Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q8B3_LEIMA

TriTrypDb:

LmjF.28.1520 , LMJLV39_280023100 , LMJSD75_280022600

Length:

641

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8B3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8B3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.551
CLV_NRD_NRD_1	151	153	PF00675	0.641
CLV_NRD_NRD_1	173	175	PF00675	0.400
CLV_NRD_NRD_1	227	229	PF00675	0.519
CLV_NRD_NRD_1	273	275	PF00675	0.483
CLV_NRD_NRD_1	35	37	PF00675	0.603
CLV_NRD_NRD_1	399	401	PF00675	0.675
CLV_NRD_NRD_1	425	427	PF00675	0.609
CLV_NRD_NRD_1	582	584	PF00675	0.719
CLV_NRD_NRD_1	609	611	PF00675	0.517
CLV_PCSK_FUR_1	149	153	PF00082	0.611
CLV_PCSK_FUR_1	33	37	PF00082	0.515
CLV_PCSK_KEX2_1	112	114	PF00082	0.551
CLV_PCSK_KEX2_1	151	153	PF00082	0.641
CLV_PCSK_KEX2_1	173	175	PF00082	0.400
CLV_PCSK_KEX2_1	227	229	PF00082	0.596
CLV_PCSK_KEX2_1	273	275	PF00082	0.483
CLV_PCSK_KEX2_1	32	34	PF00082	0.480
CLV_PCSK_KEX2_1	35	37	PF00082	0.482
CLV_PCSK_KEX2_1	399	401	PF00082	0.668
CLV_PCSK_KEX2_1	425	427	PF00082	0.577
CLV_PCSK_KEX2_1	582	584	PF00082	0.717
CLV_PCSK_KEX2_1	609	611	PF00082	0.542
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.480
CLV_PCSK_SKI1_1	151	155	PF00082	0.533
CLV_PCSK_SKI1_1	326	330	PF00082	0.514
CLV_PCSK_SKI1_1	399	403	PF00082	0.562
CLV_PCSK_SKI1_1	450	454	PF00082	0.569
CLV_PCSK_SKI1_1	456	460	PF00082	0.548
CLV_PCSK_SKI1_1	521	525	PF00082	0.627
CLV_PCSK_SKI1_1	556	560	PF00082	0.497
CLV_PCSK_SKI1_1	619	623	PF00082	0.484
CLV_PCSK_SKI1_1	91	95	PF00082	0.445
DEG_APCC_DBOX_1	216	224	PF00400	0.590
DOC_CYCLIN_RxL_1	624	638	PF00134	0.641
DOC_CYCLIN_yClb5_NLxxxL_5	368	376	PF00134	0.567
DOC_MAPK_MEF2A_6	571	578	PF00069	0.599
DOC_USP7_MATH_1	153	157	PF00917	0.587
DOC_USP7_MATH_1	158	162	PF00917	0.608
DOC_USP7_MATH_1	185	189	PF00917	0.603
DOC_USP7_MATH_1	491	495	PF00917	0.548
DOC_USP7_UBL2_3	326	330	PF12436	0.579
LIG_14-3-3_CanoR_1	112	121	PF00244	0.476
LIG_14-3-3_CanoR_1	273	282	PF00244	0.531
LIG_14-3-3_CanoR_1	295	301	PF00244	0.596
LIG_14-3-3_CanoR_1	347	355	PF00244	0.546
LIG_14-3-3_CanoR_1	399	404	PF00244	0.556
LIG_14-3-3_CanoR_1	593	598	PF00244	0.640
LIG_14-3-3_CanoR_1	609	615	PF00244	0.403
LIG_Actin_WH2_2	107	124	PF00022	0.507
LIG_Actin_WH2_2	433	448	PF00022	0.446
LIG_APCC_ABBA_1	25	30	PF00400	0.456
LIG_APCC_ABBAyCdc20_2	619	625	PF00400	0.558
LIG_BIR_II_1	1	5	PF00653	0.610
LIG_CaM_IQ_9	587	602	PF13499	0.655
