Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8D3_LEIMA

TriTrypDb:

LmjF.28.1330 , LMJLV39_280020500 , LMJSD75_280020100

Length:

349

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	6
GO:0120025	plasma membrane bounded cell projection	3	6

Expansion

Sequence features

Q4Q8D3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8D3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	182	184	PF00675	0.547
CLV_NRD_NRD_1	288	290	PF00675	0.514
CLV_NRD_NRD_1	50	52	PF00675	0.752
CLV_NRD_NRD_1	91	93	PF00675	0.769
CLV_PCSK_KEX2_1	182	184	PF00082	0.547
CLV_PCSK_KEX2_1	288	290	PF00082	0.514
CLV_PCSK_KEX2_1	50	52	PF00082	0.752
CLV_PCSK_KEX2_1	91	93	PF00082	0.730
CLV_PCSK_SKI1_1	324	328	PF00082	0.506
DEG_APCC_DBOX_1	164	172	PF00400	0.575
DEG_SCF_FBW7_1	15	21	PF00400	0.595
DOC_CKS1_1	15	20	PF01111	0.591
DOC_MAPK_gen_1	285	293	PF00069	0.526
DOC_MAPK_MEF2A_6	217	226	PF00069	0.532
DOC_MAPK_MEF2A_6	327	335	PF00069	0.606
DOC_USP7_MATH_1	129	133	PF00917	0.810
DOC_USP7_MATH_1	154	158	PF00917	0.754
DOC_USP7_MATH_1	18	22	PF00917	0.622
DOC_USP7_MATH_1	263	267	PF00917	0.613
DOC_USP7_MATH_1	42	46	PF00917	0.800
DOC_USP7_MATH_1	54	58	PF00917	0.542
DOC_WW_Pin1_4	11	16	PF00397	0.731
DOC_WW_Pin1_4	150	155	PF00397	0.742
DOC_WW_Pin1_4	30	35	PF00397	0.544
DOC_WW_Pin1_4	327	332	PF00397	0.587
DOC_WW_Pin1_4	58	63	PF00397	0.798
LIG_14-3-3_CanoR_1	165	169	PF00244	0.576
LIG_14-3-3_CanoR_1	175	180	PF00244	0.305
LIG_Actin_WH2_2	286	303	PF00022	0.583
LIG_BIR_II_1	1	5	PF00653	0.700
LIG_deltaCOP1_diTrp_1	72	77	PF00928	0.740
LIG_FHA_1	221	227	PF00498	0.536
LIG_FHA_1	272	278	PF00498	0.540
LIG_FHA_1	328	334	PF00498	0.609
LIG_FHA_1	77	83	PF00498	0.735
LIG_FHA_2	228	234	PF00498	0.544
LIG_GBD_Chelix_1	318	326	PF00786	0.370
LIG_LIR_Gen_1	233	242	PF02991	0.535
LIG_LIR_Nem_3	233	237	PF02991	0.528
LIG_PDZ_Class_1	344	349	PF00595	0.673
LIG_SH2_GRB2like	234	237	PF00017	0.418
LIG_SH2_PTP2	234	237	PF00017	0.523
LIG_SH2_SRC	213	216	PF00017	0.570
LIG_SH2_STAT5	172	175	PF00017	0.553
LIG_SH2_STAT5	213	216	PF00017	0.570
LIG_SH2_STAT5	228	231	PF00017	0.325
LIG_SH2_STAT5	234	237	PF00017	0.433
LIG_SH3_2	64	69	PF14604	0.561
LIG_SH3_3	117	123	PF00018	0.838
LIG_SH3_3	12	18	PF00018	0.698
LIG_SH3_3	131	137	PF00018	0.593
LIG_SH3_3	221	227	PF00018	0.536
LIG_SH3_3	61	67	PF00018	0.600
LIG_SH3_3	77	83	PF00018	0.595
LIG_SH3_CIN85_PxpxPR_1	64	69	PF14604	0.561
LIG_SUMO_SIM_par_1	273	278	PF11976	0.542
