Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q8B1_LEIMA

TriTrypDb:

LmjF.28.1540 , LMJLV39_280023300 , LMJSD75_280022800

Length:

856

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q8B1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q8B1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	378	382	PF00656	0.539
CLV_C14_Caspase3-7	41	45	PF00656	0.662
CLV_C14_Caspase3-7	618	622	PF00656	0.537
CLV_C14_Caspase3-7	726	730	PF00656	0.585
CLV_MEL_PAP_1	159	165	PF00089	0.616
CLV_NRD_NRD_1	130	132	PF00675	0.614
CLV_NRD_NRD_1	201	203	PF00675	0.598
CLV_NRD_NRD_1	233	235	PF00675	0.618
CLV_NRD_NRD_1	421	423	PF00675	0.476
CLV_NRD_NRD_1	488	490	PF00675	0.564
CLV_NRD_NRD_1	508	510	PF00675	0.423
CLV_NRD_NRD_1	713	715	PF00675	0.618
CLV_NRD_NRD_1	768	770	PF00675	0.359
CLV_PCSK_KEX2_1	130	132	PF00082	0.614
CLV_PCSK_KEX2_1	201	203	PF00082	0.598
CLV_PCSK_KEX2_1	233	235	PF00082	0.625
CLV_PCSK_KEX2_1	421	423	PF00082	0.476
CLV_PCSK_KEX2_1	488	490	PF00082	0.564
CLV_PCSK_KEX2_1	508	510	PF00082	0.367
CLV_PCSK_KEX2_1	670	672	PF00082	0.570
CLV_PCSK_KEX2_1	712	714	PF00082	0.622
CLV_PCSK_KEX2_1	768	770	PF00082	0.487
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.614
CLV_PCSK_PC1ET2_1	670	672	PF00082	0.570
CLV_PCSK_PC7_1	126	132	PF00082	0.656
CLV_PCSK_PC7_1	197	203	PF00082	0.592
CLV_PCSK_SKI1_1	135	139	PF00082	0.633
CLV_PCSK_SKI1_1	509	513	PF00082	0.420
CLV_PCSK_SKI1_1	670	674	PF00082	0.578
CLV_PCSK_SKI1_1	717	721	PF00082	0.623
DEG_APCC_DBOX_1	508	516	PF00400	0.455
DEG_APCC_DBOX_1	542	550	PF00400	0.377
DEG_APCC_DBOX_1	768	776	PF00400	0.368
DEG_COP1_1	813	822	PF00400	0.641
DEG_SCF_FBW7_1	159	164	PF00400	0.653
DEG_SPOP_SBC_1	225	229	PF00917	0.667
DEG_SPOP_SBC_1	828	832	PF00917	0.646
DOC_MAPK_gen_1	421	427	PF00069	0.461
DOC_MAPK_gen_1	450	458	PF00069	0.428
DOC_MAPK_gen_1	712	721	PF00069	0.596
DOC_MIT_MIM_1	398	406	PF04212	0.433
DOC_PP1_RVXF_1	140	147	PF00149	0.506
DOC_PP1_RVXF_1	265	272	PF00149	0.591
DOC_PP1_RVXF_1	422	428	PF00149	0.545
DOC_PP1_RVXF_1	715	722	PF00149	0.622
DOC_PP1_SILK_1	453	458	PF00149	0.375
DOC_PP4_FxxP_1	271	274	PF00568	0.627
DOC_USP7_MATH_1	106	110	PF00917	0.596
DOC_USP7_MATH_1	161	165	PF00917	0.631
DOC_USP7_MATH_1	171	175	PF00917	0.545
DOC_USP7_MATH_1	209	213	PF00917	0.718
DOC_USP7_MATH_1	225	229	PF00917	0.638
DOC_USP7_MATH_1	282	286	PF00917	0.595
DOC_USP7_MATH_1	353	357	PF00917	0.680