LIG_Clathr_ClatBox_1	387	391	PF01394	0.698
LIG_eIF4E_1	138	144	PF01652	0.583
LIG_FHA_1	432	438	PF00498	0.572
LIG_FHA_1	52	58	PF00498	0.439
LIG_FHA_1	530	536	PF00498	0.486
LIG_FHA_2	274	280	PF00498	0.586
LIG_FHA_2	297	303	PF00498	0.507
LIG_FHA_2	311	317	PF00498	0.504
LIG_FHA_2	376	382	PF00498	0.604
LIG_FHA_2	400	406	PF00498	0.584
LIG_FHA_2	408	414	PF00498	0.569
LIG_FHA_2	552	558	PF00498	0.627
LIG_GBD_Chelix_1	292	300	PF00786	0.402
LIG_GBD_Chelix_1	58	66	PF00786	0.469
LIG_LIR_Gen_1	360	366	PF02991	0.611
LIG_LIR_Nem_3	134	138	PF02991	0.509
LIG_LIR_Nem_3	255	259	PF02991	0.410
LIG_LIR_Nem_3	360	365	PF02991	0.615
LIG_NRBOX	266	272	PF00104	0.590
LIG_PCNA_yPIPBox_3	257	271	PF02747	0.598
LIG_PCNA_yPIPBox_3	26	38	PF02747	0.540
LIG_PDZ_Class_2	636	641	PF00595	0.682
LIG_SH2_PTP2	362	365	PF00017	0.561
LIG_SH2_STAT3	623	626	PF00017	0.536
LIG_SH2_STAT5	13	16	PF00017	0.549
LIG_SH2_STAT5	138	141	PF00017	0.575
LIG_SH2_STAT5	362	365	PF00017	0.561
LIG_SUMO_SIM_anti_2	219	224	PF11976	0.546
LIG_SUMO_SIM_anti_2	457	463	PF11976	0.495
LIG_SUMO_SIM_anti_2	5	10	PF11976	0.530
LIG_SUMO_SIM_par_1	386	393	PF11976	0.627
LIG_SUMO_SIM_par_1	480	486	PF11976	0.543
LIG_SUMO_SIM_par_1	572	577	PF11976	0.598
LIG_TRAF2_1	180	183	PF00917	0.569
LIG_TRAF2_1	200	203	PF00917	0.681
LIG_TRAF2_1	277	280	PF00917	0.515
LIG_TRAF2_1	299	302	PF00917	0.606
LIG_TRAF2_1	350	353	PF00917	0.579
LIG_TRAF2_1	389	392	PF00917	0.600
LIG_TRAF2_1	410	413	PF00917	0.668
LIG_TRAF2_1	44	47	PF00917	0.555
MOD_CK1_1	304	310	PF00069	0.612
MOD_CK1_1	377	383	PF00069	0.655
MOD_CK1_1	565	571	PF00069	0.640
MOD_CK2_1	203	209	PF00069	0.675
MOD_CK2_1	273	279	PF00069	0.542
MOD_CK2_1	296	302	PF00069	0.506
MOD_CK2_1	310	316	PF00069	0.504
MOD_CK2_1	336	342	PF00069	0.576
MOD_CK2_1	347	353	PF00069	0.583
MOD_CK2_1	375	381	PF00069	0.612
MOD_CK2_1	386	392	PF00069	0.559
MOD_CK2_1	399	405	PF00069	0.567
MOD_CK2_1	407	413	PF00069	0.590
MOD_CK2_1	551	557	PF00069	0.624
MOD_CK2_1	569	575	PF00069	0.626
MOD_CK2_1	89	95	PF00069	0.526
MOD_CMANNOS	193	196	PF00535	0.665
MOD_GlcNHglycan	114	117	PF01048	0.515
MOD_GlcNHglycan	155	159	PF01048	0.629
MOD_GlcNHglycan	205	208	PF01048	0.687
MOD_GlcNHglycan	610	613	PF01048	0.518
MOD_GlcNHglycan	91	94	PF01048	0.558
MOD_GSK3_1	139	146	PF00069	0.625
MOD_GSK3_1	154	161	PF00069	0.466
MOD_GSK3_1	386	393	PF00069	0.574
MOD_GSK3_1	565	572	PF00069	0.588
MOD_N-GLC_1	562	567	PF02516	0.556
MOD_NEK2_1	139	144	PF00069	0.556
