Putative haloacid dehalogenase-like hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

haloacid dehalogenase-like hydrolase, putative

Species:

Leishmania major

UniProt:

Q4Q8C9_LEIMA

TriTrypDb:

LmjF.28.1370 , LMJLV39_280021100 , LMJSD75_280020600

Length:

284

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8C9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8C9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	17
GO:0016787	hydrolase activity	2	17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.463
CLV_PCSK_SKI1_1	100	104	PF00082	0.318
CLV_PCSK_SKI1_1	113	117	PF00082	0.334
CLV_PCSK_SKI1_1	33	37	PF00082	0.283
DEG_SPOP_SBC_1	241	245	PF00917	0.382
DOC_CYCLIN_yClb5_NLxxxL_5	83	92	PF00134	0.370
DOC_MAPK_gen_1	275	282	PF00069	0.567
DOC_MAPK_gen_1	33	42	PF00069	0.417
DOC_MIT_MIM_1	146	154	PF04212	0.408
DOC_PP1_RVXF_1	36	43	PF00149	0.562
DOC_PP4_FxxP_1	193	196	PF00568	0.498
DOC_USP7_MATH_1	132	136	PF00917	0.395
DOC_USP7_UBL2_3	34	38	PF12436	0.418
LIG_14-3-3_CanoR_1	98	103	PF00244	0.555
LIG_BIR_II_1	1	5	PF00653	0.448
LIG_BIR_III_2	257	261	PF00653	0.463
LIG_BRCT_BRCA1_1	134	138	PF00533	0.519
LIG_BRCT_BRCA1_1	242	246	PF00533	0.421
LIG_Clathr_ClatBox_1	174	178	PF01394	0.454
LIG_FHA_1	114	120	PF00498	0.458
LIG_FHA_1	190	196	PF00498	0.510
LIG_FHA_1	242	248	PF00498	0.408
LIG_FHA_2	9	15	PF00498	0.475
LIG_FHA_2	99	105	PF00498	0.573
LIG_GBD_Chelix_1	9	17	PF00786	0.318
LIG_LIR_Apic_2	192	196	PF02991	0.491
LIG_LIR_Gen_1	52	62	PF02991	0.462
LIG_LIR_Gen_1	77	88	PF02991	0.447
LIG_LIR_Nem_3	149	154	PF02991	0.518
LIG_LIR_Nem_3	52	57	PF02991	0.479
LIG_LIR_Nem_3	77	83	PF02991	0.519
LIG_PDZ_Class_2	279	284	PF00595	0.346
LIG_Pex14_2	138	142	PF04695	0.518
LIG_SH2_NCK_1	50	54	PF00017	0.459
LIG_SH2_SRC	50	53	PF00017	0.534
LIG_SH2_STAP1	152	156	PF00017	0.446
LIG_SH2_STAP1	27	31	PF00017	0.518
LIG_SH2_STAP1	50	54	PF00017	0.459
LIG_SH2_STAT3	152	155	PF00017	0.453
LIG_SH2_STAT5	66	69	PF00017	0.443
LIG_SH3_3	99	105	PF00018	0.488
LIG_SUMO_SIM_anti_2	172	178	PF11976	0.427
LIG_SUMO_SIM_par_1	172	178	PF11976	0.421
MOD_CK2_1	104	110	PF00069	0.535
MOD_CK2_1	127	133	PF00069	0.446
MOD_NEK2_1	13	18	PF00069	0.458
MOD_NEK2_1	189	194	PF00069	0.474
MOD_NEK2_1	239	244	PF00069	0.471
MOD_NEK2_1	92	97	PF00069	0.570
MOD_PKA_1	113	119	PF00069	0.421
MOD_Plk_1	127	133	PF00069	0.446
MOD_Plk_1	234	240	PF00069	0.521
MOD_Plk_4	13	19	PF00069	0.464
MOD_Plk_4	234	240	PF00069	0.524
MOD_Plk_4	242	248	PF00069	0.529
TRG_ENDOCYTIC_2	50	53	PF00928	0.471
TRG_Pf-PMV_PEXEL_1	275	279	PF00026	0.260

