LeishMANIAdb
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Amastin surface glycofamily protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Amastin surface glycofamily protein
Gene product:
Amastin surface glycoprotein, putative
Species:
Leishmania major
UniProt:
Q4Q8C7_LEIMA
TriTrypDb:
LmjF.28.1390 , LMJLV39_280021500 * , LMJSD75_280021000
Length:
342

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Amastin, Kinetoplastid host adhesion protein. A host adhesion protein family greatly expanded in Leishmaniids.. Localization: Cell surface (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0020016 ciliary pocket 2 2
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

Q4Q8C7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8C7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 128 132 PF00656 0.611
CLV_C14_Caspase3-7 17 21 PF00656 0.737
CLV_C14_Caspase3-7 253 257 PF00656 0.461
CLV_NRD_NRD_1 184 186 PF00675 0.591
CLV_NRD_NRD_1 193 195 PF00675 0.547
CLV_NRD_NRD_1 53 55 PF00675 0.622
CLV_PCSK_KEX2_1 184 186 PF00082 0.591
CLV_PCSK_KEX2_1 193 195 PF00082 0.547
CLV_PCSK_KEX2_1 53 55 PF00082 0.617
CLV_PCSK_KEX2_1 76 78 PF00082 0.551
CLV_PCSK_PC1ET2_1 76 78 PF00082 0.528
CLV_PCSK_SKI1_1 121 125 PF00082 0.482
CLV_PCSK_SKI1_1 185 189 PF00082 0.563
CLV_PCSK_SKI1_1 196 200 PF00082 0.556
CLV_PCSK_SKI1_1 53 57 PF00082 0.417
DEG_MDM2_SWIB_1 141 149 PF02201 0.419
DOC_CKS1_1 69 74 PF01111 0.719
DOC_CYCLIN_RxL_1 50 60 PF00134 0.619
DOC_MAPK_gen_1 275 282 PF00069 0.572
DOC_MAPK_HePTP_8 127 139 PF00069 0.623
DOC_MAPK_MEF2A_6 130 139 PF00069 0.589
DOC_MAPK_MEF2A_6 275 284 PF00069 0.560
DOC_WW_Pin1_4 233 238 PF00397 0.564
DOC_WW_Pin1_4 68 73 PF00397 0.741
LIG_14-3-3_CanoR_1 184 188 PF00244 0.366
LIG_14-3-3_CanoR_1 36 42 PF00244 0.657
LIG_14-3-3_CanoR_1 64 69 PF00244 0.762
LIG_Actin_WH2_2 215 230 PF00022 0.406
LIG_CaM_IQ_9 186 202 PF13499 0.324
LIG_FHA_1 122 128 PF00498 0.681
LIG_FHA_1 134 140 PF00498 0.500
LIG_FHA_1 184 190 PF00498 0.316
LIG_FHA_2 81 87 PF00498 0.688
LIG_GBD_Chelix_1 282 290 PF00786 0.437
LIG_Integrin_isoDGR_2 260 262 PF01839 0.229
LIG_Integrin_RGD_1 77 79 PF01839 0.530
LIG_LIR_Gen_1 136 146 PF02991 0.466
LIG_LIR_Gen_1 203 212 PF02991 0.451
LIG_LIR_Gen_1 238 248 PF02991 0.500
LIG_LIR_Gen_1 291 300 PF02991 0.382
LIG_LIR_Gen_1 326 336 PF02991 0.264
LIG_LIR_Nem_3 136 141 PF02991 0.466
LIG_LIR_Nem_3 169 173 PF02991 0.288
LIG_LIR_Nem_3 203 208 PF02991 0.451
LIG_LIR_Nem_3 291 296 PF02991 0.374
LIG_LIR_Nem_3 326 332 PF02991 0.279
LIG_PALB2_WD40_1 324 332 PF16756 0.253
LIG_PDZ_Class_1 337 342 PF00595 0.441
LIG_Pex14_2 141 145 PF04695 0.390
LIG_SH2_GRB2like 240 243 PF00017 0.572
LIG_SH2_STAP1 33 37 PF00017 0.717
LIG_SH2_STAT5 138 141 PF00017 0.390
LIG_SH2_STAT5 168 171 PF00017 0.303
LIG_SH2_STAT5 182 185 PF00017 0.273