DOC_USP7_MATH_1	382	386	PF00917	0.568
DOC_USP7_MATH_1	577	581	PF00917	0.652
DOC_USP7_MATH_1	639	643	PF00917	0.607
DOC_USP7_MATH_1	706	710	PF00917	0.562
DOC_USP7_MATH_1	828	832	PF00917	0.613
DOC_USP7_MATH_1	93	97	PF00917	0.770
DOC_USP7_UBL2_3	844	848	PF12436	0.565
DOC_WW_Pin1_4	102	107	PF00397	0.613
DOC_WW_Pin1_4	157	162	PF00397	0.586
DOC_WW_Pin1_4	167	172	PF00397	0.617
DOC_WW_Pin1_4	214	219	PF00397	0.636
DOC_WW_Pin1_4	232	237	PF00397	0.635
DOC_WW_Pin1_4	250	255	PF00397	0.564
DOC_WW_Pin1_4	328	333	PF00397	0.662
DOC_WW_Pin1_4	487	492	PF00397	0.604
DOC_WW_Pin1_4	601	606	PF00397	0.587
DOC_WW_Pin1_4	63	68	PF00397	0.634
DOC_WW_Pin1_4	653	658	PF00397	0.728
DOC_WW_Pin1_4	662	667	PF00397	0.596
DOC_WW_Pin1_4	750	755	PF00397	0.528
DOC_WW_Pin1_4	792	797	PF00397	0.597
DOC_WW_Pin1_4	8	13	PF00397	0.654
DOC_WW_Pin1_4	818	823	PF00397	0.633
LIG_14-3-3_CanoR_1	201	207	PF00244	0.618
LIG_14-3-3_CanoR_1	223	231	PF00244	0.667
LIG_14-3-3_CanoR_1	283	292	PF00244	0.573
LIG_14-3-3_CanoR_1	358	364	PF00244	0.578
LIG_14-3-3_CanoR_1	489	498	PF00244	0.621
LIG_14-3-3_CanoR_1	508	512	PF00244	0.332
LIG_14-3-3_CanoR_1	578	582	PF00244	0.567
LIG_14-3-3_CanoR_1	694	700	PF00244	0.710
LIG_14-3-3_CanoR_1	712	721	PF00244	0.605
LIG_14-3-3_CanoR_1	731	741	PF00244	0.548
LIG_Actin_WH2_2	137	154	PF00022	0.484
LIG_BIR_III_2	729	733	PF00653	0.578
LIG_DLG_GKlike_1	202	210	PF00625	0.633
LIG_FHA_1	158	164	PF00498	0.641
LIG_FHA_1	191	197	PF00498	0.688
LIG_FHA_1	307	313	PF00498	0.550
LIG_FHA_1	340	346	PF00498	0.620
LIG_FHA_1	37	43	PF00498	0.700
LIG_FHA_1	408	414	PF00498	0.449
LIG_FHA_1	435	441	PF00498	0.591
LIG_FHA_1	499	505	PF00498	0.601
LIG_FHA_1	51	57	PF00498	0.554
LIG_FHA_1	602	608	PF00498	0.680
LIG_FHA_1	718	724	PF00498	0.615
LIG_FHA_1	738	744	PF00498	0.373
LIG_FHA_1	789	795	PF00498	0.675
LIG_FHA_1	828	834	PF00498	0.695
LIG_FHA_2	376	382	PF00498	0.539
LIG_LIR_Apic_2	255	260	PF02991	0.585
LIG_LIR_Apic_2	268	274	PF02991	0.598
LIG_LIR_Apic_2	66	71	PF02991	0.572
LIG_LIR_Gen_1	387	397	PF02991	0.426
LIG_LIR_Gen_1	460	470	PF02991	0.384
LIG_LIR_Gen_1	753	761	PF02991	0.467
LIG_LIR_Gen_1	839	849	PF02991	0.620
LIG_LIR_Nem_3	387	392	PF02991	0.431
LIG_LIR_Nem_3	460	466	PF02991	0.523
LIG_LIR_Nem_3	753	758	PF02991	0.478
LIG_LIR_Nem_3	839	845	PF02991	0.626
LIG_LYPXL_yS_3	133	136	PF13949	0.646
LIG_SH2_CRK	257	261	PF00017	0.583
LIG_SH2_CRK	842	846	PF00017	0.621