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7I9	Leptomonas seymouri	31%	87%
A0A0N0P7W9	Leptomonas seymouri	33%	97%
A0A0N1I1D8	Leptomonas seymouri	28%	86%
A0A0N1I836	Leptomonas seymouri	36%	97%
A0A0N1I9R7	Leptomonas seymouri	37%	100%
A0A0N1ILU0	Leptomonas seymouri	27%	75%
A0A0N1IM34	Leptomonas seymouri	60%	100%
A0A1X0NRL0	Trypanosomatidae	34%	98%
A0A1X0NYN3	Trypanosomatidae	30%	87%
A0A1X0NYY3	Trypanosomatidae	42%	97%
A0A1X0P2Q4	Trypanosomatidae	31%	82%
A0A3Q8IAZ9	Leishmania donovani	41%	98%
A0A3Q8IDX0	Leishmania donovani	27%	85%
A0A3Q8IEU6	Leishmania donovani	29%	71%
A0A3Q8IGR3	Leishmania donovani	29%	85%
A0A3R7M7Z1	Trypanosoma rangeli	33%	98%
A0A3S7X1G8	Leishmania donovani	93%	100%
A0A422MX56	Trypanosoma rangeli	38%	100%
A0A422N4F0	Trypanosoma rangeli	26%	75%
A1A8B5	Escherichia coli O1:K1 / APEC	30%	100%
A1JNL2	Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)	30%	100%
A4HGI1	Leishmania braziliensis	28%	100%
A4HGI6	Leishmania braziliensis	28%	85%
A4HGI8	Leishmania braziliensis	40%	94%
A4HGI9	Leishmania braziliensis	77%	100%
A4HGJ0	Leishmania braziliensis	25%	75%
A4I3L3	Leishmania infantum	33%	100%
A4I3L4	Leishmania infantum	28%	85%
A4I3L5	Leishmania infantum	41%	98%
A4I3L6	Leishmania infantum	93%	100%
A4I3L7	Leishmania infantum	29%	71%
A4TPD3	Yersinia pestis (strain Pestoides F)	31%	100%
A4W7B7	Enterobacter sp. (strain 638)	30%	100%
A6T5I9	Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)	30%	100%
A7FLB5	Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)	31%	100%
A7MFJ6	Cronobacter sakazakii (strain ATCC BAA-894)	29%	100%
A7ZIK4	Escherichia coli O139:H28 (strain E24377A / ETEC)	30%	100%
A7ZXA4	Escherichia coli O9:H4 (strain HS)	30%	100%
A8AK07	Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)	30%	100%
A8GAR8	Serratia proteamaculans (strain 568)	30%	100%
A9MM14	Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)	31%	100%
A9MWC0	Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)	30%	100%
A9QZP3	Yersinia pestis bv. Antiqua (strain Angola)	31%	100%
B1IZE7	Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)	29%	100%
B1JHR2	Yersinia pseudotuberculosis serotype O:3 (strain YPIII)	31%	100%
B1LJK3	Escherichia coli (strain SMS-3-5 / SECEC)	30%	100%
B1XFN4	Escherichia coli (strain K12 / DH10B)	30%	100%
B2K6W6	Yersinia pseudotuberculosis serotype IB (strain PB1/+)	31%	100%
B2U4Q1	Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)	30%	100%
B4SWV0	Salmonella newport (strain SL254)	30%	100%
B4T9F2	Salmonella heidelberg (strain SL476)	30%	100%
B4TMD5	Salmonella schwarzengrund (strain CVM19633)	30%	100%
B5BD74	Salmonella paratyphi A (strain AKU_12601)	30%	100%
B5EXJ7	Salmonella agona (strain SL483)	30%	100%
B5FKW1	Salmonella dublin (strain CT_02021853)	30%	100%
B5QU47	Salmonella enteritidis PT4 (strain P125109)	30%	100%
B5R6V8	Salmonella gallinarum (strain 287/91 / NCTC 13346)	30%	100%
B5Y0T3	Klebsiella pneumoniae (strain 342)	32%	100%
B5Z3V4	Escherichia coli O157:H7 (strain EC4115 / EHEC)	31%	100%
B6HZQ3	Escherichia coli (strain SE11)	30%	100%
