Similar to Prokaryotic YgdD inner membrane proteins.. Topology is somewhat unclear but likely to start / end in cytoplasm. Might have been acquired by horizontal gene transfer.
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 12 |
| NetGPI | no | yes: 0, no: 12 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 13 |
| GO:0110165 | cellular anatomical entity | 1 | 13 |
Related structures:
AlphaFold database: Q4Q8B6
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 40 | 42 | PF00675 | 0.274 |
| CLV_PCSK_FUR_1 | 38 | 42 | PF00082 | 0.309 |
| CLV_PCSK_KEX2_1 | 40 | 42 | PF00082 | 0.274 |
| DEG_COP1_1 | 3 | 12 | PF00400 | 0.236 |
| DOC_CKS1_1 | 109 | 114 | PF01111 | 0.261 |
| DOC_MAPK_DCC_7 | 5 | 14 | PF00069 | 0.229 |
| DOC_MAPK_gen_1 | 76 | 85 | PF00069 | 0.291 |
| DOC_MAPK_MEF2A_6 | 5 | 14 | PF00069 | 0.234 |
| DOC_PP2B_PxIxI_1 | 9 | 15 | PF00149 | 0.306 |
| DOC_PP4_FxxP_1 | 106 | 109 | PF00568 | 0.524 |
| DOC_USP7_MATH_1 | 71 | 75 | PF00917 | 0.252 |
| DOC_WW_Pin1_4 | 108 | 113 | PF00397 | 0.418 |
| DOC_WW_Pin1_4 | 67 | 72 | PF00397 | 0.342 |
| LIG_14-3-3_CanoR_1 | 38 | 44 | PF00244 | 0.480 |
| LIG_BIR_III_4 | 25 | 29 | PF00653 | 0.276 |
| LIG_DCNL_PONY_1 | 1 | 4 | PF03556 | 0.399 |
| LIG_FHA_1 | 111 | 117 | PF00498 | 0.273 |
| LIG_FHA_1 | 52 | 58 | PF00498 | 0.330 |
| LIG_FHA_1 | 9 | 15 | PF00498 | 0.279 |
| LIG_SH2_CRK | 49 | 53 | PF00017 | 0.388 |
| LIG_SH2_STAP1 | 96 | 100 | PF00017 | 0.310 |
| LIG_SH2_STAT5 | 82 | 85 | PF00017 | 0.306 |
| LIG_SH3_3 | 106 | 112 | PF00018 | 0.409 |
| LIG_Sin3_3 | 81 | 88 | PF02671 | 0.254 |
| LIG_SUMO_SIM_anti_2 | 113 | 120 | PF11976 | 0.388 |
| LIG_UBA3_1 | 1 | 5 | PF00899 | 0.395 |
| LIG_UBA3_1 | 63 | 68 | PF00899 | 0.303 |
| LIG_WRC_WIRS_1 | 19 | 24 | PF05994 | 0.298 |
| MOD_CK1_1 | 3 | 9 | PF00069 | 0.390 |
| MOD_CK1_1 | 42 | 48 | PF00069 | 0.476 |
| MOD_CK1_1 | 94 | 100 | PF00069 | 0.361 |
| MOD_GlcNHglycan | 113 | 116 | PF01048 | 0.361 |
| MOD_GlcNHglycan | 5 | 8 | PF01048 | 0.571 |
| MOD_GSK3_1 | 26 | 33 | PF00069 | 0.420 |
| MOD_GSK3_1 | 67 | 74 | PF00069 | 0.348 |
| MOD_NEK2_1 | 120 | 125 | PF00069 | 0.287 |
| MOD_NEK2_1 | 51 | 56 | PF00069 | 0.325 |
| MOD_NEK2_1 | 91 | 96 | PF00069 | 0.314 |
| MOD_PKA_2 | 39 | 45 | PF00069 | 0.483 |
| MOD_Plk_4 | 8 | 14 | PF00069 | 0.223 |
| MOD_Plk_4 | 91 | 97 | PF00069 | 0.286 |
| MOD_ProDKin_1 | 108 | 114 | PF00069 | 0.418 |
| MOD_ProDKin_1 | 67 | 73 | PF00069 | 0.342 |
| TRG_ENDOCYTIC_2 | 49 | 52 | PF00928 | 0.415 |
| TRG_ENDOCYTIC_2 | 82 | 85 | PF00928 | 0.315 |
| TRG_ER_diArg_1 | 37 | 40 | PF00400 | 0.509 |
| TRG_NES_CRM1_1 | 25 | 39 | PF08389 | 0.298 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1I149 | Leptomonas seymouri | 82% | 100% |
| A0A0N1I2H5 | Leptomonas seymouri | 26% | 100% |
| A0A0S4JA03 | Bodo saltans | 39% | 100% |
| A0A1X0NW75 | Trypanosomatidae | 42% | 100% |
| A0A1X0NYR3 | Trypanosomatidae | 45% | 100% |
| A0A3Q8IGS2 | Leishmania donovani | 96% | 100% |
| A0A3R7NJS9 | Trypanosoma rangeli | 38% | 100% |
| A0A3S7X1H0 | Leishmania donovani | 28% | 100% |
| A0A3S7X1J0 | Leishmania donovani | 30% | 96% |
| A4HGK1 | Leishmania braziliensis | 29% | 96% |
| A4HGK2 | Leishmania braziliensis | 92% | 100% |
| A4HGK3 | Leishmania braziliensis | 26% | 100% |
| A4I3M7 | Leishmania infantum | 30% | 96% |
| A4I3M8 | Leishmania infantum | 96% | 100% |
| A4I3M9 | Leishmania infantum | 28% | 100% |
| D0A7U8 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 33% | 100% |
| D0A857 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 34% | 100% |
| E9AZW8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 28% | 96% |
| E9AZW9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 95% | 100% |
| E9AZX0 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 29% | 100% |
| P39619 | Bacillus subtilis (strain 168) | 29% | 100% |
| Q2FJ60 | Staphylococcus aureus (strain USA300) | 31% | 100% |
| Q2G0J5 | Staphylococcus aureus (strain NCTC 8325 / PS 47) | 31% | 100% |
| Q2YS64 | Staphylococcus aureus (strain bovine RF122 / ET3-1) | 31% | 100% |
| Q4Q8B5 | Leishmania major | 28% | 100% |
| Q4Q8B7 | Leishmania major | 30% | 96% |
| Q5HI93 | Staphylococcus aureus (strain COL) | 31% | 100% |
| Q6GBQ4 | Staphylococcus aureus (strain MSSA476) | 31% | 100% |
| Q6GJ86 | Staphylococcus aureus (strain MRSA252) | 31% | 100% |
| Q7A1P4 | Staphylococcus aureus (strain MW2) | 31% | 100% |
| Q7A763 | Staphylococcus aureus (strain N315) | 31% | 100% |
| Q99W28 | Staphylococcus aureus (strain Mu50 / ATCC 700699) | 31% | 100% |
| Q9P7G8 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 31% | 100% |