Amastin-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like protein

Species:

Leishmania major

UniProt:

Q4Q8C6_LEIMA

TriTrypDb:

LmjF.28.1400 , LMJLV39_280021600 , LMJSD75_280021100

Length:

540

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q8C6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8C6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	200	202	PF00675	0.493
CLV_NRD_NRD_1	424	426	PF00675	0.489
CLV_NRD_NRD_1	535	537	PF00675	0.364
CLV_NRD_NRD_1	6	8	PF00675	0.412
CLV_PCSK_KEX2_1	199	201	PF00082	0.569
CLV_PCSK_KEX2_1	424	426	PF00082	0.467
CLV_PCSK_KEX2_1	535	537	PF00082	0.364
CLV_PCSK_KEX2_1	6	8	PF00082	0.412
CLV_PCSK_SKI1_1	154	158	PF00082	0.531
CLV_PCSK_SKI1_1	467	471	PF00082	0.291
CLV_PCSK_SKI1_1	8	12	PF00082	0.458
DEG_APCC_DBOX_1	466	474	PF00400	0.491
DEG_SCF_FBW7_1	105	112	PF00400	0.741
DOC_CKS1_1	269	274	PF01111	0.731
DOC_CKS1_1	418	423	PF01111	0.274
DOC_MAPK_MEF2A_6	365	374	PF00069	0.289
DOC_PP4_FxxP_1	526	529	PF00568	0.327
DOC_USP7_MATH_1	101	105	PF00917	0.751
DOC_USP7_MATH_1	119	123	PF00917	0.634
DOC_USP7_MATH_1	167	171	PF00917	0.701
DOC_USP7_MATH_1	259	263	PF00917	0.699
DOC_USP7_MATH_1	315	319	PF00917	0.641
DOC_USP7_MATH_1	380	384	PF00917	0.241
DOC_USP7_MATH_1	47	51	PF00917	0.616
DOC_USP7_MATH_1	527	531	PF00917	0.277
DOC_USP7_MATH_1	76	80	PF00917	0.634
DOC_WW_Pin1_4	105	110	PF00397	0.737
DOC_WW_Pin1_4	114	119	PF00397	0.735
DOC_WW_Pin1_4	201	206	PF00397	0.731
DOC_WW_Pin1_4	255	260	PF00397	0.695
DOC_WW_Pin1_4	268	273	PF00397	0.710
DOC_WW_Pin1_4	32	37	PF00397	0.687
DOC_WW_Pin1_4	417	422	PF00397	0.274
LIG_14-3-3_CanoR_1	102	108	PF00244	0.738
LIG_14-3-3_CanoR_1	172	176	PF00244	0.715
LIG_14-3-3_CanoR_1	277	285	PF00244	0.654
LIG_APCC_ABBAyCdc20_2	7	13	PF00400	0.614
LIG_BIR_II_1	1	5	PF00653	0.657
LIG_BRCT_BRCA1_1	317	321	PF00533	0.581
LIG_BRCT_BRCA1_1	68	72	PF00533	0.645
LIG_EH1_1	432	440	PF00400	0.381
LIG_FHA_1	202	208	PF00498	0.700
LIG_FHA_1	384	390	PF00498	0.303
LIG_FHA_1	408	414	PF00498	0.318
LIG_FHA_1	418	424	PF00498	0.398
LIG_FHA_1	435	441	PF00498	0.245
LIG_FHA_1	459	465	PF00498	0.520
LIG_FHA_1	478	484	PF00498	0.317
LIG_FHA_2	106	112	PF00498	0.700
LIG_FHA_2	220	226	PF00498	0.699
LIG_FHA_2	82	88	PF00498	0.628
LIG_LIR_Apic_2	161	166	PF02991	0.673
LIG_LIR_Apic_2	318	322	PF02991	0.592
LIG_LIR_Apic_2	409	414	PF02991	0.290
LIG_LIR_Gen_1	484	492	PF02991	0.309
LIG_LIR_Gen_1	78	86	PF02991	0.725
LIG_LIR_Nem_3	264	270	PF02991	0.758
LIG_LIR_Nem_3	313	319	PF02991	0.595
LIG_LIR_Nem_3	398	402	PF02991	0.273
LIG_LIR_Nem_3	484	488	PF02991	0.309
LIG_LIR_Nem_3	78	83	PF02991	0.727
LIG_MYND_1	322	326	PF01753	0.571
LIG_NRBOX	437	443	PF00104	0.334
LIG_SH2_CRK	163	167	PF00017	0.678
LIG_SH2_CRK	411	415	PF00017	0.258
LIG_SH2_NCK_1	163	167	PF00017	0.678
LIG_SH2_NCK_1	270	274	PF00017	0.777
LIG_SH2_PTP2	319	322	PF00017	0.597
LIG_SH2_SRC	369	372	PF00017	0.251
LIG_SH2_STAP1	290	294	PF00017	0.656
LIG_SH2_STAT5	203	206	PF00017	0.698
LIG_SH2_STAT5	270	273	PF00017	0.823
LIG_SH2_STAT5	319	322	PF00017	0.597
LIG_SH2_STAT5	358	361	PF00017	0.562
LIG_SH2_STAT5	369	372	PF00017	0.303
LIG_SH2_STAT5	411	414	PF00017	0.420
LIG_SH2_STAT5	422	425	PF00017	0.288
LIG_SH2_STAT5	51	54	PF00017	0.598
LIG_SH3_3	115	121	PF00018	0.750
LIG_SH3_3	126	132	PF00018	0.654
