Haloacid dehalogenase-like hydrolase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

haloacid dehalogenase-like hydrolase-like protein

Species:

Leishmania major

UniProt:

Q4Q8C8_LEIMA

TriTrypDb:

LmjF.28.1380 , LMJLV39_280021200 , LMJSD75_280020700

Length:

402

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 34
NetGPI	no	yes: 0, no: 34

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8C8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8C8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	31
GO:0016787	hydrolase activity	2	31

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.452
CLV_NRD_NRD_1	15	17	PF00675	0.558
CLV_NRD_NRD_1	378	380	PF00675	0.269
CLV_NRD_NRD_1	81	83	PF00675	0.253
CLV_PCSK_FUR_1	78	82	PF00082	0.327
CLV_PCSK_KEX2_1	15	17	PF00082	0.399
CLV_PCSK_KEX2_1	278	280	PF00082	0.233
CLV_PCSK_KEX2_1	80	82	PF00082	0.240
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.268
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.268
CLV_PCSK_SKI1_1	278	282	PF00082	0.274
CLV_PCSK_SKI1_1	52	56	PF00082	0.291
CLV_PCSK_SKI1_1	71	75	PF00082	0.172
DEG_APCC_DBOX_1	387	395	PF00400	0.330
DEG_APCC_DBOX_1	51	59	PF00400	0.508
DEG_SPOP_SBC_1	125	129	PF00917	0.746
DOC_CKS1_1	92	97	PF01111	0.590
DOC_CKS1_1	99	104	PF01111	0.632
DOC_MAPK_DCC_7	358	368	PF00069	0.398
DOC_MAPK_gen_1	15	22	PF00069	0.558
DOC_MAPK_gen_1	358	368	PF00069	0.468
DOC_MAPK_gen_1	78	85	PF00069	0.496
DOC_MAPK_MEF2A_6	360	368	PF00069	0.425
DOC_MAPK_MEF2A_6	90	99	PF00069	0.588
DOC_USP7_MATH_1	116	120	PF00917	0.724
DOC_USP7_MATH_1	125	129	PF00917	0.654
DOC_USP7_MATH_1	149	153	PF00917	0.482
DOC_USP7_MATH_1	266	270	PF00917	0.534
DOC_USP7_MATH_1	397	401	PF00917	0.703
DOC_WW_Pin1_4	112	117	PF00397	0.679
DOC_WW_Pin1_4	91	96	PF00397	0.560
DOC_WW_Pin1_4	98	103	PF00397	0.602
LIG_14-3-3_CanoR_1	238	242	PF00244	0.467
LIG_14-3-3_CanoR_1	255	262	PF00244	0.544
LIG_14-3-3_CanoR_1	379	387	PF00244	0.563
LIG_14-3-3_CanoR_1	71	79	PF00244	0.482
LIG_BRCT_BRCA1_1	256	260	PF00533	0.527
LIG_BRCT_BRCA1_1	381	385	PF00533	0.252
LIG_FHA_1	138	144	PF00498	0.599
LIG_FHA_1	238	244	PF00498	0.524
LIG_FHA_1	298	304	PF00498	0.505
LIG_FHA_1	49	55	PF00498	0.457
LIG_FHA_1	87	93	PF00498	0.551
LIG_FHA_2	324	330	PF00498	0.466
LIG_FHA_2	99	105	PF00498	0.629
LIG_IBAR_NPY_1	27	29	PF08397	0.289
LIG_LIR_Gen_1	177	186	PF02991	0.481
LIG_LIR_Nem_3	177	182	PF02991	0.481
LIG_LIR_Nem_3	240	244	PF02991	0.485
LIG_LIR_Nem_3	258	264	PF02991	0.462
LIG_MYND_3	363	367	PF01753	0.411
LIG_NRBOX	54	60	PF00104	0.522
LIG_Pex14_1	221	225	PF04695	0.486
LIG_SH2_CRK	206	210	PF00017	0.519
LIG_SH2_CRK	29	33	PF00017	0.331
LIG_SH2_GRB2like	206	209	PF00017	0.539
LIG_SH2_NCK_1	158	162	PF00017	0.522
LIG_SH2_NCK_1	206	210	PF00017	0.565
LIG_SH2_STAP1	166	170	PF00017	0.508
LIG_SH2_STAP1	179	183	PF00017	0.446
LIG_SH2_STAP1	50	54	PF00017	0.529
LIG_SH2_STAT5	206	209	PF00017	0.487
LIG_SH2_STAT5	301	304	PF00017	0.559
LIG_SH2_STAT5	50	53	PF00017	0.451
LIG_SH3_3	17	23	PF00018	0.553
LIG_SH3_3	96	102	PF00018	0.607
LIG_SUMO_SIM_anti_2	339	345	PF11976	0.488
LIG_TRAF2_1	217	220	PF00917	0.474
MOD_CDK_SPxxK_3	103	110	PF00069	0.500
MOD_CK1_1	106	112	PF00069	0.691
MOD_CK1_1	119	125	PF00069	0.720
MOD_CK1_1	126	132	PF00069	0.729
MOD_CK1_1	237	243	PF00069	0.506
MOD_CK1_1	308	314	PF00069	0.463
MOD_CK1_1	43	49	PF00069	0.462
MOD_CK2_1	224	230	PF00069	0.503
MOD_CK2_1	242	248	PF00069	0.441
MOD_CK2_1	267	273	PF00069	0.468
MOD_CK2_1	98	104	PF00069	0.627
MOD_GlcNHglycan	132	135	PF01048	0.630
MOD_GlcNHglycan	297	300	PF01048	0.269
MOD_GlcNHglycan	313	316	PF01048	0.223
MOD_GSK3_1	106	113	PF00069	0.700
MOD_GSK3_1	119	126	PF00069	0.457
MOD_GSK3_1	128	135	PF00069	0.626
MOD_GSK3_1	267	274	PF00069	0.522
MOD_GSK3_1	36	43	PF00069	0.485
MOD_N-GLC_1	116	121	PF02516	0.725
MOD_N-GLC_1	137	142	PF02516	0.391
MOD_N-GLC_1	43	48	PF02516	0.293
MOD_N-GLC_2	328	330	PF02516	0.168
MOD_NEK2_1	148	153	PF00069	0.476
MOD_NEK2_1	289	294	PF00069	0.379
MOD_NEK2_1	323	328	PF00069	0.461
MOD_NEK2_1	342	347	PF00069	0.510
MOD_NEK2_1	36	41	PF00069	0.452
MOD_NEK2_1	86	91	PF00069	0.378
MOD_PIKK_1	53	59	PF00454	0.450
MOD_PKA_1	379	385	PF00069	0.418
MOD_PKA_2	237	243	PF00069	0.474
MOD_PKA_2	254	260	PF00069	0.524
MOD_Plk_1	166	172	PF00069	0.533
MOD_Plk_1	266	272	PF00069	0.367
MOD_Plk_1	289	295	PF00069	0.377
MOD_Plk_1	323	329	PF00069	0.475
MOD_Plk_1	4	10	PF00069	0.409
MOD_Plk_1	43	49	PF00069	0.435
MOD_Plk_2-3	215	221	PF00069	0.522
MOD_Plk_2-3	267	273	PF00069	0.374
MOD_Plk_4	119	125	PF00069	0.502
MOD_Plk_4	177	183	PF00069	0.463
MOD_Plk_4	267	273	PF00069	0.555
MOD_Plk_4	36	42	PF00069	0.460
MOD_ProDKin_1	112	118	PF00069	0.678
MOD_ProDKin_1	91	97	PF00069	0.566
MOD_ProDKin_1	98	104	PF00069	0.612
MOD_SUMO_rev_2	210	218	PF00179	0.537
MOD_SUMO_rev_2	282	289	PF00179	0.376
TRG_DiLeu_BaEn_1	267	272	PF01217	0.365
TRG_ENDOCYTIC_2	179	182	PF00928	0.434
TRG_ENDOCYTIC_2	29	32	PF00928	0.317
TRG_ER_diArg_1	15	17	PF00400	0.404
TRG_ER_diArg_1	81	83	PF00400	0.396
TRG_NLS_MonoExtC_3	359	364	PF00514	0.368
TRG_NLS_MonoExtN_4	357	364	PF00514	0.368
TRG_NLS_MonoExtN_4	78	84	PF00514	0.527
TRG_Pf-PMV_PEXEL_1	379	383	PF00026	0.261