LIG_SH2_STAT5 26 29 PF00017 0.763
LIG_SH2_STAT5 304 307 PF00017 0.336
LIG_SH2_STAT5 309 312 PF00017 0.328
LIG_SH2_STAT5 335 338 PF00017 0.437
LIG_SH3_3 231 237 PF00018 0.510
LIG_SUMO_SIM_anti_2 158 164 PF11976 0.324
LIG_SUMO_SIM_anti_2 206 213 PF11976 0.348
LIG_SUMO_SIM_par_1 185 191 PF11976 0.229
LIG_TRAF2_1 83 86 PF00917 0.713
LIG_WW_3 40 44 PF00397 0.636
MOD_CDC14_SPxK_1 236 239 PF00782 0.523
MOD_CDC14_SPxK_1 73 76 PF00782 0.704
MOD_CDK_SPxK_1 233 239 PF00069 0.523
MOD_CDK_SPxK_1 70 76 PF00069 0.751
MOD_CDK_SPxxK_3 70 77 PF00069 0.752
MOD_CK1_1 155 161 PF00069 0.424
MOD_CK1_1 203 209 PF00069 0.385
MOD_CK1_1 213 219 PF00069 0.359
MOD_CK1_1 29 35 PF00069 0.735
MOD_CK2_1 18 24 PF00069 0.730
MOD_CK2_1 29 35 PF00069 0.698
MOD_CK2_1 80 86 PF00069 0.687
MOD_GlcNHglycan 127 130 PF01048 0.509
MOD_GlcNHglycan 154 157 PF01048 0.476
MOD_GlcNHglycan 196 199 PF01048 0.606
MOD_GlcNHglycan 202 205 PF01048 0.587
MOD_GlcNHglycan 212 215 PF01048 0.382
MOD_GlcNHglycan 29 32 PF01048 0.548
MOD_GlcNHglycan 46 49 PF01048 0.454
MOD_GSK3_1 121 128 PF00069 0.648
MOD_GSK3_1 129 136 PF00069 0.679
MOD_GSK3_1 14 21 PF00069 0.813
MOD_GSK3_1 151 158 PF00069 0.363
MOD_GSK3_1 176 183 PF00069 0.310
MOD_GSK3_1 206 213 PF00069 0.395
MOD_GSK3_1 22 29 PF00069 0.750
MOD_GSK3_1 309 316 PF00069 0.319
MOD_GSK3_1 31 38 PF00069 0.780
MOD_GSK3_1 60 67 PF00069 0.768
MOD_LATS_1 233 239 PF00433 0.500
MOD_NEK2_1 188 193 PF00069 0.327
MOD_NEK2_1 217 222 PF00069 0.382
MOD_NEK2_1 310 315 PF00069 0.310
MOD_NEK2_1 323 328 PF00069 0.334
MOD_PIKK_1 129 135 PF00454 0.633
MOD_PIKK_1 14 20 PF00454 0.743
MOD_PIKK_1 155 161 PF00454 0.336
MOD_PIKK_1 80 86 PF00454 0.753
MOD_PKA_2 129 135 PF00069 0.618
MOD_PKA_2 183 189 PF00069 0.366
MOD_PKA_2 35 41 PF00069 0.798
MOD_PKB_1 119 127 PF00069 0.685
MOD_Plk_1 22 28 PF00069 0.788
MOD_Plk_1 288 294 PF00069 0.477
MOD_Plk_4 133 139 PF00069 0.529
MOD_Plk_4 166 172 PF00069 0.289
MOD_Plk_4 213 219 PF00069 0.405
MOD_ProDKin_1 233 239 PF00069 0.564
MOD_ProDKin_1 68 74 PF00069 0.739
MOD_SUMO_for_1 57 60 PF00179 0.720
TRG_DiLeu_BaLyEn_6 51 56 PF01217 0.634
TRG_ENDOCYTIC_2 138 141 PF00928 0.385
TRG_ENDOCYTIC_2 240 243 PF00928 0.554
TRG_ENDOCYTIC_2 335 338 PF00928 0.447
TRG_ER_diArg_1 193 196 PF00400 0.298
TRG_ER_diArg_1 53 55 PF00400 0.702
TRG_NLS_Bipartite_1 76 98 PF00514 0.725
TRG_Pf-PMV_PEXEL_1 66 70 PF00026 0.592

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7I8 Leptomonas seymouri 44% 100%
A0A1X0NYN9 Trypanosomatidae 41% 100%
A0A3S7X1H6 Leishmania donovani 92% 100%
A4HDI3 Leishmania braziliensis 26% 100%
A4HGJ1 Leishmania braziliensis 63% 100%
A4I0W6 Leishmania infantum 24% 100%
A4I3L8 Leishmania infantum 92% 100%
E9AZV8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 76% 100%
V5AQB9 Trypanosoma cruzi 36% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS