LeishMANIAdb
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DNA polymerase kappa

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
DNA polymerase kappa
Gene product:
DNA polymerase kappa, putative
Species:
Leishmania major
UniProt:
Q4Q8C5_LEIMA
TriTrypDb:
LmjF.28.1410 , LMJLV39_280021800 * , LMJSD75_280021300 *
Length:
751

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 3
GO:0043226 organelle 2 3
GO:0043227 membrane-bounded organelle 3 3
GO:0043229 intracellular organelle 3 3
GO:0043231 intracellular membrane-bounded organelle 4 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

Q4Q8C5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8C5

Function

Biological processes
Term Name Level Count
GO:0000731 DNA synthesis involved in DNA repair 6 3
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006259 DNA metabolic process 4 12
GO:0006281 DNA repair 5 12
GO:0006301 postreplication repair 6 3
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0006950 response to stress 2 12
GO:0006974 DNA damage response 4 12
GO:0008152 metabolic process 1 12
GO:0009058 biosynthetic process 2 3
GO:0009059 macromolecule biosynthetic process 4 3
GO:0009987 cellular process 1 12
GO:0018130 heterocycle biosynthetic process 4 3
GO:0019438 aromatic compound biosynthetic process 4 3
GO:0019985 translesion synthesis 7 3
GO:0033554 cellular response to stress 3 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0034654 nucleobase-containing compound biosynthetic process 4 3
GO:0042276 error-prone translesion synthesis 8 3
GO:0043170 macromolecule metabolic process 3 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044249 cellular biosynthetic process 3 3
GO:0044260 obsolete cellular macromolecule metabolic process 3 12
GO:0044271 cellular nitrogen compound biosynthetic process 4 3
GO:0046483 heterocycle metabolic process 3 12
GO:0050896 response to stimulus 1 12
GO:0051716 cellular response to stimulus 2 12
GO:0071704 organic substance metabolic process 2 12
GO:0071897 DNA biosynthetic process 5 3
GO:0090304 nucleic acid metabolic process 4 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:1901362 organic cyclic compound biosynthetic process 4 3
GO:1901576 organic substance biosynthetic process 3 3
GO:0006260 DNA replication 5 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003677 DNA binding 4 12
GO:0003684 damaged DNA binding 5 12
GO:0003824 catalytic activity 1 12
GO:0003887 DNA-directed DNA polymerase activity 5 12
GO:0005488 binding 1 12
GO:0016740 transferase activity 2 12
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 12
GO:0016779 nucleotidyltransferase activity 4 12
GO:0034061 DNA polymerase activity 4 12
GO:0097159 organic cyclic compound binding 2 12
GO:0140097 catalytic activity, acting on DNA 3 12
GO:0140640 catalytic activity, acting on a nucleic acid 2 12
GO:1901363 heterocyclic compound binding 2 12
GO:0043167 ion binding 2 1
GO:0043169 cation binding 3 1
GO:0046872 metal ion binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 674 678 PF00656 0.728
CLV_NRD_NRD_1 147 149 PF00675 0.426
CLV_NRD_NRD_1 178 180 PF00675 0.441
CLV_NRD_NRD_1 273 275 PF00675 0.288
CLV_NRD_NRD_1 31 33 PF00675 0.606
CLV_NRD_NRD_1 364 366 PF00675 0.384
CLV_NRD_NRD_1 454 456 PF00675 0.459
CLV_NRD_NRD_1 504 506 PF00675 0.357
CLV_NRD_NRD_1 532 534 PF00675 0.389
CLV_NRD_NRD_1 577 579 PF00675 0.279
CLV_NRD_NRD_1 606 608 PF00675 0.311
CLV_NRD_NRD_1 651 653 PF00675 0.809
CLV_NRD_NRD_1 660 662 PF00675 0.778
CLV_PCSK_KEX2_1 31 33 PF00082 0.609
CLV_PCSK_KEX2_1 363 365 PF00082 0.376
CLV_PCSK_KEX2_1 532 534 PF00082 0.380
CLV_PCSK_KEX2_1 577 579 PF00082 0.279
CLV_PCSK_KEX2_1 605 607 PF00082 0.315
CLV_PCSK_KEX2_1 650 652 PF00082 0.673
CLV_PCSK_KEX2_1 662 664 PF00082 0.747
CLV_PCSK_PC1ET2_1 662 664 PF00082 0.824
CLV_PCSK_SKI1_1 32 36 PF00082 0.569
CLV_PCSK_SKI1_1 520 524 PF00082 0.267
CLV_PCSK_SKI1_1 577 581 PF00082 0.279
CLV_Separin_Metazoa 574 578 PF03568 0.479
DEG_APCC_DBOX_1 445 453 PF00400 0.400
DEG_APCC_DBOX_1 519 527 PF00400 0.494
DEG_APCC_DBOX_1 576 584 PF00400 0.479
DEG_SCF_FBW7_1 54 61 PF00400 0.594
DEG_SPOP_SBC_1 478 482 PF00917 0.611
DEG_SPOP_SBC_1 709 713 PF00917 0.596
DOC_ANK_TNKS_1 664 671 PF00023 0.589
DOC_CKS1_1 55 60 PF01111 0.606
DOC_MAPK_gen_1 184 193 PF00069 0.433
DOC_MAPK_gen_1 577 585 PF00069 0.433
DOC_MAPK_HePTP_8 575 587 PF00069 0.475
DOC_MAPK_MEF2A_6 227 236 PF00069 0.445
DOC_MAPK_MEF2A_6 289 296 PF00069 0.472
DOC_MAPK_MEF2A_6 578 587 PF00069 0.475
DOC_MIT_MIM_1 594 606 PF04212 0.459
DOC_PP1_RVXF_1 139 146 PF00149 0.597
DOC_PP2B_LxvP_1 583 586 PF13499 0.493
DOC_PP4_FxxP_1 126 129 PF00568 0.575
DOC_SPAK_OSR1_1 351 355 PF12202 0.479
DOC_USP7_MATH_1 102 106 PF00917 0.732
DOC_USP7_MATH_1 107 111 PF00917 0.801
DOC_USP7_MATH_1 119 123 PF00917 0.620
DOC_USP7_MATH_1 479 483 PF00917 0.688
DOC_USP7_MATH_1 672 676 PF00917 0.598
DOC_USP7_UBL2_3 165 169 PF12436 0.458
DOC_USP7_UBL2_3 560 564 PF12436 0.479
DOC_WW_Pin1_4 10 15 PF00397 0.709
DOC_WW_Pin1_4 378 383 PF00397 0.459
DOC_WW_Pin1_4 38 43 PF00397 0.672
DOC_WW_Pin1_4 46 51 PF00397 0.685
DOC_WW_Pin1_4 54 59 PF00397 0.487
DOC_WW_Pin1_4 627 632 PF00397 0.550
DOC_WW_Pin1_4 70 75 PF00397 0.691
DOC_WW_Pin1_4 713 718 PF00397 0.673
