4-hydroxybenzoate polyprenyltransferase, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

prenyltransferase, putative

Species:

Leishmania major

UniProt:

Q4Q8D4_LEIMA

TriTrypDb:

LmjF.28.1320 , LMJLV39_280020400 , LMJSD75_280020000

Length:

489

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8D4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8D4

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	11
GO:0006720	isoprenoid metabolic process	4	11
GO:0006743	ubiquinone metabolic process	5	11
GO:0006744	ubiquinone biosynthetic process	6	11
GO:0008152	metabolic process	1	11
GO:0008299	isoprenoid biosynthetic process	4	11
GO:0008610	lipid biosynthetic process	4	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0042180	cellular ketone metabolic process	3	11
GO:0042181	ketone biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044255	cellular lipid metabolic process	3	11
GO:0044281	small molecule metabolic process	2	11
GO:0044283	small molecule biosynthetic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:1901576	organic substance biosynthetic process	3	11
GO:1901661	quinone metabolic process	4	11
GO:1901663	quinone biosynthetic process	5	11

Molecular functions
Term	Name	Level	Count
GO:0002083	4-hydroxybenzoate decaprenyltransferase activity	6	11
GO:0002094	polyprenyltransferase activity	5	11
GO:0003824	catalytic activity	1	11
GO:0004659	prenyltransferase activity	4	11
GO:0008412	4-hydroxybenzoate octaprenyltransferase activity	6	11
GO:0016740	transferase activity	2	11
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	11
GO:0047293	4-hydroxybenzoate nonaprenyltransferase activity	6	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	150	152	PF00675	0.203
CLV_NRD_NRD_1	272	274	PF00675	0.282
CLV_NRD_NRD_1	289	291	PF00675	0.203
CLV_NRD_NRD_1	3	5	PF00675	0.380
CLV_NRD_NRD_1	445	447	PF00675	0.538
CLV_NRD_NRD_1	71	73	PF00675	0.329
CLV_PCSK_KEX2_1	215	217	PF00082	0.203
CLV_PCSK_KEX2_1	272	274	PF00082	0.315
CLV_PCSK_KEX2_1	3	5	PF00082	0.390
CLV_PCSK_KEX2_1	445	447	PF00082	0.538
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.203
CLV_PCSK_SKI1_1	215	219	PF00082	0.203
CLV_PCSK_SKI1_1	291	295	PF00082	0.228
CLV_PCSK_SKI1_1	394	398	PF00082	0.588
DEG_Nend_Nbox_1	1	3	PF02207	0.589
DOC_CYCLIN_RxL_1	388	402	PF00134	0.373
DOC_CYCLIN_RxL_1	66	79	PF00134	0.437
DOC_CYCLIN_yCln2_LP_2	118	124	PF00134	0.203
DOC_MAPK_gen_1	350	360	PF00069	0.448
DOC_MAPK_HePTP_8	240	252	PF00069	0.237
DOC_MAPK_MEF2A_6	243	252	PF00069	0.203
DOC_MAPK_MEF2A_6	353	362	PF00069	0.252
DOC_PP1_RVXF_1	104	111	PF00149	0.237
DOC_PP1_RVXF_1	83	90	PF00149	0.550