LIG_SH2_NCK_1	257	261	PF00017	0.583
LIG_SH2_PTP2	68	71	PF00017	0.527
LIG_SH2_SRC	257	260	PF00017	0.665
LIG_SH2_STAP1	737	741	PF00017	0.453
LIG_SH2_STAT5	264	267	PF00017	0.592
LIG_SH2_STAT5	311	314	PF00017	0.535
LIG_SH2_STAT5	463	466	PF00017	0.360
LIG_SH2_STAT5	674	677	PF00017	0.583
LIG_SH2_STAT5	68	71	PF00017	0.602
LIG_SH2_STAT5	699	702	PF00017	0.639
LIG_SH3_2	121	126	PF14604	0.683
LIG_SH3_3	118	124	PF00018	0.714
LIG_SH3_3	253	259	PF00018	0.589
LIG_SH3_3	551	557	PF00018	0.518
LIG_SH3_3	6	12	PF00018	0.616
LIG_SH3_3	651	657	PF00018	0.643
LIG_SH3_3	76	82	PF00018	0.629
LIG_SH3_3	816	822	PF00018	0.637
LIG_SUMO_SIM_anti_2	740	745	PF11976	0.497
LIG_SUMO_SIM_par_1	516	522	PF11976	0.448
LIG_SUMO_SIM_par_1	52	58	PF11976	0.620
LIG_SUMO_SIM_par_1	738	745	PF11976	0.508
LIG_TRAF2_1	519	522	PF00917	0.477
LIG_TRAF2_1	764	767	PF00917	0.476
LIG_TRFH_1	721	725	PF08558	0.607
LIG_UBA3_1	743	751	PF00899	0.492
LIG_WRC_WIRS_1	467	472	PF05994	0.418
LIG_WW_3	123	127	PF00397	0.567
LIG_WW_3	575	579	PF00397	0.572
MOD_CDK_SPK_2	157	162	PF00069	0.586
MOD_CDK_SPK_2	792	797	PF00069	0.598
MOD_CDK_SPK_2	818	823	PF00069	0.642
MOD_CDK_SPxxK_3	214	221	PF00069	0.597
MOD_CK1_1	10	16	PF00069	0.750
MOD_CK1_1	157	163	PF00069	0.584
MOD_CK1_1	172	178	PF00069	0.724
MOD_CK1_1	195	201	PF00069	0.728
MOD_CK1_1	205	211	PF00069	0.658
MOD_CK1_1	216	222	PF00069	0.682
MOD_CK1_1	286	292	PF00069	0.635
MOD_CK1_1	315	321	PF00069	0.585
MOD_CK1_1	36	42	PF00069	0.681
MOD_CK1_1	385	391	PF00069	0.533
MOD_CK1_1	47	53	PF00069	0.576
MOD_CK1_1	490	496	PF00069	0.596
MOD_CK1_1	586	592	PF00069	0.594
MOD_CK1_1	595	601	PF00069	0.612
MOD_CK1_1	61	67	PF00069	0.545
MOD_CK1_1	614	620	PF00069	0.475
MOD_CK1_1	631	637	PF00069	0.634
MOD_CK1_1	644	650	PF00069	0.629
MOD_CK1_1	690	696	PF00069	0.566
MOD_CK1_1	735	741	PF00069	0.529
MOD_CK1_1	792	798	PF00069	0.538
MOD_CK1_1	821	827	PF00069	0.678
MOD_CK1_1	840	846	PF00069	0.470
MOD_CK2_1	102	108	PF00069	0.755
MOD_CK2_1	340	346	PF00069	0.614
MOD_CK2_1	35	41	PF00069	0.713
MOD_CK2_1	760	766	PF00069	0.486
MOD_DYRK1A_RPxSP_1	63	67	PF00069	0.530
MOD_GlcNHglycan	177	180	PF01048	0.577
MOD_GlcNHglycan	207	210	PF01048	0.668
MOD_GlcNHglycan	237	240	PF01048	0.813
MOD_GlcNHglycan	280	283	PF01048	0.640
MOD_GlcNHglycan	286	289	PF01048	0.586
MOD_GlcNHglycan	295	298	PF01048	0.512
MOD_GlcNHglycan	314	317	PF01048	0.497
MOD_GlcNHglycan	332	335	PF01048	0.690
MOD_GlcNHglycan	369	372	PF01048	0.570
MOD_GlcNHglycan	384	387	PF01048	0.492
MOD_GlcNHglycan	49	52	PF01048	0.617
MOD_GlcNHglycan	492	495	PF01048	0.617
MOD_GlcNHglycan	60	63	PF01048	0.553
MOD_GlcNHglycan	617	620	PF01048	0.548
MOD_GlcNHglycan	641	644	PF01048	0.681
MOD_GlcNHglycan	649	652	PF01048	0.708
MOD_GlcNHglycan	734	737	PF01048	0.552
MOD_GlcNHglycan	762	765	PF01048	0.488
MOD_GlcNHglycan	804	807	PF01048	0.626
MOD_GlcNHglycan	826	829	PF01048	0.621
MOD_GlcNHglycan	853	856	PF01048	0.580
MOD_GlcNHglycan	96	99	PF01048	0.639
MOD_GSK3_1	102	109	PF00069	0.668
MOD_GSK3_1	157	164	PF00069	0.682
MOD_GSK3_1	167	174	PF00069	0.555
MOD_GSK3_1	191	198	PF00069	0.578
MOD_GSK3_1	201	208	PF00069	0.616
MOD_GSK3_1	209	216	PF00069	0.609
MOD_GSK3_1	278	285	PF00069	0.638
MOD_GSK3_1	36	43	PF00069	0.642
MOD_GSK3_1	432	439	PF00069	0.570
MOD_GSK3_1	458	465	PF00069	0.444
MOD_GSK3_1	46	53	PF00069	0.587
MOD_GSK3_1	507	514	PF00069	0.522
MOD_GSK3_1	595	602	PF00069	0.637
MOD_GSK3_1	611	618	PF00069	0.596
MOD_GSK3_1	63	70	PF00069	0.584
MOD_GSK3_1	641	648	PF00069	0.813
MOD_GSK3_1	662	669	PF00069	0.546
MOD_GSK3_1	690	697	PF00069	0.543
MOD_GSK3_1	700	707	PF00069	0.754
MOD_GSK3_1	708	715	PF00069	0.692
MOD_GSK3_1	756	763	PF00069	0.453
MOD_GSK3_1	786	793	PF00069	0.586
MOD_GSK3_1	797	804	PF00069	0.571
MOD_GSK3_1	8	15	PF00069	0.657
MOD_GSK3_1	810	817	PF00069	0.620
MOD_GSK3_1	824	831	PF00069	0.591
MOD_GSK3_1	832	839	PF00069	0.599
MOD_GSK3_1	89	96	PF00069	0.604
MOD_LATS_1	812	818	PF00433	0.544
MOD_N-GLC_1	157	162	PF02516	0.637
MOD_N-GLC_1	283	288	PF02516	0.591
MOD_N-GLC_1	36	41	PF02516	0.694
MOD_N-GLC_1	611	616	PF02516	0.605
MOD_N-GLC_1	644	649	PF02516	0.663
MOD_N-GLC_1	662	667	PF02516	0.506
MOD_NEK2_1	111	116	PF00069	0.581
MOD_NEK2_1	19	24	PF00069	0.627
MOD_NEK2_1	190	195	PF00069	0.578
MOD_NEK2_1	196	201	PF00069	0.599
MOD_NEK2_1	307	312	PF00069	0.718
MOD_NEK2_1	392	397	PF00069	0.412
MOD_NEK2_1	434	439	PF00069	0.524
MOD_NEK2_1	458	463	PF00069	0.422
MOD_NEK2_1	511	516	PF00069	0.432
MOD_NEK2_1	571	576	PF00069	0.552
MOD_NEK2_1	606	611	PF00069	0.607
MOD_NEK2_1	615	620	PF00069	0.593
MOD_NEK2_1	760	765	PF00069	0.426
MOD_NEK2_1	790	795	PF00069	0.536
MOD_NEK2_1	94	99	PF00069	0.620
MOD_NEK2_2	442	447	PF00069	0.467
MOD_PIKK_1	135	141	PF00454	0.627
MOD_PIKK_1	458	464	PF00454	0.425
MOD_PIKK_1	706	712	PF00454	0.714
MOD_PKA_1	201	207	PF00069	0.588
MOD_PKA_1	7	13	PF00069	0.656