LIG_14-3-3_CanoR_1 32 42 PF00244 0.737
LIG_14-3-3_CanoR_1 455 459 PF00244 0.371
LIG_14-3-3_CanoR_1 505 509 PF00244 0.483
LIG_14-3-3_CanoR_1 532 539 PF00244 0.582
LIG_Actin_WH2_2 519 534 PF00022 0.539
LIG_APCC_ABBA_1 232 237 PF00400 0.314
LIG_APCC_ABBA_1 566 571 PF00400 0.496
LIG_BIR_II_1 1 5 PF00653 0.671
LIG_BRCT_BRCA1_1 307 311 PF00533 0.502
LIG_Clathr_ClatBox_1 324 328 PF01394 0.448
LIG_EVH1_1 51 55 PF00568 0.524
LIG_FHA_1 158 164 PF00498 0.482
LIG_FHA_1 267 273 PF00498 0.461
LIG_FHA_1 379 385 PF00498 0.471
LIG_FHA_1 54 60 PF00498 0.570
LIG_FHA_1 616 622 PF00498 0.591
LIG_FHA_1 62 68 PF00498 0.558
LIG_FHA_1 637 643 PF00498 0.622
LIG_FHA_2 436 442 PF00498 0.409
LIG_FHA_2 535 541 PF00498 0.479
LIG_FHA_2 698 704 PF00498 0.585
LIG_HCF-1_HBM_1 84 87 PF13415 0.528
LIG_LIR_Apic_2 125 129 PF02991 0.576
LIG_LIR_Apic_2 389 394 PF02991 0.526
LIG_LIR_Gen_1 228 236 PF02991 0.408
LIG_LIR_Gen_1 239 247 PF02991 0.449
LIG_LIR_Gen_1 457 466 PF02991 0.391
LIG_LIR_Gen_1 589 599 PF02991 0.483
LIG_LIR_Nem_3 207 212 PF02991 0.510
LIG_LIR_Nem_3 228 232 PF02991 0.398
LIG_LIR_Nem_3 239 245 PF02991 0.461
LIG_LIR_Nem_3 308 314 PF02991 0.494
LIG_LIR_Nem_3 457 461 PF02991 0.320
LIG_LIR_Nem_3 511 517 PF02991 0.520
LIG_LIR_Nem_3 589 594 PF02991 0.467
LIG_NRBOX 579 585 PF00104 0.502
LIG_PCNA_PIPBox_1 331 340 PF02747 0.502
LIG_PCNA_yPIPBox_3 179 192 PF02747 0.408
LIG_PTB_Apo_2 247 254 PF02174 0.502
LIG_PTB_Apo_2 641 648 PF02174 0.463
LIG_PTB_Phospho_1 247 253 PF10480 0.502
LIG_PTB_Phospho_1 641 647 PF10480 0.460
LIG_Rb_pABgroove_1 466 474 PF01858 0.491
LIG_REV1ctd_RIR_1 124 128 PF16727 0.513
LIG_REV1ctd_RIR_1 635 644 PF16727 0.607
LIG_SH2_CRK 391 395 PF00017 0.401
LIG_SH2_CRK 528 532 PF00017 0.485
LIG_SH2_GRB2like 174 177 PF00017 0.412
LIG_SH2_NCK_1 253 257 PF00017 0.552
LIG_SH2_SRC 253 256 PF00017 0.448
LIG_SH2_STAP1 198 202 PF00017 0.435
LIG_SH2_STAP1 458 462 PF00017 0.372
LIG_SH2_STAT3 276 279 PF00017 0.433
LIG_SH2_STAT5 144 147 PF00017 0.431
LIG_SH2_STAT5 174 177 PF00017 0.487
LIG_SH2_STAT5 233 236 PF00017 0.335
LIG_SH2_STAT5 271 274 PF00017 0.530
LIG_SH2_STAT5 337 340 PF00017 0.496
LIG_SH2_STAT5 411 414 PF00017 0.531
LIG_SH2_STAT5 451 454 PF00017 0.369
LIG_SH2_STAT5 569 572 PF00017 0.488
LIG_SH3_3 292 298 PF00018 0.459
LIG_SH3_3 39 45 PF00018 0.669
LIG_SH3_3 47 53 PF00018 0.683
LIG_SH3_3 56 62 PF00018 0.643
LIG_SH3_4 393 400 PF00018 0.382
LIG_SUMO_SIM_anti_2 683 692 PF11976 0.573
LIG_SUMO_SIM_par_1 293 300 PF11976 0.502
LIG_SUMO_SIM_par_1 617 623 PF11976 0.566
LIG_SUMO_SIM_par_1 64 69 PF11976 0.523
LIG_SUMO_SIM_par_1 689 697 PF11976 0.656
LIG_TYR_ITIM 526 531 PF00017 0.340
LIG_UBA3_1 163 169 PF00899 0.473