MOD_NEK2_1	154	159	PF00069	0.370
MOD_NEK2_1	322	327	PF00069	0.567
MOD_NEK2_1	438	443	PF00069	0.654
MOD_NEK2_1	57	62	PF00069	0.470
MOD_PIKK_1	260	266	PF00454	0.492
MOD_PIKK_1	347	353	PF00454	0.608
MOD_PIKK_1	408	414	PF00454	0.683
MOD_PIKK_1	438	444	PF00454	0.646
MOD_PIKK_1	491	497	PF00454	0.615
MOD_PIKK_1	52	58	PF00454	0.604
MOD_PIKK_1	72	78	PF00454	0.283
MOD_PK_1	386	392	PF00069	0.629
MOD_PK_1	593	599	PF00069	0.541
MOD_PKA_1	112	118	PF00069	0.477
MOD_PKA_1	273	279	PF00069	0.588
MOD_PKA_1	399	405	PF00069	0.563
MOD_PKA_2	112	118	PF00069	0.420
MOD_PKA_2	203	209	PF00069	0.604
MOD_PKA_2	273	279	PF00069	0.542
MOD_PKA_2	304	310	PF00069	0.565
MOD_PKA_2	322	328	PF00069	0.521
MOD_PKA_2	346	352	PF00069	0.550
MOD_PKA_2	399	405	PF00069	0.598
MOD_PKA_2	408	414	PF00069	0.594
MOD_PKA_2	445	451	PF00069	0.575
MOD_PKA_2	608	614	PF00069	0.514
MOD_PKA_2	95	101	PF00069	0.568
MOD_Plk_1	301	307	PF00069	0.472
MOD_Plk_1	310	316	PF00069	0.506
MOD_Plk_1	38	44	PF00069	0.548
MOD_Plk_1	390	396	PF00069	0.658
MOD_Plk_1	565	571	PF00069	0.587
MOD_Plk_1	574	580	PF00069	0.640
MOD_Plk_1	635	641	PF00069	0.609
MOD_Plk_2-3	336	342	PF00069	0.622
MOD_Plk_2-3	95	101	PF00069	0.559
MOD_Plk_4	139	145	PF00069	0.624
MOD_Plk_4	310	316	PF00069	0.398
MOD_Plk_4	399	405	PF00069	0.588
MOD_Plk_4	565	571	PF00069	0.591
MOD_SUMO_for_1	462	465	PF00179	0.598
MOD_SUMO_for_1	538	541	PF00179	0.576
MOD_SUMO_rev_2	255	263	PF00179	0.543
MOD_SUMO_rev_2	29	34	PF00179	0.455
TRG_DiLeu_BaEn_4	301	307	PF01217	0.610
TRG_DiLeu_BaEn_4	353	359	PF01217	0.502
TRG_DiLeu_BaLyEn_6	599	604	PF01217	0.636
TRG_ENDOCYTIC_2	362	365	PF00928	0.561
TRG_ER_diArg_1	111	113	PF00400	0.547
TRG_ER_diArg_1	172	174	PF00400	0.428
TRG_ER_diArg_1	272	274	PF00400	0.639
TRG_ER_diArg_1	321	324	PF00400	0.512
TRG_ER_diArg_1	33	36	PF00400	0.517
TRG_ER_diArg_1	424	426	PF00400	0.618
TRG_ER_diArg_1	500	503	PF00400	0.413
TRG_ER_diArg_1	600	603	PF00400	0.657
TRG_NLS_MonoExtC_3	31	36	PF00514	0.516
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.485
TRG_Pf-PMV_PEXEL_1	370	375	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	602	606	PF00026	0.625

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9P5	Leptomonas seymouri	50%	100%
A0A1X0P087	Trypanosomatidae	25%	100%
A0A3S7X1I5	Leishmania donovani	92%	100%
A4HGK5	Leishmania braziliensis	80%	100%
A4I3N1	Leishmania infantum	92%	100%
E9AZX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5B7Y0	Trypanosoma cruzi	27%	100%