B7L683	Escherichia coli (strain 55989 / EAEC)	30%	100%
B7LMD3	Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)	30%	100%
B7M3T9	Escherichia coli O8 (strain IAI1)	31%	100%
B7MDA5	Escherichia coli O45:K1 (strain S88 / ExPEC)	30%	100%
B7MQG2	Escherichia coli O81 (strain ED1a)	30%	100%
B7N900	Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)	31%	100%
B7NJ48	Escherichia coli O7:K1 (strain IAI39 / ExPEC)	30%	100%
B7UJR9	Escherichia coli O127:H6 (strain E2348/69 / EPEC)	30%	100%
C4ZTK3	Escherichia coli (strain K12 / MC4100 / BW2952)	30%	100%
D0A7S2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	91%
D0A841	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	99%
E9AZV3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9AZV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	85%
E9AZV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	98%
E9AZV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9AZV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	71%
P0A8Y5	Escherichia coli (strain K12)	27%	100%
P0A8Y6	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	27%	100%
P0A8Y7	Shigella flexneri	27%	100%
P21829	Escherichia coli (strain K12)	27%	100%
P27848	Escherichia coli (strain K12)	37%	100%
P42962	Bacillus subtilis (strain 168)	24%	100%
P44447	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	25%	100%
P44771	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	32%	100%
P46891	Escherichia coli (strain K12)	30%	100%
P54947	Bacillus subtilis (strain 168)	26%	100%
P57140	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	29%	100%
P75809	Escherichia coli (strain K12)	27%	100%
P96741	Bacillus subtilis (strain 168)	26%	99%
Q0T7D7	Shigella flexneri serotype 5b (strain 8401)	30%	100%
Q0TKJ5	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	30%	100%
Q1C4L7	Yersinia pestis bv. Antiqua (strain Antiqua)	31%	100%
Q1CL56	Yersinia pestis bv. Antiqua (strain Nepal516)	31%	100%
Q1RF89	Escherichia coli (strain UTI89 / UPEC)	30%	100%
Q325F5	Shigella boydii serotype 4 (strain Sb227)	31%	100%
Q3Z4V2	Shigella sonnei (strain Ss046)	30%	100%
Q4Q8C8	Leishmania major	28%	71%
Q4Q8D0	Leishmania major	39%	98%
Q4Q8D1	Leishmania major	29%	85%
Q4Q8D2	Leishmania major	32%	100%
Q57SA6	Salmonella choleraesuis (strain SC-B67)	30%	100%
Q5PFM4	Salmonella paratyphi A (strain ATCC 9150 / SARB42)	30%	100%
Q5XD45	Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)	28%	100%
Q66DS5	Yersinia pseudotuberculosis serotype I (strain IP32953)	31%	100%
Q7CK25	Yersinia pestis	31%	100%
Q83M49	Shigella flexneri	30%	100%
Q89B25	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	31%	100%
Q8FKA2	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	30%	100%
Q8KA73	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	30%	100%
Q8X8L6	Escherichia coli O157:H7	36%	100%
Q8XE50	Escherichia coli O157:H7	31%	100%
Q8Z8U7	Salmonella typhi	30%	100%
Q8ZRB6	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	30%	100%
V5BGL5	Trypanosoma cruzi	29%	90%
V5D8D2	Trypanosoma cruzi	42%	91%