Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8C2_LEIMA

TriTrypDb:

LmjF.28.1440 , LMJLV39_280022200 , LMJSD75_280021700

Length:

725

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8C2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8C2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.520
CLV_C14_Caspase3-7	209	213	PF00656	0.550
CLV_C14_Caspase3-7	355	359	PF00656	0.566
CLV_C14_Caspase3-7	640	644	PF00656	0.557
CLV_NRD_NRD_1	117	119	PF00675	0.439
CLV_NRD_NRD_1	18	20	PF00675	0.655
CLV_NRD_NRD_1	244	246	PF00675	0.389
CLV_NRD_NRD_1	26	28	PF00675	0.578
CLV_NRD_NRD_1	276	278	PF00675	0.397
CLV_NRD_NRD_1	326	328	PF00675	0.630
CLV_NRD_NRD_1	332	334	PF00675	0.584
CLV_NRD_NRD_1	37	39	PF00675	0.523
CLV_NRD_NRD_1	545	547	PF00675	0.621
CLV_NRD_NRD_1	628	630	PF00675	0.354
CLV_NRD_NRD_1	695	697	PF00675	0.542
CLV_NRD_NRD_1	713	715	PF00675	0.622
CLV_NRD_NRD_1	95	97	PF00675	0.692
CLV_PCSK_KEX2_1	18	20	PF00082	0.655
CLV_PCSK_KEX2_1	181	183	PF00082	0.429
CLV_PCSK_KEX2_1	244	246	PF00082	0.457
CLV_PCSK_KEX2_1	26	28	PF00082	0.578
CLV_PCSK_KEX2_1	276	278	PF00082	0.397
CLV_PCSK_KEX2_1	292	294	PF00082	0.516
CLV_PCSK_KEX2_1	326	328	PF00082	0.630
CLV_PCSK_KEX2_1	332	334	PF00082	0.584
CLV_PCSK_KEX2_1	42	44	PF00082	0.642
CLV_PCSK_KEX2_1	468	470	PF00082	0.396
CLV_PCSK_KEX2_1	695	697	PF00082	0.522
CLV_PCSK_KEX2_1	713	715	PF00082	0.658
CLV_PCSK_KEX2_1	95	97	PF00082	0.692
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.505
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.516
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.642
CLV_PCSK_PC1ET2_1	468	470	PF00082	0.396
CLV_PCSK_PC1ET2_1	695	697	PF00082	0.496
CLV_PCSK_PC1ET2_1	713	715	PF00082	0.586
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.680
CLV_PCSK_PC7_1	38	44	PF00082	0.620
CLV_PCSK_SKI1_1	19	23	PF00082	0.653
CLV_PCSK_SKI1_1	327	331	PF00082	0.579
CLV_PCSK_SKI1_1	39	43	PF00082	0.623
CLV_PCSK_SKI1_1	425	429	PF00082	0.620
CLV_PCSK_SKI1_1	469	473	PF00082	0.529
CLV_PCSK_SKI1_1	588	592	PF00082	0.461
CLV_PCSK_SKI1_1	629	633	PF00082	0.376
CLV_PCSK_SKI1_1	649	653	PF00082	0.375
CLV_PCSK_SKI1_1	683	687	PF00082	0.569
CLV_PCSK_SKI1_1	692	696	PF00082	0.479
CLV_PCSK_SKI1_1	697	701	PF00082	0.441
CLV_PCSK_SKI1_1	96	100	PF00082	0.667
DEG_APCC_DBOX_1	600	608	PF00400	0.489
DEG_COP1_1	135	143	PF00400	0.508
DEG_Nend_Nbox_1	1	3	PF02207	0.629
DEG_ODPH_VHL_1	512	525	PF01847	0.472
DEG_SPOP_SBC_1	217	221	PF00917	0.672
DEG_SPOP_SBC_1	353	357	PF00917	0.619
DOC_CKS1_1	311	316	PF01111	0.509
DOC_CKS1_1	444	449	PF01111	0.436
DOC_CYCLIN_RxL_1	160	173	PF00134	0.409
DOC_MAPK_DCC_7	409	417	PF00069	0.421
DOC_MAPK_gen_1	3	13	PF00069	0.627
DOC_MAPK_gen_1	646	655	PF00069	0.437
DOC_MAPK_MEF2A_6	409	417	PF00069	0.461
DOC_MAPK_MEF2A_6	6	15	PF00069	0.788
DOC_MAPK_MEF2A_6	646	655	PF00069	0.412
DOC_PP1_MyPhoNE_1	118	125	PF00149	0.436
DOC_PP1_RVXF_1	163	170	PF00149	0.411
DOC_PP1_RVXF_1	675	681	PF00149	0.465
DOC_PP2B_LxvP_1	13	16	PF13499	0.675
DOC_PP2B_LxvP_1	138	141	PF13499	0.515
DOC_PP2B_LxvP_1	502	505	PF13499	0.466
DOC_PP4_MxPP_1	663	666	PF00568	0.372
DOC_USP7_MATH_1	113	117	PF00917	0.483
DOC_USP7_MATH_1	132	136	PF00917	0.466
DOC_USP7_MATH_1	196	200	PF00917	0.449
DOC_USP7_MATH_1	216	220	PF00917	0.686
DOC_USP7_MATH_1	304	308	PF00917	0.512
DOC_USP7_MATH_1	413	417	PF00917	0.469
DOC_USP7_MATH_1	577	581	PF00917	0.494
DOC_WW_Pin1_4	310	315	PF00397	0.462
DOC_WW_Pin1_4	371	376	PF00397	0.402
DOC_WW_Pin1_4	443	448	PF00397	0.388
DOC_WW_Pin1_4	707	712	PF00397	0.740
LIG_14-3-3_CanoR_1	133	141	PF00244	0.360
LIG_14-3-3_CanoR_1	192	196	PF00244	0.531
LIG_14-3-3_CanoR_1	38	42	PF00244	0.666
LIG_14-3-3_CanoR_1	422	428	PF00244	0.432
LIG_14-3-3_CanoR_1	482	492	PF00244	0.281
LIG_14-3-3_CanoR_1	563	570	PF00244	0.470
LIG_14-3-3_CanoR_1	596	600	PF00244	0.506
LIG_14-3-3_CanoR_1	6	12	PF00244	0.644
LIG_14-3-3_CanoR_1	649	654	PF00244	0.453
LIG_BIR_III_4	212	216	PF00653	0.655
LIG_BRCT_BRCA1_1	105	109	PF00533	0.637
LIG_BRCT_BRCA1_1	198	202	PF00533	0.424
LIG_BRCT_BRCA1_1	429	433	PF00533	0.468
LIG_BRCT_BRCA1_1	79	83	PF00533	0.605
LIG_CtBP_PxDLS_1	505	509	PF00389	0.492
LIG_eIF4E_1	466	472	PF01652	0.386
LIG_eIF4E_1	493	499	PF01652	0.345
LIG_FHA_1	143	149	PF00498	0.485
LIG_FHA_1	329	335	PF00498	0.475
LIG_FHA_1	360	366	PF00498	0.471
LIG_FHA_1	371	377	PF00498	0.326
LIG_FHA_1	454	460	PF00498	0.394
LIG_FHA_1	507	513	PF00498	0.389
LIG_FHA_1	585	591	PF00498	0.450
LIG_FHA_1	650	656	PF00498	0.372
LIG_FHA_1	8	14	PF00498	0.630
LIG_FHA_2	151	157	PF00498	0.501
LIG_FHA_2	184	190	PF00498	0.496
LIG_FHA_2	311	317	PF00498	0.451
LIG_FHA_2	613	619	PF00498	0.510
LIG_FHA_2	97	103	PF00498	0.660
LIG_LIR_Apic_2	142	147	PF02991	0.508
LIG_LIR_Gen_1	199	210	PF02991	0.402
LIG_LIR_Gen_1	446	457	PF02991	0.377
LIG_LIR_Nem_3	106	112	PF02991	0.625
LIG_LIR_Nem_3	199	205	PF02991	0.358
LIG_LIR_Nem_3	263	268	PF02991	0.358
LIG_LIR_Nem_3	446	452	PF02991	0.377
LIG_LIR_Nem_3	456	460	PF02991	0.480
LIG_LIR_Nem_3	467	473	PF02991	0.358
LIG_LIR_Nem_3	591	595	PF02991	0.510
LIG_MLH1_MIPbox_1	198	202	PF16413	0.424
LIG_PDZ_Class_2	720	725	PF00595	0.572
LIG_Pex14_2	433	437	PF04695	0.538
LIG_Pex14_2	445	449	PF04695	0.258
LIG_SH2_CRK	144	148	PF00017	0.495
LIG_SH2_CRK	592	596	PF00017	0.454
LIG_SH2_NCK_1	485	489	PF00017	0.415
LIG_SH2_PTP2	650	653	PF00017	0.422
LIG_SH2_STAP1	265	269	PF00017	0.439
LIG_SH2_STAP1	466	470	PF00017	0.442
LIG_SH2_STAP1	485	489	PF00017	0.390
LIG_SH2_STAP1	84	88	PF00017	0.605
LIG_SH2_STAT3	64	67	PF00017	0.668
LIG_SH2_STAT5	125	128	PF00017	0.527
LIG_SH2_STAT5	144	147	PF00017	0.314
LIG_SH2_STAT5	178	181	PF00017	0.493
LIG_SH2_STAT5	201	204	PF00017	0.358
LIG_SH2_STAT5	246	249	PF00017	0.536
LIG_SH2_STAT5	268	271	PF00017	0.440
LIG_SH2_STAT5	470	473	PF00017	0.472
LIG_SH2_STAT5	474	477	PF00017	0.387
LIG_SH2_STAT5	485	488	PF00017	0.355
LIG_SH2_STAT5	493	496	PF00017	0.452
LIG_SH2_STAT5	586	589	PF00017	0.450
LIG_SH2_STAT5	650	653	PF00017	0.533
LIG_SH2_STAT5	679	682	PF00017	0.461
LIG_SH3_3	308	314	PF00018	0.595
LIG_SH3_3	594	600	PF00018	0.511
LIG_SH3_3	60	66	PF00018	0.675
LIG_SH3_3	659	665	PF00018	0.502
LIG_SUMO_SIM_anti_2	385	391	PF11976	0.464
LIG_SUMO_SIM_par_1	135	142	PF11976	0.513
LIG_SUMO_SIM_par_1	413	419	PF11976	0.397
LIG_SUMO_SIM_par_1	665	671	PF11976	0.542
LIG_SUMO_SIM_par_1	9	14	PF11976	0.632
LIG_TRAF2_1	615	618	PF00917	0.487
LIG_TYR_ITIM	590	595	PF00017	0.450
LIG_UBA3_1	541	548	PF00899	0.579
LIG_WRC_WIRS_1	417	422	PF05994	0.478
MOD_CDC14_SPxK_1	710	713	PF00782	0.625
MOD_CDK_SPxK_1	707	713	PF00069	0.623
MOD_CDK_SPxxK_3	707	714	PF00069	0.623
MOD_CK1_1	361	367	PF00069	0.537
MOD_CK1_1	416	422	PF00069	0.384
MOD_CK1_1	477	483	PF00069	0.380
MOD_CK2_1	150	156	PF00069	0.429
MOD_CK2_1	310	316	PF00069	0.450
MOD_CK2_1	612	618	PF00069	0.574
MOD_Cter_Amidation	711	714	PF01082	0.681
MOD_GlcNHglycan	206	209	PF01048	0.597
MOD_GlcNHglycan	337	340	PF01048	0.640
MOD_GlcNHglycan	402	405	PF01048	0.641
MOD_GlcNHglycan	409	412	PF01048	0.614
MOD_GlcNHglycan	47	50	PF01048	0.629
MOD_GlcNHglycan	592	595	PF01048	0.384
MOD_GSK3_1	260	267	PF00069	0.354
MOD_GSK3_1	354	361	PF00069	0.702
MOD_GSK3_1	423	430	PF00069	0.536
MOD_GSK3_1	433	440	PF00069	0.367
MOD_GSK3_1	517	524	PF00069	0.395
MOD_GSK3_1	55	62	PF00069	0.641
MOD_GSK3_1	584	591	PF00069	0.481
MOD_GSK3_1	7	14	PF00069	0.667
MOD_N-GLC_1	272	277	PF02516	0.383
MOD_N-GLC_1	506	511	PF02516	0.341
MOD_N-GLC_2	552	554	PF02516	0.513
MOD_NEK2_1	1	6	PF00069	0.548
MOD_NEK2_1	191	196	PF00069	0.469
MOD_NEK2_1	204	209	PF00069	0.395
MOD_NEK2_1	22	27	PF00069	0.647
MOD_NEK2_1	272	277	PF00069	0.383
MOD_NEK2_1	31	36	PF00069	0.640
MOD_NEK2_1	37	42	PF00069	0.647
MOD_NEK2_1	433	438	PF00069	0.548
MOD_NEK2_1	453	458	PF00069	0.406
MOD_NEK2_1	498	503	PF00069	0.448
MOD_NEK2_1	508	513	PF00069	0.393
MOD_NEK2_1	517	522	PF00069	0.375
MOD_NEK2_1	590	595	PF00069	0.399
MOD_NEK2_1	656	661	PF00069	0.443
MOD_NEK2_1	678	683	PF00069	0.460
MOD_NEK2_1	685	690	PF00069	0.382
MOD_NEK2_1	83	88	PF00069	0.642
MOD_NEK2_2	113	118	PF00069	0.456
MOD_NEK2_2	196	201	PF00069	0.444
MOD_NEK2_2	413	418	PF00069	0.398
MOD_NEK2_2	533	538	PF00069	0.487
MOD_NEK2_2	577	582	PF00069	0.473
MOD_PIKK_1	55	61	PF00454	0.763
MOD_PIKK_1	554	560	PF00454	0.513
MOD_PKA_1	96	102	PF00069	0.663
MOD_PKA_2	113	119	PF00069	0.454
MOD_PKA_2	132	138	PF00069	0.354
MOD_PKA_2	191	197	PF00069	0.552
MOD_PKA_2	335	341	PF00069	0.663
MOD_PKA_2	37	43	PF00069	0.700
MOD_PKA_2	477	483	PF00069	0.438
MOD_PKA_2	521	527	PF00069	0.482
MOD_PKA_2	562	568	PF00069	0.485
MOD_PKA_2	595	601	PF00069	0.416
MOD_Plk_1	260	266	PF00069	0.352
MOD_Plk_1	77	83	PF00069	0.566
MOD_Plk_1	84	90	PF00069	0.550
MOD_Plk_4	103	109	PF00069	0.615
MOD_Plk_4	196	202	PF00069	0.364
MOD_Plk_4	264	270	PF00069	0.437
MOD_Plk_4	498	504	PF00069	0.461
MOD_Plk_4	59	65	PF00069	0.707
MOD_Plk_4	718	724	PF00069	0.654
MOD_Plk_4	78	84	PF00069	0.609
MOD_ProDKin_1	310	316	PF00069	0.463
MOD_ProDKin_1	371	377	PF00069	0.401
MOD_ProDKin_1	443	449	PF00069	0.382
MOD_ProDKin_1	707	713	PF00069	0.741
MOD_SUMO_for_1	305	308	PF00179	0.421
MOD_SUMO_for_1	41	44	PF00179	0.675
MOD_SUMO_rev_2	225	235	PF00179	0.476
TRG_DiLeu_BaEn_1	467	472	PF01217	0.385
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.439
TRG_ENDOCYTIC_2	125	128	PF00928	0.537
TRG_ENDOCYTIC_2	171	174	PF00928	0.416
TRG_ENDOCYTIC_2	201	204	PF00928	0.358
TRG_ENDOCYTIC_2	268	271	PF00928	0.378
TRG_ENDOCYTIC_2	473	476	PF00928	0.418
TRG_ENDOCYTIC_2	592	595	PF00928	0.439
TRG_ENDOCYTIC_2	650	653	PF00928	0.446
TRG_ER_diArg_1	243	245	PF00400	0.384
TRG_ER_diArg_1	325	327	PF00400	0.610
TRG_ER_diArg_1	332	334	PF00400	0.568
TRG_ER_diArg_1	635	638	PF00400	0.478
TRG_NLS_Bipartite_1	695	717	PF00514	0.548
TRG_NLS_MonoExtC_3	545	550	PF00514	0.536
TRG_NLS_MonoExtN_4	711	717	PF00514	0.600
TRG_Pf-PMV_PEXEL_1	332	337	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	579	584	PF00026	0.345
TRG_Pf-PMV_PEXEL_1	96	101	PF00026	0.616

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1D3	Leptomonas seymouri	35%	86%
A0A3S5H7J3	Leishmania donovani	92%	100%
A4HGJ6	Leishmania braziliensis	77%	100%
A4I3M3	Leishmania infantum	92%	100%
E9AZW4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%