Qa-SNARE protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Qa-SNARE protein

Gene product:

Qa-SNARE protein

Species:

Leishmania major

UniProt:

Q4Q8B8_LEIMA

TriTrypDb:

LmjF.28.1480 , LMJLV39_280022600 , LMJSD75_280022100

Length:

266

Annotations

LeishMANIAdb annotations

Homologous to animal syntaxin proteins, involved in vesulcular fusion to membranes. Although most proteins appear to be membrane-embedded, some Lesihmaniid members are likely not.. For some reason, multiple copies are seen in Leptomonas

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 11
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005886	plasma membrane	3	3
GO:0012505	endomembrane system	2	3
GO:0016020	membrane	2	13
GO:0031201	SNARE complex	3	3
GO:0032991	protein-containing complex	1	3
GO:0098796	membrane protein complex	2	3
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

Q4Q8B8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8B8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	13
GO:0006886	intracellular protein transport	4	3
GO:0006887	exocytosis	4	3
GO:0006906	vesicle fusion	6	3
GO:0006996	organelle organization	4	3
GO:0008104	protein localization	4	3
GO:0009987	cellular process	1	3
GO:0015031	protein transport	4	3
GO:0016043	cellular component organization	3	3
GO:0016050	vesicle organization	5	3
GO:0016192	vesicle-mediated transport	4	13
GO:0022406	membrane docking	2	3
GO:0032940	secretion by cell	3	3
GO:0033036	macromolecule localization	2	3
GO:0045184	establishment of protein localization	3	3
GO:0046903	secretion	4	3
GO:0046907	intracellular transport	3	3
GO:0048278	vesicle docking	4	3
GO:0048284	organelle fusion	5	3
GO:0051179	localization	1	13
GO:0051234	establishment of localization	2	13
GO:0051640	organelle localization	2	3
GO:0051641	cellular localization	2	3
GO:0051649	establishment of localization in cell	3	3
GO:0061024	membrane organization	4	3
GO:0061025	membrane fusion	5	3
GO:0070727	cellular macromolecule localization	3	3
GO:0071702	organic substance transport	4	3
GO:0071705	nitrogen compound transport	4	3
GO:0071840	cellular component organization or biogenesis	2	3
GO:0090174	organelle membrane fusion	6	3
GO:0140056	organelle localization by membrane tethering	3	3
GO:0140352	export from cell	2	3

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	3
GO:0005484	SNAP receptor activity	3	3
GO:0005488	binding	1	3
GO:0005515	protein binding	2	3
GO:0030674	protein-macromolecule adaptor activity	2	3
GO:0060090	molecular adaptor activity	1	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.477
CLV_C14_Caspase3-7	43	47	PF00656	0.575
CLV_C14_Caspase3-7	57	61	PF00656	0.412
CLV_NRD_NRD_1	213	215	PF00675	0.332
CLV_NRD_NRD_1	219	221	PF00675	0.367
CLV_NRD_NRD_1	228	230	PF00675	0.202
CLV_PCSK_KEX2_1	213	215	PF00082	0.289
CLV_PCSK_SKI1_1	107	111	PF00082	0.269
CLV_PCSK_SKI1_1	147	151	PF00082	0.286
CLV_PCSK_SKI1_1	206	210	PF00082	0.294
CLV_PCSK_SKI1_1	39	43	PF00082	0.355
DOC_CYCLIN_yClb1_LxF_4	174	180	PF00134	0.475
DOC_USP7_MATH_1	116	120	PF00917	0.500
DOC_USP7_UBL2_3	217	221	PF12436	0.546
DOC_USP7_UBL2_3	50	54	PF12436	0.531
DOC_WW_Pin1_4	238	243	PF00397	0.492
LIG_14-3-3_CanoR_1	224	228	PF00244	0.255
LIG_14-3-3_CanoR_1	92	101	PF00244	0.520
LIG_Actin_WH2_2	41	58	PF00022	0.490
LIG_BIR_II_1	1	5	PF00653	0.405
LIG_BRCT_BRCA1_1	139	143	PF00533	0.517
LIG_CaM_IQ_9	192	208	PF13499	0.512
LIG_deltaCOP1_diTrp_1	259	264	PF00928	0.361
LIG_FHA_1	197	203	PF00498	0.475
LIG_FHA_1	50	56	PF00498	0.477
LIG_FHA_1	75	81	PF00498	0.494
LIG_FHA_2	112	118	PF00498	0.494
LIG_FHA_2	12	18	PF00498	0.566
LIG_FHA_2	154	160	PF00498	0.477
LIG_GBD_Chelix_1	79	87	PF00786	0.375
LIG_LIR_Gen_1	73	83	PF02991	0.512
LIG_LIR_Nem_3	73	79	PF02991	0.483
LIG_PCNA_PIPBox_1	167	176	PF02747	0.517
LIG_SH2_GRB2like	113	116	PF00017	0.477
LIG_SH2_NCK_1	113	117	PF00017	0.457
LIG_SH2_STAP1	76	80	PF00017	0.494
LIG_SH2_STAT3	101	104	PF00017	0.478
LIG_SH2_STAT3	141	144	PF00017	0.557
LIG_SH2_STAT3	90	93	PF00017	0.476
LIG_SH2_STAT5	113	116	PF00017	0.494
LIG_SH2_STAT5	141	144	PF00017	0.557
LIG_SH2_STAT5	201	204	PF00017	0.517
LIG_SH2_STAT5	232	235	PF00017	0.280
LIG_SH2_STAT5	76	79	PF00017	0.556
LIG_TRAF2_1	242	245	PF00917	0.353
MOD_CK1_1	31	37	PF00069	0.571
MOD_CK1_1	49	55	PF00069	0.564
MOD_CK2_1	11	17	PF00069	0.566
MOD_CK2_1	149	155	PF00069	0.575
MOD_CK2_1	92	98	PF00069	0.517
MOD_CMANNOS	261	264	PF00535	0.562
MOD_GlcNHglycan	117	121	PF01048	0.317
MOD_GlcNHglycan	65	68	PF01048	0.375
MOD_GlcNHglycan	94	97	PF01048	0.357
MOD_GSK3_1	149	156	PF00069	0.575
MOD_GSK3_1	54	61	PF00069	0.512
MOD_N-GLC_1	135	140	PF02516	0.296
MOD_NEK2_1	223	228	PF00069	0.485
MOD_NEK2_1	81	86	PF00069	0.514
MOD_PIKK_1	102	108	PF00454	0.528
MOD_PK_1	54	60	PF00069	0.494
MOD_PKA_2	223	229	PF00069	0.336
MOD_PKA_2	31	37	PF00069	0.545
MOD_Plk_1	136	142	PF00069	0.510
MOD_Plk_1	163	169	PF00069	0.477
MOD_Plk_1	233	239	PF00069	0.425
MOD_Plk_1	244	250	PF00069	0.435
MOD_Plk_4	137	143	PF00069	0.509
MOD_Plk_4	149	155	PF00069	0.467
MOD_Plk_4	223	229	PF00069	0.410
MOD_ProDKin_1	238	244	PF00069	0.497
TRG_DiLeu_BaEn_1	183	188	PF01217	0.536
TRG_ENDOCYTIC_2	76	79	PF00928	0.553
TRG_ER_diArg_1	213	215	PF00400	0.549
TRG_NLS_Bipartite_1	210	225	PF00514	0.498
TRG_NLS_MonoExtC_3	209	214	PF00514	0.484
TRG_NLS_MonoExtC_3	216	221	PF00514	0.484
TRG_NLS_MonoExtN_4	214	221	PF00514	0.529
TRG_Pf-PMV_PEXEL_1	168	172	PF00026	0.294

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JI44	Bodo saltans	24%	100%
A0A1X0NYQ5	Trypanosomatidae	60%	81%
A0A3Q8IDT6	Leishmania donovani	96%	100%
A0A3R7L4L2	Trypanosoma rangeli	53%	84%
A0A3R7NXH1	Trypanosoma rangeli	25%	100%
A0A3S7X1I6	Leishmania donovani	95%	100%
A4HGJ9	Leishmania braziliensis	83%	100%
A4HGK0	Leishmania braziliensis	80%	100%
A8WVD0	Caenorhabditis briggsae	32%	91%
D0A863	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	84%
E9AHG5	Leishmania infantum	95%	100%
E9AZW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	77%
O16000	Caenorhabditis elegans	32%	91%
O35526	Mus musculus	32%	92%
O64791	Arabidopsis thaliana	30%	88%
O75558	Homo sapiens	28%	93%
P32850	Bos taurus	33%	92%
P32851	Rattus norvegicus	32%	92%
P32856	Homo sapiens	30%	92%
P50279	Rattus norvegicus	28%	92%
P61264	Mus musculus	30%	92%
P61265	Rattus norvegicus	30%	92%
P61266	Homo sapiens	30%	92%
P61267	Bos taurus	30%	92%
P61268	Ovis aries	30%	92%
P70452	Mus musculus	27%	89%
Q00262	Mus musculus	31%	92%
Q08849	Rattus norvegicus	31%	92%
Q08850	Rattus norvegicus	27%	89%
Q12846	Homo sapiens	28%	90%
Q13277	Homo sapiens	31%	92%
Q16623	Homo sapiens	32%	92%
Q16932	Aplysia californica	31%	92%
Q20024	Caenorhabditis elegans	24%	87%
Q3SWZ3	Bos taurus	26%	90%
Q42374	Arabidopsis thaliana	29%	86%
Q4Q8B9	Leishmania major	98%	93%
Q5R4L2	Pongo abelii	32%	92%
Q64704	Mus musculus	31%	92%
Q8VZU2	Arabidopsis thaliana	28%	88%
Q9D3G5	Mus musculus	28%	93%
Q9SRV7	Arabidopsis thaliana	24%	87%
Q9SVC2	Arabidopsis thaliana	28%	78%
Q9SXB0	Arabidopsis thaliana	28%	89%
Q9ZQZ8	Arabidopsis thaliana	27%	87%
Q9ZSD4	Arabidopsis thaliana	29%	77%
V5B7Y5	Trypanosoma cruzi	57%	84%