Haloacid dehalogenase-like hydrolase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

haloacid dehalogenase-like hydrolase, putative

Species:

Leishmania major

UniProt:

Q4Q8D2_LEIMA

TriTrypDb:

LmjF.28.1340 , LMJLV39_280020800 , LMJSD75_280020300

Length:

188

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8D2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8D2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.474
CLV_NRD_NRD_1	178	180	PF00675	0.300
CLV_PCSK_SKI1_1	182	186	PF00082	0.726
CLV_PCSK_SKI1_1	54	58	PF00082	0.412
CLV_PCSK_SKI1_1	62	66	PF00082	0.316
CLV_PCSK_SKI1_1	95	99	PF00082	0.362
DEG_APCC_DBOX_1	61	69	PF00400	0.431
DEG_MDM2_SWIB_1	56	64	PF02201	0.466
DEG_Nend_UBRbox_3	1	3	PF02207	0.491
DOC_CYCLIN_yCln2_LP_2	109	115	PF00134	0.449
DOC_MAPK_gen_1	126	133	PF00069	0.500
DOC_MAPK_HePTP_8	72	84	PF00069	0.500
DOC_MAPK_MEF2A_6	75	84	PF00069	0.500
DOC_PP1_RVXF_1	52	58	PF00149	0.612
DOC_PP2B_LxvP_1	109	112	PF13499	0.449
DOC_PP4_FxxP_1	84	87	PF00568	0.466
DOC_USP7_MATH_1	40	44	PF00917	0.568
DOC_USP7_MATH_2	114	120	PF00917	0.500
DOC_USP7_UBL2_3	95	99	PF12436	0.500
DOC_WW_Pin1_4	119	124	PF00397	0.500
DOC_WW_Pin1_4	153	158	PF00397	0.449
DOC_WW_Pin1_4	34	39	PF00397	0.755
LIG_14-3-3_CanoR_1	126	132	PF00244	0.487
LIG_APCC_ABBA_1	7	12	PF00400	0.447
LIG_EH1_1	16	24	PF00400	0.553
LIG_eIF4E_1	17	23	PF01652	0.558
LIG_FHA_1	27	33	PF00498	0.582
LIG_FHA_2	169	175	PF00498	0.587
LIG_FHA_2	61	67	PF00498	0.466
LIG_LIR_Apic_2	81	87	PF02991	0.466
LIG_LIR_Gen_1	104	114	PF02991	0.500
LIG_Pex14_2	56	60	PF04695	0.500
LIG_SH2_STAP1	107	111	PF00017	0.500
LIG_SH2_STAT3	15	18	PF00017	0.600
LIG_SH3_3	154	160	PF00018	0.426
LIG_SUMO_SIM_anti_2	165	171	PF11976	0.578
LIG_UBA3_1	151	158	PF00899	0.414
LIG_UBA3_1	6	11	PF00899	0.451
MOD_CDK_SPK_2	153	158	PF00069	0.449
MOD_CDK_SPxxK_3	119	126	PF00069	0.500
MOD_CK1_1	119	125	PF00069	0.500
MOD_CK1_1	36	42	PF00069	0.661
MOD_CK2_1	168	174	PF00069	0.587
MOD_CK2_1	60	66	PF00069	0.500
MOD_GlcNHglycan	12	15	PF01048	0.700
MOD_GlcNHglycan	84	87	PF01048	0.313
MOD_GSK3_1	32	39	PF00069	0.746
MOD_GSK3_1	56	63	PF00069	0.483
MOD_GSK3_1	78	85	PF00069	0.612
MOD_N-GLC_1	60	65	PF02516	0.240
MOD_NEK2_1	127	132	PF00069	0.548
MOD_NEK2_1	142	147	PF00069	0.496
MOD_NEK2_1	56	61	PF00069	0.480
MOD_NEK2_1	80	85	PF00069	0.574
MOD_Plk_1	60	66	PF00069	0.466
MOD_Plk_1	78	84	PF00069	0.476
MOD_ProDKin_1	119	125	PF00069	0.500
MOD_ProDKin_1	153	159	PF00069	0.449
MOD_ProDKin_1	34	40	PF00069	0.756
MOD_SUMO_rev_2	25	32	PF00179	0.545
TRG_DiLeu_BaEn_4	4	10	PF01217	0.399
TRG_ENDOCYTIC_2	107	110	PF00928	0.500
TRG_ENDOCYTIC_2	17	20	PF00928	0.615
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.300
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.218

