DUF423-domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF423), putative

Species:

Leishmania major

UniProt:

Q4Q8B7_LEIMA

TriTrypDb:

LmjF.28.1490 , LMJLV39_280022700 , LMJSD75_280022200

Length:

138

Annotations

LeishMANIAdb annotations

Similar to Prokaryotic YgdD inner membrane proteins.. Topology is somewhat unclear but likely to start / end in cytoplasm. Might have been acquired by horizontal gene transfer.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q8B7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8B7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	82	84	PF00675	0.251
CLV_PCSK_KEX2_1	82	84	PF00082	0.284
CLV_PCSK_SKI1_1	6	10	PF00082	0.396
DOC_USP7_MATH_1	31	35	PF00917	0.319
LIG_14-3-3_CanoR_1	99	108	PF00244	0.403
LIG_BIR_II_1	1	5	PF00653	0.605
LIG_BRCT_BRCA1_1	33	37	PF00533	0.293
LIG_EH1_1	58	66	PF00400	0.282
LIG_FHA_1	90	96	PF00498	0.198
LIG_LIR_Gen_1	34	41	PF02991	0.254
LIG_LIR_Nem_3	34	40	PF02991	0.251
LIG_LIR_Nem_3	43	49	PF02991	0.251
LIG_SH2_CRK	102	106	PF00017	0.276
LIG_SH2_CRK	55	59	PF00017	0.342
LIG_SH2_NCK_1	49	53	PF00017	0.251
LIG_SH2_SRC	100	103	PF00017	0.271
LIG_SH2_STAP1	85	89	PF00017	0.416
LIG_SH2_STAT5	100	103	PF00017	0.406
LIG_SH3_3	102	108	PF00018	0.240
LIG_SH3_3	70	76	PF00018	0.242
LIG_SUMO_SIM_par_1	91	98	PF11976	0.183
MOD_GlcNHglycan	1	4	PF01048	0.420
MOD_GlcNHglycan	21	24	PF01048	0.276
MOD_GlcNHglycan	9	12	PF01048	0.399
MOD_NEK2_1	131	136	PF00069	0.394
MOD_NEK2_1	40	45	PF00069	0.249
MOD_NEK2_1	57	62	PF00069	0.322
MOD_NEK2_1	9	14	PF00069	0.589
MOD_NEK2_1	95	100	PF00069	0.348
MOD_Plk_4	89	95	PF00069	0.297
TRG_ENDOCYTIC_2	102	105	PF00928	0.355
TRG_ENDOCYTIC_2	55	58	PF00928	0.374
TRG_ENDOCYTIC_2	85	88	PF00928	0.350
TRG_ER_diArg_1	81	83	PF00400	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUH3	Leptomonas seymouri	85%	100%
A0A0N1I149	Leptomonas seymouri	28%	100%
A0A0N1I2H5	Leptomonas seymouri	32%	100%
A0A0S4JA03	Bodo saltans	34%	100%
A0A1X0NW75	Trypanosomatidae	31%	100%
A0A1X0NYR3	Trypanosomatidae	35%	100%
A0A3Q8IGS2	Leishmania donovani	30%	100%
A0A3R7NJS9	Trypanosoma rangeli	31%	100%
A0A3S7X1H0	Leishmania donovani	35%	100%
A0A3S7X1J0	Leishmania donovani	96%	100%
A4HGK1	Leishmania braziliensis	82%	100%
A4HGK2	Leishmania braziliensis	32%	100%
A4HGK3	Leishmania braziliensis	29%	100%
A4I3M7	Leishmania infantum	96%	100%
A4I3M8	Leishmania infantum	30%	100%
A4I3M9	Leishmania infantum	35%	100%
A4K526	Bufo gargarizans	31%	100%
D0A7U8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
D0A857	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AZW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AZW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AZX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
Q4Q8B5	Leishmania major	34%	100%
Q4Q8B6	Leishmania major	30%	100%
Q568J8	Danio rerio	34%	100%