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Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Similar to

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8B4_LEIMA

TriTrypDb:

LmjF.28.1515 , LMJLV39_280023000 , LMJSD75_280022500

Length:

160

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8B4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8B4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.720
CLV_NRD_NRD_1	155	157	PF00675	0.751
CLV_NRD_NRD_1	80	82	PF00675	0.706
CLV_PCSK_KEX2_1	133	135	PF00082	0.720
CLV_PCSK_KEX2_1	154	156	PF00082	0.688
CLV_PCSK_KEX2_1	80	82	PF00082	0.650
DEG_SPOP_SBC_1	14	18	PF00917	0.654
DOC_MAPK_gen_1	154	160	PF00069	0.697
DOC_USP7_MATH_1	14	18	PF00917	0.791
DOC_USP7_MATH_1	79	83	PF00917	0.775
DOC_USP7_MATH_1	93	97	PF00917	0.557
DOC_USP7_MATH_1	99	103	PF00917	0.685
LIG_14-3-3_CanoR_1	61	70	PF00244	0.819
LIG_14-3-3_CanoR_1	80	87	PF00244	0.576
LIG_BIR_II_1	1	5	PF00653	0.814
LIG_FHA_1	40	46	PF00498	0.624
LIG_FHA_1	65	71	PF00498	0.803
LIG_TRAF2_1	114	117	PF00917	0.687
LIG_TRAF2_1	147	150	PF00917	0.691
LIG_TRAF2_1	41	44	PF00917	0.598
MOD_CK1_1	106	112	PF00069	0.696
MOD_CK1_1	15	21	PF00069	0.642
MOD_CK1_1	64	70	PF00069	0.681
MOD_CK1_1	82	88	PF00069	0.604
MOD_CK2_1	112	118	PF00069	0.620
MOD_CK2_1	144	150	PF00069	0.776
MOD_CK2_1	38	44	PF00069	0.661
MOD_GlcNHglycan	101	104	PF01048	0.669
MOD_GlcNHglycan	63	66	PF01048	0.815
MOD_GlcNHglycan	75	78	PF01048	0.677
MOD_GlcNHglycan	82	85	PF01048	0.511
MOD_GlcNHglycan	88	91	PF01048	0.602
MOD_GlcNHglycan	97	100	PF01048	0.715
MOD_GSK3_1	13	20	PF00069	0.722
MOD_GSK3_1	144	151	PF00069	0.772
MOD_GSK3_1	64	71	PF00069	0.734
MOD_GSK3_1	82	89	PF00069	0.627
MOD_GSK3_1	95	102	PF00069	0.705
MOD_LATS_1	59	65	PF00433	0.724
MOD_N-GLC_1	68	73	PF02516	0.822
MOD_PIKK_1	120	126	PF00454	0.708
MOD_PKA_1	80	86	PF00069	0.699
MOD_PKA_2	79	85	PF00069	0.708
MOD_Plk_1	148	154	PF00069	0.752
MOD_Plk_2-3	144	150	PF00069	0.776
MOD_Plk_2-3	39	45	PF00069	0.755
MOD_Plk_4	82	88	PF00069	0.615
TRG_ER_diArg_1	132	134	PF00400	0.719
TRG_ER_diArg_1	154	156	PF00400	0.667
TRG_ER_diArg_1	79	81	PF00400	0.710
TRG_Pf-PMV_PEXEL_1	133	137	PF00026	0.655

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIA3	Leptomonas seymouri	39%	100%
A0A3S7X1K8	Leishmania donovani	84%	97%
A4HGK4	Leishmania braziliensis	67%	96%
A4I3N0	Leishmania infantum	84%	97%
E9AZX1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	98%