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7I9	Leptomonas seymouri	29%	100%
A0A0N0P7W9	Leptomonas seymouri	24%	100%
A0A0N1I1D8	Leptomonas seymouri	31%	100%
A0A0N1ILU0	Leptomonas seymouri	28%	100%
A0A0N1PEM6	Leptomonas seymouri	64%	100%
A0A1X0NRL0	Trypanosomatidae	26%	100%
A0A1X0NYN3	Trypanosomatidae	30%	100%
A0A1X0NYY3	Trypanosomatidae	29%	100%
A0A1X0P2Q4	Trypanosomatidae	38%	100%
A0A3Q8IDX0	Leishmania donovani	27%	100%
A0A3Q8IEU6	Leishmania donovani	95%	100%
A0A3Q8IGR3	Leishmania donovani	28%	100%
A0A3R7M7Z1	Trypanosoma rangeli	27%	100%
A0A3S7X1G8	Leishmania donovani	31%	100%
A0A422MX56	Trypanosoma rangeli	28%	100%
A0A422N4F0	Trypanosoma rangeli	29%	100%
A4HGI1	Leishmania braziliensis	29%	100%
A4HGI6	Leishmania braziliensis	29%	100%
A4HGI9	Leishmania braziliensis	28%	100%
A4HGJ0	Leishmania braziliensis	31%	100%
A4I3L4	Leishmania infantum	28%	100%
A4I3L6	Leishmania infantum	32%	100%
A4I3L7	Leishmania infantum	95%	100%
D0A7S2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
D0A841	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AZV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AZV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AZV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AZV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
P94592	Bacillus subtilis (strain 168)	22%	100%
Q4Q8C9	Leishmania major	28%	100%
Q4Q8D1	Leishmania major	28%	100%
V5BGL5	Trypanosoma cruzi	32%	100%
V5D8D2	Trypanosoma cruzi	27%	100%