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9R7	Leptomonas seymouri	27%	66%
A0A0N1IM34	Leptomonas seymouri	29%	67%
A0A3S7X1G8	Leishmania donovani	31%	66%
A0A422MX56	Trypanosoma rangeli	32%	69%
A1A8B5	Escherichia coli O1:K1 / APEC	29%	69%
A1JNL2	Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)	38%	69%
A4HGI1	Leishmania braziliensis	75%	70%
A4HGI5	Leishmania braziliensis	74%	100%
A4HGI9	Leishmania braziliensis	29%	67%
A4I3L3	Leishmania infantum	94%	100%
A4I3L6	Leishmania infantum	31%	66%
A4TPD3	Yersinia pestis (strain Pestoides F)	34%	69%
A4W7B7	Enterobacter sp. (strain 638)	32%	69%
A6T5I9	Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)	32%	69%
A7FLB5	Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)	34%	69%
A7MFJ6	Cronobacter sakazakii (strain ATCC BAA-894)	31%	69%
A7ZIK4	Escherichia coli O139:H28 (strain E24377A / ETEC)	29%	69%
A7ZXA4	Escherichia coli O9:H4 (strain HS)	29%	69%
A8AK07	Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)	30%	69%
A8GAR8	Serratia proteamaculans (strain 568)	28%	69%
A9MWC0	Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)	31%	69%
A9QZP3	Yersinia pestis bv. Antiqua (strain Angola)	34%	69%
B1IZE7	Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)	30%	74%
B1JHR2	Yersinia pseudotuberculosis serotype O:3 (strain YPIII)	34%	69%
B1LJK3	Escherichia coli (strain SMS-3-5 / SECEC)	29%	69%
B1XFN4	Escherichia coli (strain K12 / DH10B)	29%	69%
B2K6W6	Yersinia pseudotuberculosis serotype IB (strain PB1/+)	34%	69%
B2U4Q1	Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)	29%	69%
B4T9F2	Salmonella heidelberg (strain SL476)	31%	69%
B5BD74	Salmonella paratyphi A (strain AKU_12601)	31%	69%
B5EXJ7	Salmonella agona (strain SL483)	31%	69%
B5FKW1	Salmonella dublin (strain CT_02021853)	31%	69%
B5QU47	Salmonella enteritidis PT4 (strain P125109)	31%	69%
B5R6V8	Salmonella gallinarum (strain 287/91 / NCTC 13346)	31%	69%
B5Y0T3	Klebsiella pneumoniae (strain 342)	33%	69%
B5Z3V4	Escherichia coli O157:H7 (strain EC4115 / EHEC)	29%	69%
B6HZQ3	Escherichia coli (strain SE11)	29%	69%
B7L683	Escherichia coli (strain 55989 / EAEC)	29%	69%
B7LMD3	Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)	31%	69%
B7M3T9	Escherichia coli O8 (strain IAI1)	28%	69%
B7MDA5	Escherichia coli O45:K1 (strain S88 / ExPEC)	29%	69%
B7MQG2	Escherichia coli O81 (strain ED1a)	28%	69%
B7N900	Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)	28%	69%
B7NJ48	Escherichia coli O7:K1 (strain IAI39 / ExPEC)	29%	69%
B7UJR9	Escherichia coli O127:H6 (strain E2348/69 / EPEC)	29%	69%
C4ZTK3	Escherichia coli (strain K12 / MC4100 / BW2952)	29%	69%
E9AZV3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9AZV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	66%
P27848	Escherichia coli (strain K12)	41%	71%
P44771	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	32%	69%
P46891	Escherichia coli (strain K12)	29%	69%
P57140	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	33%	69%
Q0T7D7	Shigella flexneri serotype 5b (strain 8401)	29%	69%
Q0TKJ5	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	29%	69%
Q1C4L7	Yersinia pestis bv. Antiqua (strain Antiqua)	34%	69%
Q1CL56	Yersinia pestis bv. Antiqua (strain Nepal516)	34%	69%
Q1RF89	Escherichia coli (strain UTI89 / UPEC)	29%	69%
Q325F5	Shigella boydii serotype 4 (strain Sb227)	30%	72%
Q32JB1	Shigella dysenteriae serotype 1 (strain Sd197)	33%	100%
Q3Z4V2	Shigella sonnei (strain Ss046)	29%	69%
Q4Q8C9	Leishmania major	32%	66%
Q57SA6	Salmonella choleraesuis (strain SC-B67)	31%	69%
Q5PFM4	Salmonella paratyphi A (strain ATCC 9150 / SARB42)	31%	69%
Q66DS5	Yersinia pseudotuberculosis serotype I (strain IP32953)	34%	69%
Q7CK25	Yersinia pestis	34%	69%
Q83M49	Shigella flexneri	29%	69%
Q8FKA2	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	29%	69%
Q8KA73	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	30%	69%
Q8X8L6	Escherichia coli O157:H7	41%	71%
Q8XE50	Escherichia coli O157:H7	29%	69%
Q8Z8U7	Salmonella typhi	31%	69%
Q8ZRB6	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	31%	69%