DOC_PP2B_LxvP_1	118	121	PF13499	0.203
DOC_PP2B_LxvP_1	92	95	PF13499	0.302
DOC_PP4_FxxP_1	418	421	PF00568	0.371
DOC_PP4_FxxP_1	83	86	PF00568	0.570
DOC_USP7_MATH_1	173	177	PF00917	0.337
DOC_USP7_MATH_1	312	316	PF00917	0.249
DOC_USP7_MATH_1	35	39	PF00917	0.617
DOC_USP7_MATH_1	370	374	PF00917	0.402
DOC_USP7_MATH_1	387	391	PF00917	0.318
DOC_USP7_MATH_1	45	49	PF00917	0.599
DOC_USP7_UBL2_3	277	281	PF12436	0.422
DOC_WW_Pin1_4	191	196	PF00397	0.207
DOC_WW_Pin1_4	2	7	PF00397	0.658
DOC_WW_Pin1_4	202	207	PF00397	0.301
LIG_14-3-3_CanoR_1	216	220	PF00244	0.403
LIG_14-3-3_CanoR_1	381	387	PF00244	0.529
LIG_APCC_ABBA_1	74	79	PF00400	0.475
LIG_APCC_ABBAyCdc20_2	73	79	PF00400	0.542
LIG_deltaCOP1_diTrp_1	147	153	PF00928	0.459
LIG_deltaCOP1_diTrp_1	340	348	PF00928	0.416
LIG_deltaCOP1_diTrp_1	476	484	PF00928	0.450
LIG_FHA_1	103	109	PF00498	0.296
LIG_FHA_1	347	353	PF00498	0.532
LIG_FHA_1	82	88	PF00498	0.420
LIG_GBD_Chelix_1	185	193	PF00786	0.276
LIG_HOMEOBOX	475	478	PF00046	0.329
LIG_LIR_Apic_2	416	421	PF02991	0.381
LIG_LIR_Gen_1	150	161	PF02991	0.403
LIG_LIR_Gen_1	260	269	PF02991	0.241
LIG_LIR_Gen_1	393	401	PF02991	0.456
LIG_LIR_Gen_1	447	458	PF02991	0.325
LIG_LIR_Gen_1	472	483	PF02991	0.333
LIG_LIR_Nem_3	205	211	PF02991	0.370
LIG_LIR_Nem_3	260	266	PF02991	0.241
LIG_LIR_Nem_3	393	398	PF02991	0.453
LIG_LIR_Nem_3	447	453	PF02991	0.330
LIG_LIR_Nem_3	479	484	PF02991	0.369
LIG_LIR_Nem_3	5	11	PF02991	0.669
LIG_LYPXL_S_1	210	214	PF13949	0.237
LIG_LYPXL_yS_3	211	214	PF13949	0.403
LIG_PCNA_PIPBox_1	130	139	PF02747	0.302
LIG_PCNA_yPIPBox_3	130	139	PF02747	0.302
LIG_Pex14_1	149	153	PF04695	0.433
LIG_Pex14_1	259	263	PF04695	0.237
LIG_Pex14_1	414	418	PF04695	0.371
LIG_Pex14_1	477	481	PF04695	0.351
LIG_Pex14_2	473	477	PF04695	0.407
LIG_SH2_CRK	237	241	PF00017	0.280
LIG_SH2_CRK	263	267	PF00017	0.237
LIG_SH2_NCK_1	263	267	PF00017	0.237
LIG_SH2_PTP2	319	322	PF00017	0.256
LIG_SH2_PTP2	357	360	PF00017	0.243
LIG_SH2_STAP1	237	241	PF00017	0.237
LIG_SH2_STAP1	263	267	PF00017	0.246
LIG_SH2_STAT3	219	222	PF00017	0.388
LIG_SH2_STAT3	267	270	PF00017	0.403
LIG_SH2_STAT3	448	451	PF00017	0.430
LIG_SH2_STAT5	136	139	PF00017	0.370
LIG_SH2_STAT5	292	295	PF00017	0.370
LIG_SH2_STAT5	319	322	PF00017	0.237
LIG_SH2_STAT5	357	360	PF00017	0.287
LIG_SH2_STAT5	407	410	PF00017	0.408
LIG_SH2_STAT5	448	451	PF00017	0.313
LIG_SH3_1	3	9	PF00018	0.656
LIG_SH3_3	118	124	PF00018	0.203
LIG_SH3_3	245	251	PF00018	0.216
LIG_SH3_3	3	9	PF00018	0.656
LIG_SH3_3	435	441	PF00018	0.403
LIG_SUMO_SIM_anti_2	176	182	PF11976	0.351
LIG_TYR_ITIM	235	240	PF00017	0.237
LIG_TYR_ITIM	261	266	PF00017	0.237
MOD_CK1_1	18	24	PF00069	0.573