MOD_PKA_1	712	718	PF00069	0.612
MOD_PKA_2	161	167	PF00069	0.653
MOD_PKA_2	196	202	PF00069	0.606
MOD_PKA_2	282	288	PF00069	0.586
MOD_PKA_2	507	513	PF00069	0.371
MOD_PKA_2	577	583	PF00069	0.564
MOD_PKA_2	634	640	PF00069	0.646
MOD_PKA_2	712	718	PF00069	0.612
MOD_PKA_2	732	738	PF00069	0.475
MOD_PKA_2	840	846	PF00069	0.590
MOD_Plk_1	321	327	PF00069	0.590
MOD_Plk_1	36	42	PF00069	0.657
MOD_Plk_1	611	617	PF00069	0.643
MOD_Plk_1	814	820	PF00069	0.540
MOD_Plk_2-3	340	346	PF00069	0.704
MOD_Plk_4	106	112	PF00069	0.636
MOD_Plk_4	287	293	PF00069	0.607
MOD_Plk_4	307	313	PF00069	0.462
MOD_Plk_4	392	398	PF00069	0.411
MOD_Plk_4	451	457	PF00069	0.374
MOD_Plk_4	462	468	PF00069	0.401
MOD_Plk_4	583	589	PF00069	0.584
MOD_Plk_4	695	701	PF00069	0.633
MOD_Plk_4	756	762	PF00069	0.452
MOD_Plk_4	829	835	PF00069	0.644
MOD_ProDKin_1	102	108	PF00069	0.615
MOD_ProDKin_1	157	163	PF00069	0.586
MOD_ProDKin_1	167	173	PF00069	0.615
MOD_ProDKin_1	214	220	PF00069	0.637
MOD_ProDKin_1	232	238	PF00069	0.636
MOD_ProDKin_1	250	256	PF00069	0.562
MOD_ProDKin_1	328	334	PF00069	0.663
MOD_ProDKin_1	487	493	PF00069	0.605
MOD_ProDKin_1	601	607	PF00069	0.587
MOD_ProDKin_1	63	69	PF00069	0.634
MOD_ProDKin_1	653	659	PF00069	0.725
MOD_ProDKin_1	662	668	PF00069	0.593
MOD_ProDKin_1	750	756	PF00069	0.527
MOD_ProDKin_1	792	798	PF00069	0.598
MOD_ProDKin_1	8	14	PF00069	0.658
MOD_ProDKin_1	818	824	PF00069	0.633
MOD_SUMO_for_1	479	482	PF00179	0.436
MOD_SUMO_rev_2	3	9	PF00179	0.554
MOD_SUMO_rev_2	473	481	PF00179	0.426
TRG_DiLeu_BaEn_1	603	608	PF01217	0.680
TRG_DiLeu_BaEn_1	86	91	PF01217	0.549
TRG_ENDOCYTIC_2	133	136	PF00928	0.646
TRG_ENDOCYTIC_2	389	392	PF00928	0.437
TRG_ENDOCYTIC_2	463	466	PF00928	0.381
TRG_ENDOCYTIC_2	842	845	PF00928	0.623
TRG_ER_diArg_1	200	202	PF00400	0.595
TRG_ER_diArg_1	421	424	PF00400	0.536
TRG_ER_diArg_1	487	489	PF00400	0.560
TRG_ER_diArg_1	712	714	PF00400	0.828
TRG_ER_diArg_1	731	734	PF00400	0.497
TRG_NLS_MonoExtC_3	129	134	PF00514	0.600
TRG_NLS_MonoExtN_4	129	134	PF00514	0.580
TRG_Pf-PMV_PEXEL_1	414	419	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	547	551	PF00026	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHK2	Leptomonas seymouri	40%	100%
A0A3Q8IQL8	Leishmania donovani	87%	100%
A4HGK7	Leishmania braziliensis	57%	100%
A4I3N3	Leishmania infantum	87%	100%
E9AZX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	99%