Qa-SNARE protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Qa-SNARE protein

Gene product:

Qa-SNARE protein

Species:

Leishmania major

UniProt:

Q4Q8B9_LEIMA

TriTrypDb:

LmjF.28.1470 , LMJLV39_280022600 , LMJSD75_280022000

Length:

287

Annotations

LeishMANIAdb annotations

Homologous to animal syntaxin proteins, involved in vesulcular fusion to membranes. Although most proteins appear to be membrane-embedded, some Lesihmaniid members are likely not.. For some reason, multiple copies are seen in Leptomonas

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 11
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	3
GO:0012505	endomembrane system	2	3
GO:0016020	membrane	2	13
GO:0031201	SNARE complex	3	3
GO:0032991	protein-containing complex	1	3
GO:0098796	membrane protein complex	2	3
GO:0110165	cellular anatomical entity	1	13
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

Q4Q8B9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8B9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	13
GO:0006886	intracellular protein transport	4	3
GO:0006887	exocytosis	4	3
GO:0006906	vesicle fusion	6	3
GO:0006996	organelle organization	4	3
GO:0008104	protein localization	4	3
GO:0009987	cellular process	1	3
GO:0015031	protein transport	4	3
GO:0016043	cellular component organization	3	3
GO:0016050	vesicle organization	5	3
GO:0016192	vesicle-mediated transport	4	13
GO:0022406	membrane docking	2	3
GO:0032940	secretion by cell	3	3
GO:0033036	macromolecule localization	2	3
GO:0045184	establishment of protein localization	3	3
GO:0046903	secretion	4	3
GO:0046907	intracellular transport	3	3
GO:0048278	vesicle docking	4	3
GO:0048284	organelle fusion	5	3
GO:0051179	localization	1	13
GO:0051234	establishment of localization	2	13
GO:0051640	organelle localization	2	3
GO:0051641	cellular localization	2	3
GO:0051649	establishment of localization in cell	3	3
GO:0061024	membrane organization	4	3
GO:0061025	membrane fusion	5	3
GO:0070727	cellular macromolecule localization	3	3
GO:0071702	organic substance transport	4	3
GO:0071705	nitrogen compound transport	4	3
GO:0071840	cellular component organization or biogenesis	2	3
GO:0090174	organelle membrane fusion	6	3
GO:0140056	organelle localization by membrane tethering	3	3
GO:0140352	export from cell	2	3

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	3
GO:0005484	SNAP receptor activity	3	3
GO:0005488	binding	1	3
GO:0005515	protein binding	2	3
GO:0030674	protein-macromolecule adaptor activity	2	3
GO:0060090	molecular adaptor activity	1	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.496
CLV_C14_Caspase3-7	43	47	PF00656	0.608
CLV_C14_Caspase3-7	57	61	PF00656	0.445
CLV_NRD_NRD_1	213	215	PF00675	0.334
CLV_NRD_NRD_1	219	221	PF00675	0.352
CLV_PCSK_KEX2_1	213	215	PF00082	0.308
CLV_PCSK_SKI1_1	107	111	PF00082	0.296
CLV_PCSK_SKI1_1	147	151	PF00082	0.305
CLV_PCSK_SKI1_1	206	210	PF00082	0.323
CLV_PCSK_SKI1_1	282	286	PF00082	0.556
CLV_PCSK_SKI1_1	39	43	PF00082	0.380
DEG_APCC_DBOX_1	219	227	PF00400	0.509
DOC_CYCLIN_yClb1_LxF_4	174	180	PF00134	0.494
DOC_MAPK_gen_1	217	228	PF00069	0.449
DOC_MAPK_MEF2A_6	220	228	PF00069	0.446
DOC_USP7_MATH_1	116	120	PF00917	0.519
DOC_USP7_UBL2_3	217	221	PF12436	0.549
DOC_USP7_UBL2_3	50	54	PF12436	0.553
DOC_WW_Pin1_4	250	255	PF00397	0.437
LIG_14-3-3_CanoR_1	282	287	PF00244	0.358
LIG_14-3-3_CanoR_1	92	101	PF00244	0.538
LIG_Actin_WH2_2	41	58	PF00022	0.509
LIG_BIR_II_1	1	5	PF00653	0.438
LIG_BRCT_BRCA1_1	139	143	PF00533	0.538
LIG_CaM_IQ_9	192	208	PF13499	0.545
LIG_FHA_1	197	203	PF00498	0.494
LIG_FHA_1	244	250	PF00498	0.397
LIG_FHA_1	50	56	PF00498	0.496
LIG_FHA_1	75	81	PF00498	0.527
LIG_FHA_2	112	118	PF00498	0.554
LIG_FHA_2	12	18	PF00498	0.588
LIG_FHA_2	154	160	PF00498	0.496
LIG_GBD_Chelix_1	79	87	PF00786	0.408
LIG_LIR_Gen_1	73	83	PF02991	0.545
LIG_LIR_Nem_3	73	79	PF02991	0.526
LIG_PCNA_PIPBox_1	167	176	PF02747	0.538
LIG_PDZ_Class_1	282	287	PF00595	0.358
LIG_SH2_GRB2like	113	116	PF00017	0.496
LIG_SH2_NCK_1	113	117	PF00017	0.477
LIG_SH2_STAP1	76	80	PF00017	0.527
LIG_SH2_STAT3	101	104	PF00017	0.497
LIG_SH2_STAT3	141	144	PF00017	0.590
LIG_SH2_STAT3	90	93	PF00017	0.495
LIG_SH2_STAT5	113	116	PF00017	0.506
LIG_SH2_STAT5	141	144	PF00017	0.590
LIG_SH2_STAT5	201	204	PF00017	0.538
LIG_SH2_STAT5	76	79	PF00017	0.572
LIG_SH3_1	251	257	PF00018	0.387
LIG_SH3_3	251	257	PF00018	0.427
MOD_CK1_1	31	37	PF00069	0.586
MOD_CK1_1	49	55	PF00069	0.551
MOD_CK2_1	11	17	PF00069	0.588
MOD_CK2_1	149	155	PF00069	0.608
MOD_CK2_1	92	98	PF00069	0.533
MOD_GlcNHglycan	117	121	PF01048	0.338
MOD_GlcNHglycan	65	68	PF01048	0.408
MOD_GlcNHglycan	94	97	PF01048	0.390
MOD_GSK3_1	149	156	PF00069	0.608
MOD_GSK3_1	54	61	PF00069	0.545
MOD_N-GLC_1	135	140	PF02516	0.316
MOD_NEK2_1	243	248	PF00069	0.547
MOD_NEK2_1	81	86	PF00069	0.474
MOD_PIKK_1	102	108	PF00454	0.550
MOD_PK_1	54	60	PF00069	0.527
MOD_PKA_2	31	37	PF00069	0.571
MOD_Plk_1	136	142	PF00069	0.543
MOD_Plk_1	163	169	PF00069	0.496
MOD_Plk_4	137	143	PF00069	0.541
MOD_Plk_4	149	155	PF00069	0.532
MOD_Plk_4	229	235	PF00069	0.354
MOD_ProDKin_1	250	256	PF00069	0.438
TRG_DiLeu_BaEn_1	183	188	PF01217	0.558
TRG_ENDOCYTIC_2	76	79	PF00928	0.601
TRG_ER_diArg_1	213	215	PF00400	0.573
TRG_NLS_Bipartite_1	210	224	PF00514	0.517
TRG_NLS_MonoExtC_3	209	214	PF00514	0.503
TRG_NLS_MonoExtC_3	216	221	PF00514	0.503
TRG_NLS_MonoExtN_4	214	221	PF00514	0.530
TRG_Pf-PMV_PEXEL_1	168	172	PF00026	0.314

