Amastin surface glycofamily protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Amastin surface glycoprotein, putative

Species:

Leishmania major

UniProt:

Q4Q8C7_LEIMA

TriTrypDb:

LmjF.28.1390 , LMJLV39_280021500 , LMJSD75_280021000

Length:

342

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Amastin, Kinetoplastid host adhesion protein. A host adhesion protein family greatly expanded in Leishmaniids.. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0020016	ciliary pocket	2	2
GO:0110165	cellular anatomical entity	1	10

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Expansion

Sequence features

Q4Q8C7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8C7

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.611
CLV_C14_Caspase3-7	17	21	PF00656	0.737
CLV_C14_Caspase3-7	253	257	PF00656	0.461
CLV_NRD_NRD_1	184	186	PF00675	0.591
CLV_NRD_NRD_1	193	195	PF00675	0.547
CLV_NRD_NRD_1	53	55	PF00675	0.622
CLV_PCSK_KEX2_1	184	186	PF00082	0.591
CLV_PCSK_KEX2_1	193	195	PF00082	0.547
CLV_PCSK_KEX2_1	53	55	PF00082	0.617
CLV_PCSK_KEX2_1	76	78	PF00082	0.551

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7I8	Leptomonas seymouri	44%	100%
A0A1X0NYN9	Trypanosomatidae	41%	100%
A0A3S7X1H6	Leishmania donovani	92%	100%
A4HDI3	Leishmania braziliensis	26%	100%
A4HGJ1	Leishmania braziliensis	63%	100%
A4I0W6	Leishmania infantum	24%	100%
A4I3L8	Leishmania infantum	92%	100%
E9AZV8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
V5AQB9	Trypanosoma cruzi	36%	100%

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