4-hydroxybenzoate nonaprenyltransferase activity	6	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	150	152	PF00675	0.203
CLV_NRD_NRD_1	272	274	PF00675	0.282
CLV_NRD_NRD_1	289	291	PF00675	0.203
CLV_NRD_NRD_1	3	5	PF00675	0.380
CLV_NRD_NRD_1	445	447	PF00675	0.538
CLV_NRD_NRD_1	71	73	PF00675	0.329
CLV_PCSK_KEX2_1	215	217	PF00082	0.203
CLV_PCSK_KEX2_1	272	274	PF00082	0.315
CLV_PCSK_KEX2_1	3	5	PF00082	0.390
CLV_PCSK_KEX2_1	445	447	PF00082	0.538

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDG5	Leptomonas seymouri	77%	100%
A0A1X0NRA0	Trypanosomatidae	62%	100%
A0A3Q8II29	Leishmania donovani	96%	100%
A0A3R7KN50	Trypanosoma rangeli	58%	100%
A4HGH9	Leishmania braziliensis	87%	100%
A4I3L1	Leishmania infantum	96%	100%
D0A8C8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AZV1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q10252	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
Q298G6	Drosophila pseudoobscura pseudoobscura	33%	100%

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