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JI44	Bodo saltans	25%	100%
A0A1X0NYQ5	Trypanosomatidae	59%	88%
A0A3Q8IDT6	Leishmania donovani	97%	100%
A0A3R7L4L2	Trypanosoma rangeli	52%	91%
A0A3R7NXH1	Trypanosoma rangeli	24%	100%
A0A3S7X1I6	Leishmania donovani	96%	100%
A4HGJ9	Leishmania braziliensis	83%	100%
A4HGK0	Leishmania braziliensis	80%	100%
A8WVD0	Caenorhabditis briggsae	31%	98%
D0A863	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	90%
E9AHG5	Leishmania infantum	96%	100%
E9AZW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	83%
O16000	Caenorhabditis elegans	31%	99%
O35526	Mus musculus	31%	100%
O64791	Arabidopsis thaliana	28%	95%
O75558	Homo sapiens	28%	100%
P32850	Bos taurus	33%	100%
P32851	Rattus norvegicus	31%	100%
P32856	Homo sapiens	30%	100%
P50279	Rattus norvegicus	28%	99%
P61264	Mus musculus	30%	100%
P61265	Rattus norvegicus	30%	100%
P61266	Homo sapiens	30%	100%
P61267	Bos taurus	30%	100%
P61268	Ovis aries	30%	100%
P70452	Mus musculus	26%	96%
Q00262	Mus musculus	31%	99%
Q08849	Rattus norvegicus	31%	99%
Q08850	Rattus norvegicus	26%	96%
Q12846	Homo sapiens	27%	97%
Q13277	Homo sapiens	31%	99%
Q16623	Homo sapiens	32%	100%
Q16932	Aplysia californica	32%	99%
Q20024	Caenorhabditis elegans	24%	94%
Q3SWZ3	Bos taurus	26%	97%
Q42374	Arabidopsis thaliana	29%	93%
Q4Q8B8	Leishmania major	98%	100%
Q5R4L2	Pongo abelii	32%	100%
Q64704	Mus musculus	31%	99%
Q8VZU2	Arabidopsis thaliana	28%	94%
Q9D3G5	Mus musculus	29%	100%
Q9SRV7	Arabidopsis thaliana	24%	94%
Q9SVC2	Arabidopsis thaliana	28%	84%
Q9SXB0	Arabidopsis thaliana	28%	96%
Q9ZQZ8	Arabidopsis thaliana	27%	94%
Q9ZSD4	Arabidopsis thaliana	29%	83%
V5B7Y5	Trypanosoma cruzi	55%	91%