LIG_SUMO_SIM_par_1	330	337	PF11976	0.638
LIG_TYR_ITIM	232	237	PF00017	0.527
LIG_UBA3_1	322	327	PF00899	0.390
LIG_WW_3	66	70	PF00397	0.711
MOD_CDC14_SPxK_1	155	158	PF00782	0.651
MOD_CDK_SPK_2	30	35	PF00069	0.651
MOD_CDK_SPxK_1	152	158	PF00069	0.649
MOD_CK1_1	14	20	PF00069	0.681
MOD_CK1_1	167	173	PF00069	0.524
MOD_CK1_1	21	27	PF00069	0.734
MOD_CK1_1	28	34	PF00069	0.678
MOD_CK2_1	227	233	PF00069	0.551
MOD_Cter_Amidation	286	289	PF01082	0.502
MOD_GlcNHglycan	131	134	PF01048	0.755
MOD_GlcNHglycan	245	248	PF01048	0.686
MOD_GlcNHglycan	265	268	PF01048	0.363
MOD_GlcNHglycan	30	33	PF01048	0.807
MOD_GlcNHglycan	342	345	PF01048	0.559
MOD_GlcNHglycan	44	47	PF01048	0.715
MOD_GlcNHglycan	52	55	PF01048	0.750
MOD_GlcNHglycan	56	59	PF01048	0.726
MOD_GlcNHglycan	93	97	PF01048	0.673
MOD_GSK3_1	123	130	PF00069	0.700
MOD_GSK3_1	14	21	PF00069	0.723
MOD_GSK3_1	150	157	PF00069	0.778
MOD_GSK3_1	167	174	PF00069	0.362
MOD_GSK3_1	243	250	PF00069	0.652
MOD_GSK3_1	271	278	PF00069	0.490
MOD_GSK3_1	340	347	PF00069	0.577
MOD_GSK3_1	50	57	PF00069	0.733
MOD_N-GLC_1	115	120	PF02516	0.593
MOD_N-GLC_2	236	238	PF02516	0.413
MOD_NEK2_1	171	176	PF00069	0.559
MOD_NEK2_1	76	81	PF00069	0.721
MOD_NEK2_2	18	23	PF00069	0.578
MOD_PK_1	25	31	PF00069	0.600
MOD_PKA_1	50	56	PF00069	0.752
MOD_PKA_2	164	170	PF00069	0.588
MOD_PKA_2	209	215	PF00069	0.582
MOD_PKA_2	50	56	PF00069	0.700
MOD_PKA_2	85	91	PF00069	0.770
MOD_Plk_1	115	121	PF00069	0.700
MOD_Plk_1	18	24	PF00069	0.573
MOD_Plk_1	275	281	PF00069	0.557
MOD_Plk_4	137	143	PF00069	0.704
MOD_Plk_4	209	215	PF00069	0.569
MOD_Plk_4	220	226	PF00069	0.365
MOD_Plk_4	4	10	PF00069	0.697
MOD_Plk_4	76	82	PF00069	0.651
MOD_ProDKin_1	11	17	PF00069	0.729
MOD_ProDKin_1	150	156	PF00069	0.745
MOD_ProDKin_1	30	36	PF00069	0.544
MOD_ProDKin_1	327	333	PF00069	0.594
MOD_ProDKin_1	58	64	PF00069	0.797
TRG_DiLeu_BaEn_1	107	112	PF01217	0.593
TRG_DiLeu_BaLyEn_6	184	189	PF01217	0.484
TRG_ENDOCYTIC_2	234	237	PF00928	0.523
TRG_ER_diArg_1	181	183	PF00400	0.544
TRG_ER_diArg_1	288	290	PF00400	0.541
TRG_ER_diArg_1	90	92	PF00400	0.729
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.563
TRG_Pf-PMV_PEXEL_1	324	328	PF00026	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IDS7	Leishmania donovani	88%	100%
A4HGI0	Leishmania braziliensis	63%	100%
A4I3L2	Leishmania infantum	88%	100%
E9AZV2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%