LIG_UBA3_1 449 456 PF00899 0.528
MOD_CDK_SPK_2 41 46 PF00069 0.605
MOD_CDK_SPxK_1 70 76 PF00069 0.576
MOD_CK1_1 109 115 PF00069 0.683
MOD_CK1_1 122 128 PF00069 0.559
MOD_CK1_1 168 174 PF00069 0.435
MOD_CK1_1 201 207 PF00069 0.423
MOD_CK1_1 225 231 PF00069 0.440
MOD_CK1_1 264 270 PF00069 0.412
MOD_CK1_1 41 47 PF00069 0.727
MOD_CK1_1 426 432 PF00069 0.435
MOD_CK1_1 474 480 PF00069 0.558
MOD_CK1_1 534 540 PF00069 0.330
MOD_CK1_1 645 651 PF00069 0.524
MOD_CK1_1 694 700 PF00069 0.638
MOD_CK1_1 708 714 PF00069 0.594
MOD_CK1_1 716 722 PF00069 0.679
MOD_CK1_1 8 14 PF00069 0.643
MOD_CK1_1 88 94 PF00069 0.697
MOD_CK2_1 435 441 PF00069 0.386
MOD_CK2_1 534 540 PF00069 0.324
MOD_CK2_1 620 626 PF00069 0.600
MOD_CK2_1 680 686 PF00069 0.673
MOD_CK2_1 697 703 PF00069 0.735
MOD_CK2_1 80 86 PF00069 0.591
MOD_Cter_Amidation 503 506 PF01082 0.449
MOD_Cter_Amidation 648 651 PF01082 0.502
MOD_GlcNHglycan 109 112 PF01048 0.642
MOD_GlcNHglycan 121 124 PF01048 0.671
MOD_GlcNHglycan 153 156 PF01048 0.612
MOD_GlcNHglycan 279 282 PF01048 0.482
MOD_GlcNHglycan 307 310 PF01048 0.367
MOD_GlcNHglycan 374 377 PF01048 0.355
MOD_GlcNHglycan 481 484 PF01048 0.762
MOD_GlcNHglycan 622 625 PF01048 0.631
MOD_GlcNHglycan 644 647 PF01048 0.569
MOD_GlcNHglycan 68 71 PF01048 0.641
MOD_GlcNHglycan 7 10 PF01048 0.714
MOD_GlcNHglycan 740 744 PF01048 0.716
MOD_GlcNHglycan 80 83 PF01048 0.701
MOD_GlcNHglycan 91 94 PF01048 0.662
MOD_GSK3_1 102 109 PF00069 0.722
MOD_GSK3_1 13 20 PF00069 0.587
MOD_GSK3_1 130 137 PF00069 0.639
MOD_GSK3_1 165 172 PF00069 0.409
MOD_GSK3_1 261 268 PF00069 0.288
MOD_GSK3_1 4 11 PF00069 0.643
MOD_GSK3_1 474 481 PF00069 0.640
MOD_GSK3_1 483 490 PF00069 0.707
MOD_GSK3_1 54 61 PF00069 0.726
MOD_GSK3_1 62 69 PF00069 0.647
MOD_GSK3_1 626 633 PF00069 0.605
MOD_GSK3_1 705 712 PF00069 0.693
MOD_GSK3_1 716 723 PF00069 0.605
MOD_GSK3_1 76 83 PF00069 0.710
MOD_GSK3_1 85 92 PF00069 0.720
MOD_LATS_1 558 564 PF00433 0.319
MOD_N-GLC_1 134 139 PF02516 0.563
MOD_N-GLC_1 169 174 PF02516 0.411
MOD_N-GLC_1 89 94 PF02516 0.647
MOD_NEK2_1 192 197 PF00069 0.493
MOD_NEK2_1 265 270 PF00069 0.320
MOD_NEK2_1 35 40 PF00069 0.591
MOD_NEK2_1 372 377 PF00069 0.325
MOD_NEK2_1 461 466 PF00069 0.365
MOD_NEK2_1 543 548 PF00069 0.328
MOD_NEK2_1 642 647 PF00069 0.745
MOD_NEK2_1 66 71 PF00069 0.623
MOD_NEK2_1 710 715 PF00069 0.618
MOD_NEK2_1 75 80 PF00069 0.627
MOD_NEK2_2 198 203 PF00069 0.393
MOD_NEK2_2 617 622 PF00069 0.602
MOD_PIKK_1 531 537 PF00454 0.392
MOD_PIKK_1 543 549 PF00454 0.346
MOD_PIKK_1 656 662 PF00454 0.643
MOD_PIKK_1 694 700 PF00454 0.638
MOD_PKA_2 426 432 PF00069 0.403