MOD_CK1_1	37	43	PF00069	0.610
MOD_CK1_1	390	396	PF00069	0.375
MOD_CK1_1	471	477	PF00069	0.444
MOD_CK2_1	168	174	PF00069	0.416
MOD_CK2_1	370	376	PF00069	0.512
MOD_CK2_1	41	47	PF00069	0.594
MOD_GlcNHglycan	20	23	PF01048	0.360
MOD_GlcNHglycan	307	310	PF01048	0.271
MOD_GlcNHglycan	384	387	PF01048	0.583
MOD_GlcNHglycan	427	430	PF01048	0.562
MOD_GlcNHglycan	43	46	PF01048	0.410
MOD_GlcNHglycan	453	456	PF01048	0.551
MOD_GSK3_1	301	308	PF00069	0.236
MOD_GSK3_1	35	42	PF00069	0.625
MOD_GSK3_1	382	389	PF00069	0.428
MOD_GSK3_1	9	16	PF00069	0.581
MOD_GSK3_1	98	105	PF00069	0.256
MOD_N-GLC_1	191	196	PF02516	0.409
MOD_N-GLC_1	451	456	PF02516	0.606
MOD_N-GLC_2	366	368	PF02516	0.302
MOD_NEK2_1	102	107	PF00069	0.237
MOD_NEK2_1	137	142	PF00069	0.264
MOD_NEK2_1	262	267	PF00069	0.325
MOD_NEK2_1	305	310	PF00069	0.253
MOD_NEK2_2	54	59	PF00069	0.576
MOD_PIKK_1	310	316	PF00454	0.237
MOD_PKA_1	215	221	PF00069	0.403
MOD_PKA_2	215	221	PF00069	0.414
MOD_PKA_2	380	386	PF00069	0.528
MOD_PKA_2	81	87	PF00069	0.537
MOD_Plk_1	173	179	PF00069	0.327
MOD_Plk_1	451	457	PF00069	0.402
MOD_Plk_1	463	469	PF00069	0.378
MOD_Plk_1	54	60	PF00069	0.663
MOD_Plk_4	173	179	PF00069	0.269
MOD_Plk_4	262	268	PF00069	0.265
MOD_Plk_4	301	307	PF00069	0.343
MOD_Plk_4	328	334	PF00069	0.462
MOD_Plk_4	387	393	PF00069	0.387
MOD_ProDKin_1	191	197	PF00069	0.207
MOD_ProDKin_1	2	8	PF00069	0.658
MOD_ProDKin_1	202	208	PF00069	0.301
MOD_SUMO_for_1	58	61	PF00179	0.576
MOD_SUMO_rev_2	147	153	PF00179	0.416
TRG_ENDOCYTIC_2	211	214	PF00928	0.403
TRG_ENDOCYTIC_2	237	240	PF00928	0.280
TRG_ENDOCYTIC_2	263	266	PF00928	0.237
TRG_ENDOCYTIC_2	319	322	PF00928	0.256
TRG_ENDOCYTIC_2	357	360	PF00928	0.329
TRG_ENDOCYTIC_2	475	478	PF00928	0.318
TRG_ENDOCYTIC_2	481	484	PF00928	0.358
TRG_ENDOCYTIC_2	77	80	PF00928	0.541
TRG_ER_diArg_1	2	4	PF00400	0.600
TRG_ER_diArg_1	444	446	PF00400	0.336
TRG_Pf-PMV_PEXEL_1	106	111	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	394	399	PF00026	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDG5	Leptomonas seymouri	77%	100%
A0A1X0NRA0	Trypanosomatidae	62%	100%
A0A3Q8II29	Leishmania donovani	96%	100%
A0A3R7KN50	Trypanosoma rangeli	58%	100%
A4HGH9	Leishmania braziliensis	87%	100%
A4I3L1	Leishmania infantum	96%	100%
D0A8C8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AZV1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q10252	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
Q298G6	Drosophila pseudoobscura pseudoobscura	33%	100%
Q499N4	Rattus norvegicus	39%	100%
Q66JT7	Mus musculus	39%	100%
Q8I7J4	Caenorhabditis elegans	34%	100%
Q9VHS7	Drosophila melanogaster	36%	100%
V5BFC2	Trypanosoma cruzi	57%	100%