LIG_SH3_3	182	188	PF00018	0.684
LIG_SH3_3	30	36	PF00018	0.700
LIG_SH3_3	343	349	PF00018	0.555
LIG_SH3_3	379	385	PF00018	0.306
LIG_SH3_3	413	419	PF00018	0.274
LIG_SH3_3	70	76	PF00018	0.656
LIG_SH3_3	80	86	PF00018	0.704
LIG_SUMO_SIM_anti_2	386	393	PF11976	0.284
LIG_SUMO_SIM_anti_2	434	440	PF11976	0.381
LIG_SUMO_SIM_par_1	380	387	PF11976	0.301
LIG_SUMO_SIM_par_1	460	466	PF11976	0.458
LIG_TRAF2_1	286	289	PF00917	0.651
LIG_WRC_WIRS_1	14	19	PF05994	0.730
MOD_CDK_SPK_2	105	110	PF00069	0.737
MOD_CDK_SPxxK_3	417	424	PF00069	0.274
MOD_CK1_1	15	21	PF00069	0.698
MOD_CK1_1	161	167	PF00069	0.727
MOD_CK1_1	306	312	PF00069	0.648
MOD_CK1_1	383	389	PF00069	0.309
MOD_CK1_1	409	415	PF00069	0.308
MOD_CK1_1	434	440	PF00069	0.309
MOD_CK1_1	463	469	PF00069	0.462
MOD_CK1_1	50	56	PF00069	0.662
MOD_CK2_1	114	120	PF00069	0.778
MOD_CK2_1	13	19	PF00069	0.682
MOD_CK2_1	171	177	PF00069	0.745
MOD_CK2_1	219	225	PF00069	0.697
MOD_CK2_1	255	261	PF00069	0.700
MOD_CK2_1	283	289	PF00069	0.676
MOD_CK2_1	81	87	PF00069	0.628
MOD_Cter_Amidation	197	200	PF01082	0.497
MOD_DYRK1A_RPxSP_1	114	118	PF00069	0.717
MOD_DYRK1A_RPxSP_1	201	205	PF00069	0.697
MOD_GlcNHglycan	120	124	PF01048	0.523
MOD_GlcNHglycan	143	146	PF01048	0.531
MOD_GlcNHglycan	158	161	PF01048	0.465
MOD_GlcNHglycan	163	166	PF01048	0.457
MOD_GlcNHglycan	217	220	PF01048	0.526
MOD_GlcNHglycan	284	288	PF01048	0.488
MOD_GlcNHglycan	305	308	PF01048	0.447
MOD_GlcNHglycan	40	43	PF01048	0.534
MOD_GlcNHglycan	493	496	PF01048	0.489
MOD_GlcNHglycan	55	58	PF01048	0.414
MOD_GSK3_1	101	108	PF00069	0.692
MOD_GSK3_1	167	174	PF00069	0.732
MOD_GSK3_1	215	222	PF00069	0.649
MOD_GSK3_1	251	258	PF00069	0.721
MOD_GSK3_1	380	387	PF00069	0.331
MOD_GSK3_1	477	484	PF00069	0.290
MOD_GSK3_1	62	69	PF00069	0.675
MOD_N-GLC_1	407	412	PF02516	0.491
MOD_N-GLC_1	510	515	PF02516	0.473
MOD_NEK2_1	373	378	PF00069	0.364
MOD_NEK2_1	510	515	PF00069	0.341
MOD_NEK2_1	55	60	PF00069	0.709
MOD_PIKK_1	167	173	PF00454	0.689
MOD_PIKK_1	384	390	PF00454	0.282
MOD_PIKK_1	453	459	PF00454	0.243
MOD_PIKK_1	477	483	PF00454	0.277
MOD_PKA_2	101	107	PF00069	0.751
MOD_PKA_2	171	177	PF00069	0.786
MOD_PKA_2	276	282	PF00069	0.656
MOD_Plk_1	12	18	PF00069	0.727
MOD_Plk_1	406	412	PF00069	0.379
MOD_Plk_1	510	516	PF00069	0.326
MOD_Plk_2-3	13	19	PF00069	0.679
MOD_Plk_4	315	321	PF00069	0.596
MOD_Plk_4	434	440	PF00069	0.237
MOD_Plk_4	47	53	PF00069	0.596
MOD_Plk_4	511	517	PF00069	0.389
MOD_Plk_4	95	101	PF00069	0.792
MOD_ProDKin_1	105	111	PF00069	0.739
MOD_ProDKin_1	114	120	PF00069	0.734
MOD_ProDKin_1	201	207	PF00069	0.731
MOD_ProDKin_1	255	261	PF00069	0.695
MOD_ProDKin_1	268	274	PF00069	0.706
MOD_ProDKin_1	32	38	PF00069	0.685
MOD_ProDKin_1	417	423	PF00069	0.274
MOD_SUMO_rev_2	247	255	PF00179	0.712
TRG_ENDOCYTIC_2	358	361	PF00928	0.547
TRG_ENDOCYTIC_2	369	372	PF00928	0.309
TRG_ER_diArg_1	199	201	PF00400	0.737
TRG_ER_diArg_1	423	425	PF00400	0.268
TRG_ER_diArg_1	5	7	PF00400	0.610
TRG_NLS_MonoExtC_3	6	12	PF00514	0.611
TRG_NLS_MonoExtN_4	6	11	PF00514	0.612

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZU6	Leptomonas seymouri	40%	100%
A0A3S7X1I0	Leishmania donovani	85%	100%
A4I3L9	Leishmania infantum	85%	100%
E9AIT0	Leishmania braziliensis	57%	100%
E9AZV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	99%