MOD_PKA_2 454 460 PF00069 0.424
MOD_PKA_2 474 480 PF00069 0.421
MOD_PKA_2 504 510 PF00069 0.355
MOD_PKA_2 531 537 PF00069 0.414
MOD_PKA_2 664 670 PF00069 0.749
MOD_PKA_2 720 726 PF00069 0.620
MOD_PKA_2 75 81 PF00069 0.736
MOD_PKB_1 605 613 PF00069 0.497
MOD_Plk_1 169 175 PF00069 0.413
MOD_Plk_1 198 204 PF00069 0.397
MOD_Plk_1 510 516 PF00069 0.320
MOD_Plk_2-3 17 23 PF00069 0.506
MOD_Plk_2-3 673 679 PF00069 0.692
MOD_Plk_4 122 128 PF00069 0.653
MOD_Plk_4 169 175 PF00069 0.413
MOD_Plk_4 228 234 PF00069 0.385
MOD_Plk_4 24 30 PF00069 0.644
MOD_Plk_4 261 267 PF00069 0.288
MOD_Plk_4 426 432 PF00069 0.431
MOD_Plk_4 534 540 PF00069 0.350
MOD_Plk_4 62 68 PF00069 0.514
MOD_Plk_4 705 711 PF00069 0.512
MOD_ProDKin_1 10 16 PF00069 0.707
MOD_ProDKin_1 378 384 PF00069 0.302
MOD_ProDKin_1 38 44 PF00069 0.672
MOD_ProDKin_1 46 52 PF00069 0.684
MOD_ProDKin_1 54 60 PF00069 0.486
MOD_ProDKin_1 627 633 PF00069 0.545
MOD_ProDKin_1 70 76 PF00069 0.693
MOD_ProDKin_1 713 719 PF00069 0.672
MOD_SUMO_rev_2 146 150 PF00179 0.411
MOD_SUMO_rev_2 172 181 PF00179 0.492
MOD_SUMO_rev_2 701 708 PF00179 0.556
TRG_DiLeu_BaEn_1 21 26 PF01217 0.572
TRG_DiLeu_BaLyEn_6 592 597 PF01217 0.349
TRG_ENDOCYTIC_2 233 236 PF00928 0.330
TRG_ENDOCYTIC_2 253 256 PF00928 0.150
TRG_ENDOCYTIC_2 458 461 PF00928 0.378
TRG_ENDOCYTIC_2 515 518 PF00928 0.392
TRG_ENDOCYTIC_2 528 531 PF00928 0.312
TRG_ER_diArg_1 363 365 PF00400 0.292
TRG_ER_diArg_1 446 449 PF00400 0.399
TRG_ER_diArg_1 531 533 PF00400 0.473
TRG_ER_diArg_1 576 578 PF00400 0.330
TRG_ER_diArg_1 604 607 PF00400 0.381
TRG_ER_diArg_1 650 652 PF00400 0.601
TRG_ER_diArg_1 661 664 PF00400 0.713
TRG_NES_CRM1_1 323 336 PF08389 0.364
TRG_NES_CRM1_1 574 589 PF08389 0.352
TRG_NLS_Bipartite_1 650 666 PF00514 0.598
TRG_NLS_MonoCore_2 661 666 PF00514 0.623
TRG_NLS_MonoExtC_3 660 665 PF00514 0.809
TRG_NLS_MonoExtN_4 661 666 PF00514 0.634
TRG_Pf-PMV_PEXEL_1 210 215 PF00026 0.421
TRG_Pf-PMV_PEXEL_1 357 361 PF00026 0.330
TRG_Pf-PMV_PEXEL_1 364 368 PF00026 0.267
TRG_Pf-PMV_PEXEL_1 437 441 PF00026 0.280
TRG_Pf-PMV_PEXEL_1 578 582 PF00026 0.363

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7I6 Leptomonas seymouri 54% 100%
A0A0S4JDU0 Bodo saltans 38% 84%
A0A3Q8IEM0 Leishmania donovani 89% 100%
A0A3S7X1J7 Leishmania donovani 36% 100%
A4HGJ3 Leishmania braziliensis 71% 100%
A4I3M0 Leishmania infantum 90% 100%
A4I3M1 Leishmania infantum 37% 100%
E9AZW1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
E9AZW2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
P34409 Caenorhabditis elegans 31% 100%
Q4Q8C4 Leishmania major 36% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS