Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8C1_LEIMA

TriTrypDb:

LmjF.28.1450 , LMJLV39_280022300 , LMJSD75_280021800

Length:

743

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8C1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8C1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.683
CLV_C14_Caspase3-7	158	162	PF00656	0.725
CLV_C14_Caspase3-7	66	70	PF00656	0.589
CLV_C14_Caspase3-7	722	726	PF00656	0.687
CLV_C14_Caspase3-7	731	735	PF00656	0.573
CLV_NRD_NRD_1	105	107	PF00675	0.638
CLV_NRD_NRD_1	210	212	PF00675	0.726
CLV_NRD_NRD_1	483	485	PF00675	0.598
CLV_NRD_NRD_1	494	496	PF00675	0.601
CLV_NRD_NRD_1	71	73	PF00675	0.795
CLV_NRD_NRD_1	90	92	PF00675	0.734
CLV_PCSK_KEX2_1	105	107	PF00082	0.638
CLV_PCSK_KEX2_1	210	212	PF00082	0.726
CLV_PCSK_KEX2_1	483	485	PF00082	0.624
CLV_PCSK_KEX2_1	493	495	PF00082	0.597
CLV_PCSK_KEX2_1	563	565	PF00082	0.836
CLV_PCSK_KEX2_1	71	73	PF00082	0.804
CLV_PCSK_KEX2_1	90	92	PF00082	0.740
CLV_PCSK_PC1ET2_1	563	565	PF00082	0.825
CLV_PCSK_PC7_1	206	212	PF00082	0.806
CLV_PCSK_PC7_1	490	496	PF00082	0.812
CLV_PCSK_PC7_1	67	73	PF00082	0.588
CLV_PCSK_SKI1_1	206	210	PF00082	0.722
CLV_PCSK_SKI1_1	518	522	PF00082	0.787
CLV_PCSK_SKI1_1	650	654	PF00082	0.639
CLV_PCSK_SKI1_1	666	670	PF00082	0.530
CLV_PCSK_SKI1_1	72	76	PF00082	0.595
DEG_APCC_DBOX_1	300	308	PF00400	0.723
DEG_APCC_DBOX_1	531	539	PF00400	0.751
DEG_APCC_DBOX_1	540	548	PF00400	0.524
DEG_COP1_1	567	576	PF00400	0.734
DEG_Nend_Nbox_1	1	3	PF02207	0.645
DEG_SPOP_SBC_1	129	133	PF00917	0.579
DOC_CKS1_1	639	644	PF01111	0.737
DOC_MAPK_DCC_7	219	228	PF00069	0.725
DOC_MAPK_gen_1	90	97	PF00069	0.738
DOC_MAPK_MEF2A_6	219	228	PF00069	0.721
DOC_MAPK_RevD_3	480	495	PF00069	0.677
DOC_PP1_RVXF_1	397	404	PF00149	0.531
DOC_PP2B_LxvP_1	587	590	PF13499	0.812
DOC_PP2B_LxvP_1	7	10	PF13499	0.651
DOC_PP2B_LxvP_1	738	741	PF13499	0.762
DOC_PP2B_PxIxI_1	716	722	PF00149	0.735
DOC_PP4_FxxP_1	639	642	PF00568	0.814
DOC_PP4_FxxP_1	689	692	PF00568	0.692
DOC_USP7_MATH_1	129	133	PF00917	0.595
DOC_USP7_MATH_1	218	222	PF00917	0.737
DOC_USP7_MATH_1	316	320	PF00917	0.679
DOC_USP7_MATH_1	328	332	PF00917	0.653
DOC_USP7_MATH_1	35	39	PF00917	0.574
DOC_USP7_MATH_1	407	411	PF00917	0.655
DOC_USP7_MATH_1	447	451	PF00917	0.637
DOC_USP7_MATH_1	559	563	PF00917	0.580
DOC_USP7_MATH_1	607	611	PF00917	0.670
DOC_USP7_MATH_1	664	668	PF00917	0.638
DOC_WW_Pin1_4	11	16	PF00397	0.662
DOC_WW_Pin1_4	148	153	PF00397	0.744
DOC_WW_Pin1_4	189	194	PF00397	0.697
DOC_WW_Pin1_4	317	322	PF00397	0.739
DOC_WW_Pin1_4	511	516	PF00397	0.702
DOC_WW_Pin1_4	589	594	PF00397	0.762
DOC_WW_Pin1_4	638	643	PF00397	0.813
DOC_WW_Pin1_4	687	692	PF00397	0.793
DOC_WW_Pin1_4	711	716	PF00397	0.779
LIG_14-3-3_CanoR_1	168	176	PF00244	0.763
LIG_14-3-3_CanoR_1	219	226	PF00244	0.646
LIG_14-3-3_CanoR_1	246	250	PF00244	0.662
LIG_14-3-3_CanoR_1	408	413	PF00244	0.692
LIG_14-3-3_CanoR_1	518	527	PF00244	0.800
LIG_14-3-3_CanoR_1	54	64	PF00244	0.724
LIG_14-3-3_CanoR_1	541	550	PF00244	0.609
LIG_14-3-3_CanoR_1	650	660	PF00244	0.759
LIG_14-3-3_CanoR_1	90	95	PF00244	0.787
LIG_AP2alpha_1	460	464	PF02296	0.656
LIG_BIR_III_4	134	138	PF00653	0.636
LIG_BIR_III_4	472	476	PF00653	0.592
LIG_BRCT_BRCA1_1	92	96	PF00533	0.787
LIG_Clathr_ClatBox_1	727	731	PF01394	0.596
LIG_EVH1_1	587	591	PF00568	0.707
LIG_FHA_1	149	155	PF00498	0.816
LIG_FHA_1	218	224	PF00498	0.819
LIG_FHA_1	395	401	PF00498	0.621
LIG_FHA_1	612	618	PF00498	0.721
LIG_FHA_1	668	674	PF00498	0.627
LIG_FHA_2	494	500	PF00498	0.782
LIG_Integrin_RGD_1	67	69	PF01839	0.591
LIG_LIR_Apic_2	402	406	PF02991	0.587
LIG_LIR_Apic_2	638	642	PF02991	0.809
LIG_LIR_Apic_2	688	692	PF02991	0.692
LIG_LIR_Gen_1	341	350	PF02991	0.541
LIG_LIR_Gen_1	592	600	PF02991	0.783
LIG_LIR_Nem_3	341	345	PF02991	0.538
LIG_LIR_Nem_3	461	467	PF02991	0.489
LIG_LIR_Nem_3	528	533	PF02991	0.654
LIG_LIR_Nem_3	592	597	PF02991	0.778
LIG_Pex14_2	460	464	PF04695	0.656
LIG_Pex14_2	639	643	PF04695	0.737
LIG_SH2_STAP1	630	634	PF00017	0.687
LIG_SH2_STAT5	174	177	PF00017	0.723
LIG_SH2_STAT5	576	579	PF00017	0.737
LIG_SH2_STAT5	630	633	PF00017	0.690
LIG_SH3_3	187	193	PF00018	0.703
LIG_SH3_3	315	321	PF00018	0.724
LIG_SH3_3	429	435	PF00018	0.557
LIG_SH3_3	582	588	PF00018	0.796
LIG_SH3_3	621	627	PF00018	0.676
LIG_SH3_3	641	647	PF00018	0.480
LIG_SH3_3	7	13	PF00018	0.671
LIG_SUMO_SIM_anti_2	349	355	PF11976	0.544
LIG_SUMO_SIM_par_1	123	128	PF11976	0.686
LIG_SUMO_SIM_par_1	195	205	PF11976	0.811
LIG_SUMO_SIM_par_1	534	539	PF11976	0.629
LIG_SUMO_SIM_par_1	716	722	PF11976	0.619
LIG_TRAF2_1	43	46	PF00917	0.655
LIG_WW_1	9	12	PF00397	0.643
MOD_CDK_SPK_2	148	153	PF00069	0.744
MOD_CDK_SPxxK_3	511	518	PF00069	0.809
MOD_CK1_1	199	205	PF00069	0.800
MOD_CK1_1	212	218	PF00069	0.723
MOD_CK1_1	245	251	PF00069	0.721
MOD_CK1_1	319	325	PF00069	0.706
MOD_CK1_1	346	352	PF00069	0.567
MOD_CK1_1	394	400	PF00069	0.527
MOD_CK1_1	554	560	PF00069	0.750
MOD_CK1_1	592	598	PF00069	0.602
MOD_CK1_1	638	644	PF00069	0.783
MOD_CK1_1	667	673	PF00069	0.619
MOD_CK1_1	705	711	PF00069	0.684
MOD_CK1_1	99	105	PF00069	0.710
MOD_CK2_1	28	34	PF00069	0.663
MOD_CK2_1	493	499	PF00069	0.791
MOD_CK2_1	592	598	PF00069	0.727
MOD_Cter_Amidation	491	494	PF01082	0.712
MOD_GlcNHglycan	115	118	PF01048	0.632
MOD_GlcNHglycan	211	214	PF01048	0.830
MOD_GlcNHglycan	268	271	PF01048	0.742
MOD_GlcNHglycan	277	280	PF01048	0.675
MOD_GlcNHglycan	285	288	PF01048	0.599
MOD_GlcNHglycan	30	33	PF01048	0.661
MOD_GlcNHglycan	314	317	PF01048	0.791
MOD_GlcNHglycan	332	335	PF01048	0.497
MOD_GlcNHglycan	37	40	PF01048	0.620
MOD_GlcNHglycan	373	377	PF01048	0.572
MOD_GlcNHglycan	472	476	PF01048	0.592
MOD_GlcNHglycan	486	489	PF01048	0.791
MOD_GlcNHglycan	553	556	PF01048	0.748
MOD_GlcNHglycan	609	612	PF01048	0.679
MOD_GlcNHglycan	666	669	PF01048	0.649
MOD_GlcNHglycan	679	682	PF01048	0.634
MOD_GlcNHglycan	695	698	PF01048	0.671
MOD_GlcNHglycan	707	710	PF01048	0.650
MOD_GlcNHglycan	98	101	PF01048	0.590
MOD_GSK3_1	11	18	PF00069	0.648
MOD_GSK3_1	177	184	PF00069	0.822
MOD_GSK3_1	209	216	PF00069	0.801
MOD_GSK3_1	245	252	PF00069	0.735
MOD_GSK3_1	275	282	PF00069	0.749
MOD_GSK3_1	310	317	PF00069	0.711
MOD_GSK3_1	348	355	PF00069	0.553
MOD_GSK3_1	536	543	PF00069	0.608
MOD_GSK3_1	550	557	PF00069	0.609
MOD_GSK3_1	572	579	PF00069	0.707
MOD_GSK3_1	599	606	PF00069	0.686
MOD_GSK3_1	607	614	PF00069	0.680
MOD_LATS_1	88	94	PF00433	0.593
MOD_N-GLC_1	55	60	PF02516	0.748
MOD_NEK2_1	20	25	PF00069	0.658
MOD_NEK2_1	209	214	PF00069	0.799
MOD_NEK2_1	249	254	PF00069	0.677
MOD_NEK2_1	314	319	PF00069	0.745
MOD_NEK2_1	329	334	PF00069	0.788
MOD_NEK2_1	460	465	PF00069	0.554
MOD_NEK2_1	550	555	PF00069	0.712
MOD_NEK2_1	577	582	PF00069	0.683
MOD_NEK2_1	603	608	PF00069	0.615
MOD_NEK2_1	669	674	PF00069	0.722
MOD_NEK2_1	96	101	PF00069	0.617
MOD_NEK2_2	155	160	PF00069	0.734
MOD_NEK2_2	300	305	PF00069	0.656
MOD_PIKK_1	321	327	PF00454	0.592
MOD_PIKK_1	41	47	PF00454	0.539
MOD_PIKK_1	601	607	PF00454	0.552
MOD_PK_1	90	96	PF00069	0.787
MOD_PKA_1	493	499	PF00069	0.697
MOD_PKA_1	90	96	PF00069	0.787
MOD_PKA_2	209	215	PF00069	0.799
MOD_PKA_2	218	224	PF00069	0.601
MOD_PKA_2	245	251	PF00069	0.728
MOD_PKA_2	28	34	PF00069	0.663
MOD_PKA_2	300	306	PF00069	0.733
MOD_PKA_2	407	413	PF00069	0.738
MOD_PKA_2	493	499	PF00069	0.791
MOD_PKA_2	540	546	PF00069	0.514
MOD_PKA_2	62	68	PF00069	0.781
MOD_PKA_2	90	96	PF00069	0.768
MOD_PKB_1	308	316	PF00069	0.632
MOD_Plk_1	107	113	PF00069	0.653
MOD_Plk_1	202	208	PF00069	0.695
MOD_Plk_1	291	297	PF00069	0.616
MOD_Plk_1	421	427	PF00069	0.621
MOD_Plk_1	460	466	PF00069	0.546
MOD_Plk_4	291	297	PF00069	0.646
MOD_Plk_4	348	354	PF00069	0.532
MOD_Plk_4	386	392	PF00069	0.531
MOD_Plk_4	572	578	PF00069	0.732
MOD_Plk_4	612	618	PF00069	0.679
MOD_Plk_4	90	96	PF00069	0.787
MOD_ProDKin_1	11	17	PF00069	0.659
MOD_ProDKin_1	148	154	PF00069	0.742
MOD_ProDKin_1	189	195	PF00069	0.700
MOD_ProDKin_1	317	323	PF00069	0.740
MOD_ProDKin_1	511	517	PF00069	0.703
MOD_ProDKin_1	589	595	PF00069	0.753
MOD_ProDKin_1	638	644	PF00069	0.813
MOD_ProDKin_1	687	693	PF00069	0.792
MOD_ProDKin_1	711	717	PF00069	0.775
TRG_DiLeu_BaEn_1	292	297	PF01217	0.631
TRG_DiLeu_BaLyEn_6	714	719	PF01217	0.648
TRG_ER_diArg_1	209	211	PF00400	0.669
TRG_ER_diArg_1	306	309	PF00400	0.587
TRG_ER_diArg_1	482	484	PF00400	0.652
TRG_ER_diArg_1	493	495	PF00400	0.646
TRG_ER_diArg_1	584	587	PF00400	0.728
TRG_ER_diArg_1	647	650	PF00400	0.797
TRG_ER_diArg_1	89	91	PF00400	0.734
TRG_NLS_MonoExtN_4	561	567	PF00514	0.698

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I813	Leptomonas seymouri	40%	100%
A0A3Q8ID48	Leishmania donovani	91%	100%
A4HGJ7	Leishmania braziliensis	73%	100%
A4I3M4	Leishmania infantum	91%	100%
E9AZW5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%